---
title: "Aptamers for Colorectal Cancer: Advances in Diagnosis and Targeted Therapy"
id: "pubmed-42725398"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42725398"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42725398/"
doi: "10.3892/mmr.2026.14012"
published_at: "2026-09-11T12:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Aptamers for Colorectal Cancer: Advances in Diagnosis and Targeted Therapy
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42725398
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42725398/)
- **DOI:** [10.3892/mmr.2026.14012](https://doi.org/10.3892%2Fmmr.2026.14012)
- **Published At:** 2026-09-11T12:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Colorectal cancer (CRC) has a high incidence and poor prognosis, producing a substantial public health and socioeconomic burden; improving early diagnosis and treatment is essential. - **Aptamers** are nucleotide ligands with high affinity, high specificity and programmability that confer potential for tumor‑targeted applications in CRC. - Aptamers can specifically bind receptors on the surface of cancer cells and can intervene in CRC progression by inhibiting receptor activity. - Research on CRC aptamers is organized into two principal areas: **diagnostic** detection and **targeted therapy**, with studies assessing translational value across these branches. - The SELEX aptamer technique is a key method used to identify aptamers suitable for CRC applications (MeSH indexed). - Aptamers have been investigated as tools to detect tumor **biomarkers** and as therapeutic agents for molecular targeted therapy in CRC (MeSH indexed topics include biomarkers, colorectal neoplasms, and molecular targeted therapy). - The review synthesizes current research achievements to provide a scientific basis and potential methods for clinical translation of aptamer‑based CRC diagnostics and treatments. - The article is a 2026 review in Molecular Medicine Reports (PMID 42725398, DOI 10.3892/mmr.2026.14012) authored by groups affiliated with Inner Mongolia Medical University and its affiliated hospital. - Details on specific aptamer sequences, clinical trial outcomes, or quantitative performance metrics were not reported in the PubMed abstract and therefore are not provided here.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 11. # Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review) [Yiwen Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Y&cauthor_id=42725398)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#full-view-affiliation-1 "Department of Graduate Studies, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Penghui Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+P&cauthor_id=42725398)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#full-view-affiliation-2 "Department of Nuclear Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Ji Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+J&cauthor_id=42725398)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#full-view-affiliation-3 "School of Clinical Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Binghui Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+B&cauthor_id=42725398)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#full-view-affiliation-3 "School of Clinical Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Min Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+M&cauthor_id=42725398)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#full-view-affiliation-1 "Department of Graduate Studies, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Baoliang Bao](https://pubmed.ncbi.nlm.nih.gov/?term=Bao+B&cauthor_id=42725398)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#full-view-affiliation-2 "Department of Nuclear Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China.") Affiliations Expand ### Affiliations * 1 Department of Graduate Studies, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China. * 2 Department of Nuclear Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China. * 3 School of Clinical Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China. * PMID: **42725398** * DOI: [ 10.3892/mmr.2026.14012 ](https://doi.org/10.3892/mmr.2026.14012) Item in Clipboard Review # Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review) Yiwen Li et al. Mol Med Rep. 2026 Nov. Show details Display options Display options Format Abstract PubMed PMID Mol Med Rep Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mol+Med+Rep%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Mol+Med+Rep%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42725398/) . 2026 Nov;34(5):301. doi: 10.3892/mmr.2026.14012. Epub 2026 Sep 11. ### Authors [Yiwen Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Y&cauthor_id=42725398)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#short-view-affiliation-1 "Department of Graduate Studies, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Penghui Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+P&cauthor_id=42725398)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#short-view-affiliation-2 "Department of Nuclear Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Ji Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+J&cauthor_id=42725398)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#short-view-affiliation-3 "School of Clinical Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Binghui Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+B&cauthor_id=42725398)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#short-view-affiliation-3 "School of Clinical Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Min Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+M&cauthor_id=42725398)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#short-view-affiliation-1 "Department of Graduate Studies, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China."), [Baoliang Bao](https://pubmed.ncbi.nlm.nih.gov/?term=Bao+B&cauthor_id=42725398)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42725398/#short-view-affiliation-2 "Department of Nuclear Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China.") ### Affiliations * 1 Department of Graduate Studies, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China. * 2 Department of Nuclear Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China. * 3 School of Clinical Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010050, P.R. China. * PMID: **42725398** * DOI: [ 10.3892/mmr.2026.14012 ](https://doi.org/10.3892/mmr.2026.14012) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Colorectal cancer (CRC) is one of the leading causes of cancer‑related deaths. The high incidence rate and poor prognosis of CRC pose a serious threat to public health, and impose a notable social and economic burden. Therefore, improving the accuracy of the early diagnosis and treatment of CRC is of notable importance. Aptamers have substantial potential for tumor‑targeted diagnosis and treatment due to their unique advantages, such as high affinity, high specificity and programmability. In the diagnosis and treatment of CRC, aptamers can specifically target receptors on the surface of cancer cells and intervene in the development of CRC by inhibiting receptor activity. The present study reviews the current state of research on aptamers to provide a new scientific basis and methods for diagnosing and treating CRC. The relevant research achievements are organized based on the two major branches of diagnostic detection and targeted therapy to systematically assess the translational value of various CRC aptamers. **Keywords:** CRC; aptamers; diagnosis; treatment. 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