---
title: "Intrathecal MSC‑NPs in Progressive MS: CSF Biomarker Changes After Treatment"
id: "pubmed-42754254"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42754254"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42754254/"
doi: "10.1093/stcltm/szag083"
published_at: "2026-09-18T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Intrathecal MSC‑NPs in Progressive MS: CSF Biomarker Changes After Treatment
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42754254
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42754254/)
- **DOI:** [10.1093/stcltm/szag083](https://doi.org/10.1093%2Fstcltm%2Fszag083)
- **Published At:** 2026-09-18T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Mesenchymal stem cell‑neural progenitors (**MSC‑NPs**) are derived from bone marrow mesenchymal stem cells and have trophic and immunomodulatory properties with therapeutic potential in multiple sclerosis (MS). - Early clinical trials have tested safety and efficacy of **intrathecal** autologous MSC‑NP administration in people with **progressive MS**. - Cerebrospinal fluid (**CSF**) biomarkers were analyzed in two cohorts: a phase 2 trial (n = 50) and an expanded access trial (n = 43), both receiving repeated intrathecal autologous MSC‑NPs. - Proteomic screening identified candidate biomarkers which were validated across both cohorts. - A panel of four CSF biomarkers — **CCL2** (C‑C motif chemokine ligand‑2), **MMP9** (matrix metalloproteinase‑9), **SCF** (stem cell factor/c‑kit ligand), and **CHIT1** (chitotriosidase‑1) — showed significant changes in CSF after MSC‑NP treatment; these changes were not observed in serum. - Established MS biomarkers neurofilament light (**NfL**) and glial fibrillary acidic protein (**GFAP**) did not change after treatment; NfL correlated with age, and GFAP correlated with both age and Expanded Disability Status Scale (**EDSS**). - The specific CSF biomarker changes suggest distinct biological effects attributable to MSC‑NP injections and serve as a pharmacodynamic signature of treatment. - These biomarker findings are proposed to inform the biological response to MSC‑NP therapy and help guide design of future clinical studies. - Details beyond the reported biomarker panel, such as magnitude of change, statistical values, safety outcomes, or long‑term clinical efficacy, were not reported in the abstract.
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Affiliations Expand ### Affiliation * 1 Tisch Multiple Sclerosis Research Center of New York, New York, NY 10019, United States. * PMID: **42754254** * DOI: [ 10.1093/stcltm/szag083 ](https://doi.org/10.1093/stcltm/szag083) Item in Clipboard # Effect of intrathecal injection of mesenchymal stem cell-neural progenitors on cerebrospinal fluid biomarkers in progressive multiple sclerosis Violaine K Harris et al. Stem Cells Transl Med. 2026. Show details Display options Display options Format Abstract PubMed PMID Stem Cells Transl Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Stem+Cells+Transl+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Stem+Cells+Transl+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42754254/) . 2026 Sep 18;15(10):szag083. doi: 10.1093/stcltm/szag083. ### Authors [Violaine K Harris](https://pubmed.ncbi.nlm.nih.gov/?term=Harris+VK&cauthor_id=42754254)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42754254/#short-view-affiliation-1 "Tisch Multiple Sclerosis Research Center of New York, New York, NY 10019, United States."), [Andrea Jiang](https://pubmed.ncbi.nlm.nih.gov/?term=Jiang+A&cauthor_id=42754254)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42754254/#short-view-affiliation-1 "Tisch Multiple Sclerosis Research Center of New York, New York, NY 10019, United States."), [Sofia Ricciarini](https://pubmed.ncbi.nlm.nih.gov/?term=Ricciarini+S&cauthor_id=42754254)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42754254/#short-view-affiliation-1 "Tisch Multiple Sclerosis Research Center of New York, New York, NY 10019, United States."), [Nikki Jagid](https://pubmed.ncbi.nlm.nih.gov/?term=Jagid+N&cauthor_id=42754254)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42754254/#short-view-affiliation-1 "Tisch Multiple Sclerosis Research Center of New York, New York, NY 10019, United States."), [Maureen McCormick](https://pubmed.ncbi.nlm.nih.gov/?term=McCormick+M&cauthor_id=42754254)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42754254/#short-view-affiliation-1 "Tisch Multiple Sclerosis Research Center of New York, New York, NY 10019, United States."), [Cara Kizilbash](https://pubmed.ncbi.nlm.nih.gov/?term=Kizilbash+C&cauthor_id=42754254)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42754254/#short-view-affiliation-1 "Tisch Multiple Sclerosis Research Center of New York, New York, NY 10019, United States."), [Saud A Sadiq](https://pubmed.ncbi.nlm.nih.gov/?term=Sadiq+SA&cauthor_id=42754254)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42754254/#short-view-affiliation-1 "Tisch Multiple Sclerosis Research Center of New York, New York, NY 10019, United States.") ### Affiliation * 1 Tisch Multiple Sclerosis Research Center of New York, New York, NY 10019, United States. * PMID: **42754254** * DOI: [ 10.1093/stcltm/szag083 ](https://doi.org/10.1093/stcltm/szag083) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Mesenchymal stem cell-neural progenitors (MSC-NP) are a bone marrow mesenchymal stem cell-derived population of cells with trophic and immunomodulatory properties with therapeutic potential in multiple sclerosis (MS). Early phase clinical trials have investigated the safety and efficacy of intrathecal administration of autologous MSC-NPs in people with progressive MS. To better understand the biological response to MSC-NP treatment, we analyzed cerebrospinal fluid (CSF) biomarkers in 2 separate cohorts of trial subjects with secondary progressive or primary progressive MS from both a phase 2 trial (n = 50) and an expanded access trial (n = 43) who received repeated administrations of autologous MSC-NPs. Candidate biomarkers identified through proteomic screening were validated in both cohorts, revealing a panel of 4 biomarkers (CCL2, C-C motif chemokine ligand-2; MMP9, matrix metalloproteinase-9; SCF, stem cell factor/c-kit ligand; and CHIT1, chitotriosidase-1) that were significantly changed in CSF but not serum following treatment. Other MS biomarkers neurofilament light and glial fibrillary acidic protein were unchanged following treatment but correlated with age, and both age and Expanded Disability Status Scale (EDSS), respectively. The specific biomarker changes observed following MSC-NP injections suggest distinct biological effects following MSC-NP treatment. These biomarkers help define the pharmacodynamic response to MSC-NP treatment as well as guide the design of future clinical studies. **Keywords:** autologous stem cell transplantation; biomarkers; cerebrospinal fluid; mesenchymal stem cells; multiple sclerosis. © The Author(s) 2026. Published by Oxford University Press. 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