---
title: "Cyclodextrin-enhanced delivery of resveratrol: advances, mechanisms, and translational prospects"
id: "pubmed-42493097"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42493097"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42493097/"
doi: "10.1016/j.carbpol.2026.125526"
published_at: "2026-09-15T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Cyclodextrin-enhanced delivery of resveratrol: advances, mechanisms, and translational prospects
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42493097
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42493097/)
- **DOI:** [10.1016/j.carbpol.2026.125526](https://doi.org/10.1016%2Fj.carbpol.2026.125526)
- **Published At:** 2026-09-15T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Resveratrol (RES) is a natural polyphenol with **antioxidant**, **anti-inflammatory**, **anticancer**, and **cardioprotective** properties, but its clinical use is limited by low aqueous solubility, poor chemical stability, rapid metabolism, and low oral bioavailability. - **Cyclodextrins (CDs)** and their derivatives function as host molecules that form **inclusion complexes (ICs)** with RES to improve solubility, stability, and therapeutic efficacy. - Beyond conventional CDs/RES ICs, advanced CD-based platforms include **nanosponges**, **hybrid nanosystems**, and **topical/transdermal formulations**, which can modify release kinetics and enhance biological activity. - The review summarizes the **physicochemical basis** of CD–RES interactions and the mechanisms by which CDs can increase RES bioavailability, as demonstrated in in vitro and in vivo models. - Evidence reported indicates encouraging outcomes for CDs-based delivery strategies, but specific quantitative improvements, comparative metrics, and full methodological details are not provided in the abstract and require consulting the full text. - The review also addresses current challenges for CDs-enabled RES delivery and outlines future perspectives for optimizing therapeutic performance and translation to clinical application. - Keywords emphasized in the source include **Bioavailability**, **Cyclodextrin (CDs)**, **Drug delivery**, **Inclusion complex**, **Nanocarrier**, and **Resveratrol**. - The authors declare no competing financial interests or personal relationships that influenced the work.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 4. # Cyclodextrin-mediated delivery of resveratrol: Recent advances, therapeutic potential, and future perspectives [Raheleh Boroumand](https://pubmed.ncbi.nlm.nih.gov/?term=Boroumand+R&cauthor_id=42493097)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42493097/#full-view-affiliation-1 "Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: BroumandR951@mums.ac.ir."), [Atoosa Haghighizadeh](https://pubmed.ncbi.nlm.nih.gov/?term=Haghighizadeh+A&cauthor_id=42493097)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42493097/#full-view-affiliation-2 "Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran."), [Zahra Salmasi](https://pubmed.ncbi.nlm.nih.gov/?term=Salmasi+Z&cauthor_id=42493097)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42493097/#full-view-affiliation-3 "Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran."), [Omid Rajabi](https://pubmed.ncbi.nlm.nih.gov/?term=Rajabi+O&cauthor_id=42493097)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42493097/#full-view-affiliation-4 "Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Rajabio@mums.ac.ir.") Affiliations Expand ### Affiliations * 1 Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: BroumandR951@mums.ac.ir. * 2 Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. * 3 Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. * 4 Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Rajabio@mums.ac.ir. * PMID: **42493097** * DOI: [ 10.1016/j.carbpol.2026.125526 ](https://doi.org/10.1016/j.carbpol.2026.125526) Item in Clipboard Review # Cyclodextrin-mediated delivery of resveratrol: Recent advances, therapeutic potential, and future perspectives Raheleh Boroumand et al. Carbohydr Polym. 2026. Show details Display options Display options Format Abstract PubMed PMID Carbohydr Polym Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Carbohydr+Polym%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Carbohydr+Polym%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42493097/) . 2026 Sep 15:388:125526. doi: 10.1016/j.carbpol.2026.125526. Epub 2026 Jun 4. ### Authors [Raheleh Boroumand](https://pubmed.ncbi.nlm.nih.gov/?term=Boroumand+R&cauthor_id=42493097)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42493097/#short-view-affiliation-1 "Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: BroumandR951@mums.ac.ir."), [Atoosa Haghighizadeh](https://pubmed.ncbi.nlm.nih.gov/?term=Haghighizadeh+A&cauthor_id=42493097)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42493097/#short-view-affiliation-2 "Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran."), [Zahra Salmasi](https://pubmed.ncbi.nlm.nih.gov/?term=Salmasi+Z&cauthor_id=42493097)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42493097/#short-view-affiliation-3 "Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran."), [Omid Rajabi](https://pubmed.ncbi.nlm.nih.gov/?term=Rajabi+O&cauthor_id=42493097)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42493097/#short-view-affiliation-4 "Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Rajabio@mums.ac.ir.") ### Affiliations * 1 Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: BroumandR951@mums.ac.ir. * 2 Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. * 3 Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. * 4 Department of Pharmaceutical and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Rajabio@mums.ac.ir. * PMID: **42493097** * DOI: [ 10.1016/j.carbpol.2026.125526 ](https://doi.org/10.1016/j.carbpol.2026.125526) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Resveratrol (RES) is a naturally occurring polyphenol with established antioxidant, anti-inflammatory, anticancer, and cardioprotective properties. However, low aqueous solubility, poor chemical stability, fast metabolism, and low oral bioavailability severely restrict its clinical translation. Cyclodextrins (CDs) and their derivatives, which act as host molecules, can be improved the solubility, stability, and therapeutic efficacy of RES by formation inclusion complexes (ICs). In addition to conventional CDs/RES ICs, various advanced delivery platforms, including CDs-based nanosponges, hybrid nanosystems, and topical/transdermal formulations have demonstrated encouraging outcomes in recent years in terms of enhancing biological activity and modifying release kinetics. Accordingly, a comprehensive understanding of CDs-based platforms for optimizing RES delivery and therapeutic application is necessary. This review highlights the physicochemical basis of the CDs-RES interaction, the mechanisms underlying improved bioavailability, and the effectiveness of CDs-based systems in both in vitro and in vivo models. Moreover, current challenges and future perspectives are discussed to highlight the potential of CDs-enabled strategies for optimizing RES delivery and therapeutic performance. **Keywords:** Bioavailability; Cyclodextrin (CDs); Drug delivery; Inclusion complex; Nanocarrier; Resveratrol. Copyright © 2026 Elsevier Ltd. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Cyclodextrins: Synthesis, Pharmaceutical Applications, Drug Delivery Systems and Safety Perspectives. ](https://pubmed.ncbi.nlm.nih.gov/42082778/) Kumar A, Pal RR, Patel P, Jain A, Sharma N, Patil UK, Kurmi BD.Kumar A, et al.AAPS PharmSciTech. 2026 May 4;27(4):194. doi: 10.1208/s12249-026-03400-y.AAPS PharmSciTech. 2026.PMID: 42082778Review. * [ Cyclodextrin Complexation for Enhanced Stability and Non-invasive Pulmonary Delivery of Resveratrol-Applications in Non-small Cell Lung Cancer Treatment. ](https://pubmed.ncbi.nlm.nih.gov/32632576/) Wang X, Parvathaneni V, Shukla SK, Kanabar DD, Muth A, Gupta V.Wang X, et al.AAPS PharmSciTech. 2020 Jul 6;21(5):183. doi: 10.1208/s12249-020-01724-x.AAPS PharmSciTech. 2020.PMID: 32632576 * [ Cyclodextrins as multifunctional supramolecular carriers in ocular drug delivery. ](https://pubmed.ncbi.nlm.nih.gov/42176761/) Menkudale AR, Lewis SA.Menkudale AR, et al.Int J Pharm. 2026 Jun 25;699:127003. doi: 10.1016/j.ijpharm.2026.127003. Epub 2026 May 22.Int J Pharm. 2026.PMID: 42176761Review. * [ Resveratrol-loaded nanomedicines for cancer applications. ](https://pubmed.ncbi.nlm.nih.gov/33655717/) Annaji M, Poudel I, Boddu SHS, Arnold RD, Tiwari AK, Babu RJ.Annaji M, et al.Cancer Rep (Hoboken). 2021 Jun;4(3):e1353. doi: 10.1002/cnr2.1353. Epub 2021 Mar 2.Cancer Rep (Hoboken). 2021.PMID: 33655717Free PMC article.Review. * [ Cyclodextrin complexes: Perspective from drug delivery and formulation. ](https://pubmed.ncbi.nlm.nih.gov/30188584/) Jacob S, Nair AB.Jacob S, et al.Drug Dev Res. 2018 Aug;79(5):201-217. doi: 10.1002/ddr.21452.Drug Dev Res. 2018.PMID: 30188584Review. 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