---
title: "Treatment-free remission and immune profiling after frontline second-generation TKI therapy in CML"
id: "pubmed-42314090"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42314090"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42314090/"
doi: "10.1182/bloodadvances.2026020915"
published_at: "2026-09-22T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Treatment-free remission and immune profiling after frontline second-generation TKI therapy in CML
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42314090
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42314090/)
- **DOI:** [10.1182/bloodadvances.2026020915](https://doi.org/10.1182%2Fbloodadvances.2026020915)
- **Published At:** 2026-09-22T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Article title: "Treatment-free remission and immune profiling after frontline second-generation TKI therapy in CML." - Published in Blood Advances on 22 September 2026; Volume 10, Issue 18, pages 6255–6267. DOI: 10.1182/bloodadvances.2026020915; PMID: 42314090. The article is listed as a free article on PubMed. - Lead and corresponding authors include Naoto Takahashi and a multi-institutional Japanese collaborative author group representing at least 19 departmental affiliations across academic and clinical centers in Japan. - Topic focus (from title): clinical outcomes of **treatment-free remission** (TFR) and associated **immune profiling** after frontline use of **second-generation tyrosine kinase inhibitors (TKIs)** in chronic myeloid leukemia (**CML**). - The PubMed entry provides full bibliographic metadata, author names and institutional affiliations, journal citation, DOI, and PMID but does not include the article abstract or study-specific numeric results in the provided source text. - Full-text access links are available via publisher sites (Blood Advances / Silverchair and Elsevier links shown on PubMed), but the source text here does not include the study methods, patient numbers, eligibility criteria, TKI agents used, duration of therapy, definitions of molecular response or TFR criteria, immune profiling methods, statistical analyses, key outcome data (TFR rates, relapse rates, timelines), or safety/adverse event data. - Because the PubMed page content provided is limited to bibliographic and author/affiliation information, any specific efficacy, safety, or immune biomarker findings from the study were not reported in the source text and therefore cannot be summarized here. - Readers should consult the full text via the supplied publisher links or the journal to obtain the complete abstract, methods, results, and conclusions for clinical application and detailed interpretation.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42314090/#supplemental-data) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42314090/#related-links) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42314090/#linkout) Title & authors Abstract Similar articles MeSH terms Substances Associated data Related information LinkOut - more resources Blood Adv Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Blood+Adv%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Blood+Adv%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42314090/) . 2026 Sep 22;10(18):6255-6267. doi: 10.1182/bloodadvances.2026020915. # Treatment-free remission and immune profiling after frontline second-generation TKI therapy in CML [Naoto Takahashi](https://pubmed.ncbi.nlm.nih.gov/?term=Takahashi+N&cauthor_id=42314090)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-1 "Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan."), [Yosuke Minami](https://pubmed.ncbi.nlm.nih.gov/?term=Minami+Y&cauthor_id=42314090)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-2 "Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan."), [Yuki Fujioka](https://pubmed.ncbi.nlm.nih.gov/?term=Fujioka+Y&cauthor_id=42314090)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-1 "Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan."), [Shigeki Ohtake](https://pubmed.ncbi.nlm.nih.gov/?term=Ohtake+S&cauthor_id=42314090)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-3 "Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan."), [Yoshiko Atsuta](https://pubmed.ncbi.nlm.nih.gov/?term=Atsuta+Y&cauthor_id=42314090)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-4 "Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-5 "Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan."), [Mio Kurata](https://pubmed.ncbi.nlm.nih.gov/?term=Kurata+M&cauthor_id=42314090)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-4 "Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan."), [Takaaki Ono](https://pubmed.ncbi.nlm.nih.gov/?term=Ono+T&cauthor_id=42314090)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-6 "Department of Transfusion and Cell Therapy, Hamamatsu University Hospital, Hamamatsu, Japan."), [Shinya Sato](https://pubmed.ncbi.nlm.nih.gov/?term=Sato+S&cauthor_id=42314090)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-7 "Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan."), [Shingo Yano](https://pubmed.ncbi.nlm.nih.gov/?term=Yano+S&cauthor_id=42314090)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-8 "Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan."), [Katsumichi Fujimaki](https://pubmed.ncbi.nlm.nih.gov/?term=Fujimaki+K&cauthor_id=42314090)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-9 "Department of Hematology, Fujisawa City Hospital, Fujisawa, Japan."), [Takeshi Maeda](https://pubmed.ncbi.nlm.nih.gov/?term=Maeda+T&cauthor_id=42314090)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-10 "Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan."), [Yukiyasu Ozawa](https://pubmed.ncbi.nlm.nih.gov/?term=Ozawa+Y&cauthor_id=42314090)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-11 "Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan."), [Emiko Sakaida](https://pubmed.ncbi.nlm.nih.gov/?term=Sakaida+E&cauthor_id=42314090)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-12 "Department of Hematology, Chiba University Hospital, Chiba, Japan."), [Takeshi Kondo](https://pubmed.ncbi.nlm.nih.gov/?term=Kondo+T&cauthor_id=42314090)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-13 "Blood Disorders Center, Aiiku Hospital, Sapporo, Japan."), [Masahide Yamamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Yamamoto+M&cauthor_id=42314090)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-14 "Department of Hematology, Institute of Science Tokyo, Tokyo, Japan."), [Noriyoshi Iriyama](https://pubmed.ncbi.nlm.nih.gov/?term=Iriyama+N&cauthor_id=42314090)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-15 "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan."), [Toshihiro Miyamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Miyamoto+T&cauthor_id=42314090)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-3 "Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.")[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-16 "Department of Medicine and Biosystemic Science, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan."), [Hitoshi Kiyoi](https://pubmed.ncbi.nlm.nih.gov/?term=Kiyoi+H&cauthor_id=42314090)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-17 "Department of Hematology and Oncology, Graduate School of Medicine, Nagoya University, Nagoya, Japan."), [Yasushi Miyazaki](https://pubmed.ncbi.nlm.nih.gov/?term=Miyazaki+Y&cauthor_id=42314090)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-18 "Department of Hematology, Unit for Radiation Effects on Humans, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan."), [Itaru Matsumura](https://pubmed.ncbi.nlm.nih.gov/?term=Matsumura+I&cauthor_id=42314090)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#full-view-affiliation-19 "Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka Sakai, Japan.") Affiliations Expand ### Affiliations * 1 Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan. * 2 Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan. * 3 Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. * 4 Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan. * 5 Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan. * 6 Department of Transfusion and Cell Therapy, Hamamatsu University Hospital, Hamamatsu, Japan. * 7 Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan. * 8 Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. * 9 Department of Hematology, Fujisawa City Hospital, Fujisawa, Japan. * 10 Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan. * 11 Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan. * 12 Department of Hematology, Chiba University Hospital, Chiba, Japan. * 13 Blood Disorders Center, Aiiku Hospital, Sapporo, Japan. * 14 Department of Hematology, Institute of Science Tokyo, Tokyo, Japan. * 15 Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan. * 16 Department of Medicine and Biosystemic Science, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. * 17 Department of Hematology and Oncology, Graduate School of Medicine, Nagoya University, Nagoya, Japan. * 18 Department of Hematology, Unit for Radiation Effects on Humans, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan. * 19 Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka Sakai, Japan. * PMID: **42314090** * DOI: [ 10.1182/bloodadvances.2026020915 ](https://doi.org/10.1182/bloodadvances.2026020915) Free article Item in Clipboard # Treatment-free remission and immune profiling after frontline second-generation TKI therapy in CML Naoto Takahashi et al. Blood Adv. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Blood Adv Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Blood+Adv%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Blood+Adv%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42314090/) . 2026 Sep 22;10(18):6255-6267. doi: 10.1182/bloodadvances.2026020915. ### Authors [Naoto Takahashi](https://pubmed.ncbi.nlm.nih.gov/?term=Takahashi+N&cauthor_id=42314090)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-1 "Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan."), [Yosuke Minami](https://pubmed.ncbi.nlm.nih.gov/?term=Minami+Y&cauthor_id=42314090)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-2 "Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan."), [Yuki Fujioka](https://pubmed.ncbi.nlm.nih.gov/?term=Fujioka+Y&cauthor_id=42314090)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-1 "Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan."), [Shigeki Ohtake](https://pubmed.ncbi.nlm.nih.gov/?term=Ohtake+S&cauthor_id=42314090)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-3 "Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan."), [Yoshiko Atsuta](https://pubmed.ncbi.nlm.nih.gov/?term=Atsuta+Y&cauthor_id=42314090)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-4 "Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-5 "Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan."), [Mio Kurata](https://pubmed.ncbi.nlm.nih.gov/?term=Kurata+M&cauthor_id=42314090)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-4 "Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan."), [Takaaki Ono](https://pubmed.ncbi.nlm.nih.gov/?term=Ono+T&cauthor_id=42314090)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-6 "Department of Transfusion and Cell Therapy, Hamamatsu University Hospital, Hamamatsu, Japan."), [Shinya Sato](https://pubmed.ncbi.nlm.nih.gov/?term=Sato+S&cauthor_id=42314090)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-7 "Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan."), [Shingo Yano](https://pubmed.ncbi.nlm.nih.gov/?term=Yano+S&cauthor_id=42314090)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-8 "Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan."), [Katsumichi Fujimaki](https://pubmed.ncbi.nlm.nih.gov/?term=Fujimaki+K&cauthor_id=42314090)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-9 "Department of Hematology, Fujisawa City Hospital, Fujisawa, Japan."), [Takeshi Maeda](https://pubmed.ncbi.nlm.nih.gov/?term=Maeda+T&cauthor_id=42314090)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-10 "Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan."), [Yukiyasu Ozawa](https://pubmed.ncbi.nlm.nih.gov/?term=Ozawa+Y&cauthor_id=42314090)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-11 "Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan."), [Emiko Sakaida](https://pubmed.ncbi.nlm.nih.gov/?term=Sakaida+E&cauthor_id=42314090)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-12 "Department of Hematology, Chiba University Hospital, Chiba, Japan."), [Takeshi Kondo](https://pubmed.ncbi.nlm.nih.gov/?term=Kondo+T&cauthor_id=42314090)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-13 "Blood Disorders Center, Aiiku Hospital, Sapporo, Japan."), [Masahide Yamamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Yamamoto+M&cauthor_id=42314090)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-14 "Department of Hematology, Institute of Science Tokyo, Tokyo, Japan."), [Noriyoshi Iriyama](https://pubmed.ncbi.nlm.nih.gov/?term=Iriyama+N&cauthor_id=42314090)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-15 "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan."), [Toshihiro Miyamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Miyamoto+T&cauthor_id=42314090)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-3 "Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.")[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42314090/#short-view-affiliation-16 "Department of Medicine and Biosystemic Science, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan."), [Hitoshi Kiyoi](https:
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