---
title: "Lactobacillus acidophilus Improves Hepatic and Microbial Dysregulation in MASLD and Diabetes"
id: "pubmed-42760849"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42760849"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42760849/"
doi: "10.1080/19490976.2026.2734705"
published_at: "2026-09-19T12:39:09.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Lactobacillus acidophilus Improves Hepatic and Microbial Dysregulation in MASLD and Diabetes
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42760849
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42760849/)
- **DOI:** [10.1080/19490976.2026.2734705](https://doi.org/10.1080%2F19490976.2026.2734705)
- **Published At:** 2026-09-19T12:39:09.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Gut microbial dysbiosis is implicated in metabolic dysfunction-associated steatotic liver disease (**MASLD**) and diabetes; the metabolic effects of specific probiotic strains remain incompletely defined. - The authors selected **Lactobacillus acidophilus** after validating disease-associated microbial patterns in a clinical cohort and tested its effects across multiple complementary animal models. - Mouse models included Western diet, fructose-palmitate-cholesterol diet, high-fat diet, and leptin-deficient (ob/ob) mice to represent diet- and genetically driven metabolic disease states. - **L. acidophilus** supplementation attenuated hepatic steatosis and inflammatory liver injury across several models and improved glucose tolerance in ob/ob mice. - Hepatic changes with supplementation included reduced expression of pro-inflammatory cytokines and modulation of AMPK-associated signaling pathways. - Lipid and glucose metabolic gene expression shifted: decreased lipogenic genes (**Srebf1**, **Acc**) and gluconeogenic genes (**Pepck**, **G6pc**), and increased **Ppara**, indicating coordinated regulation of hepatic glucose and lipid metabolism. - Transcriptomic profiling showed broader effects on metabolic networks, including altered **Lpin1** expression and enrichment of nutrient-sensing and metabolic regulation pathways. - Gut microbial community structure was altered by **L. acidophilus** in mouse models; human cohort analyses showed context-dependent patterns involving **Lactobacillus**, **Akkermansia**, and butyrate-producing Firmicutes across metabolic disease states. - Collectively, findings support **L. acidophilus** as a probiotic candidate that may improve metabolic dysfunction via coordinated hepatic metabolic regulation and gut microbial modulation for MASLD and diabetes-associated disease. - Specific experimental details such as probiotic dosing, treatment duration, sample sizes, and full human cohort characteristics were not reported in the abstract.
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Epub 2026 Sep 19. # Effects of _Lactobacillus acidophilus_ on hepatic and microbial dysregulation in MASLD and diabetes [Hee Jin Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+HJ&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#full-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [In Gyu Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+IG&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#full-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [Jeong Ha Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+JH&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#full-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [Hyun Joon Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+HJ&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#full-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [Jin Ju Jung](https://pubmed.ncbi.nlm.nih.gov/?term=Jung+JJ&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#full-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [Sang Hak Han](https://pubmed.ncbi.nlm.nih.gov/?term=Han+SH&cauthor_id=42760849)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#full-view-affiliation-2 "Department of Pathology, Hallym University College of Medicine, Chuncheon, Republic of Korea."), [Ki Tae Suk](https://pubmed.ncbi.nlm.nih.gov/?term=Suk+KT&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#full-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.") Affiliations Expand ### Affiliations * 1 Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea. * 2 Department of Pathology, Hallym University College of Medicine, Chuncheon, Republic of Korea. * PMID: **42760849** * DOI: [ 10.1080/19490976.2026.2734705 ](https://doi.org/10.1080/19490976.2026.2734705) Item in Clipboard # Effects of _Lactobacillus acidophilus_ on hepatic and microbial dysregulation in MASLD and diabetes Hee Jin Park et al. Gut Microbes. 2026. Show details Display options Display options Format Abstract PubMed PMID Gut Microbes Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Gut+Microbes%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Gut+Microbes%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42760849/) . 2026 Dec 31;18(1):2734705. doi: 10.1080/19490976.2026.2734705. Epub 2026 Sep 19. ### Authors [Hee Jin Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+HJ&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#short-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [In Gyu Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+IG&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#short-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [Jeong Ha Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+JH&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#short-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [Hyun Joon Park](https://pubmed.ncbi.nlm.nih.gov/?term=Park+HJ&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#short-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [Jin Ju Jung](https://pubmed.ncbi.nlm.nih.gov/?term=Jung+JJ&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#short-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea."), [Sang Hak Han](https://pubmed.ncbi.nlm.nih.gov/?term=Han+SH&cauthor_id=42760849)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#short-view-affiliation-2 "Department of Pathology, Hallym University College of Medicine, Chuncheon, Republic of Korea."), [Ki Tae Suk](https://pubmed.ncbi.nlm.nih.gov/?term=Suk+KT&cauthor_id=42760849)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42760849/#short-view-affiliation-1 "Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.") ### Affiliations * 1 Institute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea. * 2 Department of Pathology, Hallym University College of Medicine, Chuncheon, Republic of Korea. * PMID: **42760849** * DOI: [ 10.1080/19490976.2026.2734705 ](https://doi.org/10.1080/19490976.2026.2734705) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Gut microbial dysbiosis has been implicated in metabolic dysfunction-associated steatotic liver disease (MASLD) and diabetes, but the metabolic effects of candidate probiotic strains across this disease continuum remain incompletely understood. Based on the validation of disease-associated microbial patterns in a clinical cohort, _Lactobacillus acidophilus_ as selected as a candidate strain, and its effects were systematically investigated across multiple complementary models, including Western diet, fructose-palmitate-cholesterol diet, high-fat diet, and leptin-deficient ob/ob mice. _L. acidophilus_ supplementation attenuated hepatic steatosis and inflammatory injury in multiple complementary models and improved glucose tolerance in ob/ob mice. These effects were accompanied by reduced hepatic expression of pro-inflammatory cytokines, changes in AMPK-associated signaling, decreased expression of lipogenic (_Srebf1_ and _Acc_) and gluconeogenic (_Pepck_ and _G6pc_) genes, and increased _Ppara_ expression, suggesting coordinated regulation of glucose and lipid metabolism. Transcriptomic profiling further indicated that _L. acidophilus_ influenced broader metabolic networks, including altered expression of _Lpin1_ and enrichment of pathways related to nutrient sensing and metabolic regulation. In addition, _L. acidophilus_ supplementation altered gut microbial community structure in mouse models, while human cohort analyzes revealed context-dependent microbial patterns involving _Lactobacillus_ , _Akkermansia_ , and butyrate-producing Firmicutes across metabolic disease states. Collectively, these findings suggest that _L. acidophilus_ may improve metabolic dysfunction through coordinated hepatic metabolic regulation and gut microbial modulation, supporting its potential as a probiotic candidate for MASLD and diabetes-associated metabolic disease. **Keywords:** Lactobacillus acidophilus; diabetes; gut microbiota; metabolic-associated steatotic liver disease; probiotics. 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