---
title: "Methylmalonate Overload and Diabetic Heart Damage Despite Glycemic Control — Study Overview"
id: "pubmed-42522575"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42522575"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42522575/"
doi: "10.1161/CIRCRESAHA.125.327192"
published_at: "2026-08-28T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Methylmalonate Overload and Diabetic Heart Damage Despite Glycemic Control — Study Overview
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42522575
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42522575/)
- **DOI:** [10.1161/CIRCRESAHA.125.327192](https://doi.org/10.1161%2FCIRCRESAHA.125.327192)
- **Published At:** 2026-08-28T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Publication identified: Circ Res. 2026 Aug 28;139(6):e327192; doi: 10.1161/CIRCRESAHA.125.327192. Title: “Methylmalonate Overload Despite Glycemic Control Drives Diabetic Heart Damage.” - Multi-author paper led by Shanjie Wang, Miao Yan, and Yiying Zhang with many collaborators from cardiology and public health departments in China and one contributor at McMaster University. - Author affiliations include the Department of Cardiology, Second Affiliated Hospital of Harbin Medical University and The Key Laboratory of Myocardial Ischemia, SKLFZCD, with additional institutional contributions noted. - The article metadata (title, journal, DOI, publication and e-publication dates, and author list) are available in the source record provided. - The source text provided here does not include the article abstract, methods, results, numeric findings, or specific experimental details; those clinical and mechanistic data were not reported in the supplied source material. - Key clinical keywords and focus from the title: **Methylmalonate**, **glycemic control**, **diabetic heart damage** — indicating an investigation into a metabolic driver of cardiac injury in diabetes that may persist despite blood-glucose management. - No specific interventions, biomarkers, cohorts, animal models, statistical outcomes, or recommendations are present in the supplied content; readers must consult the full text or linked full-text resources for outcome data and clinical recommendations. - Full-text links are available through the PubMed record (Atypon link to the journal site) and should be consulted for complete methods, results, and potential therapeutic implications. - This summary is limited to metadata and the title-derived clinical focus; any mechanistic or therapeutic claims beyond the title were not present in the provided source content and therefore are not stated here.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jul 29. # Methylmalonate Overload Despite Glycemic Control Drives Diabetic Heart Damage [Shanjie Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+S&cauthor_id=42522575)[#](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Miao Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+M&cauthor_id=42522575)[#](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Yiying Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Y&cauthor_id=42522575)[#](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-equal-contrib-explanation "Contributed equally")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-3 "Department of Epidemiology and Biostatistics, School of Public Health, Jiamusi University, China \(Y.Z., F.T.\)."), [Fan Tang](https://pubmed.ncbi.nlm.nih.gov/?term=Tang+F&cauthor_id=42522575)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-3 "Department of Epidemiology and Biostatistics, School of Public Health, Jiamusi University, China \(Y.Z., F.T.\)."), [Ye Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Y&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Junchen Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+J&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Zhanchao Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Z&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Xiaoxuan Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+X&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Zhaoying Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Z&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Rongze Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+R&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Yan Cui](https://pubmed.ncbi.nlm.nih.gov/?term=Cui+Y&cauthor_id=42522575)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-4 "Department of Cardiology, First Affiliated Hospital of Jiamusi University, China \(Y.C.\)."), [Guanpeng Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+G&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Pengyan Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+P&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Yuanyuan Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+Y&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Yige Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Y&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Zeng Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Z&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Xing Luo](https://pubmed.ncbi.nlm.nih.gov/?term=Luo+X&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Hengxuan Cai](https://pubmed.ncbi.nlm.nih.gov/?term=Cai+H&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education and State Key Laboratory of Frigid Zone Cardiovascular Diseases \(SKLFZCD\), China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\)."), [Yanjiao Shen](https://pubmed.ncbi.nlm.nih.gov/?term=Shen+Y&cauthor_id=42522575)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-5 "Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada \(Y.S.\)."), [Wen Ge](https://pubmed.ncbi.nlm.nih.gov/?term=Ge+W&cauthor_id=42522575)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-6 "Department of Cardiology, Xijing Hospital of Fourth Military Medical University, Xi'an, China \(W.G., D.S.\)."), [Zhuozhong Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Z&cauthor_id=42522575)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-1 "Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China \(S.W., M.Y., Y.W., J.G., Z.C., X. Liu, Z.L., R.L., G.M., P.W., Y.H., Y.L., Zeng Wang, X. Luo, H.C., Zhuozhong Wang, S.Y., S.F., B.Y.\).")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42522575/#full-view-affiliation-2 "The Key
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