---
title: "Optogenetic Therapy for Restoring Visual Function — NEJM Clinical Trial Report"
id: "pubmed-42842903"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42842903"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42842903/"
doi: "10.1056/NEJMoa2602215"
published_at: "2026-10-08T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Optogenetic Therapy for Restoring Visual Function — NEJM Clinical Trial Report
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42842903
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42842903/)
- **DOI:** [10.1056/NEJMoa2602215](https://doi.org/10.1056%2FNEJMoa2602215)
- **Published At:** 2026-10-08T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- A clinical-trial report titled **Optogenetic Therapy for Restoring Aspects of Visual Function** was published in the New England Journal of Medicine (N Engl J Med) on 2026 Oct 8 (volume 395, issue 14, pages 1399–1408). - The article is indexed in PubMed with PMID **42842903** and DOI **10.1056/NEJMoa2602215**. - The publication is listed as a Clinical Trial. - The article lists a large multidisciplinary author group led by José-Alain Sahel and including coauthors from institutions in the United States, France, Switzerland, and the United Kingdom. - Affiliations reported include the Department of Ophthalmology at the University of Pittsburgh School of Medicine; Sorbonne Université/Inserm/CNRS Institut de la Vision; L'Hôpital Fondation Adolphe de Rothschild; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts; Institute of Molecular and Clinical Ophthalmology Basel and University of Basel; Streetlab; Moorfields Eye Hospital; Acefas; and GenSight Biologics. - The PubMed entry shows author names and institutional affiliations in detail and labels the work as a Clinical Trial in a high-impact journal. - The PubMed excerpt supplied does not include the article abstract text, methods, patient numbers, intervention specifics, efficacy outcomes, safety data, or conclusions; those details were not reported in the provided source excerpt. - Because the source text here contains only bibliographic and author/affiliation metadata, no trial results or clinical recommendations can be extracted from this excerpt. - The DOI and PMID permit retrieval of the full article for complete study details; those identifiers are included in the source record.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42842903/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42842903/#abstract) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42842903/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42842903/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42842903/#substances) * [ Associated data ](https://pubmed.ncbi.nlm.nih.gov/42842903/#supplemental-data) Title & authors Abstract Publication types MeSH terms Substances Associated data Clinical Trial N Engl J Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22N+Engl+J+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22N+Engl+J+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42842903/) . 2026 Oct 8;395(14):1399-1408. doi: 10.1056/NEJMoa2602215. # Optogenetic Therapy for Restoring Aspects of Visual Function [José-Alain Sahel](https://pubmed.ncbi.nlm.nih.gov/?term=Sahel+JA&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-3 "L'Hôpital Fondation Adolphe de Rothschild, Paris.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-4 "Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris."), [Stefan Futterknecht](https://pubmed.ncbi.nlm.nih.gov/?term=Futterknecht+S&cauthor_id=42842903)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-5 "Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-6 "University of Basel, Department of Ophthalmology, Basel, Switzerland."), [Isabelle Audo](https://pubmed.ncbi.nlm.nih.gov/?term=Audo+I&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-4 "Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris."), [Joseph N Martel](https://pubmed.ncbi.nlm.nih.gov/?term=Martel+JN&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [Shouyu Ling](https://pubmed.ncbi.nlm.nih.gov/?term=Ling+S&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [Chloé Pagot](https://pubmed.ncbi.nlm.nih.gov/?term=Pagot+C&cauthor_id=42842903)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-7 "Streetlab, Paris."), [Angelo Arleo](https://pubmed.ncbi.nlm.nih.gov/?term=Arleo+A&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris."), [Elise Boulanger-Scemama](https://pubmed.ncbi.nlm.nih.gov/?term=Boulanger-Scemama+E&cauthor_id=42842903)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-3 "L'Hôpital Fondation Adolphe de Rothschild, Paris."), [Antonin Duret](https://pubmed.ncbi.nlm.nih.gov/?term=Duret+A&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris."), [Jean-Baptiste de Saint Aubert](https://pubmed.ncbi.nlm.nih.gov/?term=de+Saint+Aubert+JB&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris."), [Alexandre Delaux](https://pubmed.ncbi.nlm.nih.gov/?term=Delaux+A&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris."), [Simona Degli Esposti](https://pubmed.ncbi.nlm.nih.gov/?term=Degli+Esposti+S&cauthor_id=42842903)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-8 "Moorfields Eye Hospital NHS Foundation Trust, London."), [Cécilia Coen](https://pubmed.ncbi.nlm.nih.gov/?term=Coen+C&cauthor_id=42842903)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-7 "Streetlab, Paris."), [Caroline de Montleau](https://pubmed.ncbi.nlm.nih.gov/?term=de+Montleau+C&cauthor_id=42842903)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-7 "Streetlab, Paris."), [Dana Aravich](https://pubmed.ncbi.nlm.nih.gov/?term=Aravich+D&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [William Smith](https://pubmed.ncbi.nlm.nih.gov/?term=Smith+W&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [Cecile Hayem](https://pubmed.ncbi.nlm.nih.gov/?term=Hayem+C&cauthor_id=42842903)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-9 "Acefas, Paris."), [Magali Taiel](https://pubmed.ncbi.nlm.nih.gov/?term=Taiel+M&cauthor_id=42842903)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-10 "GenSight Biologics, Paris."), [Marlene Behrmann](https://pubmed.ncbi.nlm.nih.gov/?term=Behrmann+M&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [Botond Roska](https://pubmed.ncbi.nlm.nih.gov/?term=Roska+B&cauthor_id=42842903)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-5 "Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#full-view-affiliation-6 "University of Basel, Department of Ophthalmology, Basel, Switzerland.") Affiliations Expand ### Affiliations * 1 Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh. * 2 Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris. * 3 L'Hôpital Fondation Adolphe de Rothschild, Paris. * 4 Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris. * 5 Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland. * 6 University of Basel, Department of Ophthalmology, Basel, Switzerland. * 7 Streetlab, Paris. * 8 Moorfields Eye Hospital NHS Foundation Trust, London. * 9 Acefas, Paris. * 10 GenSight Biologics, Paris. * PMID: **42842903** * DOI: [ 10.1056/NEJMoa2602215 ](https://doi.org/10.1056/nejmoa2602215) Item in Clipboard Clinical Trial # Optogenetic Therapy for Restoring Aspects of Visual Function José-Alain Sahel et al. N Engl J Med. 2026. Show details Display options Display options Format Abstract PubMed PMID N Engl J Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22N+Engl+J+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22N+Engl+J+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42842903/) . 2026 Oct 8;395(14):1399-1408. doi: 10.1056/NEJMoa2602215. ### Authors [José-Alain Sahel](https://pubmed.ncbi.nlm.nih.gov/?term=Sahel+JA&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-3 "L'Hôpital Fondation Adolphe de Rothschild, Paris.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-4 "Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris."), [Stefan Futterknecht](https://pubmed.ncbi.nlm.nih.gov/?term=Futterknecht+S&cauthor_id=42842903)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-5 "Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-6 "University of Basel, Department of Ophthalmology, Basel, Switzerland."), [Isabelle Audo](https://pubmed.ncbi.nlm.nih.gov/?term=Audo+I&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-4 "Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris."), [Joseph N Martel](https://pubmed.ncbi.nlm.nih.gov/?term=Martel+JN&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [Shouyu Ling](https://pubmed.ncbi.nlm.nih.gov/?term=Ling+S&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [Chloé Pagot](https://pubmed.ncbi.nlm.nih.gov/?term=Pagot+C&cauthor_id=42842903)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-7 "Streetlab, Paris."), [Angelo Arleo](https://pubmed.ncbi.nlm.nih.gov/?term=Arleo+A&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris."), [Elise Boulanger-Scemama](https://pubmed.ncbi.nlm.nih.gov/?term=Boulanger-Scemama+E&cauthor_id=42842903)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-3 "L'Hôpital Fondation Adolphe de Rothschild, Paris."), [Antonin Duret](https://pubmed.ncbi.nlm.nih.gov/?term=Duret+A&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris."), [Jean-Baptiste de Saint Aubert](https://pubmed.ncbi.nlm.nih.gov/?term=de+Saint+Aubert+JB&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris."), [Alexandre Delaux](https://pubmed.ncbi.nlm.nih.gov/?term=Delaux+A&cauthor_id=42842903)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-2 "Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris."), [Simona Degli Esposti](https://pubmed.ncbi.nlm.nih.gov/?term=Degli+Esposti+S&cauthor_id=42842903)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-8 "Moorfields Eye Hospital NHS Foundation Trust, London."), [Cécilia Coen](https://pubmed.ncbi.nlm.nih.gov/?term=Coen+C&cauthor_id=42842903)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-7 "Streetlab, Paris."), [Caroline de Montleau](https://pubmed.ncbi.nlm.nih.gov/?term=de+Montleau+C&cauthor_id=42842903)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-7 "Streetlab, Paris."), [Dana Aravich](https://pubmed.ncbi.nlm.nih.gov/?term=Aravich+D&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [William Smith](https://pubmed.ncbi.nlm.nih.gov/?term=Smith+W&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [Cecile Hayem](https://pubmed.ncbi.nlm.nih.gov/?term=Hayem+C&cauthor_id=42842903)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-9 "Acefas, Paris."), [Magali Taiel](https://pubmed.ncbi.nlm.nih.gov/?term=Taiel+M&cauthor_id=42842903)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-10 "GenSight Biologics, Paris."), [Marlene Behrmann](https://pubmed.ncbi.nlm.nih.gov/?term=Behrmann+M&cauthor_id=42842903)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-1 "Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh."), [Botond Roska](https://pubmed.ncbi.nlm.nih.gov/?term=Roska+B&cauthor_id=42842903)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-5 "Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42842903/#short-view-affiliation-6 "University of Basel, Department of Ophthalmology, Basel, Switzerland.") ### Affiliations * 1 Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh. * 2 Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris. * 3 L'Hôpital Fondation Adolphe de Rothschild, Paris. * 4 Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris. * 5 Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland. * 6 University of Basel, Department of Ophthalmology, Basel, Switzerland. * 7 Streetlab, Paris. * 8 Moorfields Eye Hospital NHS Foundation Trust, London. * 9 Acefas, Paris. * 10 GenSight Biologics, Paris. * PMID: **42842903** * DOI:
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