---
title: "ZNF213-AS1 is hypoxia-repressed and limits p65-driven EMT and platinum resistance in ovarian cancer"
id: "pubmed-42468178"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42468178"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42468178/"
doi: "10.1016/j.bbrc.2026.154309"
published_at: "2026-09-17T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# ZNF213-AS1 is hypoxia-repressed and limits p65-driven EMT and platinum resistance in ovarian cancer
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42468178
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42468178/)
- **DOI:** [10.1016/j.bbrc.2026.154309](https://doi.org/10.1016%2Fj.bbrc.2026.154309)
- **Published At:** 2026-09-17T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Analysis of TCGA-OV and GTEx datasets identified the long noncoding RNA **ZNF213-AS1** as downregulated in ovarian cancer and associated with poorer overall survival. - Low ZNF213-AS1 expression correlated with gene signatures for **hypoxia**, **EMT**, **NF-κB**, and **IL6/JAK/STAT3** signaling. - ZNF213-AS1 is relatively abundant in ovarian cancer cells and enriched in the chromatin-associated fraction, indicating a nuclear/chromatin-linked function. - Experimental hypoxia reduced ZNF213-AS1 expression in ovarian cancer cell lines; this repression was not reversed by HIF1α knockout or mutation of a predicted HRE, suggesting a noncanonical mechanism of hypoxic regulation. - Functional gain- and loss-of-function studies showed that ZNF213-AS1 overexpression suppressed hypoxia-induced colony formation, invasion, and **cisplatin** resistance, whereas knockdown enhanced these malignant phenotypes. - ZNF213-AS1 inhibited NF-κB reporter activity and decreased expression of NF-κB/STAT3/EMT-related genes, indicating repression of pro-EMT inflammatory signaling. - RNA pull-down and RIP assays demonstrated that ZNF213-AS1 physically associates with RELA/**p65**-containing NF-κB complexes. - Re-expression of p65 partially reversed ZNF213-AS1’s inhibitory effects on STAT3 activation, EMT marker expression, and xenograft tumor growth, supporting a functional **ZNF213-AS1–p65** axis limiting NF-κB/STAT3-driven EMT and platinum-resistant progression. - The study defines a hypoxia-repressed lncRNA that restrains **NF-κB/STAT3** signaling and EMT in ovarian cancer, with potential relevance for therapy resistance; detailed mechanistic and therapeutic translational implications beyond the reported assays were not provided in the source.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jul 17. # Hypoxia-repressed lncRNA ZNF213-AS1 restrains p65-driven epithelial-mesenchymal transition in ovarian cancer [Caixia Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+C&cauthor_id=42468178)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#full-view-affiliation-1 "Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China."), [Rong Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+R&cauthor_id=42468178)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#full-view-affiliation-1 "Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China."), [Yujie Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+Y&cauthor_id=42468178)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#full-view-affiliation-2 "Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China."), [Mengjie Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+M&cauthor_id=42468178)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#full-view-affiliation-1 "Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China."), [Wenni Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+W&cauthor_id=42468178)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#full-view-affiliation-3 "Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. Electronic address: 18817367694@163.com."), [Weihong Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+W&cauthor_id=42468178)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#full-view-affiliation-4 "Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. Electronic address: ywh8708@163.com.") Affiliations Expand ### Affiliations * 1 Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. * 2 Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. * 3 Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. Electronic address: 18817367694@163.com. * 4 Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. Electronic address: ywh8708@163.com. * PMID: **42468178** * DOI: [ 10.1016/j.bbrc.2026.154309 ](https://doi.org/10.1016/j.bbrc.2026.154309) Item in Clipboard # Hypoxia-repressed lncRNA ZNF213-AS1 restrains p65-driven epithelial-mesenchymal transition in ovarian cancer Caixia Li et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42468178/) . 2026 Sep 17:831:154309. doi: 10.1016/j.bbrc.2026.154309. Epub 2026 Jul 17. ### Authors [Caixia Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+C&cauthor_id=42468178)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#short-view-affiliation-1 "Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China."), [Rong Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+R&cauthor_id=42468178)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#short-view-affiliation-1 "Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China."), [Yujie Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+Y&cauthor_id=42468178)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#short-view-affiliation-2 "Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China."), [Mengjie Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+M&cauthor_id=42468178)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#short-view-affiliation-1 "Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China."), [Wenni Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+W&cauthor_id=42468178)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#short-view-affiliation-3 "Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. Electronic address: 18817367694@163.com."), [Weihong Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+W&cauthor_id=42468178)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42468178/#short-view-affiliation-4 "Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. Electronic address: ywh8708@163.com.") ### Affiliations * 1 Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. * 2 Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. * 3 Department of Gynecology and Obstetrics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. Electronic address: 18817367694@163.com. * 4 Department of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. Electronic address: ywh8708@163.com. * PMID: **42468178** * DOI: [ 10.1016/j.bbrc.2026.154309 ](https://doi.org/10.1016/j.bbrc.2026.154309) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Hypoxia promotes ovarian cancer progression, EMT and platinum resistance, but the lncRNA mediators involved remain unclear. Here, we identified ZNF213-AS1 as a downregulated lncRNA in ovarian cancer by analyzing TCGA-OV and GTEx datasets. Low ZNF213-AS1 expression predicted poor overall survival and was associated with hypoxia, EMT, NF-κB and IL6/JAK/STAT3 signatures. ZNF213-AS1 was relatively abundant and enriched in the chromatin-associated fraction. Hypoxia reduced ZNF213-AS1 expression in ovarian cancer cells, but this repression was not rescued by HIF1α knockout or mutation of the predicted HRE motif, suggesting a noncanonical hypoxic regulatory mechanism. Functionally, ZNF213-AS1 overexpression suppressed hypoxia-induced colony formation, invasion and cisplatin resistance, whereas ZNF213-AS1 knockdown enhanced these phenotypes. Mechanistically, ZNF213-AS1 inhibited NF-κB reporter activity and reduced NF-κB/STAT3/EMT-related gene expression. RNA pull-down and RIP assays showed that ZNF213-AS1 associates with RELA/p65-containing NF-κB complexes. Moreover, p65 re-expression partially reversed the inhibitory effects of ZNF213-AS1 on STAT3 activation, EMT markers and xenograft growth. These findings define a hypoxia-repressed ZNF213-AS1-p65 axis that limits NF-κB/STAT3-driven EMT and platinum-resistant ovarian cancer progression. **Keywords:** EMT; Hypoxia; NF-κB signaling; Ovarian cancer; ZNF213-AS1. Copyright © 2026. Published by Elsevier Inc. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ LncRNA FLVCR1-AS1 mediates miR-513/YAP1 signaling to promote cell progression, migration, invasion and EMT process in ovarian cancer. ](https://pubmed.ncbi.nlm.nih.gov/31412903/) Yan H, Li H, Silva MA, Guan Y, Yang L, Zhu L, Zhang Z, Li G, Ren C.Yan H, et al.J Exp Clin Cancer Res. 2019 Aug 14;38(1):356. doi: 10.1186/s13046-019-1356-z.J Exp Clin Cancer Res. 2019.PMID: 31412903Free PMC article. * [ Long noncoding RNA MLK7-AS1 promotes ovarian cancer cells progression by modulating miR-375/YAP1 axis. ](https://pubmed.ncbi.nlm.nih.gov/30249278/) Yan H, Li H, Li P, Li X, Lin J, Zhu L, Silva MA, Wang X, Wang P, Zhang Z.Yan H, et al.J Exp Clin Cancer Res. 2018 Sep 24;37(1):237. doi: 10.1186/s13046-018-0910-4.J Exp Clin Cancer Res. 2018.Retraction in: [J Exp Clin Cancer Res. 2020 Nov 05;39(1):233. doi: 10.1186/s13046-020-01746-0.](https://pubmed.ncbi.nlm.nih.gov/33153490/)PMID: 30249278Free PMC article.Retracted. * [ Novel role of lncRNA CHRF in cisplatin resistance of ovarian cancer is mediated by miR-10b induced EMT and STAT3 signaling. ](https://pubmed.ncbi.nlm.nih.gov/32901049/) Tan WX, Sun G, Shangguan MY, Gui Z, Bao Y, Li YF, Jia ZH.Tan WX, et al.Sci Rep. 2020 Sep 8;10(1):14768. doi: 10.1038/s41598-020-71153-0.Sci Rep. 2020.PMID: 32901049Free PMC article. * [ SP1-induced lncRNA MCF2L-AS1 promotes cisplatin resistance in ovarian cancer by regulating IGF2BP1/IGF2/MEK/ERK axis. ](https://pubmed.ncbi.nlm.nih.gov/36245227/) Zhu Y, Yang L, Wang J, Li Y, Chen Y.Zhu Y, et al.J Gynecol Oncol. 2022 Nov;33(6):e75. doi: 10.3802/jgo.2022.33.e75. Epub 2022 Aug 23.J Gynecol Oncol. 2022.PMID: 36245227Free PMC article. * [ The Role of MNX1-AS1 in Ovarian Cancer Resistance and Tumor Progression via RNA-RNA Interactions. ](https://pubmed.ncbi.nlm.nih.gov/42074071/) Gutierrez A, Larronde C, Silva S, Castro C, Maldonado R, León D, Machuca J, Ili CG, Brebi P, Buchegger K, Viscarra T.Gutierrez A, et al.Int J Mol Sci. 2026 Apr 11;27(8):3428. doi: 10.3390/ijms27083428.Int J Mol Sci. 2026.PMID: 42074071Free PMC article. 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