---
title: "Organophosphate Flame Retardants and Risk of Type 2 Diabetes: Population Evidence and Modification"
id: "pubmed-42632240"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42632240"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42632240/"
doi: "10.1016/j.jhazmat.2026.143347"
published_at: "2026-09-15T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Organophosphate Flame Retardants and Risk of Type 2 Diabetes: Population Evidence and Modification
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42632240
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42632240/)
- **DOI:** [10.1016/j.jhazmat.2026.143347](https://doi.org/10.1016%2Fj.jhazmat.2026.143347)
- **Published At:** 2026-09-15T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This article, published in Journal of Hazardous Materials, examines links between **organophosphate flame retardants** (OPFRs) and incident **type 2 diabetes** by integrating population-level epidemiology, mechanistic biology, and potential modification by **healthy lifestyle** factors. - The paper is authored by Xueyan Wu and colleagues from Zhengzhou University and affiliated hospitals; PMID 42632240, DOI 10.1016/j.jhazmat.2026.143347. - The report aims to synthesize observational evidence and mechanistic insights and to evaluate whether lifestyle modifies OPFR-associated diabetes risk. - The PubMed entry provides bibliographic and author information but does not include the article abstract or primary results in the supplied source text. - Specifics on study design, population cohorts, exposure metrics, statistical estimates (e.g., hazard ratios, confidence intervals), mechanistic experiments, or quantified effect modification by lifestyle are not reported in the provided source content. - Because primary data, results, and detailed methods are not available in the source text provided, no outcome measures, effect sizes, or definitive conclusions can be restated here. - The article appears to be an integrative review or synthesis combining epidemiologic studies and mechanistic evidence; however, whether it includes meta-analysis, new primary data, or pooled estimates is not specified in the source record. - The PubMed record lists affiliations across epidemiology, occupational/environmental health, hypertension, ultrasound, and environmental health departments, indicating multidisciplinary contributions. - For full clinical and research implications, readers should consult the full text via the journal link or DOI because the supplied source text lacks the abstract and results necessary to summarize evidence or make practice recommendations.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 20. # Organophosphate flame retardants and incident type 2 diabetes: Integrating population evidence, mechanistic insights, and effect modification by healthy lifestyle [Xueyan Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+X&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Yilin Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+Y&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Yue Nie](https://pubmed.ncbi.nlm.nih.gov/?term=Nie+Y&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Haoran Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+H&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Hengrui Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Mengke Cheng](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+M&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Yao Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+Y&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Fangyuan Lin](https://pubmed.ncbi.nlm.nih.gov/?term=Lin+F&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Xin Tang](https://pubmed.ncbi.nlm.nih.gov/?term=Tang+X&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Peihan Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+P&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Dandan Wei](https://pubmed.ncbi.nlm.nih.gov/?term=Wei+D&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Jian Hou](https://pubmed.ncbi.nlm.nih.gov/?term=Hou+J&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Wenqian Huo](https://pubmed.ncbi.nlm.nih.gov/?term=Huo+W&cauthor_id=42632240)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-2 "Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Xiaotian Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+X&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Linlin Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+L&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Chongjian Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+C&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Caini Fan](https://pubmed.ncbi.nlm.nih.gov/?term=Fan+C&cauthor_id=42632240)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-3 "Department of Hypertension, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, PR China."), [Haiying Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+H&cauthor_id=42632240)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-4 "Department of Ultrasound, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China."), [Tian Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+T&cauthor_id=42632240)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-5 "Department of Environmental Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, PR China."), [Zhenxing Mao](https://pubmed.ncbi.nlm.nih.gov/?term=Mao+Z&cauthor_id=42632240)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#full-view-affiliation-6 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: mzx@zzu.edu.cn.") Affiliations Expand ### Affiliations * 1 Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. * 2 Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. * 3 Department of Hypertension, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, PR China. * 4 Department of Ultrasound, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China. * 5 Department of Environmental Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, PR China. * 6 Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: mzx@zzu.edu.cn. * PMID: **42632240** * DOI: [ 10.1016/j.jhazmat.2026.143347 ](https://doi.org/10.1016/j.jhazmat.2026.143347) Item in Clipboard # Organophosphate flame retardants and incident type 2 diabetes: Integrating population evidence, mechanistic insights, and effect modification by healthy lifestyle Xueyan Wu et al. J Hazard Mater. 2026. Show details Display options Display options Format Abstract PubMed PMID J Hazard Mater Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Hazard+Mater%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Hazard+Mater%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42632240/) . 2026 Sep 15:516:143347. doi: 10.1016/j.jhazmat.2026.143347. Epub 2026 Aug 20. ### Authors [Xueyan Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+X&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Yilin Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+Y&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Yue Nie](https://pubmed.ncbi.nlm.nih.gov/?term=Nie+Y&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Haoran Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+H&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Hengrui Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Mengke Cheng](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+M&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Yao Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+Y&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Fangyuan Lin](https://pubmed.ncbi.nlm.nih.gov/?term=Lin+F&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Xin Tang](https://pubmed.ncbi.nlm.nih.gov/?term=Tang+X&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Peihan Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+P&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Dandan Wei](https://pubmed.ncbi.nlm.nih.gov/?term=Wei+D&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Jian Hou](https://pubmed.ncbi.nlm.nih.gov/?term=Hou+J&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Wenqian Huo](https://pubmed.ncbi.nlm.nih.gov/?term=Huo+W&cauthor_id=42632240)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-2 "Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Xiaotian Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+X&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Linlin Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+L&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Chongjian Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+C&cauthor_id=42632240)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China."), [Caini Fan](https://pubmed.ncbi.nlm.nih.gov/?term=Fan+C&cauthor_id=42632240)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-3 "Department of Hypertension, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, PR China."), [Haiying Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+H&cauthor_id=42632240)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-4 "Department of Ultrasound, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China."), [Tian Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+T&cauthor_id=42632240)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-5 "Department of Environmental Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, PR China."), [Zhenxing Mao](https://pubmed.ncbi.nlm.nih.gov/?term=Mao+Z&cauthor_id=42632240)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42632240/#short-view-affiliation-6 "Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: mzx@zzu.edu.cn.") ### Affiliations * 1 Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. * 2 Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. * 3 Department of Hypertension, Henan Provincial People's Hospital, Zhengzhou University People's H
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