---
title: "MCC950 Improves Glycemic Control, Lipids, and Sympathetic Markers in STZ-Induced Type 1 Diabetic R"
id: "pubmed-42669910"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42669910"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42669910/"
published_at: "2026-08-31T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# MCC950 Improves Glycemic Control, Lipids, and Sympathetic Markers in STZ-Induced Type 1 Diabetic R
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42669910
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42669910/)
- **Published At:** 2026-08-31T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Aim: The study tested whether MCC950, a selective **NLRP3 inflammasome** inhibitor, affects glycemic control, lipid profiles, and sympathetic dysfunction in a streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) rat model. - Model: Male Wistar rats were rendered diabetic with a single intraperitoneal injection of STZ (50 mg/kg). Diabetes was confirmed by persistent hyperglycemia, reduced serum **C-peptide**, and pancreatic histopathological changes. - Cardiac autonomic neuropathy model: Elevated serum **noradrenaline (NA)** before treatment indicated sympathetic dysfunction in diabetic animals. - Interventions: Diabetic rats received MCC950, insulin, or normal saline for four weeks; outcomes were measured before and after treatment. - Outcomes measured: Fasting blood glucose, serum lipid profile (total cholesterol, triglycerides, LDL, HDL), C-peptide, pancreatic histology, and serum NA. - Key results: MCC950 significantly reduced fasting blood glucose, total cholesterol, triglycerides, and LDL-cholesterol versus untreated diabetic rats (all P<0.0001). HDL was unchanged. - Additional effects: MCC950 partially restored **C-peptide** concentrations, improved pancreatic histological appearance, and reduced serum **NA** levels. - Interpretation: Inhibition of the **NLRP3 inflammasome** with MCC950 improved metabolic disturbances and markers of sympathetic overactivity in this experimental T1DM model. - Caveat: The authors note that direct functional assessments of cardiac autonomic function were not included; further studies are required to define the role of NLRP3 inhibition in diabetic cardiac autonomic neuropathy. - Clinical translation: Findings support further preclinical investigation of NLRP3-targeted therapy for metabolic abnormalities in T1DM, but functional cardiac autonomic data and additional validation are needed.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliation * 1 Razif Abas, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, razifabas@upm.edu.my. * PMID: **42669910** Item in Clipboard # Effects of MCC950 on lipid profiles, glycemic control, and sympathetic dysfunction in a streptozotocin-induced type 1 diabetic rat model Shamala Devi Subramaniam et al. Croat Med J. 2026. Show details Display options Display options Format Abstract PubMed PMID Croat Med J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Croat+Med+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Croat+Med+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42669910/) . 2026 Aug 31;67(4):285-296. ### Authors [Shamala Devi Subramaniam](https://pubmed.ncbi.nlm.nih.gov/?term=Subramaniam+SD&cauthor_id=42669910), [Xin Yi](https://pubmed.ncbi.nlm.nih.gov/?term=Yi+X&cauthor_id=42669910), [Rajesh Ramasamy](https://pubmed.ncbi.nlm.nih.gov/?term=Ramasamy+R&cauthor_id=42669910), [Nurul Izzati Uda Zahli](https://pubmed.ncbi.nlm.nih.gov/?term=Zahli+NIU&cauthor_id=42669910), [Siti Saleha Masrudin](https://pubmed.ncbi.nlm.nih.gov/?term=Masrudin+SS&cauthor_id=42669910), [Razif Abas](https://pubmed.ncbi.nlm.nih.gov/?term=Abas+R&cauthor_id=42669910)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42669910/#short-view-affiliation-1 "Razif Abas, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, razifabas@upm.edu.my.") ### Affiliation * 1 Razif Abas, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia, razifabas@upm.edu.my. * PMID: **42669910** Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Aim:** To evaluate the effects of MCC950, a selective NLRP3 inflammasome inhibitor, on glycemic control, lipid profiles, and sympathetic dysfunction in a streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) rat model. **Methods:** Male Wistar rats were rendered diabetic by intraperitoneal injection of STZ (50 mg/kg). T1DM induction was confirmed by persistent hyperglycemia, reduced serum C-peptide, and pancreatic histopathological changes. Diabetic cardiac autonomic neuropathy was established by elevated serum noradrenaline (NA) before treatment. Diabetic rats subsequently received MCC950, insulin, or normal saline for four weeks. Fasting blood glucose, serum lipid profiles, C-peptide, pancreatic histology, and serum NA were evaluated before and after treatment. **Results:** MCC950-treated rats showed significantly reduced fasting blood glucose, total cholesterol, triglycerides, and LDL-cholesterol (all P<0.0001) levels compared with untreated diabetic rats, while HDL levels remained unchanged, which suggests an improvement in diabetes-associated dyslipidemia. MCC950 treatment also partially restored C-peptide concentrations, improved pancreatic histology, and reduced serum NA levels. **Conclusion:** These findings suggest that NLRP3 inflammasome inhibition may improve metabolic disturbances associated with experimental T1DM. Further studies incorporating direct functional assessments of cardiac autonomic function are required to determine its role in diabetic cardiac autonomic neuropathy. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ NLRP3 inhibitor alleviates glycemic variability-induced cognitive impairment in aged rats with type 2 diabetes mellitus. ](https://pubmed.ncbi.nlm.nih.gov/39489213/) Yang W, Si SC, Li J, Ma YX, Zhao H, Liu J.Yang W, et al.Mol Cell Endocrinol. 2025 Jan 1;595:112406. doi: 10.1016/j.mce.2024.112406. Epub 2024 Nov 1.Mol Cell Endocrinol. 2025.PMID: 39489213 * [ Targeting NLRP3 inflammasome attenuates cardiac pyroptosis and fibrosis in estrogen-deficient diabetic rats. ](https://pubmed.ncbi.nlm.nih.gov/40383837/) Phungphong S, Suthivanich P, Boonhoh W, Punsawad C, Cheng Z, Bupha-Intr T.Phungphong S, et al.Pflugers Arch. 2025 Jul;477(7):935-952. doi: 10.1007/s00424-025-03092-6. Epub 2025 May 19.Pflugers Arch. 2025.PMID: 40383837 * [ Anti-diabetic effects of shubat in type 2 diabetic rats induced by combination of high-glucose-fat diet and low-dose streptozotocin. ](https://pubmed.ncbi.nlm.nih.gov/25922265/) Manaer T, Yu L, Zhang Y, Xiao XJ, Nabi XH.Manaer T, et al.J Ethnopharmacol. 2015 Jul 1;169:269-74. doi: 10.1016/j.jep.2015.04.032. Epub 2015 Apr 25.J Ethnopharmacol. 2015.PMID: 25922265 * [ MCC950 targets the ROS-NEK7-NLRP3 axis to improve type 2 diabetic retinopathy. ](https://pubmed.ncbi.nlm.nih.gov/40987781/) Ren K, Li X.Ren K, et al.Sci Rep. 2025 Sep 23;15(1):32637. doi: 10.1038/s41598-025-18438-4.Sci Rep. 2025.PMID: 40987781Free PMC article. * [ The Anti-Diabetic Effect of Some Plant Extracts Against Streptozotocin - Induced Diabetes Type 2 in Male Albino Rats. ](https://pubmed.ncbi.nlm.nih.gov/33069202/) Gomaa HF, Abdelmalek IB, Abdel-Wahhab KG.Gomaa HF, et al.Endocr Metab Immune Disord Drug Targets. 2021;21(8):1431-1440. doi: 10.2174/1871530320666201016145502.Endocr Metab Immune Disord Drug Targets. 2021.PMID: 33069202 [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42669910) ## MeSH terms * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH 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