---
title: "LRX activatable fluorescence probe for real-time peroxynitrite imaging in diabetic wounds"
id: "pubmed-42365674"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42365674"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42365674/"
doi: "10.1016/j.bioorg.2026.110177"
published_at: "2026-09-15T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# LRX activatable fluorescence probe for real-time peroxynitrite imaging in diabetic wounds
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42365674
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42365674/)
- **DOI:** [10.1016/j.bioorg.2026.110177](https://doi.org/10.1016%2Fj.bioorg.2026.110177)
- **Published At:** 2026-09-15T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Diabetic wound (DW) is a serious complication of diabetes mellitus characterized by delayed healing and persistent inflammation, and current clinical biomarkers are insufficient for early diagnosis and real-time monitoring. - The study reports development of an activatable fluorescent molecular probe named **LRX** designed for selective detection of **peroxynitrite (ONOO-)**, a reactive nitrogen/oxygen species implicated in nitro-oxidative stress. - Systematic evaluations in the report showed that **LRX** demonstrated excellent **selectivity** for ONOO-, high chemical **stability**, and favorable **biocompatibility** in the contexts tested. - Application of LRX in a diabetic wound **mouse model** enabled visualization and real-time monitoring of dynamic changes in ONOO- levels in vivo. - The authors propose that LRX can serve as a sensitive and practical platform for imaging ONOO- fluctuations under diabetic pathological conditions, offering a molecular imaging tool for diagnostic and therapeutic studies. - The work is positioned as providing new insight into **nitro-oxidative stress** mechanisms involved in diabetic complications. - The study was conducted in animal models (male mice, C57BL inbred strain listed among MeSH terms); detailed experimental protocols, quantitative results, and specific imaging parameters were not reported in the abstract and would require consultation of the full text for methodological and numerical data. - Authors declared no competing financial interests or personal relationships that could have influenced the reported work. - Keywords reported: **Diabetic wound**; **Fluorescence**; **Peroxynitrite**; Probe.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 27. # An Activatable fluorescence probe for real-time monitoring of Peroxynitrite in diabetic wound mouse model [Le-Yan Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+LY&cauthor_id=42365674)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#full-view-affiliation-1 "Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. Electronic address: 522311669@qq.com."), [Qi-Zi Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+QZ&cauthor_id=42365674)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#full-view-affiliation-2 "Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China."), [Han Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42365674)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#full-view-affiliation-2 "Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China."), [You-Zhen Feng](https://pubmed.ncbi.nlm.nih.gov/?term=Feng+YZ&cauthor_id=42365674)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#full-view-affiliation-3 "Department of Radiology, the First Affiliated Hospital, Jinan University, No.613, Huangpu West Road, Tianhe District, Guangzhou 510632, China. Electronic address: fengyouzhen@jnu.edu.cn."), [Zhong-Yuan Cheng](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+ZY&cauthor_id=42365674)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#full-view-affiliation-4 "Department of Radiology, the First Affiliated Hospital, Jinan University, No.613, Huangpu West Road, Tianhe District, Guangzhou 510632, China; Department of Radiology, Linzhi People's Hospital, Linzhi 860099, China. Electronic address: chengzy@jnu.edu.cn."), [Ru Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+R&cauthor_id=42365674)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#full-view-affiliation-5 "Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. Electronic address: yanlinru08@163.com.") Affiliations Expand ### Affiliations * 1 Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. Electronic address: 522311669@qq.com. * 2 Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. * 3 Department of Radiology, the First Affiliated Hospital, Jinan University, No.613, Huangpu West Road, Tianhe District, Guangzhou 510632, China. Electronic address: fengyouzhen@jnu.edu.cn. * 4 Department of Radiology, the First Affiliated Hospital, Jinan University, No.613, Huangpu West Road, Tianhe District, Guangzhou 510632, China; Department of Radiology, Linzhi People's Hospital, Linzhi 860099, China. Electronic address: chengzy@jnu.edu.cn. * 5 Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. Electronic address: yanlinru08@163.com. * PMID: **42365674** * DOI: [ 10.1016/j.bioorg.2026.110177 ](https://doi.org/10.1016/j.bioorg.2026.110177) Item in Clipboard # An Activatable fluorescence probe for real-time monitoring of Peroxynitrite in diabetic wound mouse model Le-Yan Zhou et al. Bioorg Chem. 2026. Show details Display options Display options Format Abstract PubMed PMID Bioorg Chem Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Bioorg+Chem%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Bioorg+Chem%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42365674/) . 2026 Sep 15:180:110177. doi: 10.1016/j.bioorg.2026.110177. Epub 2026 Jun 27. ### Authors [Le-Yan Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+LY&cauthor_id=42365674)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#short-view-affiliation-1 "Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. Electronic address: 522311669@qq.com."), [Qi-Zi Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+QZ&cauthor_id=42365674)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#short-view-affiliation-2 "Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China."), [Han Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42365674)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#short-view-affiliation-2 "Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China."), [You-Zhen Feng](https://pubmed.ncbi.nlm.nih.gov/?term=Feng+YZ&cauthor_id=42365674)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#short-view-affiliation-3 "Department of Radiology, the First Affiliated Hospital, Jinan University, No.613, Huangpu West Road, Tianhe District, Guangzhou 510632, China. Electronic address: fengyouzhen@jnu.edu.cn."), [Zhong-Yuan Cheng](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+ZY&cauthor_id=42365674)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#short-view-affiliation-4 "Department of Radiology, the First Affiliated Hospital, Jinan University, No.613, Huangpu West Road, Tianhe District, Guangzhou 510632, China; Department of Radiology, Linzhi People's Hospital, Linzhi 860099, China. Electronic address: chengzy@jnu.edu.cn."), [Ru Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+R&cauthor_id=42365674)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42365674/#short-view-affiliation-5 "Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. Electronic address: yanlinru08@163.com.") ### Affiliations * 1 Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. Electronic address: 522311669@qq.com. * 2 Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. * 3 Department of Radiology, the First Affiliated Hospital, Jinan University, No.613, Huangpu West Road, Tianhe District, Guangzhou 510632, China. Electronic address: fengyouzhen@jnu.edu.cn. * 4 Department of Radiology, the First Affiliated Hospital, Jinan University, No.613, Huangpu West Road, Tianhe District, Guangzhou 510632, China; Department of Radiology, Linzhi People's Hospital, Linzhi 860099, China. Electronic address: chengzy@jnu.edu.cn. * 5 Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China. Electronic address: yanlinru08@163.com. * PMID: **42365674** * DOI: [ 10.1016/j.bioorg.2026.110177 ](https://doi.org/10.1016/j.bioorg.2026.110177) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Diabetic wound (DW) is a severe and disabling complication of diabetes mellitus (DM), generally characterized by delayed healing, persistent inflammation, and insufficient reliable biomarkers for early diagnosis. These clinical limitations emphasize the urgent need for sensitive, non-invasive, and real-time analytical strategies to monitor disease progression. In this study, we developed LRX, an activatable fluorescent molecular probe designed for the selective detection of peroxynitrite (ONOO-). Systematic evaluations demonstrated that LRX exhibited excellent selectivity toward ONOO-, high chemical stability, and favorable biocompatibility. By applying this probe in a DW mouse model, dynamic changes in ONOO- levels were successfully visualized and monitored in vivo. These results indicate that LRX can serve as a sensitive and practical platform for real-time imaging of ONOO- fluctuations under diabetic pathological conditions. Overall, this work provides new insight into nitro-oxidative stress-related mechanisms involved in diabetic complications and offers a useful molecular imaging tool for future diagnostic and therapeutic studies. **Keywords:** Diabetic wound; Fluorescence; Peroxynitrite; Probe. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Ratiometric near-infrared fluorescent probe for imaging Peroxynitrite fluxes in rheumatoid arthritis and drug-induced liver injury models. ](https://pubmed.ncbi.nlm.nih.gov/42401456/) Li R, Wang R, Li M, Zhang L.Li R, et al.Anal Chim Acta. 2026 Sep 22;1416:345732. doi: 10.1016/j.aca.2026.345732. Epub 2026 May 27.Anal Chim Acta. 2026.PMID: 42401456 * [ Peroxynitrite-responsive dicyanoisophorone-xanthene NIR fluorescent probe for monitoring and therapeutic evaluation of diabetic liver injury. ](https://pubmed.ncbi.nlm.nih.gov/41056644/) Kong F, Yang M, Yang T, Qin J.Kong F, et al.Spectrochim Acta A Mol Biomol Spectrosc. 2026 Feb 15;347:127003. doi: 10.1016/j.saa.2025.127003. Epub 2025 Oct 1.Spectrochim Acta A Mol Biomol Spectrosc. 2026.PMID: 41056644 * [ Single-Molecule Dual-Channel NIR Fluorescence Probe for Simultaneous Monitoring ATP and ONOO- during Ferroptosis and Hepatic Ischemia-Reperfusion Injury. ](https://pubmed.ncbi.nlm.nih.gov/42037181/) Zhang W, Li D, Pu Y, Jiang W, Shao J, Li Y, Feng G, Xu L, Feng S.Zhang W, et al.Anal Chem. 2026 May 12;98(18):13665-13675. doi: 10.1021/acs.analchem.6c00509. Epub 2026 Apr 27.Anal Chem. 2026.PMID: 42037181 * [ Fluorescence Dynamics Imaging Reveals Inflammation Driven by Ferroptosis through a MAO/ONOO- Dual-Responsive Probe. ](https://pubmed.ncbi.nlm.nih.gov/42085431/) Wu W, Yan H, Zhang L, Huo F, Yin C.Wu W, et al.Anal Chem. 2026 May 19;98(19):14493-14502. doi: 10.1021/acs.analchem.6c01178. Epub 2026 May 5.Anal Chem. 2026.PMID: 42085431 * [ Peroxynitrite activatable NIR-II probe for tumor diagnosis and photothermal therapy in vivo. ](https://pubmed.ncbi.nlm.nih.gov/39643299/) Xu M, Ma Y, Zhao Y, Xu L, Lin W.Xu M, et al.Anal Chim Acta. 2025 Jan 15;1335:343443. doi: 10.1016/j.aca.2024.343443. 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