---
title: "Lipoprotein apheresis and contemporary lipid-lowering therapies: a 2026 Eur Heart J review"
id: "pubmed-42155048"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42155048"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42155048/"
doi: "10.1093/eurheartj/ehag328"
published_at: "2026-10-26T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Lipoprotein apheresis and contemporary lipid-lowering therapies: a 2026 Eur Heart J review
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42155048
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42155048/)
- **DOI:** [10.1093/eurheartj/ehag328](https://doi.org/10.1093%2Feurheartj%2Fehag328)
- **Published At:** 2026-10-26T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article is a peer-reviewed review titled “Lipoprotein apheresis in the era of new lipid-lowering therapies,” published in the European Heart Journal on 26 October 2026; investigators included Francesco Sbrana and a multi-national author group. - The PubMed entry (PMID: 42155048; DOI: 10.1093/eurheartj/ehag328) identifies the paper as a review but the accessible PubMed snippet does not include the article abstract text or explicit outcome data. - The authors are affiliated with multiple clinical and apheresis centers across Italy, Germany, Japan, Canada, and the USA, indicating a broad clinical and technical perspective informing the review. - The PubMed record links to full-text options (Silverchair/European Heart Journal platform) but the PubMed page excerpt shown here does not provide methods, patient cohorts, or quantified results. - Because the source text provided lacked the abstract or body, this rewrite reports only bibliographic facts and structural observations; the source did not report specific clinical endpoints, dosing, comparative efficacy data, safety outcomes, or guideline recommendations in the displayed content. - Key unanswered items in the PubMed excerpt include: exact scope of clinical questions addressed by the review; summaries of comparative data between **lipoprotein apheresis** and novel **lipid-lowering therapies**; practical recommendations for patient selection; and any proposed algorithms or research priorities. - The PubMed page indicates the full text is available via journal links; readers should consult the full article for detailed methodology, synthesized evidence, and the authors’ conclusions.
## Clinical Analysis & Structured Key Points
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more resources ](https://pubmed.ncbi.nlm.nih.gov/42155048/#linkout) Title & authors Abstract Similar articles Cited by Publication types MeSH terms Substances Related information LinkOut - more resources Review Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42155048/) . 2026 Oct 26;47(40):5959-5978. doi: 10.1093/eurheartj/ehag328. # Lipoprotein apheresis in the era of new lipid-lowering therapies [Francesco Sbrana](https://pubmed.ncbi.nlm.nih.gov/?term=Sbrana+F&cauthor_id=42155048)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-1 "Lipoapheresis Unit-Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi, 1, Pisa 56124, Italy."), [Beatrice Dal Pino](https://pubmed.ncbi.nlm.nih.gov/?term=Dal+Pino+B&cauthor_id=42155048)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-1 "Lipoapheresis Unit-Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi, 1, Pisa 56124, Italy."), [Volker J J Schettler](https://pubmed.ncbi.nlm.nih.gov/?term=Schettler+VJJ&cauthor_id=42155048)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-2 "Centre of Nephrology Göttingen GbR, Göttingen, Germany."), [Eri Muso](https://pubmed.ncbi.nlm.nih.gov/?term=Muso+E&cauthor_id=42155048)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-3 "Department of Food and Nutrition, Faculty of Contemporary Life Studies, Kyoto Kacho University, Kyoto, Japan."), [Mariko Harada-Shiba](https://pubmed.ncbi.nlm.nih.gov/?term=Harada-Shiba+M&cauthor_id=42155048)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-4 "Cardiovascular Center, Osaka Medical and Pharmaceutical University, Osaka, Japan."), [Maria Di Mola](https://pubmed.ncbi.nlm.nih.gov/?term=Di+Mola+M&cauthor_id=42155048)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-5 "Dialysis and Apheresis Program, Department of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada."), [Maki Kagitani](https://pubmed.ncbi.nlm.nih.gov/?term=Kagitani+M&cauthor_id=42155048)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-6 "Blood Purification Center, Osaka Medical and Pharmaceutical University, Osaka, Japan."), [Eleanor Pineda](https://pubmed.ncbi.nlm.nih.gov/?term=Pineda+E&cauthor_id=42155048)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-3 "Department of Food and Nutrition, Faculty of Contemporary Life Studies, Kyoto Kacho University, Kyoto, Japan."), [Nathalie Selke](https://pubmed.ncbi.nlm.nih.gov/?term=Selke+N&cauthor_id=42155048)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-7 "Rostock Division, akquinet Tech@Spree GmbH, Rostock, Germany."), [Sebastian Jenke](https://pubmed.ncbi.nlm.nih.gov/?term=Jenke+S&cauthor_id=42155048)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-7 "Rostock Division, akquinet Tech@Spree GmbH, Rostock, Germany."), [Thomas Zimmermann](https://pubmed.ncbi.nlm.nih.gov/?term=Zimmermann+T&cauthor_id=42155048)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-8 "BioArtProducts GmbH \(B.A.P.\), Rostock, Germany."), [Wanja Bernhardt](https://pubmed.ncbi.nlm.nih.gov/?term=Bernhardt+W&cauthor_id=42155048)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-9 "Center for Nephrology, Hypertension, and Metabolic Diseases, Hannover, Germany."), [Federico Bigazzi](https://pubmed.ncbi.nlm.nih.gov/?term=Bigazzi+F&cauthor_id=42155048)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-1 "Lipoapheresis Unit-Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi, 1, Pisa 56124, Italy."), [Franz Heigl](https://pubmed.ncbi.nlm.nih.gov/?term=Heigl+F&cauthor_id=42155048)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-10 "Medical Care Center Kempten-Allgäu, Kempten, Germany."), [Peter Grützmacher](https://pubmed.ncbi.nlm.nih.gov/?term=Gr%C3%BCtzmacher+P&cauthor_id=42155048)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-11 "AGAPLESION MVZ Markus Hospital, Frankfurt, Germany."), [Iris Löhlein](https://pubmed.ncbi.nlm.nih.gov/?term=L%C3%B6hlein+I&cauthor_id=42155048)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-12 "German Society of Lipidology e. V. \(DGFL\)-Lipid League, Gelnhausen, Germany."), [Reinhard Klingel](https://pubmed.ncbi.nlm.nih.gov/?term=Klingel+R&cauthor_id=42155048)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-13 "Apheresis Research Institute, Cologne, Germany."), [Carmen Corciulo](https://pubmed.ncbi.nlm.nih.gov/?term=Corciulo+C&cauthor_id=42155048)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-1 "Lipoapheresis Unit-Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi, 1, Pisa 56124, Italy."), [Bernd Hohenstein](https://pubmed.ncbi.nlm.nih.gov/?term=Hohenstein+B&cauthor_id=42155048)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-14 "1st Dept. Internal Medicine, University of Mainz, Germany.")[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-15 "Nephrological Center Villingen-Schwenningen, Villingen-Schwenningen, Germany."), [Wolfang Ramlow](https://pubmed.ncbi.nlm.nih.gov/?term=Ramlow+W&cauthor_id=42155048)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-16 "Apheresis Center Rostock \(ACR\), Rostock, Germany."), [Anja Vogt](https://pubmed.ncbi.nlm.nih.gov/?term=Vogt+A&cauthor_id=42155048)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-17 "Medizinische Klinik und Poliklinik 4, Universität München, Munich, Germany."), [Alfonso Ramunni](https://pubmed.ncbi.nlm.nih.gov/?term=Ramunni+A&cauthor_id=42155048)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-18 "Department of Internal and Public Medicine, Division of Nephrology, University of Bari, Italy."), [Michele Emdin](https://pubmed.ncbi.nlm.nih.gov/?term=Emdin+M&cauthor_id=42155048)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-1 "Lipoapheresis Unit-Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi, 1, Pisa 56124, Italy.")[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-19 "Health Science Interdisciplinary Center Scuola Superiore Sant'Anna, Pisa, Italy."), [Tiziana Sampietro](https://pubmed.ncbi.nlm.nih.gov/?term=Sampietro+T&cauthor_id=42155048)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-1 "Lipoapheresis Unit-Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi, 1, Pisa 56124, Italy."), [Ulrich Julius](https://pubmed.ncbi.nlm.nih.gov/?term=Julius+U&cauthor_id=42155048)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-20 "Department of Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany."), [Georg Schlieper](https://pubmed.ncbi.nlm.nih.gov/?term=Schlieper+G&cauthor_id=42155048)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-9 "Center for Nephrology, Hypertension, and Metabolic Diseases, Hannover, Germany."), [Claudia Stefanutti](https://pubmed.ncbi.nlm.nih.gov/?term=Stefanutti+C&cauthor_id=42155048)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-21 "Department of Molecular Medicine, Extracorporeal Therapeutic Techniques Unit, Lipid Clinic and Atherosclerosis Prevention Centre, Regional Centre for Rare Diseases, Immunohematology and Transfusion Medicine, Umberto I Hospital, 'Sapienza' University of Rome, Rome, Italy."), [Patrick M Moriarty](https://pubmed.ncbi.nlm.nih.gov/?term=Moriarty+PM&cauthor_id=42155048)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#full-view-affiliation-22 "Atherosclerosis and Lipid-Apheresis Center, University of Kansas Medical Center, Kansas City, KS, USA.") Affiliations Expand ### Affiliations * 1 Lipoapheresis Unit-Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi, 1, Pisa 56124, Italy. * 2 Centre of Nephrology Göttingen GbR, Göttingen, Germany. * 3 Department of Food and Nutrition, Faculty of Contemporary Life Studies, Kyoto Kacho University, Kyoto, Japan. * 4 Cardiovascular Center, Osaka Medical and Pharmaceutical University, Osaka, Japan. * 5 Dialysis and Apheresis Program, Department of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada. * 6 Blood Purification Center, Osaka Medical and Pharmaceutical University, Osaka, Japan. * 7 Rostock Division, akquinet Tech@Spree GmbH, Rostock, Germany. * 8 BioArtProducts GmbH (B.A.P.), Rostock, Germany. * 9 Center for Nephrology, Hypertension, and Metabolic Diseases, Hannover, Germany. * 10 Medical Care Center Kempten-Allgäu, Kempten, Germany. * 11 AGAPLESION MVZ Markus Hospital, Frankfurt, Germany. * 12 German Society of Lipidology e. V. (DGFL)-Lipid League, Gelnhausen, Germany. * 13 Apheresis Research Institute, Cologne, Germany. * 14 1st Dept. Internal Medicine, University of Mainz, Germany. * 15 Nephrological Center Villingen-Schwenningen, Villingen-Schwenningen, Germany. * 16 Apheresis Center Rostock (ACR), Rostock, Germany. * 17 Medizinische Klinik und Poliklinik 4, Universität München, Munich, Germany. * 18 Department of Internal and Public Medicine, Division of Nephrology, University of Bari, Italy. * 19 Health Science Interdisciplinary Center Scuola Superiore Sant'Anna, Pisa, Italy. * 20 Department of Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany. * 21 Department of Molecular Medicine, Extracorporeal Therapeutic Techniques Unit, Lipid Clinic and Atherosclerosis Prevention Centre, Regional Centre for Rare Diseases, Immunohematology and Transfusion Medicine, Umberto I Hospital, 'Sapienza' University of Rome, Rome, Italy. * 22 Atherosclerosis and Lipid-Apheresis Center, University of Kansas Medical Center, Kansas City, KS, USA. * PMID: **42155048** * DOI: [ 10.1093/eurheartj/ehag328 ](https://doi.org/10.1093/eurheartj/ehag328) Item in Clipboard Review # Lipoprotein apheresis in the era of new lipid-lowering therapies Francesco Sbrana et al. Eur Heart J. 2026. Show details Display options Display options Format Abstract PubMed PMID Eur Heart J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+Heart+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+Heart+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42155048/) . 2026 Oct 26;47(40):5959-5978. doi: 10.1093/eurheartj/ehag328. ### Authors [Francesco Sbrana](https://pubmed.ncbi.nlm.nih.gov/?term=Sbrana+F&cauthor_id=42155048)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#short-view-affiliation-1 "Lipoapheresis Unit-Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi, 1, Pisa 56124, Italy."), [Beatrice Dal Pino](https://pubmed.ncbi.nlm.nih.gov/?term=Dal+Pino+B&cauthor_id=42155048)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#short-view-affiliation-1 "Lipoapheresis Unit-Reference Center for Diagnosis and Treatment of Inherited Dyslipidemias, Fondazione Toscana 'Gabriele Monasterio', Via Moruzzi, 1, Pisa 56124, Italy."), [Volker J J Schettler](https://pubmed.ncbi.nlm.nih.gov/?term=Schettler+VJJ&cauthor_id=42155048)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#short-view-affiliation-2 "Centre of Nephrology Göttingen GbR, Göttingen, Germany."), [Eri Muso](https://pubmed.ncbi.nlm.nih.gov/?term=Muso+E&cauthor_id=42155048)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#short-view-affiliation-3 "Department of Food and Nutrition, Faculty of Contemporary Life Studies, Kyoto Kacho University, Kyoto, Japan."), [Mariko Harada-Shiba](https://pubmed.ncbi.nlm.nih.gov/?term=Harada-Shiba+M&cauthor_id=42155048)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#short-view-affiliation-4 "Cardiovascular Center, Osaka Medical and Pharmaceutical University, Osaka, Japan."), [Maria Di Mola](https://pubmed.ncbi.nlm.nih.gov/?term=Di+Mola+M&cauthor_id=42155048)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#short-view-affiliation-5 "Dialysis and Apheresis Program, Department of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada."), [Maki Kagitani](https://pubmed.ncbi.nlm.nih.gov/?term=Kagitani+M&cauthor_id=42155048)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#short-view-affiliation-6 "Blood Purification Center, Osaka Medical and Pharmaceutical University, Osaka, Japan."), [Eleanor Pineda](https://pubmed.ncbi.nlm.nih.gov/?term=Pineda+E&cauthor_id=42155048)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42155048/#short-view
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