---
title: "Three-gene prognostic signature (ABCE1, ATAD5, FUT4) for colorectal cancer"
id: "pubmed-42349120"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42349120"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42349120/"
doi: "10.1016/j.bbrc.2026.154124"
published_at: "2026-09-03T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Three-gene prognostic signature (ABCE1, ATAD5, FUT4) for colorectal cancer
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42349120
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42349120/)
- **DOI:** [10.1016/j.bbrc.2026.154124](https://doi.org/10.1016%2Fj.bbrc.2026.154124)
- **Published At:** 2026-09-03T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This study identified and validated a compact three-gene signature—**ABCE1**, **ATAD5**, and **FUT4**—for colorectal cancer (CRC) prognosis using an integrative multi-omics strategy. - Sample sources included paired tumor and adjacent tissues from 15 patients plus public transcriptomic datasets (TCGA, GSE231559). - Machine learning methods (LASSO, SVM-RFE) were applied to derive the signature and prioritize genes. - The three genes were consistently upregulated in tumor tissue and validated by qPCR in the study cohort. - Functional annotations linked ABCE1 to protein synthesis and immune modulation, ATAD5 to DNA replication stress response, and FUT4 to cell adhesion and immune evasion. - Diagnostic performance of the signature showed high accuracy with an reported AUC of 0.85. - Prognostically, the signature stratified patients into distinct risk groups with significantly different survival outcomes. - Single-cell RNA-seq localized gene expression to specific cellular compartments, and immune deconvolution correlated the signature with a **macrophage-dominated** tumor microenvironment. - A clinically interpretable nomogram incorporating the signature was developed and reported to have excellent calibration. - The authors conclude the three-gene panel is a biologically coherent, tissue-based molecular classifier for CRC with potential implications for therapeutic targeting and clinical risk stratification.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 18. # A three-gene signature (ABCE1, ATAD5, FUT4) for colorectal cancer prognosis: integrative analysis of transcriptomic, single-cell, and machine learning data [Yong Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Y&cauthor_id=42349120)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#full-view-affiliation-1 "The Clinical College, Anhui Medical University, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China; Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Tianbing Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+T&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#full-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Jian He](https://pubmed.ncbi.nlm.nih.gov/?term=He+J&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#full-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Tao Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+T&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#full-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Rong Jin](https://pubmed.ncbi.nlm.nih.gov/?term=Jin+R&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#full-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Dalong Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+D&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#full-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Zhiqi Hu](https://pubmed.ncbi.nlm.nih.gov/?term=Hu+Z&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#full-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Qing Pang](https://pubmed.ncbi.nlm.nih.gov/?term=Pang+Q&cauthor_id=42349120)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#full-view-affiliation-3 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. Electronic address: portxiu2@126.com."), [Huichun Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42349120)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#full-view-affiliation-4 "The Clinical College, Anhui Medical University, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China; Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. Electronic address: liuhcdoctor@126.com.") Affiliations Expand ### Affiliations * 1 The Clinical College, Anhui Medical University, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China; Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. * 2 Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. * 3 Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. Electronic address: portxiu2@126.com. * 4 The Clinical College, Anhui Medical University, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China; Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. Electronic address: liuhcdoctor@126.com. * PMID: **42349120** * DOI: [ 10.1016/j.bbrc.2026.154124 ](https://doi.org/10.1016/j.bbrc.2026.154124) Item in Clipboard # A three-gene signature (ABCE1, ATAD5, FUT4) for colorectal cancer prognosis: integrative analysis of transcriptomic, single-cell, and machine learning data Yong Wang et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42349120/) . 2026 Sep 3:829:154124. doi: 10.1016/j.bbrc.2026.154124. Epub 2026 Jun 18. ### Authors [Yong Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Y&cauthor_id=42349120)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#short-view-affiliation-1 "The Clinical College, Anhui Medical University, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China; Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Tianbing Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+T&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#short-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Jian He](https://pubmed.ncbi.nlm.nih.gov/?term=He+J&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#short-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Tao Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+T&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#short-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Rong Jin](https://pubmed.ncbi.nlm.nih.gov/?term=Jin+R&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#short-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Dalong Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+D&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#short-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Zhiqi Hu](https://pubmed.ncbi.nlm.nih.gov/?term=Hu+Z&cauthor_id=42349120)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#short-view-affiliation-2 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China."), [Qing Pang](https://pubmed.ncbi.nlm.nih.gov/?term=Pang+Q&cauthor_id=42349120)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#short-view-affiliation-3 "Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. Electronic address: portxiu2@126.com."), [Huichun Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42349120)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42349120/#short-view-affiliation-4 "The Clinical College, Anhui Medical University, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China; Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. Electronic address: liuhcdoctor@126.com.") ### Affiliations * 1 The Clinical College, Anhui Medical University, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China; Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. * 2 Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. * 3 Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. Electronic address: portxiu2@126.com. * 4 The Clinical College, Anhui Medical University, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China; Department of General Surgery, Anhui No.2 Provincial People's Hospital, Hefei, Anhui, 230041, China. Electronic address: liuhcdoctor@126.com. * PMID: **42349120** * DOI: [ 10.1016/j.bbrc.2026.154124 ](https://doi.org/10.1016/j.bbrc.2026.154124) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Colorectal cancer (CRC) remains a leading cause of cancer-related death, highlighting an unmet need for robust, mechanistically grounded prognostic biomarkers. Through an integrative multi-omics approach, we identified and validated a novel three-gene signature for CRC. Utilizing paired tumor and adjacent tissues from 15 patients, public datasets (TCGA, GSE231559), and machine learning (LASSO, SVM-RFE), we derived a signature comprising ABCE1, ATAD5, and FUT4. These genes were consistently upregulated in tumors, as confirmed by qPCR, and are functionally linked to core oncogenic pathways: ABCE1 (protein synthesis/immune modulation), ATAD5 (DNA replication stress response), and FUT4 (cell adhesion/immune evasion). The signature demonstrated high diagnostic accuracy (AUC 0.85) and significant prognostic value, stratifying patients into distinct risk groups with divergent survival outcomes. Single-cell RNA-seq analysis localized expression to specific cellular compartments, while immune deconvolution revealed a correlated macrophage-dominated microenvironment. A clinically interpretable nomogram was developed with excellent calibration. This study establishes a compact, biologically coherent three-gene signature as a promising tissue-based molecular classifier for CRC, offering novel insights into the intertwined mechanisms of metabolism, genomic instability, and immune suppression, and presenting potential targets for therapeutic development. **Keywords:** Colorectal cancer; Gene signature; Machine learning; Prognostic biomarkers; Single-cell rna sequencing; Transcriptomic analysis. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Integrative Single-Cell and Bulk RNA Sequencing Identifies a Macrophage-Related Prognostic Signature for Predicting Prognosis and Therapy Responses in Colorectal Cancer. ](https://pubmed.ncbi.nlm.nih.gov/39859524/) Xie S, Hou S, Chen J, Qi X.Xie S, et al.Int J Mol Sci. 2025 Jan 19;26(2):811. doi: 10.3390/ijms26020811.Int J Mol Sci. 2025.PMID: 39859524Free PMC article. * [ Tumor-infiltrating immune cell signature score reveals prognostic biomarkers and therapeutic targets for colorectal cancer. ](https://pubmed.ncbi.nlm.nih.gov/40438100/) Zuo X, Long W, Lin K, Jia G.Zuo X, et al.Front Immunol. 2025 May 14;16:1583327. doi: 10.3389/fimmu.2025.1583327. eCollection 2025.Front Immunol. 2025.PMID: 40438100Free PMC article. * [ Multi-omics profiling of sodium-overload (NECSO) programs identifies NEK8 as a central driver of colorectal cancer progression through single-cell and spatial transcriptomics. ](https://pubmed.ncbi.nlm.nih.gov/41743703/) Ji Y, Yu B, Yin X, Yu T, Wu X, Zhao Z, Wang Z, Gao X, Zhao J, Fang Z, Wang Y, Yu Y.Ji Y, et al.Front Immunol. 2026 Feb 10;17:1765055. doi: 10.3389/fimmu.2026.1765055. eCollection 2026.Front Immunol. 2026.PMID: 41743703Free PMC article. * [ Integrated multi-omics and machine learning reveal an immunogenic cell death-related signature for prognostic stratification and therapeutic optimization in colorectal cancer. ](https://pubmed.ncbi.nlm.nih.gov/40740776/) Hou S, Heng S, Xie S, Zhao Y, Chen J, Yu C, Lin Y, Qi X.Hou S, et al.Front Immunol. 2025 Jul 16;16:1606874. doi: 10.3389/fimmu.2025.1606874. eCollection 2025.Front Immunol. 2025.PMID: 40740776Free PMC article. * [ Integrative meta-analysis and experimental validation reveal the oncogenic role of SACS and its therapeutic targeting potential in colorectal cancer. ](https://pubmed.ncbi.nlm.nih.gov/41219406/) Chen C, Li J, Wen B, Dou W, Zhu H.Chen C, et al.Sci Rep. 2025 Nov 11;15(1):39522. doi: 10.1038/s41598-025-23339-7.Sci Rep. 2025.PMID: 41219406Free PMC article. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42349120) ## MeSH terms * ATPases Associated with Diverse Cellular Activities* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22ATPases+Associated+with+Diverse+Cellular+Activities%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=ATPases+Associated+with+Diverse+Cellular+Activities) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42349120/) * Biomarkers, Tumor / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biomarkers%2C+Tumor%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Biomarkers%2C+Tumor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42349120/) * Colorectal Neoplasms* / diagnosis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+Neoplasms%2Fdiagnosis%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colorectal+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42349120/) * Colorectal Neoplasms* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colorectal+N
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