---
title: "Oral deucrictibant for on‑demand treatment of hereditary angioedema attacks: phase 3 crossover tri"
id: "pubmed-42849489"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42849489"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42849489/"
doi: "10.1016/S0140-6736(26)01296-1"
published_at: "2026-10-24T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Oral deucrictibant for on‑demand treatment of hereditary angioedema attacks: phase 3 crossover tri
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42849489
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42849489/)
- **DOI:** [10.1016/S0140-6736(26)01296-1](https://doi.org/10.1016%2FS0140-6736(26)01296-1)
- **Published At:** 2026-10-24T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article reports a phase 3, multicentre, randomised, double‑blind, placebo‑controlled crossover clinical trial evaluating oral **deucrictibant** for on‑demand treatment of **hereditary angioedema** attacks. - The trial was published in Lancet (2026 Oct 24;408(10565):1717–1731) with DOI 10.1016/S0140-6736(26)01296-1 and was e-published on Oct 8, 2026. - The author list is extensive and international; lead author listed as Marc A Riedl and more than 40 contributing clinicians across North America, Europe, Asia, Africa, and South America. - The source text explicitly states the study design (phase 3, multicentre, randomised, double‑blind, placebo‑controlled, crossover). - The PubMed record provided here does not include trial outcomes, efficacy measures, safety data, dosing, primary or secondary endpoint definitions, sample size, statistical results, or patient demographics; those details were not reported in the supplied excerpt. - Because results and numerical data are absent from the provided source text, this summary notes the trial's existence, design, publication provenance, and authorship while flagging the absence of efficacy and safety data in the excerpt. - Key unanswered clinical questions in the supplied record: magnitude and timing of clinical benefit, adverse event profile, dose and administration regimen, crossover washout procedures, and generalisability across hereditary angioedema phenotypes. - For clinicians and formulary committees, the next step is to consult the full Lancet article or journal-hosted supplementary material for concrete efficacy, safety, and methodological data omitted from the PubMed excerpt.
## Clinical Analysis & Structured Key Points
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Epub 2026 Oct 8. # Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial [Marc A Riedl](https://pubmed.ncbi.nlm.nih.gov/?term=Riedl+MA&cauthor_id=42849489)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-1 "Division of Allergy & Immunology, University of California, San Diego, La Jolla, CA, USA. Electronic address: mriedl@health.ucsd.edu."), [Philip H Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+PH&cauthor_id=42849489)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-2 "Division of Rheumatology and Clinical Immunology, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China."), [Adil Adatia](https://pubmed.ncbi.nlm.nih.gov/?term=Adatia+A&cauthor_id=42849489)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-3 "University of Alberta, Department of Medicine, Edmonton, AB, Canada."), [Mauro Cancian](https://pubmed.ncbi.nlm.nih.gov/?term=Cancian+M&cauthor_id=42849489)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-4 "Azienda Ospedale Universita di Padova, Padua, Italy."), [Marcin Stobiecki](https://pubmed.ncbi.nlm.nih.gov/?term=Stobiecki+M&cauthor_id=42849489)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-5 "Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland."), [Anna Valerieva](https://pubmed.ncbi.nlm.nih.gov/?term=Valerieva+A&cauthor_id=42849489)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-6 "Medical University of Sofia, Department of Allergology, Sofia, Bulgaria."), [Anete S Grumach](https://pubmed.ncbi.nlm.nih.gov/?term=Grumach+AS&cauthor_id=42849489)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-7 "Clinical Immunology, Centro Universitario FMABC, São Paulo, Brazil."), [William R Lumry](https://pubmed.ncbi.nlm.nih.gov/?term=Lumry+WR&cauthor_id=42849489)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-8 "AARA Research Centre, Dallas, TX, USA."), [Daniel F Soteres](https://pubmed.ncbi.nlm.nih.gov/?term=Soteres+DF&cauthor_id=42849489)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-9 "Colorado Allergy and Asthma Society, University CO Health Sciences Center, Asthma & Allergy Associates and Research Center, PC, Colorado Springs, CO, USA."), [Nicholas Brodszki](https://pubmed.ncbi.nlm.nih.gov/?term=Brodszki+N&cauthor_id=42849489)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-10 "Division of Hematology and Immunology, Children's Hospital, Skåne University Hospital, Lund, Sweden."), [Natalia L Fili](https://pubmed.ncbi.nlm.nih.gov/?term=Fili+NL&cauthor_id=42849489)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-11 "Allergy and Clinical Immunology Department, Hospital Publico Materno Infantil, Salta, Argentina."), [Roman Hakl](https://pubmed.ncbi.nlm.nih.gov/?term=Hakl+R&cauthor_id=42849489)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-12 "St Anne's University Hospital in Brno and Faculty of Medicine, Masaryk University, Department of Clinical Immunology and Allergology, Brno, Czech Republic."), [Hye-Ryun Kang](https://pubmed.ncbi.nlm.nih.gov/?term=Kang+HR&cauthor_id=42849489)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-13 "Seoul National University College of Medicine, Department of Internal Medicine, Seoul, South Korea; Seoul National University Hospital, Division of Allergy and Clinical Immunology, Seoul, South Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Centre, Seoul, South Korea; Korean Drug Allergy Research Consortium, Seoul, South Korea."), [Gul Karakaya](https://pubmed.ncbi.nlm.nih.gov/?term=Karakaya+G&cauthor_id=42849489)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-14 "Division of Allergy and Clinical Immunology Department of Chest Diseases, Hacettepe University Faculty of Medicine, Ankara, Türkiye."), [Birger Kränke](https://pubmed.ncbi.nlm.nih.gov/?term=Kr%C3%A4nke+B&cauthor_id=42849489)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-15 "Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria."), [H Henry Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+HH&cauthor_id=42849489)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-16 "Institute for Asthma and Allergy, Chevy Chase, MD, USA."), [Jonny Peter](https://pubmed.ncbi.nlm.nih.gov/?term=Peter+J&cauthor_id=42849489)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-17 "Groote Schuur Hospital, Division of Allergy and Clinical Immunology; University of Cape Town and Allergy and Immunology Unit; University of Cape Town Lung Institute, Cape Town, South Africa."), [Andreas Recke](https://pubmed.ncbi.nlm.nih.gov/?term=Recke+A&cauthor_id=42849489)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-18 "Department of Dermatology, Allergology and Venereology, University of Lübeck, Lübeck, Germany."), [Raffi Tachdjian](https://pubmed.ncbi.nlm.nih.gov/?term=Tachdjian+R&cauthor_id=42849489)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-19 "Division of Allergy, Immunology, and Rheumatology, University of California Los Angeles, Los Angeles, CA, USA."), [Paola Triggianese](https://pubmed.ncbi.nlm.nih.gov/?term=Triggianese+P&cauthor_id=42849489)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-20 "University of Rome Tor Vergata, Department of Biomedicine and Prevention, Rome, Italy."), [Andrea Zanichelli](https://pubmed.ncbi.nlm.nih.gov/?term=Zanichelli+A&cauthor_id=42849489)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-21 "Dipartimento di Scienze Biomediche per la Salute, Universita degli Studi di Milano, Milan, Italy; IRCCS, Policlinico San Donato, UO Medicina, Centro Angioedema, San Donato Milanese, Milan, Italy."), [John Anderson](https://pubmed.ncbi.nlm.nih.gov/?term=Anderson+J&cauthor_id=42849489)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-22 "Clinical Research Center of Alabama, AllerVie Health Birmingham, AL, USA."), [Emel Aygören-Pürsün](https://pubmed.ncbi.nlm.nih.gov/?term=Ayg%C3%B6ren-P%C3%BCrs%C3%BCn+E&cauthor_id=42849489)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-23 "Department of Pediatrics, Goethe University Frankfurt, Frankfurt am Main, Germany."), [Timothy J Craig](https://pubmed.ncbi.nlm.nih.gov/?term=Craig+TJ&cauthor_id=42849489)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-24 "Departments of Medicine, Pediatrics, MFM/OB/GYN, and Biomedical Sciences, Penn State University, Hershey, PA, USA; Vinmec-VinUni Institute of Immunology, Vinmec Hospital, Times City, Viet Nam; Vin University, Hanoi, Viet Nam."), [Henriette Farkas](https://pubmed.ncbi.nlm.nih.gov/?term=Farkas+H&cauthor_id=42849489)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-25 "Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary."), [Francesco Giardino](https://pubmed.ncbi.nlm.nih.gov/?term=Giardino+F&cauthor_id=42849489)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-26 "AOU Policlinico G. Rodolico-San Marco, Department of Internal Medicine, Catania, Italy."), [Pedro Giavina-Bianchi](https://pubmed.ncbi.nlm.nih.gov/?term=Giavina-Bianchi+P&cauthor_id=42849489)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-27 "Disciplina de Imunologia Clínica e Alergia da FMUSP, São Paulo, Brazil."), [Sujeong Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+S&cauthor_id=42849489)[ 28 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-28 "School of Medicine, Kyungpook National University, Daegu, South Korea."), [Tamar Kinaciyan](https://pubmed.ncbi.nlm.nih.gov/?term=Kinaciyan+T&cauthor_id=42849489)[ 29 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-29 "Department of Dermatology, Medical University of Vienna, Vienna, Austria."), [Inmaculada Martinez-Saguer](https://pubmed.ncbi.nlm.nih.gov/?term=Martinez-Saguer+I&cauthor_id=42849489)[ 30 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-30 "HZRM Hämophilie Zentrum Rhein Main, Frankfurt, Germany."), [Francesca Perego](https://pubmed.ncbi.nlm.nih.gov/?term=Perego+F&cauthor_id=42849489)[ 31 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-31 "Istituti Clinici Scientifci Maugeri IRCCS, Department of Internal Medicine and Rehabilitation, Milan, Italy."), [Karl V Sitz](https://pubmed.ncbi.nlm.nih.gov/?term=Sitz+KV&cauthor_id=42849489)[ 32 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-32 "Acuro Research, Little Rock, AR, USA."), [Maria Staevska](https://pubmed.ncbi.nlm.nih.gov/?term=Staevska+M&cauthor_id=42849489)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-6 "Medical University of Sofia, Department of Allergology, Sofia, Bulgaria."), [H James Wedner](https://pubmed.ncbi.nlm.nih.gov/?term=Wedner+HJ&cauthor_id=42849489)[ 33 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-33 "Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA."), [Rafael H Zaragoza-Urdaz](https://pubmed.ncbi.nlm.nih.gov/?term=Zaragoza-Urdaz+RH&cauthor_id=42849489)[ 34 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-34 "University Paediatric Hospital, Medical Sciences Campus, San Juan, Puerto Rico."), [Ricardo D Zwiener](https://pubmed.ncbi.nlm.nih.gov/?term=Zwiener+RD&cauthor_id=42849489)[ 35 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-35 "Servicio de Alergia e Inmunología, Hospital Universitario Austral, Buenos Aires, Argentina."), [Asli Gelincik](https://pubmed.ncbi.nlm.nih.gov/?term=Gelincik+A&cauthor_id=42849489)[ 36 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-36 "Division of Immunology and Allergic Diseases, Istanbul University, Istanbul, Türkiye."), [Francesco Arcoleo](https://pubmed.ncbi.nlm.nih.gov/?term=Arcoleo+F&cauthor_id=42849489)[ 37 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-37 "AOR Villa Sofia-Cervello, UOC di Patologia Clinica e Immunologia, Palermo, Italy."), [Rand Arnaout](https://pubmed.ncbi.nlm.nih.gov/?term=Arnaout+R&cauthor_id=42849489)[ 38 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-38 "Department of Medicine, Section of Allergy & Immunology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia."), [Alan P Baptist](https://pubmed.ncbi.nlm.nih.gov/?term=Baptist+AP&cauthor_id=42849489)[ 39 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-39 "Henry Ford Health, Detroit, MI, USA."), [Régis de Albuquerque Campos](https://pubmed.ncbi.nlm.nih.gov/?term=de+Albuquerque+Campos+R&cauthor_id=42849489)[ 40 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-40 "Ensino e Terapia de Inovacao Clinica AMO, Salvador, Bahia, Brazil."), [Anthony D Dorr](https://pubmed.ncbi.nlm.nih.gov/?term=Dorr+AD&cauthor_id=42849489)[ 41 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-41 "Barts Health NHS Trust, London, UK."), [Mariana Paes Leme Ferriani](https://pubmed.ncbi.nlm.nih.gov/?term=Ferriani+MPL&cauthor_id=42849489)[ 42 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-42 "Department of Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil."), [Atsushi Fukunaga](https://pubmed.ncbi.nlm.nih.gov/?term=Fukunaga+A&cauthor_id=42849489)[ 43 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-43 "Department of Dermatology, Division of Medicine for Function and Morphology of Sensory Organs, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan."), [Delphine Gobert](https://pubmed.ncbi.nlm.nih.gov/?term=Gobert+D&cauthor_id=42849489)[ 44 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-44 "Sorbonne Université, Médecine Interne, Centre de Référence des Angioedèmes à Kinines, Hôpital Saint-Antoine, AP-HP, Paris, France."), [Padmalal Gurugama](https://pubmed.ncbi.nlm.nih.gov/?term=Gurugama+P&cauthor_id=42849489)[ 45 ](https://pubmed.ncbi.nlm.nih.gov/42849489/#full-view-affiliation-45 "Department of Clinical Immunology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK."), [Michihiro Hide](https://pubmed.ncbi.nlm.nih.gov/?term=Hide+M&cauthor_id=42849489)[ 46 ](https://pubm
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