---
title: "Synbiotic supplementation, gut microbiome function, and white matter development in preterm infants"
id: "pubmed-42841652"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42841652"
content_type: "clinical_feed_article"
specialty: "Pediatrics"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42841652/"
doi: "10.1080/19490976.2026.2743949"
published_at: "2026-10-07T22:42:44.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Synbiotic supplementation, gut microbiome function, and white matter development in preterm infants
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42841652
- **Specialty:** [Pediatrics](https://medichelpline.com/clinical-feed/pediatrics.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42841652/)
- **DOI:** [10.1080/19490976.2026.2743949](https://doi.org/10.1080%2F19490976.2026.2743949)
- **Published At:** 2026-10-07T22:42:44.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This PubMed entry describes a randomized controlled trial reported in Gut Microbes titled: “Synbiotic supplementation leads to gut microbiome communities with functional capacity linked to better brain white matter development in preterm infants.” - The study involves **preterm infants** and evaluates **synbiotic** supplementation with reported links to **gut microbiome** community functional capacity and **brain white matter** development. - Publication metadata: journal Gut Microbes; PMID 42841652; DOI 10.1080/19490976.2026.2743949; Epub 2026 Oct 7; issue dated 2026 Dec 31; volume 18(1):2743949. - Study type listed as a **Randomized Controlled Trial** in the PubMed record. - Lead and coauthors and multiple institutional affiliations are provided, including Wageningen University & Research, University Medical Center Utrecht Brain Center, Wilhelmina Children's Hospital neonatology, Danone Research & Innovation, and several Dutch pediatric centers. - The PubMed entry lists many contributing authors and 17 institutional affiliations across microbiology, neonatology, pediatrics, radiology, imaging, biomedical engineering, and industry research groups. - The abstract text and trial details (sample size, randomization details, synbiotic composition, comparator, outcome measures, statistical results, imaging methods, and specific microbiome functional pathways) are not included in the provided PubMed page excerpt; those details were not reported in the source content supplied here. - Because the supplied source is limited to metadata and author/affiliation information, no additional trial methods, numerical results, or specific mechanistic findings can be summarized beyond the article title’s claims. - Readers should consult the full article (DOI 10.1080/19490976.2026.2743949) for complete methods, results, and interpretation; the PubMed record alone does not provide those data.
## Clinical Analysis & Structured Key Points
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Epub 2026 Oct 7. # Synbiotic supplementation leads to gut microbiome communities with functional capacity linked to better brain white matter development in preterm infants [Anna Voulgari-Kokota](https://pubmed.ncbi.nlm.nih.gov/?term=Voulgari-Kokota+A&cauthor_id=42841652)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-1 "Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands."), [Els Janson](https://pubmed.ncbi.nlm.nih.gov/?term=Janson+E&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-3 "University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands."), [Ineke Heikamp de Jong](https://pubmed.ncbi.nlm.nih.gov/?term=Heikamp+de+Jong+I&cauthor_id=42841652)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-1 "Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands."), [Jan Knol](https://pubmed.ncbi.nlm.nih.gov/?term=Knol+J&cauthor_id=42841652)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-4 "Danone Research & Innovation, Utrecht, The Netherlands."), [Ruurd van Elburg](https://pubmed.ncbi.nlm.nih.gov/?term=van+Elburg+R&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-5 "Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands."), [Niek E van der Aa](https://pubmed.ncbi.nlm.nih.gov/?term=van+der+Aa+NE&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-3 "University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands."), [Lisa M Hortensius](https://pubmed.ncbi.nlm.nih.gov/?term=Hortensius+LM&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-3 "University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands."), [Jeroen Dudink](https://pubmed.ncbi.nlm.nih.gov/?term=Dudink+J&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-3 "University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands."), [Caroline G M de Theije](https://pubmed.ncbi.nlm.nih.gov/?term=de+Theije+CGM&cauthor_id=42841652)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-6 "Department for Developmental Origins of Disease, University Medical Center Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, Utrecht, The Netherlands."), [Lidewij Schipper](https://pubmed.ncbi.nlm.nih.gov/?term=Schipper+L&cauthor_id=42841652)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-4 "Danone Research & Innovation, Utrecht, The Netherlands."), [Marta Kozior](https://pubmed.ncbi.nlm.nih.gov/?term=Kozior+M&cauthor_id=42841652)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-4 "Danone Research & Innovation, Utrecht, The Netherlands."), [Monique van de Lagemaat](https://pubmed.ncbi.nlm.nih.gov/?term=van+de+Lagemaat+M&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-3 "University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands."), [Floris Groenendaal](https://pubmed.ncbi.nlm.nih.gov/?term=Groenendaal+F&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-3 "University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands."), [Frank van Bel](https://pubmed.ncbi.nlm.nih.gov/?term=van+Bel+F&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-3 "University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands."), [Annemieke Wildt-Grootendorst](https://pubmed.ncbi.nlm.nih.gov/?term=Wildt-Grootendorst+A&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands."), [Sandra Drost-Verhoef](https://pubmed.ncbi.nlm.nih.gov/?term=Drost-Verhoef+S&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands."), [Annelies Hennink](https://pubmed.ncbi.nlm.nih.gov/?term=Hennink+A&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands."), [Charlie C Obihara](https://pubmed.ncbi.nlm.nih.gov/?term=Obihara+CC&cauthor_id=42841652)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-7 "Department of Pediatrics, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands."), [Jacqueline L A M van Hillegersberg-Schilder](https://pubmed.ncbi.nlm.nih.gov/?term=van+Hillegersberg-Schilder+JLAM&cauthor_id=42841652)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-8 "Department of Pediatrics, Sint Antonius Hospital, Nieuwegein, The Netherlands."), [Carin M Dassel](https://pubmed.ncbi.nlm.nih.gov/?term=Dassel+CM&cauthor_id=42841652)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-9 "Department of Pediatrics, Deventer Hospital, Deventer, The Netherlands."), [Johanna H Oudshoorn](https://pubmed.ncbi.nlm.nih.gov/?term=Oudshoorn+JH&cauthor_id=42841652)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-10 "Department of Pediatrics, Gelre Hospital, Apeldoorn, The Netherlands."), [Clemens B Meijssen](https://pubmed.ncbi.nlm.nih.gov/?term=Meijssen+CB&cauthor_id=42841652)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-11 "Department of Pediatrics, Meander Medical Centre, Amersfoort, The Netherlands."), [Inge P de Boer](https://pubmed.ncbi.nlm.nih.gov/?term=de+Boer+IP&cauthor_id=42841652)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-12 "Department of Pediatrics, Diakonessenhuis, Utrecht, The Netherlands."), [Károly E Illy](https://pubmed.ncbi.nlm.nih.gov/?term=Illy+KE&cauthor_id=42841652)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-13 "Department of Pediatrics, Hospital Rivierenland, Tiel, The Netherlands."), [Nathalie Claessens](https://pubmed.ncbi.nlm.nih.gov/?term=Claessens+N&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-3 "University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands."), [Max A Viergever](https://pubmed.ncbi.nlm.nih.gov/?term=Viergever+MA&cauthor_id=42841652)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-14 "Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands."), [Ivana Isgum](https://pubmed.ncbi.nlm.nih.gov/?term=Isgum+I&cauthor_id=42841652)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-14 "Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.")[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-15 "Department of Biomedical Engineering & Physics, Amsterdam University Medical Center, Amsterdam, The Netherlands.")[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-16 "Informatics Institute, University of Amsterdam, Amsterdam, The Netherlands.")[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-17 "Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands."), [Sudarshan Shetty](https://pubmed.ncbi.nlm.nih.gov/?term=Shetty+S&cauthor_id=42841652)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-4 "Danone Research & Innovation, Utrecht, The Netherlands."), [Harm Wopereis](https://pubmed.ncbi.nlm.nih.gov/?term=Wopereis+H&cauthor_id=42841652)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-4 "Danone Research & Innovation, Utrecht, The Netherlands."), [Manon Benders](https://pubmed.ncbi.nlm.nih.gov/?term=Benders+M&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-3 "University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands."), [Clara Belzer](https://pubmed.ncbi.nlm.nih.gov/?term=Belzer+C&cauthor_id=42841652)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#full-view-affiliation-1 "Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.") Affiliations Expand ### Affiliations * 1 Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands. * 2 Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. * 3 University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands. * 4 Danone Research & Innovation, Utrecht, The Netherlands. * 5 Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands. * 6 Department for Developmental Origins of Disease, University Medical Center Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, Utrecht, The Netherlands. * 7 Department of Pediatrics, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands. * 8 Department of Pediatrics, Sint Antonius Hospital, Nieuwegein, The Netherlands. * 9 Department of Pediatrics, Deventer Hospital, Deventer, The Netherlands. * 10 Department of Pediatrics, Gelre Hospital, Apeldoorn, The Netherlands. * 11 Department of Pediatrics, Meander Medical Centre, Amersfoort, The Netherlands. * 12 Department of Pediatrics, Diakonessenhuis, Utrecht, The Netherlands. * 13 Department of Pediatrics, Hospital Rivierenland, Tiel, The Netherlands. * 14 Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands. * 15 Department of Biomedical Engineering & Physics, Amsterdam University Medical Center, Amsterdam, The Netherlands. * 16 Informatics Institute, University of Amsterdam, Amsterdam, The Netherlands. * 17 Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands. * PMID: **42841652** * DOI: [ 10.1080/19490976.2026.2743949 ](https://doi.org/10.1080/19490976.2026.2743949) Item in Clipboard Randomized Controlled Trial # Synbiotic supplementation leads to gut microbiome communities with functional capacity linked to better brain white matter development in preterm infants Anna Voulgari-Kokota et al. Gut Microbes. 2026. Show details Display options Display options Format Abstract PubMed PMID Gut Microbes Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Gut+Microbes%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Gut+Microbes%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42841652/) . 2026 Dec 31;18(1):2743949. doi: 10.1080/19490976.2026.2743949. Epub 2026 Oct 7. ### Authors [Anna Voulgari-Kokota](https://pubmed.ncbi.nlm.nih.gov/?term=Voulgari-Kokota+A&cauthor_id=42841652)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#short-view-affiliation-1 "Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands."), [Els Janson](https://pubmed.ncbi.nlm.nih.gov/?term=Janson+E&cauthor_id=42841652)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42841652/#short-view-affiliation-2 "Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.")[ 3 ](https://pubmed.ncbi.nlm.nih.g
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