---
title: "Lifestyle Intervention Lowers Type 2 Diabetes Risk After Gestational Diabetes: Randomized Trial"
id: "pubmed-41823088"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-41823088"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/41823088/"
doi: "10.1097/CM9.0000000000004043"
published_at: "2026-08-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Lifestyle Intervention Lowers Type 2 Diabetes Risk After Gestational Diabetes: Randomized Trial
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-41823088
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/41823088/)
- **DOI:** [10.1097/CM9.0000000000004043](https://doi.org/10.1097%2FCM9.0000000000004043)
- **Published At:** 2026-08-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This item is a **randomized controlled trial** titled “Lifestyle intervention reduces type 2 diabetes incidence among young women with previous gestational diabetes: A randomized controlled trial.” - The study is reported in Chin Med J (Engl), volume 139, issue 15, pages 2299–2308, with PubMed PMID **41823088** and DOI 10.1097/CM9.0000000000004043. It was Epub 2026 Mar 15 and listed with a publication date of 2026 Aug 5. - The title indicates that a **lifestyle intervention** reduced incidence of **type 2 diabetes** in young women with prior **gestational diabetes**, but the PubMed entry shown does not include the abstract text or outcome metrics in the visible source content. - The article is a multi-author, multi-institution collaboration with contributors from the United States, China, Finland, and Canada; affiliations include Pennington Biomedical Research Center, Tianjin Women and Children’s Health Center, Kaiser Permanente Division of Research, Tulane University, Dalhousie University, Tianjin Medical University, and University of Helsinki. - Authors listed include Gang Hu, Huikun Liu, Weiqin Li, Leishen Wang, Shuang Zhang, Junhong Leng, Wei Li, Gongshu Liu, Yun Shen, Shengping Yang, Erica Gunderson, Lu Qi, Zhijie Yu, Xilin Yang, Ming Liu, Ping Shao, Fuxia Zhang, Huiguang Tian, and Jaakko Tuomilehto. - The PubMed record labels the study as a Randomized Controlled Trial; however, the detailed **methods**, sample size, intervention components, follow-up duration, statistical outcomes, and safety/adverse-event data were not shown in the provided source content. - Because the source excerpt lacks the abstract and full-text content, specific numerical results, relative risk reductions, confidence intervals, p values, and participant characteristics are not available from the provided material and therefore are not reported here. - Publication identifiers and bibliographic metadata are provided and verifiable: PMID 41823088 and DOI 10.1097/CM9.0000000000004043. - Users seeking detailed trial data, effect sizes, or clinical applicability should consult the full-text article via the DOI or journal link; the PubMed entry as shown does not supply those details.
## Clinical Analysis & Structured Key Points
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Epub 2026 Mar 15. # Lifestyle intervention reduces type 2 diabetes incidence among young women with previous gestational diabetes: A randomized controlled trial [Gang Hu](https://pubmed.ncbi.nlm.nih.gov/?term=Hu+G&cauthor_id=41823088)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-1 "Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA."), [Huikun Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=41823088)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-2 "Disease Screening Center, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Weiqin Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+W&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Leishen Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+L&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Shuang Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+S&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Junhong Leng](https://pubmed.ncbi.nlm.nih.gov/?term=Leng+J&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Wei Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+W&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Gongshu Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+G&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Yun Shen](https://pubmed.ncbi.nlm.nih.gov/?term=Shen+Y&cauthor_id=41823088)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-1 "Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA."), [Shengping Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+S&cauthor_id=41823088)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-1 "Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA."), [Erica Gunderson](https://pubmed.ncbi.nlm.nih.gov/?term=Gunderson+E&cauthor_id=41823088)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-4 "Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-5 "Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA 91101, USA."), [Lu Qi](https://pubmed.ncbi.nlm.nih.gov/?term=Qi+L&cauthor_id=41823088)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-6 "Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA."), [Zhijie Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+Z&cauthor_id=41823088)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-7 "Population Cancer Research Program, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada."), [Xilin Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+X&cauthor_id=41823088)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-8 "Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China."), [Ming Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+M&cauthor_id=41823088)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-9 "Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China."), [Ping Shao](https://pubmed.ncbi.nlm.nih.gov/?term=Shao+P&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Fuxia Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+F&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Huiguang Tian](https://pubmed.ncbi.nlm.nih.gov/?term=Tian+H&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Jaakko Tuomilehto](https://pubmed.ncbi.nlm.nih.gov/?term=Tuomilehto+J&cauthor_id=41823088)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-10 "Department of Public Health, University of Helsinki, Helsinki 00014, Finland.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#full-view-affiliation-11 "Population Health Unit, Finnish Institute for Health and Welfare, Helsinki 00271, Finland.") Affiliations Expand ### Affiliations * 1 Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. * 2 Disease Screening Center, Tianjin Women and Children's Health Center, Tianjin 300070, China. * 3 Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China. * 4 Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA. * 5 Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA 91101, USA. * 6 Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. * 7 Population Cancer Research Program, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. * 8 Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China. * 9 Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China. * 10 Department of Public Health, University of Helsinki, Helsinki 00014, Finland. * 11 Population Health Unit, Finnish Institute for Health and Welfare, Helsinki 00271, Finland. * PMID: **41823088** * DOI: [ 10.1097/CM9.0000000000004043 ](https://doi.org/10.1097/cm9.0000000000004043) Item in Clipboard Randomized Controlled Trial # Lifestyle intervention reduces type 2 diabetes incidence among young women with previous gestational diabetes: A randomized controlled trial Gang Hu et al. Chin Med J (Engl). 2026. Show details Display options Display options Format Abstract PubMed PMID Chin Med J (Engl) Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Chin+Med+J+%28Engl%29%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Chin+Med+J+%28Engl%29%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/41823088/) . 2026 Aug 5;139(15):2299-2308. doi: 10.1097/CM9.0000000000004043. Epub 2026 Mar 15. ### Authors [Gang Hu](https://pubmed.ncbi.nlm.nih.gov/?term=Hu+G&cauthor_id=41823088)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-1 "Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA."), [Huikun Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=41823088)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-2 "Disease Screening Center, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Weiqin Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+W&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Leishen Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+L&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Shuang Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+S&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Junhong Leng](https://pubmed.ncbi.nlm.nih.gov/?term=Leng+J&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Wei Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+W&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Gongshu Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+G&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Yun Shen](https://pubmed.ncbi.nlm.nih.gov/?term=Shen+Y&cauthor_id=41823088)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-1 "Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA."), [Shengping Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+S&cauthor_id=41823088)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-1 "Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA."), [Erica Gunderson](https://pubmed.ncbi.nlm.nih.gov/?term=Gunderson+E&cauthor_id=41823088)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-4 "Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-5 "Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA 91101, USA."), [Lu Qi](https://pubmed.ncbi.nlm.nih.gov/?term=Qi+L&cauthor_id=41823088)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-6 "Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA."), [Zhijie Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+Z&cauthor_id=41823088)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-7 "Population Cancer Research Program, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada."), [Xilin Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+X&cauthor_id=41823088)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-8 "Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China."), [Ming Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+M&cauthor_id=41823088)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-9 "Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China."), [Ping Shao](https://pubmed.ncbi.nlm.nih.gov/?term=Shao+P&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Fuxia Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+F&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Huiguang Tian](https://pubmed.ncbi.nlm.nih.gov/?term=Tian+H&cauthor_id=41823088)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-3 "Preparatory Institute of Maternal and Child Health, Tianjin Women and Children's Health Center, Tianjin 300070, China."), [Jaakko Tuomilehto](https://pubmed.ncbi.nlm.nih.gov/?term=Tuomilehto+J&cauthor_id=41823088)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-10 "Department of Public Health, University of Helsinki, Helsinki 00014, Finland.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/41823088/#short-view-affiliation-11 "Population Health Unit, Finnish Institute for Health and Welfare, Helsinki 00271, Finland.") ### Affiliations * 1 Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. * 2 Disease Screening Center, Tianjin Women and Children's Health Center, Tianjin 300070, China. * 3 Preparatory Institute of Maternal and Child Health, Tianjin W
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