---
title: "15d-PGJ2–Loaded PLGA Nanoparticles Integrated into SIS for Diabetic Wound Healing"
id: "pubmed-42330890"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42330890"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42330890/"
doi: "10.1016/j.bbrc.2026.153935"
published_at: "2026-09-03T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# 15d-PGJ2–Loaded PLGA Nanoparticles Integrated into SIS for Diabetic Wound Healing
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42330890
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42330890/)
- **DOI:** [10.1016/j.bbrc.2026.153935](https://doi.org/10.1016%2Fj.bbrc.2026.153935)
- **Published At:** 2026-09-03T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This study developed biodegradable extracellular matrix–mimicking wound dressings for **diabetic wound healing**, combining anti-inflammatory drug–loaded nanoparticles with a natural scaffold. - The anti-inflammatory agent **prostaglandin J2 (15d-PGJ2)** was encapsulated in **PLGA nanoparticles (NPs)** to control inflammation at the wound site. - Formulated NPs had an average hydrodynamic size of 261.6 nm, a zeta potential of −14.3 mV, and a polydispersity index below 0.2, indicating a relatively uniform population. - Entrapment efficiency was reported at 96.7% with drug loading of 18.5%; about 50% of the encapsulated drug was released within 240 minutes under the reported in vitro conditions. - Cellular assays included MTT viability testing and scratch migration assays to assess cytotoxicity and define a safe nanoparticle dose for cells. - Porcine **small intestinal submucosa (SIS)** sheets were chemically cross-linked using **EDC/NHS** and then integrated with the 15d-PGJ2-loaded NPs to form modified scaffolds. - The integrated scaffolds underwent in vitro characterization: FTIR spectroscopy, enzymatic degradation, swelling behavior, contact angle (surface hydrophilicity), mechanical testing, and cell adhesion studies. - Results showed the modified SIS had a **hydrophilic surface**, appropriate water adsorption, a low degradation rate, improved mechanical strength, and effective interaction with fibroblast cells. - The EDC-crosslinked SIS carrying anti-inflammatory NPs displayed physicochemical and biological properties that the authors describe as promising for application in diabetic wound repair. - The authors conclude the combined NP–SIS construct can be considered a suitable candidate for diabetic wound healing based on the reported in vitro findings.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 10. # Formulation and characterization of 15d-PGJ2 loaded PLGA nanoparticles and in vitro evaluation of small intestinal submucosa integrated with nanoparticles for diabetic wound [Zeinab Koolabadi](https://pubmed.ncbi.nlm.nih.gov/?term=Koolabadi+Z&cauthor_id=42330890)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#full-view-affiliation-1 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Niloofar Taghipour](https://pubmed.ncbi.nlm.nih.gov/?term=Taghipour+N&cauthor_id=42330890)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#full-view-affiliation-2 "Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Maryam Rouhani](https://pubmed.ncbi.nlm.nih.gov/?term=Rouhani+M&cauthor_id=42330890)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#full-view-affiliation-3 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Masoud Soleimani](https://pubmed.ncbi.nlm.nih.gov/?term=Soleimani+M&cauthor_id=42330890)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#full-view-affiliation-4 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: soleimani.masoud@gmail.com."), [Saeed Heidari Keshel](https://pubmed.ncbi.nlm.nih.gov/?term=Keshel+SH&cauthor_id=42330890)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#full-view-affiliation-5 "Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Saeed.heidari@sbmu.ac.ir."), [Azam Rahimi](https://pubmed.ncbi.nlm.nih.gov/?term=Rahimi+A&cauthor_id=42330890)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#full-view-affiliation-1 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Bahareh Pourjabbar](https://pubmed.ncbi.nlm.nih.gov/?term=Pourjabbar+B&cauthor_id=42330890)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#full-view-affiliation-1 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Farzaneh Saeedi Landi](https://pubmed.ncbi.nlm.nih.gov/?term=Saeedi+Landi+F&cauthor_id=42330890)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#full-view-affiliation-1 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.") Affiliations Expand ### Affiliations * 1 Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. * 2 Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. * 3 Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. * 4 Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: soleimani.masoud@gmail.com. * 5 Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Saeed.heidari@sbmu.ac.ir. * PMID: **42330890** * DOI: [ 10.1016/j.bbrc.2026.153935 ](https://doi.org/10.1016/j.bbrc.2026.153935) Item in Clipboard # Formulation and characterization of 15d-PGJ2 loaded PLGA nanoparticles and in vitro evaluation of small intestinal submucosa integrated with nanoparticles for diabetic wound Zeinab Koolabadi et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42330890/) . 2026 Sep 3:829:153935. doi: 10.1016/j.bbrc.2026.153935. Epub 2026 Jun 10. ### Authors [Zeinab Koolabadi](https://pubmed.ncbi.nlm.nih.gov/?term=Koolabadi+Z&cauthor_id=42330890)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#short-view-affiliation-1 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Niloofar Taghipour](https://pubmed.ncbi.nlm.nih.gov/?term=Taghipour+N&cauthor_id=42330890)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#short-view-affiliation-2 "Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Maryam Rouhani](https://pubmed.ncbi.nlm.nih.gov/?term=Rouhani+M&cauthor_id=42330890)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#short-view-affiliation-3 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Masoud Soleimani](https://pubmed.ncbi.nlm.nih.gov/?term=Soleimani+M&cauthor_id=42330890)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#short-view-affiliation-4 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: soleimani.masoud@gmail.com."), [Saeed Heidari Keshel](https://pubmed.ncbi.nlm.nih.gov/?term=Keshel+SH&cauthor_id=42330890)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#short-view-affiliation-5 "Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Saeed.heidari@sbmu.ac.ir."), [Azam Rahimi](https://pubmed.ncbi.nlm.nih.gov/?term=Rahimi+A&cauthor_id=42330890)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#short-view-affiliation-1 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Bahareh Pourjabbar](https://pubmed.ncbi.nlm.nih.gov/?term=Pourjabbar+B&cauthor_id=42330890)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#short-view-affiliation-1 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."), [Farzaneh Saeedi Landi](https://pubmed.ncbi.nlm.nih.gov/?term=Saeedi+Landi+F&cauthor_id=42330890)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42330890/#short-view-affiliation-1 "Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.") ### Affiliations * 1 Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. * 2 Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. * 3 Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. * 4 Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: soleimani.masoud@gmail.com. * 5 Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Saeed.heidari@sbmu.ac.ir. * PMID: **42330890** * DOI: [ 10.1016/j.bbrc.2026.153935 ](https://doi.org/10.1016/j.bbrc.2026.153935) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Diabetic foot ulcers represent chronic and often non-healing wounds. Their treatment is particularly challenging due to persistent inflammation and infection, necessitating the exploration of innovative strategies for more effective therapeutic approaches. This study aimed to develop a biodegradable extracellular matrix-mimicking wound dressing with anti-inflammatory properties designed to control inflammation and support cell proliferation and migration in the wound area. The anti-inflammatory drug prostaglandin J2 (15d-PGJ2) was encapsulated in PLGA nanoparticles (NPs). The average hydrodynamic size and zeta potential of 15d-PGJ2-loaded NPs were 261.6 nm and -14.3 mV, respectively, with a polydispersity index below 0.2. The entrapment efficiency and drug loading were 96.7% and 18.5%, respectively, with 50% of the drug released within 240 min. Cellular studies, including MTT assays and scratch tests, were performed to evaluate drug toxicity and determine the safe dose of NPs. Porcine small intestinal submucosa (SIS) sheets were cross-linked with EDC/NHS and integrated with NPs. The modified scaffolds were subjected to in vitro characterization, including FTIR analysis, enzymatic degradation, swelling behavior, contact angle measurements, mechanical evaluation, and cell adhesion studies. They demonstrated a hydrophilic surface with suitable water adsorption capacity, a low degradation rate, enhanced mechanical strength, and effective interaction with fibroblast cells. The EDC-crosslinked SIS scaffold carrying anti-inflammatory NPs exhibited promising characteristics based on its physicochemical and biological properties. Thus, it can be considered a suitable option for diabetic wound healing. **Keywords:** Diabetic wound healing; Inflammation; PLGA nanoparticles; Prostaglandin J2; SIS. Copyright © 2026. Published by Elsevier Inc. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known financial or personal conflicts of interest that could have influenced the work presented in this manuscript. ## Similar articles * [ Sesamol-Loaded PLGA Nanosuspension for Accelerating Wound Healing in Diabetic Foot Ulcer in Rats. ](https://pubmed.ncbi.nlm.nih.gov/33262587/) Gourishetti K, Keni R, Nayak PG, Jitta SR, Bhaskaran NA, Kumar L, Kumar N, Krishnadas N, Shenoy RR.Gourishetti K, et al.Int J Nanomedicine. 2020 Nov 23;15:9265-9282. doi: 10.2147/IJN.S268941. eCollection 2020.Int J Nanomedicine. 2020.PMID: 33262587Free PMC article. * [ 15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation. ](https://pubmed.ncbi.nlm.nih.gov/27575486/) de Melo NF, de Macedo CG, Bonfante R, Abdalla HB, da Silva CM, Pasquoto T, de Lima R, Fraceto LF, Clemente-Napimoga JT, Napimoga MH.de Melo NF, et al.PLoS One. 2016 Aug 30;11(8):e0161796. doi: 10.1371/journal.pone.0161796. eCollection 2016.PLoS One. 2016.PMID: 27575486Free PMC article. * [ The incorporation of poly(lactic-co-glycolic) acid nanoparticles into porcine small intestinal submucosa biomaterials. ](https://pubmed.ncbi.nlm.nih.gov/18076986/) Mondalek FG, Lawrence BJ, Kropp BP, Grady BP, Fung KM, Madihally SV, Lin HK.Mondalek FG, et al.Biomaterials. 2008 Mar;29(9):1159-66. doi: 10.1016/j.biomaterials.2007.11.020.Biomaterials. 2008.PMID: 18076986Free PMC article. * [ Preparation and characterization of surface-modified PLGA-polymeric nanoparticles used to target treatment of intestinal cancer. ](https://pubmed.ncbi.nlm.nih.gov/28503995/) Ahmad N, Alam MA, Ahmad R, Naqvi AA, Ahmad FJ.Ahmad N, et al.Artif Cells Nanomed Biotechnol. 2018 Mar;46(2):432-446. doi: 10.1080/21691401.2017.1324466. Epub 2017 May 14.Artif Cells Nanomed Biotechnol. 2018.Retraction in: [Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):1328. doi: 10.1080/21691401.2020.1842979.](https://pubmed.ncbi.nlm.nih.gov/3
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