---
title: "PLGA-gelatin nanofibrous scaffold with Vitex negundo and Jatropha multifida for diabetic wound hea"
id: "pubmed-42701137"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42701137"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42701137/"
doi: "10.1007/s10735-026-10903-2"
published_at: "2026-09-06T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# PLGA-gelatin nanofibrous scaffold with Vitex negundo and Jatropha multifida for diabetic wound hea
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42701137
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42701137/)
- **DOI:** [10.1007/s10735-026-10903-2](https://doi.org/10.1007%2Fs10735-026-10903-2)
- **Published At:** 2026-09-06T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This study developed bioinspired **PLGA-gelatin nanofibrous scaffolds** loaded with phytoextracts from Vitex negundo (VN) and Jatropha multifida (JM) to treat diabetic wounds in vitro and in vivo. - Nanofibers had uniform nanoscale morphology with fiber diameters of approximately **255–280 nm** and showed successful incorporation of phytoconstituents and a crystalline-to-amorphous transformation on XRD, suggesting improved solubility. - Physical properties supportive of wound dressing function included high porosity (83.6 ± 0.9%), strong swelling capacity (450 ± 18% at 24 h), and controlled biodegradation (63.5 ± 4.5% weight loss at 28 days). - The formulation provided **sustained drug release** over 168 hours with about **90% cumulative release**, enabling prolonged local availability of phytoactive compounds. - In HUVEC cell studies the VN-JM nanofibers at optimal doses increased cell viability, reduced reactive oxygen species (DCFH intensity), enhanced colony formation, and improved migration/wound-closure in vitro. - In streptozotocin-induced diabetic rats, daily topical application of the nanofibrous scaffold for 21 days produced superior wound closure at day 21 compared with gels and extracts. - Treated animals showed reduced proinflammatory markers (TNF-α, IL-6), decreased lipid peroxidation, lower DCF and nitrite levels, and histological evidence of complete re-epithelialization, fibroblast proliferation, neovascularization, and organized collagen. - Authors conclude that VN+JM-loaded nanofibers are a promising regenerative, bioresorbable scaffold for diabetic wounds acting via **anti-inflammatory** and **antioxidant** mechanisms. - Conflict of interest: the authors declared no competing interests. - Keywords reported: HUVEC cell migration; Inflammation modulation; Nanofibrous scaffolds; TNF-α IL-6 suppression; Wound closure regeneration.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Department of Pharmacognosy, United Institute of Pharmacy, Naini, Prayagraj, 211010, India. gari2193@gmail.com. * 2 Dr. APJ Abdul Kalam Technical University, Lucknow, Uttar Pradesh, 226031, India. gari2193@gmail.com. * 3 Department of Pharmacognosy, United Institute of Pharmacy, Naini, Prayagraj, 211010, India. * 4 Department of Pharmacology, Faculty of Pharmacy, School of Pharmacy, Parul University, Waghodia Vadodara, Gujarat, 391760, India. satyamsharma.phe17@itbhu.ac.in. * 5 Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, 244001, India. * 6 Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India. # Contributed equally. * PMID: **42701137** * DOI: [ 10.1007/s10735-026-10903-2 ](https://doi.org/10.1007/s10735-026-10903-2) Item in Clipboard # Phytoextract-loaded bioinspired PLGA nanofibrous scaffold promotes diabetic wound healing via anti-inflammatory and antioxidant effects in in vitro and in vivo experimental models Garima Sahu et al. J Mol Histol. 2026. Show details Display options Display options Format Abstract PubMed PMID J Mol Histol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Mol+Histol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Mol+Histol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) . 2026 Sep 6;57(5):298. doi: 10.1007/s10735-026-10903-2. ### Authors [Garima Sahu](https://pubmed.ncbi.nlm.nih.gov/?term=Sahu+G&cauthor_id=42701137)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42701137/#short-view-affiliation-1 "Department of Pharmacognosy, United Institute of Pharmacy, Naini, Prayagraj, 211010, India. gari2193@gmail.com.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42701137/#short-view-affiliation-2 "Dr. APJ Abdul Kalam Technical University, Lucknow, Uttar Pradesh, 226031, India. gari2193@gmail.com."), [Mukul Maurya](https://pubmed.ncbi.nlm.nih.gov/?term=Maurya+M&cauthor_id=42701137)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42701137/#short-view-affiliation-3 "Department of Pharmacognosy, United Institute of Pharmacy, Naini, Prayagraj, 211010, India."), [Satyam Sharma](https://pubmed.ncbi.nlm.nih.gov/?term=Sharma+S&cauthor_id=42701137)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42701137/#short-view-affiliation-4 "Department of Pharmacology, Faculty of Pharmacy, School of Pharmacy, Parul University, Waghodia Vadodara, Gujarat, 391760, India. satyamsharma.phe17@itbhu.ac.in."), [Virendra Kumar Kushwaha](https://pubmed.ncbi.nlm.nih.gov/?term=Kushwaha+VK&cauthor_id=42701137)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42701137/#short-view-affiliation-5 "Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, 244001, India."), [Alok Mukerjee](https://pubmed.ncbi.nlm.nih.gov/?term=Mukerjee+A&cauthor_id=42701137)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42701137/#short-view-affiliation-3 "Department of Pharmacognosy, United Institute of Pharmacy, Naini, Prayagraj, 211010, India."), [Brahmeshwar Mishra](https://pubmed.ncbi.nlm.nih.gov/?term=Mishra+B&cauthor_id=42701137)[#](https://pubmed.ncbi.nlm.nih.gov/42701137/#short-view-equal-contrib-explanation "Contributed equally")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42701137/#short-view-affiliation-6 "Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology \(BHU\), Varanasi, 221005, India.") ### Affiliations * 1 Department of Pharmacognosy, United Institute of Pharmacy, Naini, Prayagraj, 211010, India. gari2193@gmail.com. * 2 Dr. APJ Abdul Kalam Technical University, Lucknow, Uttar Pradesh, 226031, India. gari2193@gmail.com. * 3 Department of Pharmacognosy, United Institute of Pharmacy, Naini, Prayagraj, 211010, India. * 4 Department of Pharmacology, Faculty of Pharmacy, School of Pharmacy, Parul University, Waghodia Vadodara, Gujarat, 391760, India. satyamsharma.phe17@itbhu.ac.in. * 5 Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, 244001, India. * 6 Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India. # Contributed equally. * PMID: **42701137** * DOI: [ 10.1007/s10735-026-10903-2 ](https://doi.org/10.1007/s10735-026-10903-2) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Diabetic wounds pose significant healing challenges due to persistent inflammation, oxidative stress, and impaired tissue regeneration. This study developed bioinspired PLGA-gelatin nanofibrous scaffolds encapsulating Vitex negundo (VN) and Jatropha multifida (JM) phytoextracts to mimic the extracellular matrix, enhance drug release, and promote wound healing via anti-inflammatory and antioxidant mechanisms in in vitro (HUVEC cells) and in vivo (streptozotocin-induced diabetic rat) models. VN-JM nanofibers exhibited uniform nanoscale morphology (255-280 nm) with successful phytoconstituent incorporation, while XRD analysis confirmed crystalline-to-amorphous transformation, indicating enhanced solubility. The nanofibers demonstrated high porosity (83.6 ± 0.9%), excellent swelling capacity (450 ± 18% at 24 h), and controlled biodegradation (63.5 ± 4.5% weight loss at 28 days), supporting their suitability as bioresorbable wound dressings. Furthermore, the formulation provided sustained drug release over 168 h, achieving approximately 90% cumulative release, thereby ensuring prolonged therapeutic availability at the wound site. At optimal doses, nanofibers enhanced HUVEC viability, reduced ROS (DCFH intensity, boosted colony formation, and enhances migration wound closure. In diabetic rats, daily topical application for 21 days yielded better wound closure at day 21, markedly lowered TNF-α, IL-6, and diminished lipid peroxidation, DCF, nitrite levels compared to gels and extracts. Histology showed complete re-epithelialization, fibroblast proliferation, neovascularization, and organized collagen in nanofiber-treated groups, outperforming diabetic controls and matching standard groups. These findings demonstrate VN+JM-loaded nanofibers could be taken as a promising regenerative scaffold for diabetic wounds by mitigating oxidative stress and inflammation. **Keywords:** HUVEC cell migration; Inflammation modulation; Nanofibrous scaffolds; TNF-α IL-6 suppression; Wound closure regeneration. © 2026. The Author(s), under exclusive licence to Springer Nature B.V. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declarations. Conflict of interest: The authors declare no competing interests. ## References 1. 1. Abraham N et al (2026) Multifunctional bilayered nanofibrous scaffold of chitosan/poly (caprolactone) enriched with simvastatin and thymoquinone for accelerated diabetic wound healing. Int J Biol Macromol. - [DOI](https://doi.org/10.1016/j.ijbiomac.2026.151109) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/42442579/) 2. 1. AbuHaweeleh MN et al (2026) Unravelling the pathophysiology of diabetic foot ulcer: insights into a complex wound healing process. Front Clinic Diabetes Healthc 7:1759605 - [DOI](https://doi.org/10.3389/fcdhc.2026.1759605) 3. 1. Ajmal G et al (2023) PLGA/Gelatin-based electrospun nanofiber scaffold encapsulating antibacterial and antioxidant molecules for accelerated tissue regeneration. Mater Today Commun 35:105633 - [DOI](https://doi.org/10.1016/j.mtcomm.2023.105633) 4. 1. Altay F, Alakaş E, Yiğit R (2026) Electrospinning encapsulation of electrolytes and their in vitro transdermal release modeling. Food Bioprocess Technol 19(3):124 - [DOI](https://doi.org/10.1007/s11947-026-04209-0) 5. 1. Armstrong DG, Boulton AJ and Sicco A (2017) Bus. Diabetic foot ulcers and their recurrence. New England J Med . 376(24):2367–2375 Show all 51 references ## MeSH terms * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Anti-Inflammatory Agents* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anti-Inflammatory+Agents%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Anti-Inflammatory+Agents) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Anti-Inflammatory Agents* / pharmacology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anti-Inflammatory+Agents%2Fpharmacology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Anti-Inflammatory+Agents) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Antioxidants* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Antioxidants%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Antioxidants) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Antioxidants* / pharmacology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Antioxidants%2Fpharmacology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Antioxidants) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Diabetes Mellitus, Experimental* / drug therapy Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Diabetes+Mellitus%2C+Experimental%2Fdrug+therapy%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Diabetes+Mellitus%2C+Experimental) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Human Umbilical Vein Endothelial Cells Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Human+Umbilical+Vein+Endothelial+Cells%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Human+Umbilical+Vein+Endothelial+Cells) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Male Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Male) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Nanofibers* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Nanofibers%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Nanofibers) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Nanofibers* / ultrastructure Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Nanofibers%2Fultrastructure%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Nanofibers) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42701137/) * Plant Extracts* / chemistry Actions * [ Search in Pub
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