---
title: "Global HICC Registry report on Homozygous Familial Hypercholesterolaemia"
id: "pubmed-42149947"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42149947"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42149947/"
doi: "10.1093/eurheartj/ehag357"
published_at: "2026-10-26T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Global HICC Registry report on Homozygous Familial Hypercholesterolaemia
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42149947
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42149947/)
- **DOI:** [10.1093/eurheartj/ehag357](https://doi.org/10.1093%2Feurheartj%2Fehag357)
- **Published At:** 2026-10-26T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article titled “Homozygous familial hypercholesterolaemia: insights from the Global HICC Registry” was published in the European Heart Journal and is listed as an observational study (PMID 42149947; DOI 10.1093/eurheartj/ehag357). - The publication date shown is 26 October 2026; the report is authored by a multinational team led by Willemijn A M Schonck and colleagues. - The research originates from an international collaboration across cardiovascular and lipid specialty centres in Europe, North America, Africa, and the Middle East; institutional affiliations are provided for each named author. - The registry named in the title is the **Global HICC Registry**; the source identifies the work as an international clinical collaboration under the Homozygous Familial Hypercholesterolaemia International Clinical Collaborators. - The article type is classified as an observational study by the journal listing; the PubMed entry includes author lists, affiliations, journal citation, DOI, and PMID. - The PubMed record excerpt provided does not include the study abstract, numerical results, enrolment numbers, patient demographics, specific endpoints, treatment regimens, or statistical outcomes; those methodological and outcome details were not reported in the available source text. - Readers seeking outcome data, sample size, genetic testing methods, lipid values, treatment patterns, or cardiovascular event rates must consult the full-text version linked through the journal. - The registry topic concerns **Homozygous familial hypercholesterolaemia**, a rare genetic condition affecting LDL cholesterol handling, and the Global HICC collaboration implies pooled international clinical data collection, but the excerpt did not present those data elements. - The PubMed entry lists detailed author affiliations spanning Amsterdam UMC, Erasmus MC, University of Pennsylvania, Prince Sultan Cardiac Centre, McGill, and others, indicating broad geographic representation within the registry effort. - For clinical interpretation or guideline application, clinicians should review the full article for endpoints, inclusion criteria, diagnostic definitions, and therapeutic details, since the source excerpt omitted these critical items.
## Clinical Analysis & Structured Key Points
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* [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42149947/#linkout) Title & authors Abstract Similar articles Cited by Publication types MeSH terms Substances Related information Grants and funding LinkOut - more resources Observational Study Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42149947/) . 2026 Oct 26;47(40):5979-5990. doi: 10.1093/eurheartj/ehag357. # Homozygous familial hypercholesterolaemia: insights from the Global HICC Registry [Willemijn A M Schonck](https://pubmed.ncbi.nlm.nih.gov/?term=Schonck+WAM&cauthor_id=42149947)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-1 "Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands."), [Janneke W C M Mulder](https://pubmed.ncbi.nlm.nih.gov/?term=Mulder+JWCM&cauthor_id=42149947)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-2 "Department of Internal Medicine, Erasmus MC Cardiovascular Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands."), [Marina Cuchel](https://pubmed.ncbi.nlm.nih.gov/?term=Cuchel+M&cauthor_id=42149947)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-3 "Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA."), [Laurens F Reeskamp](https://pubmed.ncbi.nlm.nih.gov/?term=Reeskamp+LF&cauthor_id=42149947)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-1 "Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands."), [Fahad Alnouri](https://pubmed.ncbi.nlm.nih.gov/?term=Alnouri+F&cauthor_id=42149947)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-4 "Cardiovascular Prevention Unit, Department of Adult Cardiology, Prince Sultan Cardiac Centre, Riyadh, Saudi Arabia."), [Iulia Iatan](https://pubmed.ncbi.nlm.nih.gov/?term=Iatan+I&cauthor_id=42149947)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-5 "Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada."), [Tomas Freiberger](https://pubmed.ncbi.nlm.nih.gov/?term=Freiberger+T&cauthor_id=42149947)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-6 "Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-7 "Medical Faculty, Masaryk University, Brno, Czech Republic."), [Meral Kayıkçıoğlu](https://pubmed.ncbi.nlm.nih.gov/?term=Kay%C4%B1k%C3%A7%C4%B1o%C4%9Flu+M&cauthor_id=42149947)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-8 "Department of Cardiology, Ege University Medical Faculty, Izmir, Türkiye."), [Tycho R Tromp](https://pubmed.ncbi.nlm.nih.gov/?term=Tromp+TR&cauthor_id=42149947)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-9 "Department of Internal Medicine, St.Antonius Hospital, Nieuwegein, The Netherlands."), [M Doortje Reijman](https://pubmed.ncbi.nlm.nih.gov/?term=Reijman+MD&cauthor_id=42149947)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-10 "Department of Paediatrics, Spaarne Gasthuis Hospital, Haarlem, The Netherlands."), [Albert Wiegman](https://pubmed.ncbi.nlm.nih.gov/?term=Wiegman+A&cauthor_id=42149947)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-11 "Department of Paediatrics, Amsterdam University Medical Centre, Academic Medical Centre, Amsterdam, The Netherlands."), [G Kees Hovingh](https://pubmed.ncbi.nlm.nih.gov/?term=Hovingh+GK&cauthor_id=42149947)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-12 "Novo Nordisk A/S, Copenhagen, Denmark."), [Jeanine E Roeters van Lennep](https://pubmed.ncbi.nlm.nih.gov/?term=Roeters+van+Lennep+JE&cauthor_id=42149947)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-2 "Department of Internal Medicine, Erasmus MC Cardiovascular Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands."), [Frederick J Raal](https://pubmed.ncbi.nlm.nih.gov/?term=Raal+FJ&cauthor_id=42149947)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-13 "Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa."), [Dirk J Blom](https://pubmed.ncbi.nlm.nih.gov/?term=Blom+DJ&cauthor_id=42149947)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-14 "Department of Medicine, Division of Lipidology and Cape Heart Institute, University of Cape Town, Cape Town, South Africa."), [Alberico L Catapano](https://pubmed.ncbi.nlm.nih.gov/?term=Catapano+AL&cauthor_id=42149947)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-15 "IRCCS MultiMedica, Sesto San Giovanni, Center for the Study of Atherosclerosis, via Milanese 300, 20099 Milan, Italy.")[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#full-view-affiliation-16 "Department of Pharmacological and Biomolecular Sciences, University of Milan, via Balzaretti 9, 20133 Milan, Italy."); [Homozygous Familial Hypercholesterolaemia International Clinical Collaborators](https://pubmed.ncbi.nlm.nih.gov/?term=Homozygous+Familial+Hypercholesterolaemia+International+Clinical+Collaborators%5BCorporate+Author%5D) Affiliations Expand ### Affiliations * 1 Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. * 2 Department of Internal Medicine, Erasmus MC Cardiovascular Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands. * 3 Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. * 4 Cardiovascular Prevention Unit, Department of Adult Cardiology, Prince Sultan Cardiac Centre, Riyadh, Saudi Arabia. * 5 Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada. * 6 Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic. * 7 Medical Faculty, Masaryk University, Brno, Czech Republic. * 8 Department of Cardiology, Ege University Medical Faculty, Izmir, Türkiye. * 9 Department of Internal Medicine, St.Antonius Hospital, Nieuwegein, The Netherlands. * 10 Department of Paediatrics, Spaarne Gasthuis Hospital, Haarlem, The Netherlands. * 11 Department of Paediatrics, Amsterdam University Medical Centre, Academic Medical Centre, Amsterdam, The Netherlands. * 12 Novo Nordisk A/S, Copenhagen, Denmark. * 13 Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa. * 14 Department of Medicine, Division of Lipidology and Cape Heart Institute, University of Cape Town, Cape Town, South Africa. * 15 IRCCS MultiMedica, Sesto San Giovanni, Center for the Study of Atherosclerosis, via Milanese 300, 20099 Milan, Italy. * 16 Department of Pharmacological and Biomolecular Sciences, University of Milan, via Balzaretti 9, 20133 Milan, Italy. * PMID: **42149947** * DOI: [ 10.1093/eurheartj/ehag357 ](https://doi.org/10.1093/eurheartj/ehag357) Item in Clipboard Observational Study # Homozygous familial hypercholesterolaemia: insights from the Global HICC Registry Willemijn A M Schonck et al. Eur Heart J. 2026. Show details Display options Display options Format Abstract PubMed PMID Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42149947/) . 2026 Oct 26;47(40):5979-5990. doi: 10.1093/eurheartj/ehag357. ### Authors [Willemijn A M Schonck](https://pubmed.ncbi.nlm.nih.gov/?term=Schonck+WAM&cauthor_id=42149947)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-1 "Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands."), [Janneke W C M Mulder](https://pubmed.ncbi.nlm.nih.gov/?term=Mulder+JWCM&cauthor_id=42149947)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-2 "Department of Internal Medicine, Erasmus MC Cardiovascular Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands."), [Marina Cuchel](https://pubmed.ncbi.nlm.nih.gov/?term=Cuchel+M&cauthor_id=42149947)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-3 "Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA."), [Laurens F Reeskamp](https://pubmed.ncbi.nlm.nih.gov/?term=Reeskamp+LF&cauthor_id=42149947)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-1 "Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands."), [Fahad Alnouri](https://pubmed.ncbi.nlm.nih.gov/?term=Alnouri+F&cauthor_id=42149947)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-4 "Cardiovascular Prevention Unit, Department of Adult Cardiology, Prince Sultan Cardiac Centre, Riyadh, Saudi Arabia."), [Iulia Iatan](https://pubmed.ncbi.nlm.nih.gov/?term=Iatan+I&cauthor_id=42149947)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-5 "Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada."), [Tomas Freiberger](https://pubmed.ncbi.nlm.nih.gov/?term=Freiberger+T&cauthor_id=42149947)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-6 "Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-7 "Medical Faculty, Masaryk University, Brno, Czech Republic."), [Meral Kayıkçıoğlu](https://pubmed.ncbi.nlm.nih.gov/?term=Kay%C4%B1k%C3%A7%C4%B1o%C4%9Flu+M&cauthor_id=42149947)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-8 "Department of Cardiology, Ege University Medical Faculty, Izmir, Türkiye."), [Tycho R Tromp](https://pubmed.ncbi.nlm.nih.gov/?term=Tromp+TR&cauthor_id=42149947)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-9 "Department of Internal Medicine, St.Antonius Hospital, Nieuwegein, The Netherlands."), [M Doortje Reijman](https://pubmed.ncbi.nlm.nih.gov/?term=Reijman+MD&cauthor_id=42149947)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-10 "Department of Paediatrics, Spaarne Gasthuis Hospital, Haarlem, The Netherlands."), [Albert Wiegman](https://pubmed.ncbi.nlm.nih.gov/?term=Wiegman+A&cauthor_id=42149947)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-11 "Department of Paediatrics, Amsterdam University Medical Centre, Academic Medical Centre, Amsterdam, The Netherlands."), [G Kees Hovingh](https://pubmed.ncbi.nlm.nih.gov/?term=Hovingh+GK&cauthor_id=42149947)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-12 "Novo Nordisk A/S, Copenhagen, Denmark."), [Jeanine E Roeters van Lennep](https://pubmed.ncbi.nlm.nih.gov/?term=Roeters+van+Lennep+JE&cauthor_id=42149947)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-2 "Department of Internal Medicine, Erasmus MC Cardiovascular Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands."), [Frederick J Raal](https://pubmed.ncbi.nlm.nih.gov/?term=Raal+FJ&cauthor_id=42149947)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-13 "Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa."), [Dirk J Blom](https://pubmed.ncbi.nlm.nih.gov/?term=Blom+DJ&cauthor_id=42149947)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-14 "Department of Medicine, Division of Lipidology and Cape Heart Institute, University of Cape Town, Cape Town, South Africa."), [Alberico L Catapano](https://pubmed.ncbi.nlm.nih.gov/?term=Catapano+AL&cauthor_id=42149947)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-15 "IRCCS MultiMedica, Sesto San Giovanni, Center for the Study of Atherosclerosis, via Milanese 300, 20099 Milan, Italy.")[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42149947/#short-view-affiliation-16 "Department of Pharmacological and Biomolecular Sciences, University of Milan, via Balzaretti 9, 20133 Milan, Italy."); [Homozygous Familial Hypercholesterolaemia International Clinical Collaborators](https://pubmed.ncbi.nlm.nih.gov/?term=Homozygous+Familial+Hypercholesterolaemia+International+Clinical+Collaborators%5BCorporate+Author%5D) ### Affiliations * 1 Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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