---
title: "Spatial profiling links STING to Kawasaki disease cardiac inflammation"
id: "biorxiv-2-spatial-profiling-of-kawasaki-disease-cardiac-inflammation-identifies-sting-as"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-2-spatial-profiling-of-kawasaki-disease-cardiac-inflammation-identifies-sting-as"
content_type: "clinical_feed_article"
specialty: "Pediatrics"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.16.757759v1?rss=1"
published_at: "2026-10-22T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Spatial profiling links STING to Kawasaki disease cardiac inflammation
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-2-spatial-profiling-of-kawasaki-disease-cardiac-inflammation-identifies-sting-as
- **Specialty:** [Pediatrics](https://medichelpline.com/clinical-feed/pediatrics.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.16.757759v1?rss=1)
- **Published At:** 2026-10-22T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- Investigators applied **64-plex immunofluorescence** to autopsy coronary artery specimens from Kawasaki disease (KD) patients to map cellular composition and spatial organization of cardiac inflammation. - The cohort showed spatially organized immune infiltrates dominated by neutrophils, macrophages, and T cells collocated with areas of arterial wall destruction and remodeling. - Data indicated disrupted colocalization between stromal cells and muscle cells within affected arterial regions, plus diffuse myocardial inflammation beyond the coronary arteries. - Spatial analysis revealed expression of the innate immune sensor **STING** within myeloid cells in KD coronary artery tissues. - The study team observed that both pharmacological and genetic inhibition of **STING** reduced vasculitis development in a mouse model of KD, implying a functional role for STING in disease pathogenesis. - The preprint did not report clinical dosing, safety data, human interventional trial results, or regulatory steps; translation to human therapy remains an open question. - Authors noted that these findings identify **STING** as a potential therapeutic target for treatment-resistant or severe KD and map inflammatory injury that extends beyond coronary arteries.
## Clinical Analysis & Structured Key Points
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Ross, Asli E. Atici, Youngho Lee, Paul Ngai, Emily Schahrer, Malcolm E. Lane, Michael F. Fishbein, Yuki Yokouchi, Kei Takahashi, Moshe Arditi, David Zemmour, [ View ORCID Profile](http://orcid.org/0000-0001-5570-8928)Magali Noval Rivas doi: https://doi.org/10.64898/2026.10.16.757759 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Benjamin L. Ross 1 Cedars-Sinai Medical center; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Benjamin%2BL.%2BRoss%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Ross%20BL&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ABenjamin%2BL.%2BRoss%2B) Asli E. Atici 2 Cedars-Sinai Medical Center; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Asli%2BE.%2BAtici%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Atici%20AE&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAsli%2BE.%2BAtici%2B) Youngho Lee 2 Cedars-Sinai Medical Center; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Youngho%2BLee%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Lee%20Y&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AYoungho%2BLee%2B) Paul Ngai 3 University of Chicago; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Paul%2BNgai%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Ngai%20P&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3APaul%2BNgai%2B) Emily Schahrer 3 University of Chicago; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Emily%2BSchahrer%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Schahrer%20E&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AEmily%2BSchahrer%2B) Malcolm E. 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We characterized the cellular composition and spatial organization of cardiac inflammation in autopsy coronary artery (CA) specimens from KD patients using 64-plex immunofluorescence. We identified spatially organized immune infiltrates of neutrophils, macrophages, and T cells associated with arterial wall destruction and remodeling, as well as disrupted stromal/muscle cell colocalization and diffuse myocardial inflammation. Spatial analysis also revealed expression of the innate immune sensor STING in myeloid cells in KD CA tissues. Pharmacological and genetic inhibition of STING reduced vasculitis development in a mouse model of KD. These findings define the spatial immune architecture of KD cardiac inflammation, reveal inflammatory injury beyond the coronary arteries, and identify STING as a potential therapeutic target for treatment-resistant or severe KD. ### Competing Interest Statement The authors have declared no competing interest. ## Funder Information Declared NHLBI, R01 HL139766, R01 HL170580 NIAID, R21 AI193709 American Heart Association, https://ror.org/013kjyp64, Career Development Award #1586278 CTSI UCLA, UL1TR001881 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY-NC 4.0 International license](http://creativecommons.org/licenses/by-nc/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. [Donate to openRxiv ](https://www.zeffy.com/en-US/donation-form/donate-to-make-a-difference-10981) [ Back to top](https://www.biorxiv.org/content/10.64898/2026.10.16.757759v1?rss=1#page) [ Previous](https://www.biorxiv.org/content/10.64898/2026.10.16.759774v1 "Differential Protection against Acetaminophen-induced Liver and Kidney Injury by N-Acetylcysteine and Fomepizole in Female Mice") Posted October 22, 2026. [ Download PDF](https://www.biorxiv.org/content/10.64898/2026.10.16.757759v1.full.pdf) Print/Save Options [Download PDF](https://www.biorxiv.org/content/biorxiv/early/2026/10/22/2026.10.16.757759.full.pdf)Full Text & In-line FiguresXML [More Info](https://www.biorxiv.org/about/FAQ#PrintOptions "More Information on Print/Save Options") [Supplementary Material ](https://www.biorxiv.org/content/10.64898/2026.10.16.757759v1.supplementary-material) [ Email](https://www.biorxiv.org/ "Email this Article") [ Share](https://www.biorxiv.org/) Spatial profiling of Kawasaki disease cardiac inflammation identifies STING as a therapeutic target Benjamin L. Ross, Asli E. Atici, Youngho Lee, Paul Ngai, Emily Schahrer, Malcolm E. Lane, Michael F. Fishbein, Yuki Yokouchi, Kei Takahashi, Moshe Arditi, David Zemmour, Magali Noval Rivas bioRxiv 2026.10.16.757759; doi: https://doi.org/10.64898/2026.10.16.757759 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. 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