---
title: "Patient-derived Organoid and Xenograft Models to Guide Precision Chemotherapy for Gastric Cancer"
id: "pubmed-42674710"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42674710"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42674710/"
doi: "10.21873/anticanres.18341"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Patient-derived Organoid and Xenograft Models to Guide Precision Chemotherapy for Gastric Cancer
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42674710
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42674710/)
- **DOI:** [10.21873/anticanres.18341](https://doi.org/10.21873%2Fanticanres.18341)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study established paired **patient-derived organoid (PDO)** and **patient-derived xenograft (PDX)** models from the same gastric cancer (GC) clinical specimens to evaluate translational value for individualized drug selection. - Endoscopic and surgical GC tissues were processed synchronously to generate matched PDOs and PDXs from identical patient tumors. - Model fidelity was assessed using hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and short tandem repeat (STR) profiling; STR showed >90% genetic matching between models and source tissues. - Both PDOs and PDXs preserved the histopathological and immunophenotypic features of the original tumors, as demonstrated by H&E and IHC consistency. - The platform implemented **in vitro** drug sensitivity testing on PDOs and **in vivo** pharmacodynamic validation in PDXs, enabling comparison of model-predicted responses with actual clinical therapeutic outcomes. - The integrated PDO–PDX approach showed high concordance in drug sensitivity prediction and correlated well with patients’ clinical responses, supporting use as a precision therapy platform in GC. - The study reports that the integrated platform can inform individualized chemotherapy choices for gastric cancer, providing a translational bridge from preclinical testing to clinical treatment decisions. - Specifics such as sample numbers, exact drug panels tested, timelines, and statistical measures were not reported in the abstract and therefore are not available from the source.
## Clinical Analysis & Structured Key Points
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China."), [Xing He](https://pubmed.ncbi.nlm.nih.gov/?term=He+X&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Xilu Hou](https://pubmed.ncbi.nlm.nih.gov/?term=Hou+X&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Guobin Liao](https://pubmed.ncbi.nlm.nih.gov/?term=Liao+G&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Haiqing Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+H&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Xiaowei Duan](https://pubmed.ncbi.nlm.nih.gov/?term=Duan+X&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Jiaoxue Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+J&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Qian Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+Q&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Senyuan Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+S&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Shicun Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+S&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Mingjin Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+M&cauthor_id=42674710)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-2 "Department of Surgery, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Honglin Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+H&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Jun Tang](https://pubmed.ncbi.nlm.nih.gov/?term=Tang+J&cauthor_id=42674710)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#full-view-affiliation-3 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China; tangjun1974@163.com.") Affiliations Expand ### Affiliations * 1 Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China. * 2 Department of Surgery, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China. * 3 Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China; tangjun1974@163.com. * PMID: **42674710** * DOI: [ 10.21873/anticanres.18341 ](https://doi.org/10.21873/anticanres.18341) Item in Clipboard # Integrating Patient-derived Organoid and Patient-derived Xenograft Models to Guide Precision Chemotherapy for Gastric Cancer Hezhong Yan et al. Anticancer Res. 2026 Sep. Show details Display options Display options Format Abstract PubMed PMID Anticancer Res Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anticancer+Res%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Anticancer+Res%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42674710/) . 2026 Sep;46(9):4895-4908. doi: 10.21873/anticanres.18341. ### Authors [Hezhong Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+H&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Xing He](https://pubmed.ncbi.nlm.nih.gov/?term=He+X&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Xilu Hou](https://pubmed.ncbi.nlm.nih.gov/?term=Hou+X&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Guobin Liao](https://pubmed.ncbi.nlm.nih.gov/?term=Liao+G&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Haiqing Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+H&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Xiaowei Duan](https://pubmed.ncbi.nlm.nih.gov/?term=Duan+X&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Jiaoxue Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+J&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Qian Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+Q&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Senyuan Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+S&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Shicun Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+S&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Mingjin Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+M&cauthor_id=42674710)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-2 "Department of Surgery, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Honglin Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+H&cauthor_id=42674710)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-1 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China."), [Jun Tang](https://pubmed.ncbi.nlm.nih.gov/?term=Tang+J&cauthor_id=42674710)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42674710/#short-view-affiliation-3 "Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China; tangjun1974@163.com.") ### Affiliations * 1 Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China. * 2 Department of Surgery, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China. * 3 Department of Gastroenterology, The 901 Hospital of Joint Logistics Support Force, Hefei, P.R. China; tangjun1974@163.com. * PMID: **42674710** * DOI: [ 10.21873/anticanres.18341 ](https://doi.org/10.21873/anticanres.18341) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background/aim:** The present study aimed to establish patient-derived organoid (PDO) and patient-derived xenograft (PDX) models from clinical gastric cancer (GC) tissue samples and analyze their drug sensitivity data to evaluate their translational value in GC research. The present study investigated the integrated construction of PDOs and PDXs from the same patient and evaluated their utility in individualized drug sensitivity prediction and clinical translation. **Materials and methods:** By constructing GC PDOs and PDXs, drug sensitivity assays with multiple agents were performed and validated results against clinical therapeutic responses. Endoscopic and surgical GC specimens were synchronously processed to generate paired PDO and PDX models from identical patient tissues. Model fidelity was validated using hematoxylin and zeosin (H&E) staining, immunohistochemistry (IHC) and short tandem repeat (STR) profiling. _In vitro_ drug sensitivity testing and _in vivo_ PDX pharmacodynamic validation were performed and predicted outcomes were compared to clinical treatment responses. **Results:** The findings demonstrated that PDOs and PDXs effectively preserve key histopathological and genetic features of the original tumors, with high concordance between drug sensitivity profiles and actual clinical outcomes, providing a platform for precision therapy in GC. Both PDOs and PDXs recapitulated the histological features of primary tumors. IHC confirmed their consistency with the original tissue profiles, while STR analysis demonstrated >90% genetic matching between the models and the source tissues. The integrated PDO-PDX platform showed a high correlation in predicting drug sensitivity. **Conclusion:** The integrated PDO-PDX platform achieved clinical concordance in predicting drug sensitivity, providing a platform for precision therapy in GC. **Keywords:** Gastric cancer organoids; drug sensitivity testing; gastric cancer xenograft tumors; precision medicine. Copyright © 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. 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