---
title: "Three-Dimensional Malignant Transition: Spatial Profiling Links Precancer to Invasion in Breast an"
id: "pubmed-42676100"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42676100"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42676100/"
doi: "10.1158/2159-8290.CD-26-1266"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Three-Dimensional Malignant Transition: Spatial Profiling Links Precancer to Invasion in Breast an
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42676100
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42676100/)
- **DOI:** [10.1158/2159-8290.CD-26-1266](https://doi.org/10.1158%2F2159-8290.CD-26-1266)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Breast and **prostate** cancers show notable parallels in how they progress from precancerous lesions to invasive disease, offering an opportunity to identify shared mechanisms of malignant transition. - Storrs and colleagues integrated **volumetric reconstruction** with **multimodal spatial profiling** to analyze the precancer-to-cancer transition in three dimensions. - The group characterized the transition as a continuous **three-dimensional** process rather than a discrete, binary step. - Their work identified **shared molecular programs** associated with **invasion** across both cancer types. - The study demonstrates the value of combining high-resolution spatial technologies with volumetric tissue reconstruction to reveal processes that are not apparent in two-dimensional sections. - The PubMed abstract highlights the methodological integration and the conceptual finding but does not report specific genes, pathways, sample numbers, or quantitative results; those details are in the related article by Storrs et al. - This approach may inform future comparative studies across tumor types and guide spatially informed biomarkers or therapeutic strategies, but specific translational implications were not enumerated in the abstract.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Statistical Center for Single-Cell and Spatial Genomics, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. * 2 Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. * PMID: **42676100** * DOI: [ 10.1158/2159-8290.CD-26-1266 ](https://doi.org/10.1158/2159-8290.cd-26-1266) Item in Clipboard # Malignant Transition in Three Dimensions Zehua Jing et al. Cancer Discov. 2026. Show details Display options Display options Format Abstract PubMed PMID Cancer Discov Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer+Discov%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cancer+Discov%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42676100/) . 2026 Sep 1;16(9):1720-1723. doi: 10.1158/2159-8290.CD-26-1266. ### Authors [Zehua Jing](https://pubmed.ncbi.nlm.nih.gov/?term=Jing+Z&cauthor_id=42676100)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42676100/#short-view-affiliation-1 "Statistical Center for Single-Cell and Spatial Genomics, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania."), [Mingyao Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+M&cauthor_id=42676100)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42676100/#short-view-affiliation-1 "Statistical Center for Single-Cell and Spatial Genomics, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42676100/#short-view-affiliation-2 "Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.") ### Affiliations * 1 Statistical Center for Single-Cell and Spatial Genomics, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. * 2 Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. * PMID: **42676100** * DOI: [ 10.1158/2159-8290.CD-26-1266 ](https://doi.org/10.1158/2159-8290.cd-26-1266) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Breast and prostate cancers share notable similarities in their progression to invasive disease, providing a unique opportunity to uncover common mechanisms of malignant transition. By integrating volumetric reconstruction with multimodal spatial profiling, Storrs and colleagues revealed the precancer-to-cancer transition as a continuous three-dimensional process and identified shared molecular programs associated with invasion. See related article by Storrs et al., p. 1819. ©2026 American Association for Cancer Research. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Breast and prostate cancers harbor common somatic copy number alterations that consistently differ by race and are associated with survival. ](https://pubmed.ncbi.nlm.nih.gov/32819446/) Chen Y, Sadasivan SM, She R, Datta I, Taneja K, Chitale D, Gupta N, Davis MB, Newman LA, Rogers CG, Paris PL, Li J, Rybicki BA, Levin AM.Chen Y, et al.BMC Med Genomics. 2020 Aug 20;13(1):116. doi: 10.1186/s12920-020-00765-2.BMC Med Genomics. 2020.PMID: 32819446Free PMC article. * [ Molecular insights into prostate cancer progression: the missing link of tumor microenvironment. ](https://pubmed.ncbi.nlm.nih.gov/15592017/) Chung LW, Baseman A, Assikis V, Zhau HE.Chung LW, et al.J Urol. 2005 Jan;173(1):10-20. doi: 10.1097/01.ju.0000141582.15218.10.J Urol. 2005.PMID: 15592017Review. * [ Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. ](https://pubmed.ncbi.nlm.nih.gov/26384318/) Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, Ricci L, Fan F, Tawfik O, Marks JR, Knapp JR, Yeh HW, Thomas P, Carrasco DR, Fields TA, Godwin AK, Behbod F.Elsarraj HS, et al.Breast Cancer Res. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z.Breast Cancer Res. 2015.PMID: 26384318Free PMC article. * [ Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs. ](https://pubmed.ncbi.nlm.nih.gov/15342375/) Ashida S, Nakagawa H, Katagiri T, Furihata M, Iiizumi M, Anazawa Y, Tsunoda T, Takata R, Kasahara K, Miki T, Fujioka T, Shuin T, Nakamura Y.Ashida S, et al.Cancer Res. 2004 Sep 1;64(17):5963-72. doi: 10.1158/0008-5472.CAN-04-0020.Cancer Res. 2004.PMID: 15342375 * [ Possible Roles for Purinergic Receptor P2RX4 in Breast and Prostate Cancers. ](https://pubmed.ncbi.nlm.nih.gov/41009609/) Ho WHJ, Lam KP.Ho WHJ, et al.Int J Mol Sci. 2025 Sep 17;26(18):9043. doi: 10.3390/ijms26189043.Int J Mol Sci. 2025.PMID: 41009609Free PMC article.Review. 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