---
title: "Perioperative Management of Acromegaly-Related Heart Failure: Case Report and Outcomes"
id: "pubmed-42766639"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42766639"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42766639/"
doi: "10.1213/XAA.0000000000002255"
published_at: "2026-09-22T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Perioperative Management of Acromegaly-Related Heart Failure: Case Report and Outcomes
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42766639
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42766639/)
- **DOI:** [10.1213/XAA.0000000000002255](https://doi.org/10.1213%2FXAA.0000000000002255)
- **Published At:** 2026-09-22T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- A 73-year-old female with previously undiagnosed **acromegaly** presented for a planned robotic supracervical hysterectomy and experienced severe intraoperative cardiopulmonary intolerance. - During prolonged abdominal insufflation, the patient demonstrated hemodynamic intolerance that was attributed to a severely depressed **ejection fraction (EF)** measured at 10%–15% intraoperatively, prompting abortion of the procedure. - The patient was subsequently evaluated and treated for both **acromegaly** and **heart failure**; specific medical treatments were not detailed in the source abstract. - Over the following 15 months after treatment, the patient’s EF improved to 50%–55%, representing a substantial recovery of left ventricular systolic function. - With improved cardiac function, the patient underwent a later pelvic organ prolapse repair without perioperative complications. - The case highlights that when clinical suspicion for **acromegaly** exists, early diagnosis and medical management may permit optimization of cardiovascular function and reduce **perioperative instability**. - The report cites relevant literature including clinical practice guidelines and reviews on acromegalic cardiomyopathy and perioperative cardiovascular consequences of laparoscopic surgery; full reference details are listed in the original article.
## Clinical Analysis & Structured Key Points
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A A Pract. 2026. Show details Display options Display options Format Abstract PubMed PMID A A Pract Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22A+A+Pract%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22A+A+Pract%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42766639/) . 2026 Sep 22;20(9):e02255. doi: 10.1213/XAA.0000000000002255. eCollection 2026 Sep 1. ### Authors [Christian Zbihley](https://pubmed.ncbi.nlm.nih.gov/?term=Zbihley+C&cauthor_id=42766639)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42766639/#short-view-affiliation-1 "From the Virginia Commonwealth University School of Medicine."), [Temitayo Olasehinde](https://pubmed.ncbi.nlm.nih.gov/?term=Olasehinde+T&cauthor_id=42766639)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42766639/#short-view-affiliation-1 "From the Virginia Commonwealth University School of Medicine."), [Alex Will](https://pubmed.ncbi.nlm.nih.gov/?term=Will+A&cauthor_id=42766639)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42766639/#short-view-affiliation-2 "Department of Anesthesiology, VCU Medical Center, Richmond, Virginia."); [Collaborators](https://pubmed.ncbi.nlm.nih.gov/?term=Collaborators%5BCorporate+Author%5D) ### Affiliations * 1 From the Virginia Commonwealth University School of Medicine. * 2 Department of Anesthesiology, VCU Medical Center, Richmond, Virginia. * PMID: **42766639** * DOI: [ 10.1213/XAA.0000000000002255 ](https://doi.org/10.1213/xaa.0000000000002255) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract This report describes a case of undiagnosed acromegaly in a 73-year-old female presenting for robotic supracervical hysterectomy. During the index operation, prolonged abdominal insufflation was not tolerated secondary to a severely depressed ejection fraction (EF) of 10% to 15%. The procedure was aborted and the patient was treated for acromegaly and heart failure. Fifteen months following treatment, her EF improved to 50% to 55%, and she underwent successful pelvic organ prolapse repair without complications. If clinical suspicion for acromegaly arises, early diagnosis and medical management may allow for optimization of cardiovascular function and reduced risks of perioperative instability. Copyright © 2026 International Anesthesia Research Society. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement The authors declare no conflicts of interest. ## References 1. 1. Katznelson L, Laws ER Jr, Melmed S, et al.; Endocrine Society. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99:3933–3951. 2. 1. Sharma AN, Tan M, Amsterdam EA, Singh GD. Acromegalic cardiomyopathy: epidemiology, diagnosis, and management. Clin Cardiol. 2018;41:419–425. 3. 1. Sherin RPV, Vietor NO, Usman A, Hoang TD, Shakir MKM. Cardiovascular disorders associated with acromegaly: an update. Endocr Pract. 2024;30:1212–1219. 4. 1. Atkinson TM, Giraud GD, Togioka BM, Jones DB, Cigarroa JE. Cardiovascular and ventilatory consequences of laparoscopic surgery. Circulation. 2017;135:700–710. 5. 1. Burton T, Le Nestour E, Neary M, Ludlam WH. Incidence and prevalence of acromegaly in a large US health plan database. Pituitary. 2016;19:262–267. 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