---
title: "Patient Knowledge of Anticoagulant Use in Atrial Fibrillation: Cross-Sectional Survey Results"
id: "pubmed-42788824"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42788824"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42788824/"
doi: "10.5543/tkda.2026.23942"
published_at: "2026-10-02T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Patient Knowledge of Anticoagulant Use in Atrial Fibrillation: Cross-Sectional Survey Results
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42788824
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42788824/)
- **DOI:** [10.5543/tkda.2026.23942](https://doi.org/10.5543%2Ftkda.2026.23942)
- **Published At:** 2026-10-02T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Study evaluated awareness of **anticoagulant** therapy among Turkish patients with non-valvular **atrial fibrillation (AF)** using a structured questionnaire. - Single-center, cross-sectional survey performed between July 1, 2024 and January 1, 2025; included consecutive adults on warfarin or direct oral anticoagulants for ≥3 months. - Questionnaire captured demographics, comorbidities, medication use, adherence, and knowledge across six domains: arrhythmia name, treatment indication, dosing schedule, side effects, drug/drug interactions, food interactions, and consequences of dose modification. - Sample: 261 patients; median age 67 years; 50.2% women. Hypertension in 64.8% and diabetes mellitus in 32.2%. - Treatment: 72.4% on **DOACs**, 27.6% on warfarin. Median AF duration: 36% had AF >6 years. - Awareness findings: only 16.5% could correctly name their arrhythmia; 92% knew they were taking an anticoagulant but 24% misunderstood its indication. - Safety knowledge limited: 68% reported no awareness of side effects; 88% unaware of drug–drug interactions; 71% unaware of food interactions. - Adherence and dosing: 92.3% knew dosing schedule; 99.6% would not double a missed dose; self-reported adherence high (94% 'always', 4% 'often'). Taking medication with meals correlated with better adherence (statistic reported in source, P < 0.001). - Composite knowledge score mean 2.8 ± 1.3 (range 0–6); internal consistency Cronbach's alpha = 0.50. - Predictors: higher education level and female sex associated with greater knowledge; increasing age inversely associated with knowledge. - Authors conclude substantial knowledge gaps persist despite high self-reported adherence and recommend targeted, health-literacy-sensitive educational strategies to improve safety and outcomes. - Ethics approval and written informed consent were obtained. Details about recruitment setting, exact statistical coefficients beyond those reported, and study limitations were not reported in the abstract.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 25. # Assessment of Patients' Awareness of Anticoagulant Use in Atrial Fibrillation: A Cross-Sectional Survey [Fidan Pirmammadova](https://pubmed.ncbi.nlm.nih.gov/?term=Pirmammadova+F&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#full-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Hakan G Kalp Uzun](https://pubmed.ncbi.nlm.nih.gov/?term=Uzun+HGK&cauthor_id=42788824)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#full-view-affiliation-2 "Department of Cardiology, ��zmir City Hospital, ��zmir, T��rkiye."), [Aytan Mammadli](https://pubmed.ncbi.nlm.nih.gov/?term=Mammadli+A&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#full-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Ahmet Can Urganc](https://pubmed.ncbi.nlm.nih.gov/?term=Urganc+AC&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#full-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Yasaman Borna](https://pubmed.ncbi.nlm.nih.gov/?term=Borna+Y&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#full-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Arzu Rzayeva](https://pubmed.ncbi.nlm.nih.gov/?term=Rzayeva+A&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#full-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Mehdi Zoghi](https://pubmed.ncbi.nlm.nih.gov/?term=Zoghi+M&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#full-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Meral Kay K O Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Kay+K+O+Lu+M&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#full-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Evrim Im Ek](https://pubmed.ncbi.nlm.nih.gov/?term=Im+Ek+E&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#full-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye.") Affiliations Expand ### Affiliations * 1 Department of Cardiology, Ege University, ��zmir, T��rkiye. * 2 Department of Cardiology, ��zmir City Hospital, ��zmir, T��rkiye. * PMID: **42788824** * DOI: [ 10.5543/tkda.2026.23942 ](https://doi.org/10.5543/tkda.2026.23942) Free article Item in Clipboard # Assessment of Patients' Awareness of Anticoagulant Use in Atrial Fibrillation: A Cross-Sectional Survey Fidan Pirmammadova et al. Turk Kardiyol Dern Ars. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Turk Kardiyol Dern Ars Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Turk+Kardiyol+Dern+Ars%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Turk+Kardiyol+Dern+Ars%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42788824/) . 2026 Oct 2;54(7):606-615. doi: 10.5543/tkda.2026.23942. Epub 2026 Sep 25. ### Authors [Fidan Pirmammadova](https://pubmed.ncbi.nlm.nih.gov/?term=Pirmammadova+F&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#short-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Hakan G Kalp Uzun](https://pubmed.ncbi.nlm.nih.gov/?term=Uzun+HGK&cauthor_id=42788824)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#short-view-affiliation-2 "Department of Cardiology, ��zmir City Hospital, ��zmir, T��rkiye."), [Aytan Mammadli](https://pubmed.ncbi.nlm.nih.gov/?term=Mammadli+A&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#short-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Ahmet Can Urganc](https://pubmed.ncbi.nlm.nih.gov/?term=Urganc+AC&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#short-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Yasaman Borna](https://pubmed.ncbi.nlm.nih.gov/?term=Borna+Y&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#short-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Arzu Rzayeva](https://pubmed.ncbi.nlm.nih.gov/?term=Rzayeva+A&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#short-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Mehdi Zoghi](https://pubmed.ncbi.nlm.nih.gov/?term=Zoghi+M&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#short-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Meral Kay K O Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Kay+K+O+Lu+M&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#short-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye."), [Evrim Im Ek](https://pubmed.ncbi.nlm.nih.gov/?term=Im+Ek+E&cauthor_id=42788824)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42788824/#short-view-affiliation-1 "Department of Cardiology, Ege University, ��zmir, T��rkiye.") ### Affiliations * 1 Department of Cardiology, Ege University, ��zmir, T��rkiye. * 2 Department of Cardiology, ��zmir City Hospital, ��zmir, T��rkiye. * PMID: **42788824** * DOI: [ 10.5543/tkda.2026.23942 ](https://doi.org/10.5543/tkda.2026.23942) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract **Objective:** Atrial fibrillation (AF) increases thromboembolic risk, and oral anticoagulants (OACs) substantially reduce this risk; however, their safe and effective use requires adequate patient knowledge. We aimed to assess AF- and OAC-related awareness among Turkish patients and to identify predictors of knowledge. **Method:** This single-center, cross-sectional survey was conducted between July 1, 2024 and January 1, 2025, and included consecutive adults with non-valvular AF receiving warfarin or direct OACs for at least three months. A structured questionnaire collected data on demographic characteristics, comorbidities, medication use, adherence, and knowledge across six domains: arrhythmia name, treatment indication, dosing schedule, side effects, drug and food interactions, and consequences of dose modification. A composite knowledge score (range, 0���6) was calculated. Multivariable linear regression was used to evaluate predictors of knowledge, including age, sex, and education level. Ethics approval was obtained, and all participants provided written informed consent. **Results:** A total of 261 patients were included (median age, 67 years; 50.2% women). Hypertension and diabetes mellitus were present in 64.8% and 32.2% of patients, respectively. Direct oral anticoagulants (DOACs) accounted for 72.4% of prescriptions, whereas 27.6% of patients received warfarin. Although 36% of participants had AF for more than six years, only 16.5% could correctly name their arrhythmia. While 92% knew they were taking an anticoagulant, 24% misunderstood its indication. Knowledge of side effects was limited, with 68% reporting no awareness. Awareness of interactions was poor: 88% reported no knowledge of drug���drug interactions, and 71% were unaware of food interactions. Most patients knew their dosing schedule (92.3%) and reported that they would not double a missed dose (99.6%). Self-reported adherence was high (94% 'always' and 4% 'often'), and taking medication with meals was associated with better adherence (���� = 17.0, P < 0.001). The mean knowledge score was 2.8 +- 1.3 (Cronbach's �� = 0.50). Higher educational attainment and female sex were associated with greater knowledge, whereas age was inversely associated with knowledge. **Conclusion:** Despite high self-reported adherence, substantial knowledge gaps persist among patients receiving anticoagulation for AF, particularly regarding side effects and drug or food interactions. Targeted, health-literacy-sensitive educational strategies may improve medication safety and clinical outcomes in patients receiving anticoagulation for AF. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ The relationship between knowledge, health literacy, and adherence among patients taking oral anticoagulants for stroke thromboprophylaxis in atrial fibrillation. ](https://pubmed.ncbi.nlm.nih.gov/28869793/) Rolls CA, Obamiro KO, Chalmers L, Bereznicki LRE.Rolls CA, et al.Cardiovasc Ther. 2017 Dec;35(6). doi: 10.1111/1755-5922.12304. Epub 2017 Sep 25.Cardiovasc Ther. 2017.PMID: 28869793 * [ Real-World Clinical Characteristics and Treatment Patterns of Individuals Aged 80 and Older with Nonvalvular Atrial Fibrillation: Results from the ReAl-life Multicenter Survey Evaluating Stroke Study. ](https://pubmed.ncbi.nlm.nih.gov/28394435/) Biteker M, Başaran Ö, Doğan V, Altun İ, Özpamuk Karadeniz F, Tekkesin Aİ, Çakıllı Y, Türkkan C, Hamidi M, Demir V, Gürsoy MO, Tek Öztürk M, Aksan G, Seyis S, Ballı M, Alıcı MH, Bozyel S.Biteker M, et al.J Am Geriatr Soc. 2017 Aug;65(8):1684-1690. doi: 10.1111/jgs.14855. Epub 2017 Apr 10.J Am Geriatr Soc. 2017.PMID: 28394435 * [ Development of a conceptual model of adherence to oral anticoagulants to reduce risk of stroke in patients with atrial fibrillation. ](https://pubmed.ncbi.nlm.nih.gov/22663168/) Brown TM, Siu K, Walker D, Pladevall-Vila M, Sander S, Mordin M.Brown TM, et al.J Manag Care Pharm. 2012 Jun;18(5):351-62. doi: 10.18553/jmcp.2012.18.5.351.J Manag Care Pharm. 2012.PMID: 22663168Free PMC article. * [ Effectiveness and Safety of Direct Oral Anticoagulants in an Asian Population with Atrial Fibrillation Undergoing Dialysis: A Population-Based Cohort Study and Meta-Analysis. ](https://pubmed.ncbi.nlm.nih.gov/33211254/) See LC, Lee HF, Chao TF, Li PR, Liu JR, Wu LS, Chang SH, Yeh YH, Kuo CT, Chan YH, Lip GYH.See LC, et al.Cardiovasc Drugs Ther. 2021 Oct;35(5):975-986. doi: 10.1007/s10557-020-07108-4. Epub 2020 Nov 19.Cardiovasc Drugs Ther. 2021.PMID: 33211254 * [ Differences in attitude, education, and knowledge about oral anticoagulation therapy among patients with atrial fibrillation in Europe: result of a self-assessment patient survey conducted by the European Heart Rhythm Association. ](https://pubmed.ncbi.nlm.nih.gov/26899998/) Hernández Madrid A, Potpara TS, Dagres N, Chen J, Larsen TB, Estner H, Todd D, Bongiorni MG, Sciaraffia E, Proclemer A, Cheggour S, Amara W, Blomstrom-Lundqvist C.Hernández Madrid A, et al.Europace. 2016 Mar;18(3):463-7. doi: 10.1093/europace/euv448. Epub 2016 Feb 21.Europace. 2016.PMID: 26899998Review. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42788824) ## MeSH terms * Administration, Oral Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Administration%2C+Oral%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Administration%2C+Oral) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42788824/) * Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42788824/) * Aged, 80 and over Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%2C+80+and+over%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged%2C+80+and+over) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42788824/) * Anticoagulants* / administration & dosage Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anticoagulants%2Fadministration+and+dosage%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Anticoagulants) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42788824/) * Anticoagulants* / adverse effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anticoagulants%2Fadverse+effects%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Anticoagulants) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42788824/) * Anticoagulants* / therapeutic use Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anticoagulants%2Ftherapeutic+use%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Anticoagulants) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42788824/) * Atrial Fibrillation* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Atrial+Fibrillation%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Atrial+Fibrillation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42788824/) * Atrial Fibrillation* / drug therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Atrial+Fibrillation%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Atrial+Fibrillation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42788824/) * Cross-Sectional Studies Actions * [ Search in PubMed ]
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