---
title: "Thermosensitive Hydrogel with Catanionic Vesicles for Localized Doxorubicin Delivery in Melanoma"
id: "pubmed-42504495"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42504495"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42504495/"
doi: "10.1021/acsabm.6c00633"
published_at: "2026-08-17T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Thermosensitive Hydrogel with Catanionic Vesicles for Localized Doxorubicin Delivery in Melanoma
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42504495
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42504495/)
- **DOI:** [10.1021/acsabm.6c00633](https://doi.org/10.1021%2Facsabm.6c00633)
- **Published At:** 2026-08-17T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study describes a thermosensitive hybrid hydrogel designed as a localized delivery platform for **doxorubicin (DOX)** targeting melanoma. - The system embeds pH-sensitive **12-2-12/SLSar catanionic vesicles** loaded with DOX into a **poloxamer F87 (poloxamer 237)** thermoresponsive scaffold. - Comprehensive characterization included rheological behavior, biocompatibility, in vitro drug-release kinetics, and anti-melanoma efficacy in both 2D monolayer cultures and 3D spheroids. - Molecular-level investigations showed strong **polymer–surfactant interactions** that produce mixed polymer/surfactant micelles and vesicles and alter aggregate physicochemical properties, notably surface charge. - These polymer–surfactant interactions were thermally driven and depended markedly on the polymer-to-surfactant ratio. - The catanionic vesicles demonstrated high DOX encapsulation efficiency and remained stably dispersed within the F87 hydrogel matrix. - The hybrid hydrogel exhibited controlled release kinetics, offering potential advantages over vesicle-only formulations for localized delivery. - Biocompatibility testing indicated an excellent safety profile for the hybrid system relative to vehicle controls reported in the source. - Functionally, the hybrid hydrogel improved DOX internalization by melanoma cells and induced greater melanoma cell death in vitro than neat F87 hydrogels. - The authors present this hybrid thermoresponsive polymeric scaffold as a tunable and versatile platform for localized melanoma therapy using embedded surfactant-based vesicles.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 CIQUP (Centre of Research in Chemistry), IMS (Institute of Molecular Sciences), Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007Porto, Portugal. * 2 CBMA (Centre of Molecular and Environmental Biology), Department of Biology, School of Sciences, University of Minho, Campus of Gualtar, 4710-057Braga, Portugal. * PMID: **42504495** * DOI: [ 10.1021/acsabm.6c00633 ](https://doi.org/10.1021/acsabm.6c00633) Item in Clipboard # Thermosensitive Block Copolymer Hydrogel with Embedded Catanionic Vesicles as a Localized Doxorubicin Delivery Platform for Melanoma Rui L Machado et al. ACS Appl Bio Mater. 2026. Show details Display options Display options Format Abstract PubMed PMID ACS Appl Bio Mater Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22ACS+Appl+Bio+Mater%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22ACS+Appl+Bio+Mater%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42504495/) . 2026 Aug 17;9(16):7467-7485. doi: 10.1021/acsabm.6c00633. ### Authors [Rui L Machado](https://pubmed.ncbi.nlm.nih.gov/?term=Machado+RL&cauthor_id=42504495)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42504495/#short-view-affiliation-1 "CIQUP \(Centre of Research in Chemistry\), IMS \(Institute of Molecular Sciences\), Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007Porto, Portugal."), [Aitana Zoco](https://pubmed.ncbi.nlm.nih.gov/?term=Zoco+A&cauthor_id=42504495)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42504495/#short-view-affiliation-1 "CIQUP \(Centre of Research in Chemistry\), IMS \(Institute of Molecular Sciences\), Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007Porto, Portugal."), [Isabel S Oliveira](https://pubmed.ncbi.nlm.nih.gov/?term=Oliveira+IS&cauthor_id=42504495)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42504495/#short-view-affiliation-1 "CIQUP \(Centre of Research in Chemistry\), IMS \(Institute of Molecular Sciences\), Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007Porto, Portugal."), [Bruna Silva](https://pubmed.ncbi.nlm.nih.gov/?term=Silva+B&cauthor_id=42504495)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42504495/#short-view-affiliation-2 "CBMA \(Centre of Molecular and Environmental Biology\), Department of Biology, School of Sciences, University of Minho, Campus of Gualtar, 4710-057Braga, Portugal."), [Andreia C Gomes](https://pubmed.ncbi.nlm.nih.gov/?term=Gomes+AC&cauthor_id=42504495)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42504495/#short-view-affiliation-2 "CBMA \(Centre of Molecular and Environmental Biology\), Department of Biology, School of Sciences, University of Minho, Campus of Gualtar, 4710-057Braga, Portugal."), [Eduardo F Marques](https://pubmed.ncbi.nlm.nih.gov/?term=Marques+EF&cauthor_id=42504495)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42504495/#short-view-affiliation-1 "CIQUP \(Centre of Research in Chemistry\), IMS \(Institute of Molecular Sciences\), Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007Porto, Portugal.") ### Affiliations * 1 CIQUP (Centre of Research in Chemistry), IMS (Institute of Molecular Sciences), Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007Porto, Portugal. * 2 CBMA (Centre of Molecular and Environmental Biology), Department of Biology, School of Sciences, University of Minho, Campus of Gualtar, 4710-057Braga, Portugal. * PMID: **42504495** * DOI: [ 10.1021/acsabm.6c00633 ](https://doi.org/10.1021/acsabm.6c00633) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Skin cancer, particularly melanoma, remains a major therapeutic challenge due to its high metastatic potential and limited efficacy of systemic chemotherapy. Localized and controlled delivery of chemotherapeutic agents such as doxorubicin (DOX) represents a promising alternative to systemic treatments and costly immunotherapies. Hybrid hydrogels that integrate polymeric scaffolds with embedded nanostructures (e.g., vesicles, micelles, or nanoparticles) have emerged as particularly effective platforms for enhancing therapeutic performance. Herein, we report the development of a thermosensitive hybrid hydrogel for potential melanoma drug delivery applications, obtained by dispersing DOX-loaded, pH-sensitive 12-2-12/SLSar catanionic vesicles within a poloxamer 237 (F87) scaffold. The system was comprehensively characterized in terms of rheological behavior, biocompatibility, drug-release kinetics, and in vitro anti-melanoma activity in 2D monolayer cell cultures and 3D spheroids. In parallel, molecular-level interactions between the F87 matrix and the surfactant-based vesicles were investigated. Strong polymer-surfactant interactions were observed, leading to the formation of mixed polymer/surfactant micelles and vesicles, and inducing significant modifications in aggregate physicochemical properties, particularly surface charge. These interactions were found to be thermally driven and strongly dependent on the polymer-to-surfactant ratio. The catanionic vesicles exhibited high DOX encapsulation efficiency and remained stably dispersed within the F87 scaffold. The resulting hybrid hydrogel demonstrated controlled release kinetics, offering potential advantages for localized drug delivery compared with vesicle-only formulations. Moreover, the hybrid system demonstrated excellent biocompatibility and significantly outperformed neat F87 hydrogels in enhancing DOX internalization and inducing melanoma cell death in vitro. Overall, this work presents a versatile and tunable strategy for integrating catanionic vesicles into thermosensitive polymeric scaffolds, providing a promising platform for localized melanoma drug delivery. **Keywords:** catanionic vesicles; controlled release; melanoma therapy; poloxamer F87; polymer/surfactant interactions; thermoresponsive hydrogel. © 2026 The Authors. Published by American Chemical Society. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Nonfouling Core-Shell Microneedle for Sequential and Sustained Drug Release: Enhancing Synergistic Photothermal Chemotherapy in Melanoma Treatment. ](https://pubmed.ncbi.nlm.nih.gov/40180602/) Huang D, Yu Q, Yang K, Li X, Huang C, Yang X, Wu C, Cao C, Zhang L, Zhu D, Li J.Huang D, et al.ACS Appl Bio Mater. 2025 Apr 21;8(4):3356-3374. doi: 10.1021/acsabm.5c00120. 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Epub 2026 Mar 31.ACS Appl Bio Mater. 2026.PMID: 41915704 * [ Poly(d,l-lactide-_co_ -glycolide) Nanoparticles Encapsulating Doxorubicin for Improved Treatment in Cholangiocarcinoma and Drug-Resistant Cells. ](https://pubmed.ncbi.nlm.nih.gov/40533874/) Rattanaseth P, Katewongsa K, Intuyod K, Pinlaor S, Thanan R, Sakonsinsiri C.Rattanaseth P, et al.ACS Appl Bio Mater. 2025 Jul 21;8(7):6055-6065. doi: 10.1021/acsabm.5c00628. Epub 2025 Jun 18.ACS Appl Bio Mater. 2025.PMID: 40533874Free PMC article. * [ Beyond nanomicelles and hydrogels: exploring micelle-containing hydrogels as cutting-edge drug delivery system for effective breast cancer treatment. ](https://pubmed.ncbi.nlm.nih.gov/41151737/) Bishnoi A, Bonde GV.Bishnoi A, et al.Int J Pharm. 2025 Dec 25;686:126307. doi: 10.1016/j.ijpharm.2025.126307. Epub 2025 Oct 26.Int J Pharm. 2025.PMID: 41151737Review. 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