---
title: "Cryoneurolysis for Sacroiliac Joint Pain: Multicenter Retrospective Cohort Results"
id: "pubmed-42681856"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42681856"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42681856/"
doi: "10.12659/MSM.953551"
published_at: "2026-09-02T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Cryoneurolysis for Sacroiliac Joint Pain: Multicenter Retrospective Cohort Results
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42681856
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42681856/)
- **DOI:** [10.12659/MSM.953551](https://doi.org/10.12659%2FMSM.953551)
- **Published At:** 2026-09-02T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This multicenter retrospective cohort study evaluated **cryoneurolysis** of the sacral lateral branches for chronic **sacroiliac joint (SIJ)** pain in 107 patients whose diagnosis was confirmed by a diagnostic SIJ block producing ≥50% pain relief. - Procedures targeted the lateral branches of the L5 and S1–S3 dorsal rami. Outcomes were measured with the **Numeric Rating Scale (NRS)**, **Visual Analog Scale (VAS)**, and **Oswestry Disability Index (ODI)** at baseline, 3 months, and 6 months. - Mean NRS fell from 7.4 ± 1.1 at baseline to 3.6 ± 1.5 at 3 months and 4.2 ± 1.7 at 6 months; these reductions were statistically significant (P < 0.001). - Mean VAS decreased from 74 ± 12 mm at baseline to 38 ± 15 mm at 3 months and 45 ± 17 mm at 6 months. - Mean ODI improved from 42 ± 9% at baseline to 24 ± 10% at 3 months and 28 ± 11% at 6 months, indicating functional benefit. - At least 50% pain reduction was achieved by 59.8% of patients at 3 months and 48.6% at 6 months. - No serious adverse events were reported in the cohort. - The authors conclude that cryoneurolysis is a safe, minimally invasive option that provides short- to mid-term pain relief and functional improvement for chronic SIJ-mediated pain. - The study design was retrospective and multicenter; detailed procedural protocols, patient selection criteria beyond the diagnostic block threshold, long-term durability beyond 6 months, and comparative data versus other modalities were not reported in the abstract.
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Affiliations Expand ### Affiliations * 1 Neurolocus Pain Management Centre, Warsaw, Poland. * 2 Pain Treatment Clinic, Our Lady of Perpetual Help Hospital in Wołomin, Wołomin, Poland. * 3 Department of Neurosurgery, Faculty of Medicine, Academy of Silesia, Katowice, Poland. * 4 Osteo Clinic, Warsaw, Poland. * 5 Pain Medicine Centre, Piła, Poland. * 6 Department of Anesthesiology and Intensive Care, Centre of Postgraduate Medical Education, Warsaw, Poland. * 7 Collegium Medicum, WSB University, Dąbrowa Górnicza, Poland. * 8 Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland. * PMID: **42681856** * DOI: [ 10.12659/MSM.953551 ](https://doi.org/10.12659/msm.953551) Item in Clipboard Multicenter Study # Cryoneurolysis of Sacral Lateral Branches for Chronic Sacroiliac Joint Pain: A Multicenter Retrospective Cohort Study Paweł Gogol et al. Med Sci Monit. 2026. Show details Display options Display options Format Abstract PubMed PMID Med Sci Monit Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Med+Sci+Monit%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Med+Sci+Monit%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) . 2026 Sep 2:32:e953551. doi: 10.12659/MSM.953551. ### Authors [Paweł Gogol](https://pubmed.ncbi.nlm.nih.gov/?term=Gogol+P&cauthor_id=42681856)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-1 "Neurolocus Pain Management Centre, Warsaw, Poland.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-2 "Pain Treatment Clinic, Our Lady of Perpetual Help Hospital in Wołomin, Wołomin, Poland.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-3 "Department of Neurosurgery, Faculty of Medicine, Academy of Silesia, Katowice, Poland."), [Małgorzata Gierczak](https://pubmed.ncbi.nlm.nih.gov/?term=Gierczak+M&cauthor_id=42681856)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-4 "Osteo Clinic, Warsaw, Poland."), [Robert Szczepaniak](https://pubmed.ncbi.nlm.nih.gov/?term=Szczepaniak+R&cauthor_id=42681856)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-1 "Neurolocus Pain Management Centre, Warsaw, Poland.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-2 "Pain Treatment Clinic, Our Lady of Perpetual Help Hospital in Wołomin, Wołomin, Poland."), [Rafał Pasztaleniec](https://pubmed.ncbi.nlm.nih.gov/?term=Pasztaleniec+R&cauthor_id=42681856)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-5 "Pain Medicine Centre, Piła, Poland."), [Rafał Wiśniewski](https://pubmed.ncbi.nlm.nih.gov/?term=Wi%C5%9Bniewski+R&cauthor_id=42681856)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-1 "Neurolocus Pain Management Centre, Warsaw, Poland."), [Małgorzata Malec-Milewska](https://pubmed.ncbi.nlm.nih.gov/?term=Malec-Milewska+M&cauthor_id=42681856)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-6 "Department of Anesthesiology and Intensive Care, Centre of Postgraduate Medical Education, Warsaw, Poland."), [Rafał Staszkiewicz](https://pubmed.ncbi.nlm.nih.gov/?term=Staszkiewicz+R&cauthor_id=42681856)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-3 "Department of Neurosurgery, Faculty of Medicine, Academy of Silesia, Katowice, Poland."), [Beniamin Oskar Grabarek](https://pubmed.ncbi.nlm.nih.gov/?term=Grabarek+BO&cauthor_id=42681856)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-7 "Collegium Medicum, WSB University, Dąbrowa Górnicza, Poland."), [Michał Sobstyl](https://pubmed.ncbi.nlm.nih.gov/?term=Sobstyl+M&cauthor_id=42681856)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42681856/#short-view-affiliation-8 "Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland.") ### Affiliations * 1 Neurolocus Pain Management Centre, Warsaw, Poland. * 2 Pain Treatment Clinic, Our Lady of Perpetual Help Hospital in Wołomin, Wołomin, Poland. * 3 Department of Neurosurgery, Faculty of Medicine, Academy of Silesia, Katowice, Poland. * 4 Osteo Clinic, Warsaw, Poland. * 5 Pain Medicine Centre, Piła, Poland. * 6 Department of Anesthesiology and Intensive Care, Centre of Postgraduate Medical Education, Warsaw, Poland. * 7 Collegium Medicum, WSB University, Dąbrowa Górnicza, Poland. * 8 Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland. * PMID: **42681856** * DOI: [ 10.12659/MSM.953551 ](https://doi.org/10.12659/msm.953551) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract BACKGROUND Chronic sacroiliac joint (SIJ) pain is a common cause of chronic low back pain and disability. Cryoneurolysis targeting the sacral lateral branches has emerged as a minimally invasive treatment option for SIJ-mediated pain. MATERIAL AND METHODS This multicenter retrospective cohort study included 107 patients with chronic SIJ-mediated pain confirmed by a diagnostic SIJ block that achieved at least 50% pain relief. All patients underwent cryoneurolysis of the lateral branches of the L5 and S1 to S3 dorsal rami. Pain intensity was assessed using the Numeric Rating Scale (NRS) and Visual Analog Scale (VAS); functional disability was evaluated using the Oswestry Disability Index (ODI). Outcomes were analyzed at baseline and at 3 and 6 months post-procedure. RESULTS Significant reductions in pain intensity were observed at both follow-up time points (P<0.001). Mean NRS scores decreased from 7.4±1.1 at baseline to 3.6±1.5 at 3 months and 4.2±1.7 at 6 months. Mean VAS scores decreased from 74±12 mm at baseline to 38±15 mm and 45±17 mm, respectively. Mean ODI scores improved from 42±9% at baseline to 24±10% at 3 months and 28±11% at 6 months. At least 50% pain reduction was achieved in 59.8% of patients at 3 months and 48.6% at 6 months. No serious adverse events were observed. CONCLUSIONS Cryoneurolysis offers a safe and potentially effective minimally invasive treatment for chronic SIJ-mediated pain, providing short- to mid-term pain relief and functional improvement. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Publication types * Multicenter Study Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Multicenter+Study%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Multicenter+Study) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) ## MeSH terms * Adult Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Adult%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Adult) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Chronic Pain / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Chronic+Pain%2Ftherapy%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Chronic+Pain) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Cryosurgery* / methods Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cryosurgery%2Fmethods%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cryosurgery) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Female Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Female) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Low Back Pain / therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Low+Back+Pain%2Ftherapy%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Low+Back+Pain) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Male Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Male) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Middle Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Middle+Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Pain Management / methods Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Pain+Management%2Fmethods%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Pain+Management) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Pain Measurement / methods Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Pain+Measurement%2Fmethods%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Pain+Measurement) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Retrospective Studies Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Retrospective+Studies%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Retrospective+Studies) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Sacroiliac Joint* / physiopathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Sacroiliac+Joint%2Fphysiopathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Sacroiliac+Joint) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Sacroiliac Joint* / surgery Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Sacroiliac+Joint%2Fsurgery%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Sacroiliac+Joint) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) * Treatment Outcome Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Treatment+Outcome%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Treatment+Outcome) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42681856/) [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM **Send To** * [Clipboard](https://pubmed.ncbi.nlm.nih.gov/42681856/) * [Email](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42681856%2F%23open-email-panel) * [Save](https://pubmed.ncbi.nlm.nih.g
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