---
title: "USP16 drives osteosarcoma progression by stabilizing ESRRA and enhancing mitochondrial OXPHOS"
id: "pubmed-42659864"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42659864"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42659864/"
doi: "10.1016/j.bbrc.2026.154473"
published_at: "2026-10-08T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# USP16 drives osteosarcoma progression by stabilizing ESRRA and enhancing mitochondrial OXPHOS
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42659864
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42659864/)
- **DOI:** [10.1016/j.bbrc.2026.154473](https://doi.org/10.1016%2Fj.bbrc.2026.154473)
- **Published At:** 2026-10-08T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Osteosarcoma shows metabolic reprogramming; the study identifies **USP16** as an oncogenic driver in osteosarcoma. - Bioinformatics analysis indicated **USP16** is markedly upregulated in osteosarcoma tissues and correlates with poorer patient prognosis. - Loss of USP16 reduced osteosarcoma cell proliferation and colony formation in vitro and suppressed subcutaneous xenograft growth in vivo, with concurrent downregulation of cell cycle regulators. - Overexpression of USP16 promoted cell proliferation in osteosarcoma models. - Seahorse extracellular flux assays showed USP16 depletion markedly impaired mitochondrial oxygen consumption rate (OCR) and parameters of **oxidative phosphorylation (OXPHOS)**. - Mechanistically, USP16 deubiquitinates and stabilizes **ESRRA** (estrogen-related receptor alpha), sustaining mitochondrial respiration. - Reintroducing ESRRA into USP16-knockout cells rescued both proliferative capacity and mitochondrial respiratory defects. - Pharmacologic inhibition of **OXPHOS** abolished the proliferative advantage driven by USP16 overexpression. - The data support a **USP16/ESRRA deubiquitination axis** as a potential therapeutic target in osteosarcoma. - Specific experimental details (exact datasets for bioinformatics, cell lines, xenograft models, sample numbers, statistical measures, and inhibitor identities/doses) were not reported in the abstract and are not available in the provided source text.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42659864/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42659864%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42659864/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42659864/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42659864/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/a447896c-976f-490b-b86b-2668b65114a8/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42659864/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42659864/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42659864%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42659864%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42659864/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42659864/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42659864/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42659864/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Elsevier Science full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif) Elsevier Science ](https://linkinghub.elsevier.com/retrieve/pii/S0006-291X\(26\)01237-4 "See full text options at Elsevier Science") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/42659864/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42659864/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Experimental Resource Linked Discoveries ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42659864/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42659864/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42659864/#conflict-of-interest) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42659864/#similar) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42659864/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42659864/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42659864/#related-links) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42659864/#linkout) Title & authors Abstract Conflict of interest statement Similar articles MeSH terms Substances Related information LinkOut - more resources Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) . 2026 Oct 8:834:154473. doi: 10.1016/j.bbrc.2026.154473. Epub 2026 Aug 24. # USP16 promotes osteosarcoma progression by stabilizing ESRRA to enhance mitochondrial oxidative phosphorylation [Zhonglun Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Z&cauthor_id=42659864)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42659864/#full-view-affiliation-1 "The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China."), [Xuan Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+X&cauthor_id=42659864)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42659864/#full-view-affiliation-1 "The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China."), [Yifan Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+Y&cauthor_id=42659864)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42659864/#full-view-affiliation-2 "Capital Medical University Affiliated Capital Institute of Pediatrics, Beijing, 100020, China."), [Bolun Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+B&cauthor_id=42659864)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42659864/#full-view-affiliation-3 "The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China. Electronic address: 202336014@mail.sdu.edu.cn.") Affiliations Expand ### Affiliations * 1 The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China. * 2 Capital Medical University Affiliated Capital Institute of Pediatrics, Beijing, 100020, China. * 3 The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China. Electronic address: 202336014@mail.sdu.edu.cn. * PMID: **42659864** * DOI: [ 10.1016/j.bbrc.2026.154473 ](https://doi.org/10.1016/j.bbrc.2026.154473) Item in Clipboard # USP16 promotes osteosarcoma progression by stabilizing ESRRA to enhance mitochondrial oxidative phosphorylation Zhonglun Liu et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) . 2026 Oct 8:834:154473. doi: 10.1016/j.bbrc.2026.154473. Epub 2026 Aug 24. ### Authors [Zhonglun Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Z&cauthor_id=42659864)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42659864/#short-view-affiliation-1 "The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China."), [Xuan Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+X&cauthor_id=42659864)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42659864/#short-view-affiliation-1 "The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China."), [Yifan Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+Y&cauthor_id=42659864)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42659864/#short-view-affiliation-2 "Capital Medical University Affiliated Capital Institute of Pediatrics, Beijing, 100020, China."), [Bolun Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+B&cauthor_id=42659864)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42659864/#short-view-affiliation-3 "The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China. Electronic address: 202336014@mail.sdu.edu.cn.") ### Affiliations * 1 The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China. * 2 Capital Medical University Affiliated Capital Institute of Pediatrics, Beijing, 100020, China. * 3 The Second Qilu Hospital of Shandong University, Jinan, Shandong, 250033, China. Electronic address: 202336014@mail.sdu.edu.cn. * PMID: **42659864** * DOI: [ 10.1016/j.bbrc.2026.154473 ](https://doi.org/10.1016/j.bbrc.2026.154473) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract Osteosarcoma is a highly aggressive primary bone malignancy, yet the underlying mechanisms driving its metabolic reprogramming remain incompletely understood. In this study, we identified ubiquitin-specific protease 16 (USP16) as a critical oncogenic driver in osteosarcoma. Bioinformatics analysis showed that USP16 was markedly upregulated in osteosarcoma tissues and predicted poor patient prognosis. Functional assays revealed that USP16 depletion significantly suppressed osteosarcoma cell proliferation and colony formation in vitro, as well as subcutaneous xenograft tumor growth in vivo, accompanied by the downregulation of cell cycle regulators. Conversely, USP16 overexpression promoted cell proliferation. Seahorse extracellular flux analysis demonstrated that USP16 depletion drastically impaired mitochondrial oxygen consumption rate (OCR) and oxidative phosphorylation (OXPHOS) parameters. Mechanistically, USP16 sustained mitochondrial respiration by deubiquitinating and stabilizing estrogen-related receptor alpha (ESRRA). Crucially, ectopic expression of ESRRA in USP16-knockout cells effectively rescued the suppressed cell proliferation and mitochondrial respiratory defects, whereas pharmacological inhibition of OXPHOS abolished USP16-induced hyperproliferation. Collectively, our findings demonstrate that USP16 drives osteosarcoma progression by orchestrating ESRRA-mediated mitochondrial OXPHOS, highlighting the USP16/ESRRA deubiquitination axis as a promising therapeutic target. **Keywords:** ESRRA; Mitochondrial respiration; Osteosarcoma; Oxidative phosphorylation; USP16. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ STUB1-mediated ubiquitination of SLC25A10 regulates mitochondrial function and drives osteosarcoma progression: A novel therapeutic target. ](https://pubmed.ncbi.nlm.nih.gov/40349811/) Feng J, Zhao M, Chen Z, Lin C, Jin J, Ma N, Bai C, Li ZH, Xu W, She C.Feng J, et al.Cell Signal. 2025 Aug;132:111855. doi: 10.1016/j.cellsig.2025.111855. Epub 2025 May 9.Cell Signal. 2025.PMID: 40349811 * [ Targeting _ABCB6_ induces ferroptosis in osteosarcoma cells via _HIF1A_ /_GPX4_ pathway. ](https://pubmed.ncbi.nlm.nih.gov/42565568/) Lin Z, Luo H, Li X, Luo W.Lin Z, et al.Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2026 May 28;51(5):903-923. doi: 10.11817/j.issn.1672-7347.2026.250446.Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2026.PMID: 42565568Free PMC article. * [ The integrin α2-osteoclast axis: a key driver of bone destruction and therapeutic target in osteosarcoma. ](https://pubmed.ncbi.nlm.nih.gov/41174632/) Wei H, Shi K, Huang D, Lin H, Wang S, Chen X, Zhang W.Wei H, et al.J Transl Med. 2025 Oct 31;23(1):1204. doi: 10.1186/s12967-025-06906-4.J Transl Med. 2025.PMID: 41174632Free PMC article. * [ Targeting the mitochondrial protein YME1L to inhibit osteosarcoma cell growth in vitro and in vivo. ](https://pubmed.ncbi.nlm.nih.gov/38769124/) Sun X, Shi C, Dai J, Zhang MQ, Pei DS, Yang L.Sun X, et al.Cell Death Dis. 2024 May 20;15(5):346. doi: 10.1038/s41419-024-06722-6.Cell Death Dis. 2024.PMID: 38769124Free PMC article. * [ Chemokine-Like Receptor 1 Knockdown Suppresses Oral Squamous Cell Carcinoma Progression by Reducing Oxidative Phosphorylation. ](https://pubmed.ncbi.nlm.nih.gov/41850175/) Lin Y, Zhao L, Huang Y, Chen Y, Wan Q, Lu Z, Zhang X.Lin Y, et al.Int Dent J. 2026 Jun;76(3):109479. doi: 10.1016/j.identj.2026.109479. Epub 2026 Mar 17.Int Dent J. 2026.PMID: 41850175Free PMC article. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42659864) ## MeSH terms * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Bone Neoplasms* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Bone+Neoplasms%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Bone+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Bone Neoplasms* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Bone+Neoplasms%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Bone+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Bone Neoplasms* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Bone+Neoplasms%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Bone+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Cell Line, Tumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Line%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Line%2C+Tumor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Cell Proliferation Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Proliferation%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Proliferation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Disease Progression Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Disease+Progression%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Disease+Progression) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * ERRalpha Estrogen-Related Receptor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22ERRalpha+Estrogen-Related+Receptor%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=ERRalpha+Estrogen-Related+Receptor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Mice Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mice) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Mitochondria* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitochondria%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mitochondria) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Mitochondria* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mitochondria%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Mitochondria) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Osteosarcoma* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteosarcoma%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Osteosarcoma) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Osteosarcoma* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteosarcoma%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Osteosarcoma) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Osteosarcoma* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Osteosarcoma%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Osteosarcoma) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Oxidative Phosphorylation* Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Oxidative+Phosphorylation%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Oxidative+Phosphorylation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Ubiquitin Thiolesterase* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Ubiquitin+Thiolesterase%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Ubiquitin+Thiolesterase) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42659864/) * Ubiquitin Thiolesterase* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Ubiquitin+Thiolesterase%2Fme
## Related Clinical Research

- [Moderna-Merck cancer vaccine data reveal expected at ESMO — what the STAT dispatch reports](https://medichelpline.com/clinical-feed/stat-news-3-stat-what-to-expect-from-the-moderna-merck-cancer-vaccine-data-reveal.md)
- [Design rules for a modular peptide-tag adaptor BRiDGE CAR T cell system](https://medichelpline.com/clinical-feed/biorxiv-8-development-and-design-rules-for-a-modular-human-peptide-tag-adaptor-car-t-cell.md)
- [ResponseVerdict improves immunotherapy response prediction vs TIDE and published signatures](https://medichelpline.com/clinical-feed/biorxiv-12-responseverdict-overturns-computationally-validated-immunotherapy-signatures.md)
- [Editorial Expression of Concern: Image concerns in EphA2–arachidonic acid prostate cancer paper](https://medichelpline.com/clinical-feed/british-journal-of-cancer-0-editorial-expression-of-concern-ligand-independent-activation-of-epha2-by.md)
- [Cipepofol induces ferroptosis and limits breast cancer cell growth](https://medichelpline.com/clinical-feed/pubmed-42731367.md) (DOI: 10.1016/j.bbrc.2026.154570)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.