---
title: "Lacosamide Adsorption to Dialysis Membranes During CRRT: Effects on Drug Dosing"
id: "pubmed-42698197"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42698197"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42698197/"
doi: "10.12659/MSM.952323"
published_at: "2026-09-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Lacosamide Adsorption to Dialysis Membranes During CRRT: Effects on Drug Dosing
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42698197
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42698197/)
- **DOI:** [10.12659/MSM.952323](https://doi.org/10.12659%2FMSM.952323)
- **Published At:** 2026-09-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- In vitro study evaluated **lacosamide** adsorption to three dialysis filter membranes (polysulfone **PS**, polyacrylonitrile **PAN**, and polyacrylonitrile polyethyleneimine **PAN-PEI**) and assessed drug stability in saline and plasma solutions. - Lacosamide at 200 µg/mL was prepared in 0.9% NaCl and bovine plasma, perfused through each filter, and samples collected up to 90 minutes for HPLC measurement. - Chemical stability: lacosamide concentrations in saline and plasma varied by less than 7% over 90 minutes, indicating **stability** in both matrices. - In 0.9% NaCl, measurable **adsorption** occurred with concentration reductions at 90 minutes of 33.52% (PS), 20.71% (PAN), and 14.73% (PAN-PEI). - In plasma, adsorption differed: PS showed 17.96% reduction, PAN-PEI 23.04%, and PAN 27.71% at 90 minutes. - Statistical testing found no significant differences in adsorption among the three membrane types (P > 0.05). - Overall, adsorption was more pronounced in plasma than saline for PAN and PAN-PEI membranes; PS showed greater adsorption in saline than plasma. - Clinical implication: measurable lacosamide loss on dialysis membranes suggests potential decreases in circulating drug concentrations during extracorporeal circulation; consideration is warranted when dosing lacosamide during hemodialysis or continuous renal replacement therapy (**CRRT**) in critically ill renal patients. - Methodological note: study was in vitro using bovine plasma and specific membrane types; direct extrapolation to all clinical CRRT settings or patient outcomes is not provided in the source.
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Affiliations Expand ### Affiliations * 1 Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury, Olsztyn, Poland. * 2 Department of Anesthesiology and Intensive Therapy, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland. * 3 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland. * 4 Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland. * 5 Clinic of Endocrinology, Diabetology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland. * 6 Department of Biomedical Sciences, School of Veterinary Medicine, Ross University, Basseterre, Saint Kitts and Nevis. * PMID: **42698197** * DOI: [ 10.12659/MSM.952323 ](https://doi.org/10.12659/msm.952323) Item in Clipboard # Membrane-Dependent Adsorption of Lacosamide in CRRT: Implications for Drug Dosing in Critically Ill Renal Patients Krzysztof Nosek et al. Med Sci Monit. 2026. Show details Display options Display options Format Abstract PubMed PMID Med Sci Monit Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Med+Sci+Monit%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Med+Sci+Monit%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42698197/) . 2026 Sep 5:32:e952323. doi: 10.12659/MSM.952323. ### Authors [Krzysztof Nosek](https://pubmed.ncbi.nlm.nih.gov/?term=Nosek+K&cauthor_id=42698197)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42698197/#short-view-affiliation-1 "Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury, Olsztyn, Poland."), [Milena Samiec](https://pubmed.ncbi.nlm.nih.gov/?term=Samiec+M&cauthor_id=42698197)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42698197/#short-view-affiliation-2 "Department of Anesthesiology and Intensive Therapy, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland."), [Hubert Ziółkowski](https://pubmed.ncbi.nlm.nih.gov/?term=Zi%C3%B3%C5%82kowski+H&cauthor_id=42698197)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42698197/#short-view-affiliation-3 "Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland."), [Robert Maksymowicz](https://pubmed.ncbi.nlm.nih.gov/?term=Maksymowicz+R&cauthor_id=42698197)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42698197/#short-view-affiliation-4 "Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland."), [Wojciech Matuszewski](https://pubmed.ncbi.nlm.nih.gov/?term=Matuszewski+W&cauthor_id=42698197)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42698197/#short-view-affiliation-5 "Clinic of Endocrinology, Diabetology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland."), [Dariusz Onichimowski](https://pubmed.ncbi.nlm.nih.gov/?term=Onichimowski+D&cauthor_id=42698197)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42698197/#short-view-affiliation-2 "Department of Anesthesiology and Intensive Therapy, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland."), [Paulina Markowska-Buńka](https://pubmed.ncbi.nlm.nih.gov/?term=Markowska-Bu%C5%84ka+P&cauthor_id=42698197)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42698197/#short-view-affiliation-3 "Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland."), [Krzysztof Czaja](https://pubmed.ncbi.nlm.nih.gov/?term=Czaja+K&cauthor_id=42698197)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42698197/#short-view-affiliation-6 "Department of Biomedical Sciences, School of Veterinary Medicine, Ross University, Basseterre, Saint Kitts and Nevis.") ### Affiliations * 1 Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury, Olsztyn, Poland. * 2 Department of Anesthesiology and Intensive Therapy, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland. * 3 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland. * 4 Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury, Olsztyn, Poland. * 5 Clinic of Endocrinology, Diabetology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland. * 6 Department of Biomedical Sciences, School of Veterinary Medicine, Ross University, Basseterre, Saint Kitts and Nevis. * PMID: **42698197** * DOI: [ 10.12659/MSM.952323 ](https://doi.org/10.12659/msm.952323) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract BACKGROUND Lacosamide is an antiepileptic drug widely used to treat partial-onset seizures. During extracorporeal therapies or intravenous administration, lacosamide adsorption to filtration membranes and its stability in solutions may influence therapeutic efficacy. This in vitro study evaluated lacosamide adsorption to different dialysis filter membranes in saline and plasma solutions, as well as its stability in these solutions. MATERIAL AND METHODS Lacosamide (200 µg/mL) was prepared in 0.9% NaCl and bovine plasma, then perfused through 3 types of dialysis filters: polysulfone (PS), polyacrylonitrile (PAN), and polyacrylonitrile polyethyleneimine (PAN-PEI). Samples were collected at 0, 5, 15, 30, 45, 60, and 90 minutes. Lacosamide concentrations were measured using high-performance liquid chromatography. Repeated-measures analysis of variance and post hoc tests were used to evaluate concentration changes over time among filter types. RESULTS Lacosamide remained stable in saline and plasma solutions over 90 minutes, showing under 7% variation in concentration. In 0.9% NaCl, significant adsorption occurred across all filters, with total reductions of 14.73% for PAN-PEI, 20.71% for PAN, and 33.52% for PS filters at 90 minutes. In plasma, adsorption was lower for PS filters (17.96%) but greater for PAN-PEI (23.04%) and PAN (27.71%) filters. No significant differences in adsorption were detected among filters (P>0.05). CONCLUSIONS Lacosamide demonstrated chemical stability with measurable adsorption to dialysis membranes. Adsorption was more pronounced in plasma than in saline for PAN-PEI and PAN membranes. These findings indicate that lacosamide concentrations may decrease during extracorporeal circulation and should be considered in settings involving hemodialysis or continuous renal replacement therapy. 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