---
title: "Conversational diagnostic artificial intelligence in ambulatory primary care — feasibility study ("
id: "pubmed-42849491"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42849491"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42849491/"
doi: "10.1016/S0140-6736(26)01535-7"
published_at: "2026-10-24T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Conversational diagnostic artificial intelligence in ambulatory primary care — feasibility study (
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42849491
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42849491/)
- **DOI:** [10.1016/S0140-6736(26)01535-7](https://doi.org/10.1016%2FS0140-6736(26)01535-7)
- **Published At:** 2026-10-24T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The PubMed record documents a Lancet article titled “Conversational diagnostic artificial intelligence in ambulatory primary care: a prospective feasibility study.” The citation includes PMID 42849491 and DOI 10.1016/S0140-6736(26)01535-7. - The item is dated 2026 Oct 24 (Lancet, volume 408, issue 10565, pages 1732–1744) and was posted online 2026 Oct 8. The full author list and institutional affiliations are provided in the record. - Authors are affiliated with Beth Israel Deaconess Medical Center, Google Research, Google DeepMind, and Harvard Medical School; the multidisciplinary team mixes academic clinicians and industry researchers. - The article title identifies the intervention as **conversational diagnostic artificial intelligence** deployed in **ambulatory primary care** and describes the design as a “prospective feasibility study.” The record does not include study results in the excerpt supplied here. - The supplied PubMed entry includes a link to Elsevier Science for full text access, but the excerpt provided to this rewrite contains only bibliographic metadata and no abstract-level outcomes, endpoints, sample size, or methodology. - Key trial elements (study population, enrollment numbers, diagnostic endpoints, comparator details, safety or accuracy metrics, and statistical analyses) were not reported in the provided source text and therefore cannot be summarized or interpreted here. - For clinicians and policymakers evaluating this work, the unanswered items to check in the full article include diagnostic accuracy, false-positive and false-negative rates, clinician workflow impact, patient experience measures, safety events, and data governance details.
## Clinical Analysis & Structured Key Points
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Epub 2026 Oct 8. # Conversational diagnostic artificial intelligence in ambulatory primary care: a prospective feasibility study [Peter G Brodeur](https://pubmed.ncbi.nlm.nih.gov/?term=Brodeur+PG&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Jacob M Koshy](https://pubmed.ncbi.nlm.nih.gov/?term=Koshy+JM&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Anil Palepu](https://pubmed.ncbi.nlm.nih.gov/?term=Palepu+A&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Khaled Saab](https://pubmed.ncbi.nlm.nih.gov/?term=Saab+K&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Ava Homiar](https://pubmed.ncbi.nlm.nih.gov/?term=Homiar+A&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Roma Ruparel](https://pubmed.ncbi.nlm.nih.gov/?term=Ruparel+R&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Charles Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+C&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Ryutaro Tanno](https://pubmed.ncbi.nlm.nih.gov/?term=Tanno+R&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Joseph Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+J&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Amy Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+A&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [David Stutz](https://pubmed.ncbi.nlm.nih.gov/?term=Stutz+D&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Wei-Hung Weng](https://pubmed.ncbi.nlm.nih.gov/?term=Weng+WH&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Hannah M Ferrera](https://pubmed.ncbi.nlm.nih.gov/?term=Ferrera+HM&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [David Barrett](https://pubmed.ncbi.nlm.nih.gov/?term=Barrett+D&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Lindsey Crowley](https://pubmed.ncbi.nlm.nih.gov/?term=Crowley+L&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Jihyeon Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+J&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Spencer E Rittner](https://pubmed.ncbi.nlm.nih.gov/?term=Rittner+SE&cauthor_id=42849491)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-4 "Harvard Medical School, Boston, MA, USA."), [Ellery Wulczyn](https://pubmed.ncbi.nlm.nih.gov/?term=Wulczyn+E&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Selena K Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+SK&cauthor_id=42849491)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-4 "Harvard Medical School, Boston, MA, USA."), [Elahe Vedadi](https://pubmed.ncbi.nlm.nih.gov/?term=Vedadi+E&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Christine G Kohn](https://pubmed.ncbi.nlm.nih.gov/?term=Kohn+CG&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Kavita Kulkarni](https://pubmed.ncbi.nlm.nih.gov/?term=Kulkarni+K&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Vinay Kadiyala](https://pubmed.ncbi.nlm.nih.gov/?term=Kadiyala+V&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [S Sara Mahdavi](https://pubmed.ncbi.nlm.nih.gov/?term=Mahdavi+SS&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Wendy Du](https://pubmed.ncbi.nlm.nih.gov/?term=Du+W&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Jessica M Williams](https://pubmed.ncbi.nlm.nih.gov/?term=Williams+JM&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [David Feinbloom](https://pubmed.ncbi.nlm.nih.gov/?term=Feinbloom+D&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Renee Wong](https://pubmed.ncbi.nlm.nih.gov/?term=Wong+R&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Tao Tu](https://pubmed.ncbi.nlm.nih.gov/?term=Tu+T&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Petar Sirkovic](https://pubmed.ncbi.nlm.nih.gov/?term=Sirkovic+P&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Alessio Orlandi](https://pubmed.ncbi.nlm.nih.gov/?term=Orlandi+A&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Christopher Semturs](https://pubmed.ncbi.nlm.nih.gov/?term=Semturs+C&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Yun Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Y&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Juraj Gottweis](https://pubmed.ncbi.nlm.nih.gov/?term=Gottweis+J&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Dale R Webster](https://pubmed.ncbi.nlm.nih.gov/?term=Webster+DR&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Joëlle Barral](https://pubmed.ncbi.nlm.nih.gov/?term=Barral+J&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Katherine Chou](https://pubmed.ncbi.nlm.nih.gov/?term=Chou+K&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Pushmeet Kohli](https://pubmed.ncbi.nlm.nih.gov/?term=Kohli+P&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Avinatan Hassidim](https://pubmed.ncbi.nlm.nih.gov/?term=Hassidim+A&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Yossi Matias](https://pubmed.ncbi.nlm.nih.gov/?term=Matias+Y&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [James Manyika](https://pubmed.ncbi.nlm.nih.gov/?term=Manyika+J&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Rob Fields](https://pubmed.ncbi.nlm.nih.gov/?term=Fields+R&cauthor_id=42849491)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-4 "Harvard Medical School, Boston, MA, USA."), [Jonathan X Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+JX&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Marc L Cohen](https://pubmed.ncbi.nlm.nih.gov/?term=Cohen+ML&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Vivek Natarajan](https://pubmed.ncbi.nlm.nih.gov/?term=Natarajan+V&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Mike Schaekermann](https://pubmed.ncbi.nlm.nih.gov/?term=Schaekermann+M&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Alan Karthikesalingam](https://pubmed.ncbi.nlm.nih.gov/?term=Karthikesalingam+A&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-3 "Google DeepMind, London, UK."), [Adam Rodman](https://pubmed.ncbi.nlm.nih.gov/?term=Rodman+A&cauthor_id=42849491)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#full-view-affiliation-5 "Google Research, Mountain View, CA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: arodman@bidmc.harvard.edu.") Affiliations Expand ### Affiliations * 1 Beth Israel Deaconess Medical Center, Boston, MA, USA. * 2 Google Research, Mountain View, CA, USA. * 3 Google DeepMind, London, UK. * 4 Harvard Medical School, Boston, MA, USA. * 5 Google Research, Mountain View, CA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: arodman@bidmc.harvard.edu. * PMID: **42849491** * DOI: [ 10.1016/S0140-6736(26)01535-7 ](https://doi.org/10.1016/s0140-6736\(26\)01535-7) Item in Clipboard # Conversational diagnostic artificial intelligence in ambulatory primary care: a prospective feasibility study Peter G Brodeur et al. Lancet. 2026. Show details Display options Display options Format Abstract PubMed PMID Lancet Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lancet%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Lancet%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42849491/) . 2026 Oct 24;408(10565):1732-1744. doi: 10.1016/S0140-6736(26)01535-7. Epub 2026 Oct 8. ### Authors [Peter G Brodeur](https://pubmed.ncbi.nlm.nih.gov/?term=Brodeur+PG&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#short-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Jacob M Koshy](https://pubmed.ncbi.nlm.nih.gov/?term=Koshy+JM&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#short-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Anil Palepu](https://pubmed.ncbi.nlm.nih.gov/?term=Palepu+A&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#short-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Khaled Saab](https://pubmed.ncbi.nlm.nih.gov/?term=Saab+K&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#short-view-affiliation-3 "Google DeepMind, London, UK."), [Ava Homiar](https://pubmed.ncbi.nlm.nih.gov/?term=Homiar+A&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#short-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Roma Ruparel](https://pubmed.ncbi.nlm.nih.gov/?term=Ruparel+R&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#short-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Charles Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+C&cauthor_id=42849491)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#short-view-affiliation-1 "Beth Israel Deaconess Medical Center, Boston, MA, USA."), [Ryutaro Tanno](https://pubmed.ncbi.nlm.nih.gov/?term=Tanno+R&cauthor_id=42849491)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#short-view-affiliation-3 "Google DeepMind, London, UK."), [Joseph Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+J&cauthor_id=42849491)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849491/#short-view-affiliation-2 "Google Research, Mountain View, CA, USA."), [Amy Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+A&cauthor_id=42849491)[
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