---
title: "Multifunctional Hydrogels for Skin Wound Care: Materials, Fabrication, and Therapeutic Mechanisms"
id: "pubmed-42575157"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42575157"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42575157/"
doi: "10.1088/1748-605X/ae97ce"
published_at: "2026-09-02T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Multifunctional Hydrogels for Skin Wound Care: Materials, Fabrication, and Therapeutic Mechanisms
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42575157
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42575157/)
- **DOI:** [10.1088/1748-605X/ae97ce](https://doi.org/10.1088%2F1748-605X%2Fae97ce)
- **Published At:** 2026-09-02T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The review summarizes recent advances in **hydrogels** as advanced wound dressings due to their hydrated 3D networks, tunable physicochemical properties, and biocompatibility. - Hydrogels can integrate multiple therapeutic functions important for skin repair, including **hemostasis**, **antibacterial** action, immunomodulation, antioxidant regulation, promotion of **angiogenesis**, scar reduction, and controlled **drug delivery**. - The article links specific hydrogel functions to distinct stages of the biological process of **wound healing**, emphasizing coordinated tissue regeneration. - It presents a classification of hydrogel materials and details fabrication and crosslinking strategies used to produce multifunctional dressings. - Advantages and limitations of various hydrogel systems are highlighted, noting that conventional dressings often fall short of meeting complex and dynamic wound requirements. - Current challenges identified include mechanical property optimization, barriers to clinical translation, need for large-animal evaluation, and manufacturing standardization. - Emerging strategies discussed include stimulus-responsive hydrogels and programmable therapeutic systems as promising directions for future wound management. - The review frames hydrogels as versatile platforms that combine physical protection with active therapeutic functions to address infection control, hemostasis, inflammation, oxidative stress, vascularization, scarring, and targeted delivery across healing stages.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Nanobiotechnology, Yanshan University, Qinhuangdao 066004, People's Republic of China. * 2 Department of Critical Care Medicine, The First Hospital of Qinhuangdao, Qinhuangdao 06600, People's Republic of China. * PMID: **42575157** * DOI: [ 10.1088/1748-605X/ae97ce ](https://doi.org/10.1088/1748-605x/ae97ce) Item in Clipboard Review # Recent advance in multifunctional hydrogels for skin wound care: from material classification and fabrication to therapeutic mechanisms Meijin Yan et al. Biomed Mater. 2026. Show details Display options Display options Format Abstract PubMed PMID Biomed Mater Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biomed+Mater%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biomed+Mater%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42575157/) . 2026 Sep 2;21(5). doi: 10.1088/1748-605X/ae97ce. ### Authors [Meijin Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+M&cauthor_id=42575157)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42575157/#short-view-affiliation-1 "State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Nanobiotechnology, Yanshan University, Qinhuangdao 066004, People's Republic of China."), [Xinyu Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+X&cauthor_id=42575157)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42575157/#short-view-affiliation-1 "State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Nanobiotechnology, Yanshan University, Qinhuangdao 066004, People's Republic of China."), [Wenbo Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+W&cauthor_id=42575157)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42575157/#short-view-affiliation-1 "State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Nanobiotechnology, Yanshan University, Qinhuangdao 066004, People's Republic of China."), [Wei Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+W&cauthor_id=42575157)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42575157/#short-view-affiliation-1 "State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Nanobiotechnology, Yanshan University, Qinhuangdao 066004, People's Republic of China."), [Xiujuan Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+X&cauthor_id=42575157)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42575157/#short-view-affiliation-2 "Department of Critical Care Medicine, The First Hospital of Qinhuangdao, Qinhuangdao 06600, People's Republic of China."), [Tifeng Jiao](https://pubmed.ncbi.nlm.nih.gov/?term=Jiao+T&cauthor_id=42575157)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42575157/#short-view-affiliation-1 "State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Nanobiotechnology, Yanshan University, Qinhuangdao 066004, People's Republic of China.") ### Affiliations * 1 State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Nanobiotechnology, Yanshan University, Qinhuangdao 066004, People's Republic of China. * 2 Department of Critical Care Medicine, The First Hospital of Qinhuangdao, Qinhuangdao 06600, People's Republic of China. * PMID: **42575157** * DOI: [ 10.1088/1748-605X/ae97ce ](https://doi.org/10.1088/1748-605x/ae97ce) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract The skin serves as the primary barrier against external physical damage and microbial invasion. When the skin is compromised, effective wound management becomes essential for maintaining tissue integrity and preventing complications. Although conventional wound dressings provide basic protection, they often fail to meet the complex and dynamic requirements of different stages of wound healing. Owing to their highly hydrated three-dimensional networks, tunable physicochemical properties, and excellent biocompatibility, hydrogels have emerged as promising platforms for advanced wound care. Recent advances in material engineering have enabled hydrogels to integrate multiple therapeutic functions, including hemostasis, antibacterial activity, immunomodulation, antioxidant regulation, angiogenesis promotion, scar reduction, and controlled drug delivery, thereby facilitating coordinated tissue regeneration. This review summarizes recent advances in hydrogel-based wound dressings, including the biological process of skin wound healing, hydrogel material classification, fabrication and crosslinking strategies, and multifunctional hydrogel design. Particular attention is given to the relationship between hydrogel functions and different stages of wound healing, as well as the advantages and limitations of various hydrogel systems. Finally, current challenges related to mechanical properties, clinical translation, large-animal evaluation, and manufacturing standardization are discussed, together with emerging strategies such as stimulus-responsive hydrogels and programmable therapeutic systems for future wound management. **Keywords:** crosslinking method; hydrogel; skin wound healing; wound dressing. © 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Multifunctional Microgels: From Material Design to Skin Wound Healing Applications. ](https://pubmed.ncbi.nlm.nih.gov/42405475/) Bhardwaj D, Kumar S, Agrawal G.Bhardwaj D, et al.Small. 2026 Jul 6:e74406. doi: 10.1002/smll.74406. Online ahead of print.Small. 2026.PMID: 42405475Review. * [ Innovative applications of multidimensional engineered hydrogels in wound healing. ](https://pubmed.ncbi.nlm.nih.gov/40780310/) Hu M, Zhang Q, Qin L.Hu M, et al.J Adv Res. 2026 May;83:347-378. doi: 10.1016/j.jare.2025.08.006. Epub 2025 Aug 6.J Adv Res. 2026.PMID: 40780310Free PMC article.Review. * [ Material Design, Fabrication Strategies, and the Development of Multifunctional Hydrogel Composites Dressings for Skin Wound Management. ](https://pubmed.ncbi.nlm.nih.gov/39960380/) Wu Z, Lu D, Sun S, Cai M, Lin L, Zhu M.Wu Z, et al.Biomacromolecules. 2025 Mar 10;26(3):1419-1460. doi: 10.1021/acs.biomac.4c01715. Epub 2025 Feb 17.Biomacromolecules. 2025.PMID: 39960380Review. * [ Advances in Nanohybrid Hydrogels for Wound Healing: From Functional Mechanisms to Translational Prospects. ](https://pubmed.ncbi.nlm.nih.gov/40710646/) Mo Y, Zhou T, Li W, Niu Y, Sheu C.Mo Y, et al.Gels. 2025 Jun 23;11(7):483. doi: 10.3390/gels11070483.Gels. 2025.PMID: 40710646Free PMC article.Review. * [ Research Progress of Natural Polysaccharide-Based Hydrogels in Skin Tissue Regeneration. ](https://pubmed.ncbi.nlm.nih.gov/41590047/) Jia X, Fan D, Yang Z, Chang J, Wang Q, Cui X, Liu D, Cui N, Jin Y.Jia X, et al.Gels. 2025 Dec 25;12(1):21. doi: 10.3390/gels12010021.Gels. 2025.PMID: 41590047Free PMC article.Review. 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