---
title: "Centrally Acting Medications and Chronic Pain in Former American Football Players: Study Overview"
id: "pubmed-42664488"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42664488"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42664488/"
doi: "10.1212/WNL.0000000000218475"
published_at: "2026-08-28T22:03:12.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Centrally Acting Medications and Chronic Pain in Former American Football Players: Study Overview
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42664488
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42664488/)
- **DOI:** [10.1212/WNL.0000000000218475](https://doi.org/10.1212%2FWNL.0000000000218475)
- **Published At:** 2026-08-28T22:03:12.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The source article titled **Centrally Acting Medications, Chronic Pain, and Orthopedic Surgical History Among Former American Football Players** is indexed in PubMed (PMID 42664488) and published in Neurology (2026 Sep 22;107[6]:e218475), DOI 10.1212/WNL.0000000000218475. - Authors are listed (Alexa Puleio et al.) with multiple institutional affiliations including Boston University, NYU Grossman School of Medicine, UC San Diego, Mayo Clinic, Cleveland Clinic, Concussion Legacy Foundation, Banner Alzheimer's Institute, Brigham and Women's Hospital, and others; the work is identified as from the DIAGNOSE CTE Research Project. - The title indicates the study focuses on the intersection of **centrally acting medications**, **chronic pain**, and **orthopedic surgical history** in a population of **former American football players**. - The PubMed entry includes bibliographic metadata (authors, affiliations, journal, publication date, PMID, DOI) but the abstract and study details (objectives, design, sample size, methods, results, conclusions) are not available in the provided source text. - Because the abstract/body text are not present in the source provided, specific findings, statistical results, medication classes evaluated, measures of chronic pain, and details of orthopedic surgical history were not reported and therefore cannot be summarized or interpreted here. - The available information allows accurate citation and identification of the article but does not permit extraction of clinical recommendations, efficacy or safety data, or study limitations beyond the lack of reported abstract content in this source. - Users should consult the full text of the article or the PubMed record with full abstract access for clinical details, data, and conclusions relevant to **pharmacologic management** and outcomes in this population.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42664488/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42664488%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42664488/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42664488/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42664488/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42664488/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42664488/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42664488/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42664488%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42664488%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42664488/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42664488/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42664488/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42664488/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42664488/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42664488/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42664488/#abstract) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42664488/#mesh-terms) Title & authors Abstract MeSH terms Neurology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Neurology%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Neurology%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42664488/) . 2026 Sep 22;107(6):e218475. doi: 10.1212/WNL.0000000000218475. Epub 2026 Aug 28. # Centrally Acting Medications, Chronic Pain, and Orthopedic Surgical History Among Former American Football Players [Alexa Puleio](https://pubmed.ncbi.nlm.nih.gov/?term=Puleio+A&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA."), [Ina Hoti](https://pubmed.ncbi.nlm.nih.gov/?term=Hoti+I&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA."), [William B Barr](https://pubmed.ncbi.nlm.nih.gov/?term=Barr+WB&cauthor_id=42664488)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-3 "NYU Grossman School of Medicine, New York City, NY."), [Sarah J Banks](https://pubmed.ncbi.nlm.nih.gov/?term=Banks+SJ&cauthor_id=42664488)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-4 "University of California, San Diego, La Jolla, CA."), [Jennifer Voreis Wethe](https://pubmed.ncbi.nlm.nih.gov/?term=Wethe+JV&cauthor_id=42664488)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-5 "Mayo Clinic College of Medicine, Scottsdale, AZ."), [Yorghos Tripodis](https://pubmed.ncbi.nlm.nih.gov/?term=Tripodis+Y&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-6 "Boston University School of Public Health, MA."), [Charles H Adler](https://pubmed.ncbi.nlm.nih.gov/?term=Adler+CH&cauthor_id=42664488)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-7 "Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, AZ."), [Laura J Balcer](https://pubmed.ncbi.nlm.nih.gov/?term=Balcer+LJ&cauthor_id=42664488)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-3 "NYU Grossman School of Medicine, New York City, NY."), [Charles Bernick](https://pubmed.ncbi.nlm.nih.gov/?term=Bernick+C&cauthor_id=42664488)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-8 "Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV."), [David W Dodick](https://pubmed.ncbi.nlm.nih.gov/?term=Dodick+DW&cauthor_id=42664488)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-5 "Mayo Clinic College of Medicine, Scottsdale, AZ."), [Robert C Cantu](https://pubmed.ncbi.nlm.nih.gov/?term=Cantu+RC&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-9 "Concussion Legacy Foundation, Boston, MA."), [Douglas I Katz](https://pubmed.ncbi.nlm.nih.gov/?term=Katz+DI&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA."), [Jesse Mez](https://pubmed.ncbi.nlm.nih.gov/?term=Mez+J&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-10 "Boston University Chronic Traumatic Encephalopathy Center, Boston, MA."), [Joseph Palmisano](https://pubmed.ncbi.nlm.nih.gov/?term=Palmisano+J&cauthor_id=42664488)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-6 "Boston University School of Public Health, MA."), [Brett Martin](https://pubmed.ncbi.nlm.nih.gov/?term=Martin+B&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-6 "Boston University School of Public Health, MA."), [Jeffrey L Cummings](https://pubmed.ncbi.nlm.nih.gov/?term=Cummings+JL&cauthor_id=42664488)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-11 "Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, NV."), [Eric M Reiman](https://pubmed.ncbi.nlm.nih.gov/?term=Reiman+EM&cauthor_id=42664488)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-12 "Banner Alzheimer's Institute, Phoenix, AZ; and."), [Martha E Shenton](https://pubmed.ncbi.nlm.nih.gov/?term=Shenton+ME&cauthor_id=42664488)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-13 "Brigham and Women's Hospital, Founding Member of Mass General Brigham, and Harvard Medical School, Boston, MA."), [Robert A Stern](https://pubmed.ncbi.nlm.nih.gov/?term=Stern+RA&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-10 "Boston University Chronic Traumatic Encephalopathy Center, Boston, MA."), [Michael L Alosco](https://pubmed.ncbi.nlm.nih.gov/?term=Alosco+ML&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-10 "Boston University Chronic Traumatic Encephalopathy Center, Boston, MA."), [Steven Lenio](https://pubmed.ncbi.nlm.nih.gov/?term=Lenio+S&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#full-view-affiliation-10 "Boston University Chronic Traumatic Encephalopathy Center, Boston, MA."); [as the DIAGNOSE CTE Research Project](https://pubmed.ncbi.nlm.nih.gov/?term=as+the+DIAGNOSE+CTE+Research+Project%5BCorporate+Author%5D) Affiliations Expand ### Affiliations * 1 Boston University Chobanian & Avedisian School of Medicine, Boston, MA. * 2 Boston University Alzheimer's Disease Research Center, Boston, MA. * 3 NYU Grossman School of Medicine, New York City, NY. * 4 University of California, San Diego, La Jolla, CA. * 5 Mayo Clinic College of Medicine, Scottsdale, AZ. * 6 Boston University School of Public Health, MA. * 7 Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, AZ. * 8 Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV. * 9 Concussion Legacy Foundation, Boston, MA. * 10 Boston University Chronic Traumatic Encephalopathy Center, Boston, MA. * 11 Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, NV. * 12 Banner Alzheimer's Institute, Phoenix, AZ; and. * 13 Brigham and Women's Hospital, Founding Member of Mass General Brigham, and Harvard Medical School, Boston, MA. * PMID: **42664488** * DOI: [ 10.1212/WNL.0000000000218475 ](https://doi.org/10.1212/wnl.0000000000218475) Item in Clipboard # Centrally Acting Medications, Chronic Pain, and Orthopedic Surgical History Among Former American Football Players Alexa Puleio et al. Neurology. 2026. Show details Display options Display options Format Abstract PubMed PMID Neurology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Neurology%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Neurology%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42664488/) . 2026 Sep 22;107(6):e218475. doi: 10.1212/WNL.0000000000218475. Epub 2026 Aug 28. ### Authors [Alexa Puleio](https://pubmed.ncbi.nlm.nih.gov/?term=Puleio+A&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA."), [Ina Hoti](https://pubmed.ncbi.nlm.nih.gov/?term=Hoti+I&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA."), [William B Barr](https://pubmed.ncbi.nlm.nih.gov/?term=Barr+WB&cauthor_id=42664488)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-3 "NYU Grossman School of Medicine, New York City, NY."), [Sarah J Banks](https://pubmed.ncbi.nlm.nih.gov/?term=Banks+SJ&cauthor_id=42664488)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-4 "University of California, San Diego, La Jolla, CA."), [Jennifer Voreis Wethe](https://pubmed.ncbi.nlm.nih.gov/?term=Wethe+JV&cauthor_id=42664488)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-5 "Mayo Clinic College of Medicine, Scottsdale, AZ."), [Yorghos Tripodis](https://pubmed.ncbi.nlm.nih.gov/?term=Tripodis+Y&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-6 "Boston University School of Public Health, MA."), [Charles H Adler](https://pubmed.ncbi.nlm.nih.gov/?term=Adler+CH&cauthor_id=42664488)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-7 "Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, AZ."), [Laura J Balcer](https://pubmed.ncbi.nlm.nih.gov/?term=Balcer+LJ&cauthor_id=42664488)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-3 "NYU Grossman School of Medicine, New York City, NY."), [Charles Bernick](https://pubmed.ncbi.nlm.nih.gov/?term=Bernick+C&cauthor_id=42664488)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-8 "Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV."), [David W Dodick](https://pubmed.ncbi.nlm.nih.gov/?term=Dodick+DW&cauthor_id=42664488)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-5 "Mayo Clinic College of Medicine, Scottsdale, AZ."), [Robert C Cantu](https://pubmed.ncbi.nlm.nih.gov/?term=Cantu+RC&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-9 "Concussion Legacy Foundation, Boston, MA."), [Douglas I Katz](https://pubmed.ncbi.nlm.nih.gov/?term=Katz+DI&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA."), [Jesse Mez](https://pubmed.ncbi.nlm.nih.gov/?term=Mez+J&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-10 "Boston University Chronic Traumatic Encephalopathy Center, Boston, MA."), [Joseph Palmisano](https://pubmed.ncbi.nlm.nih.gov/?term=Palmisano+J&cauthor_id=42664488)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-6 "Boston University School of Public Health, MA."), [Brett Martin](https://pubmed.ncbi.nlm.nih.gov/?term=Martin+B&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-6 "Boston University School of Public Health, MA."), [Jeffrey L Cummings](https://pubmed.ncbi.nlm.nih.gov/?term=Cummings+JL&cauthor_id=42664488)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-11 "Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, NV."), [Eric M Reiman](https://pubmed.ncbi.nlm.nih.gov/?term=Reiman+EM&cauthor_id=42664488)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-12 "Banner Alzheimer's Institute, Phoenix, AZ; and."), [Martha E Shenton](https://pubmed.ncbi.nlm.nih.gov/?term=Shenton+ME&cauthor_id=42664488)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-13 "Brigham and Women's Hospital, Founding Member of Mass General Brigham, and Harvard Medical School, Boston, MA."), [Robert A Stern](https://pubmed.ncbi.nlm.nih.gov/?term=Stern+RA&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-1 "Boston University Chobanian & Avedisian School of Medicine, Boston, MA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-2 "Boston University Alzheimer's Disease Research Center, Boston, MA.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-10 "Boston University Chronic Traumatic Encephalopathy Center, Boston, MA."), [Michael L Alosco](https://pubmed.ncbi.nlm.nih.gov/?term=Alosco+ML&cauthor_id=42664488)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42664488/#short-view-affiliation-1 "Boston University Cho
## Related Clinical Research

- [GLP-1 receptor agonists and reduced dementia risk in patients with CKD and type 2 diabetes](https://medichelpline.com/clinical-feed/pubmed-41697144.md) (DOI: 10.1093/ndt/gfag032)
- [MTHFR 677C>T variant drives prodromal cerebrovascular and synaptic signatures in a mouse model of](https://medichelpline.com/clinical-feed/biorxiv-0-mthfr-677c-t-produces-distinct-prodromal-disease-signatures-in-a-mouse-model-of.md)
- [Where Polygenic and Proteomic Risk Scores Diverge in Neurodegenerative Disease: Absorption and Co-](https://medichelpline.com/clinical-feed/medrxiv-10-absorption-and-co-expression-modules-show-where-polygenic-and-proteomic-risk.md)
- [Keto Diet Shows Superior Metabolic Benefits Over Mediterranean and Low-Fat Diets](https://medichelpline.com/clinical-feed/medical-news-today-1-keto-diet-may-have-metabolic-advantages-over-mediterranean-low-fat-diets.md)
- [Integrated multi-omics detection of m6A‑SNP–related diagnostic biomarkers for ALS](https://medichelpline.com/clinical-feed/frontiers-in-immunology-11-integrated-multi-omics-identification-of-m6a-snp-related-diagnostic-biomarkers.md)

## Navigation
- [← Back to Pharmacology Feed](https://medichelpline.com/clinical-feed/pharmacology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.