---
title: "Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab in Metastatic NSCLC"
id: "pubmed-42360104"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42360104"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42360104/"
doi: "10.1158/1078-0432.CCR-25-0942"
published_at: "2026-08-14T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab in Metastatic NSCLC
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42360104
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42360104/)
- **DOI:** [10.1158/1078-0432.CCR-25-0942](https://doi.org/10.1158%2F1078-0432.CCR-25-0942)
- **Published At:** 2026-08-14T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This record is a published clinical trial titled “Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab-Based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer.” - The article appears in Clinical Cancer Research (Clin Cancer Res) with publication details: 2026 Aug 14;32(16):3517-3530, DOI 10.1158/1078-0432.CCR-25-0942, PMID 42360104. - The study focuses on first-line combination immunotherapy with **nivolumab** plus **ipilimumab**-based regimens in patients with **metastatic non-small cell lung cancer** (NSCLC); the record is designated as a **Clinical Trial**. - The author list is extensive and multinational, with primary affiliations including Fox Chase Cancer Center, Bristol Myers Squibb, Hospital Universitario 12 de Octubre (Madrid), LungenClinic Grosshansdorf (Germany), Shanghai Lung Cancer Center, Winship Cancer Institute (Emory), Johns Hopkins, The Ohio State University, and other academic and industry institutions. - Full-text access options are indicated (link to Silverchair Information Systems noted on the PubMed page); DOI and PMID are provided for retrieval. - The PubMed record includes metadata, author affiliations, and links but does not include outcome data, methods, numerical results, or conclusions in the excerpt provided here; specific study findings and detailed methodology were not reported in the source content supplied. - For full study details (design, endpoints, sample size, statistical analysis, results, and authors’ conclusions) the reader must consult the full text via the DOI or publisher links cited on the PubMed record.
## Clinical Analysis & Structured Key Points
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& authors Abstract Similar articles Publication types MeSH terms Substances Related information Grants and funding LinkOut - more resources Clinical Trial Clin Cancer Res Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Clin+Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Clin+Cancer+Res%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42360104/) . 2026 Aug 14;32(16):3517-3530. doi: 10.1158/1078-0432.CCR-25-0942. # Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab-Based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer [Hossein Borghaei](https://pubmed.ncbi.nlm.nih.gov/?term=Borghaei+H&cauthor_id=42360104)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-1 "Hematology and Oncology Department, Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania."), [David Balli](https://pubmed.ncbi.nlm.nih.gov/?term=Balli+D&cauthor_id=42360104)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-2 "Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, New Jersey."), [Luis G Paz-Ares](https://pubmed.ncbi.nlm.nih.gov/?term=Paz-Ares+LG&cauthor_id=42360104)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-3 "Medical Oncology Department, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain."), [Martin Reck](https://pubmed.ncbi.nlm.nih.gov/?term=Reck+M&cauthor_id=42360104)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-4 "Department of Thoracic Oncology, Airway Research Center North, German Center for Lung Research, LungenClinic Grosshansdorf, Grosshansdorf, Germany."), [Shun Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+S&cauthor_id=42360104)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-5 "Department of Medical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China."), [Suresh S Ramalingam](https://pubmed.ncbi.nlm.nih.gov/?term=Ramalingam+SS&cauthor_id=42360104)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-6 "Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia."), [Julie R Brahmer](https://pubmed.ncbi.nlm.nih.gov/?term=Brahmer+JR&cauthor_id=42360104)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-7 "Department of Oncology, The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland."), [Thomas John](https://pubmed.ncbi.nlm.nih.gov/?term=John+T&cauthor_id=42360104)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-8 "Medical Oncology Department, Austin Hospital, Heidelberg, Australia."), [David P Carbone](https://pubmed.ncbi.nlm.nih.gov/?term=Carbone+DP&cauthor_id=42360104)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-9 "Department of Medical Oncology, The Ohio State University Comprehensive Cancer Center and the Pelotonia Institute for Immuno-Oncology, Columbus, Ohio."), [Tudor-Eliade Ciuleanu](https://pubmed.ncbi.nlm.nih.gov/?term=Ciuleanu+TE&cauthor_id=42360104)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-10 "Department of Medical Oncology, Institutul Oncologic Prof. Dr. Ion Chiricuta, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania."), [Michael Schenker](https://pubmed.ncbi.nlm.nih.gov/?term=Schenker+M&cauthor_id=42360104)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-11 "Department of Medical Oncology, Sf Nectarie Oncology Center, University of Medicine and Pharmacy of Craiova, Craiova, Romania."), [Manuel Cobo](https://pubmed.ncbi.nlm.nih.gov/?term=Cobo+M&cauthor_id=42360104)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-12 "Department of Medical Oncology, Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain."), [Bogdan Zurawski](https://pubmed.ncbi.nlm.nih.gov/?term=Zurawski+B&cauthor_id=42360104)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-13 "Chemotherapy Department, Ambulatorium Chemioterapii, Bydgoszcz, Poland."), [Adam Pluzanski](https://pubmed.ncbi.nlm.nih.gov/?term=Pluzanski+A&cauthor_id=42360104)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-14 "Department of Lung Cancer and Chest Tumours, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland."), [Jong-Seok Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+JS&cauthor_id=42360104)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-15 "Department of Hematology/Oncology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea."), [Shruti Agrawal](https://pubmed.ncbi.nlm.nih.gov/?term=Agrawal+S&cauthor_id=42360104)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-16 "Global Drug Development, Bristol Myers Squibb, Princeton, New Jersey."), [Thomas Spires](https://pubmed.ncbi.nlm.nih.gov/?term=Spires+T&cauthor_id=42360104)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-17 "Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey."), [Jaclyn Neely](https://pubmed.ncbi.nlm.nih.gov/?term=Neely+J&cauthor_id=42360104)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-17 "Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey."), [Virginia Ip](https://pubmed.ncbi.nlm.nih.gov/?term=Ip+V&cauthor_id=42360104)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-18 "Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey."), [Laura J Eccles](https://pubmed.ncbi.nlm.nih.gov/?term=Eccles+LJ&cauthor_id=42360104)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-18 "Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey."), [Han Chang](https://pubmed.ncbi.nlm.nih.gov/?term=Chang+H&cauthor_id=42360104)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-2 "Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, New Jersey."), [Joseph D Szustakowski](https://pubmed.ncbi.nlm.nih.gov/?term=Szustakowski+JD&cauthor_id=42360104)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-19 "Translational Bioinformatics, Bristol Myers Squibb, Princeton, New Jersey."), [Sumeena Bhatia](https://pubmed.ncbi.nlm.nih.gov/?term=Bhatia+S&cauthor_id=42360104)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-18 "Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey."), [Akshay Yadav](https://pubmed.ncbi.nlm.nih.gov/?term=Yadav+A&cauthor_id=42360104)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-20 "Data Science, Bristol Myers Squibb, Princeton, New Jersey."), [Nathanial Eddy](https://pubmed.ncbi.nlm.nih.gov/?term=Eddy+N&cauthor_id=42360104)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-20 "Data Science, Bristol Myers Squibb, Princeton, New Jersey."), [William J Geese](https://pubmed.ncbi.nlm.nih.gov/?term=Geese+WJ&cauthor_id=42360104)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-17 "Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey."), [Kenneth J O'Byrne](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Byrne+KJ&cauthor_id=42360104)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#full-view-affiliation-21 "Department of Medical Oncology, Princess Alexandra Hospital, Translational Research Institute and Queensland University of Technology, Brisbane, Australia.") Affiliations Expand ### Affiliations * 1 Hematology and Oncology Department, Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania. * 2 Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, New Jersey. * 3 Medical Oncology Department, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain. * 4 Department of Thoracic Oncology, Airway Research Center North, German Center for Lung Research, LungenClinic Grosshansdorf, Grosshansdorf, Germany. * 5 Department of Medical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. * 6 Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia. * 7 Department of Oncology, The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland. * 8 Medical Oncology Department, Austin Hospital, Heidelberg, Australia. * 9 Department of Medical Oncology, The Ohio State University Comprehensive Cancer Center and the Pelotonia Institute for Immuno-Oncology, Columbus, Ohio. * 10 Department of Medical Oncology, Institutul Oncologic Prof. Dr. Ion Chiricuta, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania. * 11 Department of Medical Oncology, Sf Nectarie Oncology Center, University of Medicine and Pharmacy of Craiova, Craiova, Romania. * 12 Department of Medical Oncology, Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain. * 13 Chemotherapy Department, Ambulatorium Chemioterapii, Bydgoszcz, Poland. * 14 Department of Lung Cancer and Chest Tumours, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. * 15 Department of Hematology/Oncology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. * 16 Global Drug Development, Bristol Myers Squibb, Princeton, New Jersey. * 17 Translational Medicine, Bristol Myers Squibb, Princeton, New Jersey. * 18 Global Medical Oncology, Bristol Myers Squibb, Princeton, New Jersey. * 19 Translational Bioinformatics, Bristol Myers Squibb, Princeton, New Jersey. * 20 Data Science, Bristol Myers Squibb, Princeton, New Jersey. * 21 Department of Medical Oncology, Princess Alexandra Hospital, Translational Research Institute and Queensland University of Technology, Brisbane, Australia. * PMID: **42360104** * DOI: [ 10.1158/1078-0432.CCR-25-0942 ](https://doi.org/10.1158/1078-0432.ccr-25-0942) Item in Clipboard Clinical Trial # Early Detriment Analysis of First-Line Nivolumab plus Ipilimumab-Based Therapy in Patients with Metastatic Non-Small Cell Lung Cancer Hossein Borghaei et al. Clin Cancer Res. 2026. Show details Display options Display options Format Abstract PubMed PMID Clin Cancer Res Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Clin+Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Clin+Cancer+Res%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42360104/) . 2026 Aug 14;32(16):3517-3530. doi: 10.1158/1078-0432.CCR-25-0942. ### Authors [Hossein Borghaei](https://pubmed.ncbi.nlm.nih.gov/?term=Borghaei+H&cauthor_id=42360104)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-1 "Hematology and Oncology Department, Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania."), [David Balli](https://pubmed.ncbi.nlm.nih.gov/?term=Balli+D&cauthor_id=42360104)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-2 "Informatics and Predictive Sciences, Bristol Myers Squibb, Princeton, New Jersey."), [Luis G Paz-Ares](https://pubmed.ncbi.nlm.nih.gov/?term=Paz-Ares+LG&cauthor_id=42360104)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-3 "Medical Oncology Department, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain."), [Martin Reck](https://pubmed.ncbi.nlm.nih.gov/?term=Reck+M&cauthor_id=42360104)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-4 "Department of Thoracic Oncology, Airway Research Center North, German Center for Lung Research, LungenClinic Grosshansdorf, Grosshansdorf, Germany."), [Shun Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+S&cauthor_id=42360104)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-5 "Department of Medical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China."), [Suresh S Ramalingam](https://pubmed.ncbi.nlm.nih.gov/?term=Ramalingam+SS&cauthor_id=42360104)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-6 "Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia."), [Julie R Brahmer](https://pubmed.ncbi.nlm.nih.gov/?term=Brahmer+JR&cauthor_id=42360104)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-7 "Department of Oncology, The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland."), [Thomas John](https://pubmed.ncbi.nlm.nih.gov/?term=John+T&cauthor_id=42360104)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-8 "Medical Oncology Department, Austin Hospital, Heidelberg, Australia."), [David P Carbone](https://pubmed.ncbi.nlm.nih.gov/?term=Carbone+DP&cauthor_id=42360104)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-9 "Department of Medical Oncology, The Ohio State University Comprehensive Cancer Center and the Pelotonia Institute for Immuno-Oncology, Columbus, Ohio."), [Tudor-Eliade Ciuleanu](https://pubmed.ncbi.nlm.nih.gov/?term=Ciuleanu+TE&cauthor_id=42360104)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42360104/#short-view-affiliation-10 "Department of Medical Oncology, Institutul Onc
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