---
title: "Liposuction versus conservative therapy for lipoedema: multicentre randomised trial in Germany"
id: "pubmed-42692034"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42692034"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42692034/"
doi: "10.1016/S0140-6736(26)00910-4"
published_at: "2026-09-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Liposuction versus conservative therapy for lipoedema: multicentre randomised trial in Germany
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42692034
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42692034/)
- **DOI:** [10.1016/S0140-6736(26)00910-4](https://doi.org/10.1016%2FS0140-6736(26)00910-4)
- **Published At:** 2026-09-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This is a multicentre, **randomised controlled trial** comparing **liposuction** with conservative therapy for patients with **lipoedema** conducted in Germany and published in Lancet. - Publication details: Lancet. 2026 Sep 5;408(10558):910-923. DOI 10.1016/S0140-6736(26)00910-4. PubMed PMID 42692034. - The trial is described in the PubMed record with a full author list led by Maurizio Podda and includes multiple investigators and clinical sites across Germany. - Participating authors and institutions include departments of dermatology, plastic and reconstructive surgery, clinical trials centre and medical statistics groups at multiple German centres (Darmstadt, Bad Belzig, Düsseldorf, Cologne, Bonn, Potsdam, and others). - The PubMed entry classifies the work as a Randomized Controlled Trial and shows it appeared in a high-impact general medical journal. - The PubMed page excerpt available here lists authors, affiliations, citation, PMID and DOI but does not include the abstract text, trial methods, primary or secondary endpoints, sample size, numerical results, safety data, or conclusions in the provided content. - Specific trial details (eligibility criteria, randomisation method, interventions, follow-up duration, outcome measures, statistical analysis, results, and interpretation) were not reported in the source excerpt and therefore cannot be summarised from this source alone. - For complete study protocol, methods, results and clinical conclusions, consult the Lancet full text (DOI provided) or the PubMed record external links for the full abstract and article text.
## Clinical Analysis & Structured Key Points
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Faculty of Health Sciences Brandenburg \(FGW Brandenburg\), Potsdam, Germany."), [Maximilian Kovacs](https://pubmed.ncbi.nlm.nih.gov/?term=Kovacs+M&cauthor_id=42692034)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#full-view-affiliation-1 "Department of Dermatology, Medical Centre Klinikum Darmstadt, Teaching Hospital Goethe-University Frankfurt, Darmstadt, Germany."), [Sabine Schmid](https://pubmed.ncbi.nlm.nih.gov/?term=Schmid+S&cauthor_id=42692034)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#full-view-affiliation-1 "Department of Dermatology, Medical Centre Klinikum Darmstadt, Teaching Hospital Goethe-University Frankfurt, Darmstadt, Germany."), [Daria Kraus](https://pubmed.ncbi.nlm.nih.gov/?term=Kraus+D&cauthor_id=42692034)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#full-view-affiliation-8 "Clinical Trials Centre Cologne \(ZKS Köln\), Faculty of Medicine, University of Cologne and University Hospital Cologne; Cologne, Germany."), [Martin Hellmich](https://pubmed.ncbi.nlm.nih.gov/?term=Hellmich+M&cauthor_id=42692034)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#full-view-affiliation-9 "Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany."), [Wiebke Müller](https://pubmed.ncbi.nlm.nih.gov/?term=M%C3%BCller+W&cauthor_id=42692034)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#full-view-affiliation-10 "Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany."), [Petra Schiller](https://pubmed.ncbi.nlm.nih.gov/?term=Schiller+P&cauthor_id=42692034)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#full-view-affiliation-10 "Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany."), [Oliver A Cornely](https://pubmed.ncbi.nlm.nih.gov/?term=Cornely+OA&cauthor_id=42692034)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#full-view-affiliation-11 "Clinical Trials Centre Cologne \(ZKS Köln\), Faculty of Medicine, University of Cologne and University Hospital Cologne; Cologne, Germany; Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases \(CECAD\), Cologne, Germany; Department I of Internal Medicine, Division of Infectious Diseases, Cologne, Germany; German Centre for Infection Research \(DZIF\), Partner Site Bonn-Cologne, Cologne, Germany. Electronic address: oliver.cornely@uk-koeln.de.") Affiliations Expand ### Affiliations * 1 Department of Dermatology, Medical Centre Klinikum Darmstadt, Teaching Hospital Goethe-University Frankfurt, Darmstadt, Germany. * 2 Department of Plastic, Aesthetic, and Reconstructive Microsurgery, Ernst von Bergmann Hospital, Bad Belzig, Germany. * 3 MVZ Dermatology Practice Düsseldorf, and LY.SEARCH Institute for Basic Research in Lymphology, Düsseldorf, Germany. * 4 Dermatology Practice Diana Rajewski, Cologne, Germany. * 5 Institute: Plastic, Reconstructive, and Aesthetic Surgery, Wald Hospital Bonn, Germany. * 6 Clinic and Outpatient Clinic for Plastic Surgery, Cologne, Germany. * 7 Department of Plastic, Aesthetic, and Reconstructive Microsurgery, Ernst von Bergmann Hospital, Bad Belzig, Germany; Faculty of Health Sciences Brandenburg (FGW Brandenburg), Potsdam, Germany. * 8 Clinical Trials Centre Cologne (ZKS Köln), Faculty of Medicine, University of Cologne and University Hospital Cologne; Cologne, Germany. * 9 Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany. * 10 Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. * 11 Clinical Trials Centre Cologne (ZKS Köln), Faculty of Medicine, University of Cologne and University Hospital Cologne; Cologne, Germany; Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Department I of Internal Medicine, Division of Infectious Diseases, Cologne, Germany; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany. Electronic address: oliver.cornely@uk-koeln.de. * PMID: **42692034** * DOI: [ 10.1016/S0140-6736(26)00910-4 ](https://doi.org/10.1016/s0140-6736\(26\)00910-4) Item in Clipboard Randomized Controlled Trial # Liposuction versus conservative therapy for patients with lipoedema in Germany: a multicentre, randomised controlled clinical trial Maurizio Podda et al. Lancet. 2026. Show details Display options Display options Format Abstract PubMed PMID Lancet Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lancet%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Lancet%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42692034/) . 2026 Sep 5;408(10558):910-923. doi: 10.1016/S0140-6736(26)00910-4. ### Authors [Maurizio Podda](https://pubmed.ncbi.nlm.nih.gov/?term=Podda+M&cauthor_id=42692034)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-1 "Department of Dermatology, Medical Centre Klinikum Darmstadt, Teaching Hospital Goethe-University Frankfurt, Darmstadt, Germany."), [Jeremias Schmidt](https://pubmed.ncbi.nlm.nih.gov/?term=Schmidt+J&cauthor_id=42692034)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-2 "Department of Plastic, Aesthetic, and Reconstructive Microsurgery, Ernst von Bergmann Hospital, Bad Belzig, Germany."), [Manuel E Cornely](https://pubmed.ncbi.nlm.nih.gov/?term=Cornely+ME&cauthor_id=42692034)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-3 "MVZ Dermatology Practice Düsseldorf, and LY.SEARCH Institute for Basic Research in Lymphology, Düsseldorf, Germany."), [Marten I Steinmetz](https://pubmed.ncbi.nlm.nih.gov/?term=Steinmetz+MI&cauthor_id=42692034)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-1 "Department of Dermatology, Medical Centre Klinikum Darmstadt, Teaching Hospital Goethe-University Frankfurt, Darmstadt, Germany."), [Diana Rajewski](https://pubmed.ncbi.nlm.nih.gov/?term=Rajewski+D&cauthor_id=42692034)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-4 "Dermatology Practice Diana Rajewski, Cologne, Germany."), [Kay-Hendrik Busch](https://pubmed.ncbi.nlm.nih.gov/?term=Busch+KH&cauthor_id=42692034)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-5 "Institute: Plastic, Reconstructive, and Aesthetic Surgery, Wald Hospital Bonn, Germany."), [Ziah Taufig](https://pubmed.ncbi.nlm.nih.gov/?term=Taufig+Z&cauthor_id=42692034)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-6 "Clinic and Outpatient Clinic for Plastic Surgery, Cologne, Germany."), [Mojtaba Ghods](https://pubmed.ncbi.nlm.nih.gov/?term=Ghods+M&cauthor_id=42692034)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-7 "Department of Plastic, Aesthetic, and Reconstructive Microsurgery, Ernst von Bergmann Hospital, Bad Belzig, Germany; Faculty of Health Sciences Brandenburg \(FGW Brandenburg\), Potsdam, Germany."), [Maximilian Kovacs](https://pubmed.ncbi.nlm.nih.gov/?term=Kovacs+M&cauthor_id=42692034)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-1 "Department of Dermatology, Medical Centre Klinikum Darmstadt, Teaching Hospital Goethe-University Frankfurt, Darmstadt, Germany."), [Sabine Schmid](https://pubmed.ncbi.nlm.nih.gov/?term=Schmid+S&cauthor_id=42692034)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-1 "Department of Dermatology, Medical Centre Klinikum Darmstadt, Teaching Hospital Goethe-University Frankfurt, Darmstadt, Germany."), [Daria Kraus](https://pubmed.ncbi.nlm.nih.gov/?term=Kraus+D&cauthor_id=42692034)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-8 "Clinical Trials Centre Cologne \(ZKS Köln\), Faculty of Medicine, University of Cologne and University Hospital Cologne; Cologne, Germany."), [Martin Hellmich](https://pubmed.ncbi.nlm.nih.gov/?term=Hellmich+M&cauthor_id=42692034)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-9 "Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany."), [Wiebke Müller](https://pubmed.ncbi.nlm.nih.gov/?term=M%C3%BCller+W&cauthor_id=42692034)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-10 "Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany."), [Petra Schiller](https://pubmed.ncbi.nlm.nih.gov/?term=Schiller+P&cauthor_id=42692034)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-10 "Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany."), [Oliver A Cornely](https://pubmed.ncbi.nlm.nih.gov/?term=Cornely+OA&cauthor_id=42692034)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42692034/#short-view-affiliation-11 "Clinical Trials Centre Cologne \(ZKS Köln\), Faculty of Medicine, University of Cologne and University Hospital Cologne; Cologne, Germany; Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases \(CECAD\), Cologne, Germany; Department I of Internal Medicine, Division of Infectious Diseases, Cologne, Germany; German Centre for Infection Research \(DZIF\), Partner Site Bonn-Cologne, Cologne, Germany. Electronic address: oliver.cornely@uk-koeln.de.") ### Affiliations * 1 Department of Dermatology, Medical Centre Klinikum Darmstadt, Teaching Hospital Goethe-University Frankfurt, Darmstadt, Germany. * 2 Department of Plastic, Aesthetic, and Reconstructive Microsurgery, Ernst von Bergmann Hospital, Bad Belzig, Germany. * 3 MVZ Dermatology Practice Düsseldorf, and LY.SEARCH Institute for Basic Research in Lymphology, Düsseldorf, Germany. * 4 Dermatology Practice Diana Rajewski, Cologne, Germany. * 5 Institute: Plastic, Reconstructive, and Aesthetic Surgery, Wald Hospital Bonn, Germany. * 6 Clinic and Outpatient Clinic for Plastic Surgery, Cologne, Germany. * 7 Department of Plastic, Aesthetic, and Reconstructive Microsurgery, Ernst von Bergmann Hospital, Bad Belzig, Germany; Faculty of Health Sciences Brandenburg (FGW Brandenburg), Potsdam, Germany. * 8 Clinical Trials Centre Cologne (ZKS Köln), Faculty of Medicine, University of Cologne and University Hospital Cologne; Cologne, Germany. * 9 Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany. * 10 Institute of Medical Statistics and Computational Biology, F
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