---
title: "Lymphocyte Count as a Predictor of Adjuvant Chemotherapy Completion After Severe Postoperative Com"
id: "pubmed-42674714"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42674714"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42674714/"
doi: "10.21873/anticanres.18354"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Lymphocyte Count as a Predictor of Adjuvant Chemotherapy Completion After Severe Postoperative Com
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42674714
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42674714/)
- **DOI:** [10.21873/anticanres.18354](https://doi.org/10.21873%2Fanticanres.18354)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This multicenter study, published in Anticancer Research (Sept 2026), evaluates whether **lymphocyte count** predicts completion of **adjuvant chemotherapy (ACT)** after severe postoperative complications in patients with **colorectal cancer**. - Authors include Takuki Yagyu and colleagues from multiple surgical departments across institutions in Tottori Prefecture and other Japanese hospitals; the work has PMID 42674714 and DOI 10.21873/anticanres.18354. - The abstract states the study background/aim: postoperative complications can interfere with continuation and completion of ACT for stage III colorectal cancer and there is a need for simple predictive indicators. - The source text available on PubMed is truncated; key information on study design, patient population, specific lymphocyte metrics, statistical methods, results, and conclusions were not reported in the accessible source content. - Because the PubMed entry provided here is incomplete, outcome data, effect sizes, thresholds, and authors' conclusions cannot be summarized from this source. - The article is a multicenter clinical research report; full details should be obtained from the published paper in Anticancer Research (2026 Sep;46(9):5055-5065) or via the DOI link for complete methods and findings. - For clinicians and researchers, the study topic—linking immune cell counts to ACT adherence after surgical complications—addresses an important clinical problem, but evidence and actionable thresholds are not available in the truncated source.
## Clinical Analysis & Structured Key Points
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t-yagyu@tottori-u.ac.jp."), [Manabu Yamamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Yamamoto+M&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Ayumi Tsuda](https://pubmed.ncbi.nlm.nih.gov/?term=Tsuda+A&cauthor_id=42674714)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-3 "Department of Surgery, Tottori Prefectural Central Hospital, Tottori, Japan."), [Keigo Ashida](https://pubmed.ncbi.nlm.nih.gov/?term=Ashida+K&cauthor_id=42674714)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-4 "Department of Surgery, Japanese Red Cross Tottori Hospital, Tottori, Japan."), [Yasuro Kurisu](https://pubmed.ncbi.nlm.nih.gov/?term=Kurisu+Y&cauthor_id=42674714)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-5 "Department of Surgery, National Hospital Organization Hamada Medical Center, Hamada, Japan."), [Shunsuke Shibata](https://pubmed.ncbi.nlm.nih.gov/?term=Shibata+S&cauthor_id=42674714)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-6 "Department of Surgery, San-in Rosai Hospital, Yonago, Japan."), [Akemi Iwamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Iwamoto+A&cauthor_id=42674714)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-7 "Department of Gastroenterological Surgery, Tottori Prefectural Kosei Hospital, Kurayoshi, Japan."), [Takuji Naka](https://pubmed.ncbi.nlm.nih.gov/?term=Naka+T&cauthor_id=42674714)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-8 "Department of Surgery, National Hospital Organization, Yonago Medical Center, Yonago, Japan."), [Yoshihiko Maeta](https://pubmed.ncbi.nlm.nih.gov/?term=Maeta+Y&cauthor_id=42674714)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-9 "Department of Gastrointestinal Surgery, Matsue City Hospital, Matsue, Japan."), [Akira Kondo](https://pubmed.ncbi.nlm.nih.gov/?term=Kondo+A&cauthor_id=42674714)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-10 "Department of Surgery, Hakuai Hospital, Yonago, Japan."), [Hirohiko Kuroda](https://pubmed.ncbi.nlm.nih.gov/?term=Kuroda+H&cauthor_id=42674714)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-11 "Department of Surgery, Masuda Red Cross Hospital, Masuda, Japan."), [Kei Urakami](https://pubmed.ncbi.nlm.nih.gov/?term=Urakami+K&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Kotaro Osaki](https://pubmed.ncbi.nlm.nih.gov/?term=Osaki+K&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Chiharu Yasui](https://pubmed.ncbi.nlm.nih.gov/?term=Yasui+C&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Yusuke Kono](https://pubmed.ncbi.nlm.nih.gov/?term=Kono+Y&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Kyoichi Kihara](https://pubmed.ncbi.nlm.nih.gov/?term=Kihara+K&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Tomoyuki Matsunaga](https://pubmed.ncbi.nlm.nih.gov/?term=Matsunaga+T&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Teruhisa Sakamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Sakamoto+T&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Yoshiyuki Fujiwara](https://pubmed.ncbi.nlm.nih.gov/?term=Fujiwara+Y&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#full-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.") Affiliations Expand ### Affiliations * 1 Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan; t-yagyu@tottori-u.ac.jp. * 2 Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan. * 3 Department of Surgery, Tottori Prefectural Central Hospital, Tottori, Japan. * 4 Department of Surgery, Japanese Red Cross Tottori Hospital, Tottori, Japan. * 5 Department of Surgery, National Hospital Organization Hamada Medical Center, Hamada, Japan. * 6 Department of Surgery, San-in Rosai Hospital, Yonago, Japan. * 7 Department of Gastroenterological Surgery, Tottori Prefectural Kosei Hospital, Kurayoshi, Japan. * 8 Department of Surgery, National Hospital Organization, Yonago Medical Center, Yonago, Japan. * 9 Department of Gastrointestinal Surgery, Matsue City Hospital, Matsue, Japan. * 10 Department of Surgery, Hakuai Hospital, Yonago, Japan. * 11 Department of Surgery, Masuda Red Cross Hospital, Masuda, Japan. * PMID: **42674714** * DOI: [ 10.21873/anticanres.18354 ](https://doi.org/10.21873/anticanres.18354) Item in Clipboard Multicenter Study # Lymphocyte Count Predicts Adjuvant Chemotherapy Completion After Severe Postoperative Complications in Colorectal Cancer Takuki Yagyu et al. Anticancer Res. 2026 Sep. Show details Display options Display options Format Abstract PubMed PMID Anticancer Res Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anticancer+Res%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Anticancer+Res%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42674714/) . 2026 Sep;46(9):5055-5065. doi: 10.21873/anticanres.18354. ### Authors [Takuki Yagyu](https://pubmed.ncbi.nlm.nih.gov/?term=Yagyu+T&cauthor_id=42674714)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-1 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan; t-yagyu@tottori-u.ac.jp."), [Manabu Yamamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Yamamoto+M&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Ayumi Tsuda](https://pubmed.ncbi.nlm.nih.gov/?term=Tsuda+A&cauthor_id=42674714)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-3 "Department of Surgery, Tottori Prefectural Central Hospital, Tottori, Japan."), [Keigo Ashida](https://pubmed.ncbi.nlm.nih.gov/?term=Ashida+K&cauthor_id=42674714)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-4 "Department of Surgery, Japanese Red Cross Tottori Hospital, Tottori, Japan."), [Yasuro Kurisu](https://pubmed.ncbi.nlm.nih.gov/?term=Kurisu+Y&cauthor_id=42674714)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-5 "Department of Surgery, National Hospital Organization Hamada Medical Center, Hamada, Japan."), [Shunsuke Shibata](https://pubmed.ncbi.nlm.nih.gov/?term=Shibata+S&cauthor_id=42674714)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-6 "Department of Surgery, San-in Rosai Hospital, Yonago, Japan."), [Akemi Iwamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Iwamoto+A&cauthor_id=42674714)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-7 "Department of Gastroenterological Surgery, Tottori Prefectural Kosei Hospital, Kurayoshi, Japan."), [Takuji Naka](https://pubmed.ncbi.nlm.nih.gov/?term=Naka+T&cauthor_id=42674714)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-8 "Department of Surgery, National Hospital Organization, Yonago Medical Center, Yonago, Japan."), [Yoshihiko Maeta](https://pubmed.ncbi.nlm.nih.gov/?term=Maeta+Y&cauthor_id=42674714)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-9 "Department of Gastrointestinal Surgery, Matsue City Hospital, Matsue, Japan."), [Akira Kondo](https://pubmed.ncbi.nlm.nih.gov/?term=Kondo+A&cauthor_id=42674714)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-10 "Department of Surgery, Hakuai Hospital, Yonago, Japan."), [Hirohiko Kuroda](https://pubmed.ncbi.nlm.nih.gov/?term=Kuroda+H&cauthor_id=42674714)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-11 "Department of Surgery, Masuda Red Cross Hospital, Masuda, Japan."), [Kei Urakami](https://pubmed.ncbi.nlm.nih.gov/?term=Urakami+K&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Kotaro Osaki](https://pubmed.ncbi.nlm.nih.gov/?term=Osaki+K&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Chiharu Yasui](https://pubmed.ncbi.nlm.nih.gov/?term=Yasui+C&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Yusuke Kono](https://pubmed.ncbi.nlm.nih.gov/?term=Kono+Y&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Kyoichi Kihara](https://pubmed.ncbi.nlm.nih.gov/?term=Kihara+K&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Tomoyuki Matsunaga](https://pubmed.ncbi.nlm.nih.gov/?term=Matsunaga+T&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Teruhisa Sakamoto](https://pubmed.ncbi.nlm.nih.gov/?term=Sakamoto+T&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan."), [Yoshiyuki Fujiwara](https://pubmed.ncbi.nlm.nih.gov/?term=Fujiwara+Y&cauthor_id=42674714)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674714/#short-view-affiliation-2 "Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.") ### Affiliations * 1 Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan; t-yagyu@tottori-u.ac.jp. * 2 Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago, Japan. * 3 Department of Surgery, Tottori Prefectural Central Hospital, Tottori, Japan. * 4 Department of Surgery, Japanese Red Cross Tottori Hospital, Tottori, Japan. * 5 Department of Surgery, National Hospital Organization Hamada Medical Center, Hamada, Japan. * 6 Department of Surgery, San-in Rosai Hospital, Yonago, Japan. * 7 Department of Gastroenterological Surgery, Tottori Prefectural Kosei Hospital, Kurayoshi, Japan. * 8 Department of Surgery, National Hospital Organization, Yonago Medical Center, Yonago, Japan. * 9 Department of Gastrointestinal Surgery, Matsue City Hospital, Matsue, Japan. * 10 Department of Surgery, Hakuai Hospital, Yonago, Japan. * 11 Department of Surgery, Masuda Red Cross Hospital, Masuda, Japan. * PMID: **42674714** * DOI: [ 10.21873/anticanres.18354 ](https://doi.org/10.21873/anticanres.18354) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background/aim:** Postoperative complications can interfere with the continuation and completion of adjuvant chemotherapy (ACT) in stage III colorectal cancer. However, simple indicators for predicting treatment completion after severe postoperative c
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