---
title: "Poly(glutamic acid)-Based Microgels for Osteoarthritis: Durable Lubrication and MMP-Responsive Dex"
id: "pubmed-42734288"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42734288"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42734288/"
doi: "10.1021/acs.biomac.6c00920"
published_at: "2026-09-14T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Poly(glutamic acid)-Based Microgels for Osteoarthritis: Durable Lubrication and MMP-Responsive Dex
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42734288
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42734288/)
- **DOI:** [10.1021/acs.biomac.6c00920](https://doi.org/10.1021%2Facs.biomac.6c00920)
- **Published At:** 2026-09-14T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study reports development of **poly(glutamic acid)-based microgels** (Lipo/PADM) assembled by multiple cross-linking to combine long-term **lubrication** with matrix metalloproteinase (**MMP**)-responsive anti-inflammatory delivery for osteoarthritis (OA) therapy. - Microgels maintained a low coefficient of friction (0.029) and remained **24.3% lower** than phosphate-buffered saline (PBS) after 8 weeks of in vitro degradation, indicating durable lubricating performance. - In an **MMP-rich OA microenvironment**, ester-bond cleavage in the microgels triggered sustained, on-demand release of **dexamethasone**, reaching **70% cumulative release within 14 days** in reported in vitro assays. - Cellular assays showed restoration of **type II collagen** expression and suppression of **MMP-13** in bone marrow mesenchymal stem cells, indicating mitigation of the OA-associated catabolic microenvironment. - Intra-articular administration of the microgels significantly reduced cartilage degeneration and delayed OA progression in the reported experimental model, while providing prolonged intra-articular retention. - The platform integrates **sustained lubrication**, **responsive drug release**, and extended joint residence time as a combined therapeutic strategy for OA. - The abstract and metadata note MeSH indexing for anti-inflammatory agents, dexamethasone, lubrication, MMP-13, collagen type II, drug delivery systems, and mesenchymal stem cells; details on experimental species and specific in vivo model parameters were not reported in the abstract.
## Clinical Analysis & Structured Key Points
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China."), [Yanyang Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Y&cauthor_id=42734288)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#full-view-affiliation-2 "Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai200025, P. R. China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#full-view-affiliation-3 "Department of Orthopedics, The First Affiliated Hospital of Bengbu Medical University, Bengbu233004, China."), [Junyu Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+J&cauthor_id=42734288)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#full-view-affiliation-1 "Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai200444, P.R. China."), [Kaixuan Ren](https://pubmed.ncbi.nlm.nih.gov/?term=Ren+K&cauthor_id=42734288)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#full-view-affiliation-1 "Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai200444, P.R. China."), [Wenguo Cui](https://pubmed.ncbi.nlm.nih.gov/?term=Cui+W&cauthor_id=42734288)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#full-view-affiliation-2 "Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai200025, P. R. China."), [Jingbo Yin](https://pubmed.ncbi.nlm.nih.gov/?term=Yin+J&cauthor_id=42734288)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#full-view-affiliation-1 "Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai200444, P.R. China.") Affiliations Expand ### Affiliations * 1 Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai200444, P.R. China. * 2 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai200025, P. R. China. * 3 Department of Orthopedics, The First Affiliated Hospital of Bengbu Medical University, Bengbu233004, China. * PMID: **42734288** * DOI: [ 10.1021/acs.biomac.6c00920 ](https://doi.org/10.1021/acs.biomac.6c00920) Item in Clipboard # Poly(l-glutamic Acid)-Based Microgels with Long-Term Synergistic Lubrication and MMP-Responsive Anti-Inflammatory Delivery for Osteoarthritis Therapy Rong Wu et al. Biomacromolecules. 2026. Show details Display options Display options Format Abstract PubMed PMID Biomacromolecules Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biomacromolecules%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biomacromolecules%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42734288/) . 2026 Sep 14;27(9):6058-6073. doi: 10.1021/acs.biomac.6c00920. ### Authors [Rong Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+R&cauthor_id=42734288)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#short-view-affiliation-1 "Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai200444, P.R. China."), [Yanyang Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Y&cauthor_id=42734288)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#short-view-affiliation-2 "Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai200025, P. R. China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#short-view-affiliation-3 "Department of Orthopedics, The First Affiliated Hospital of Bengbu Medical University, Bengbu233004, China."), [Junyu Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+J&cauthor_id=42734288)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#short-view-affiliation-1 "Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai200444, P.R. China."), [Kaixuan Ren](https://pubmed.ncbi.nlm.nih.gov/?term=Ren+K&cauthor_id=42734288)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#short-view-affiliation-1 "Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai200444, P.R. China."), [Wenguo Cui](https://pubmed.ncbi.nlm.nih.gov/?term=Cui+W&cauthor_id=42734288)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#short-view-affiliation-2 "Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai200025, P. R. China."), [Jingbo Yin](https://pubmed.ncbi.nlm.nih.gov/?term=Yin+J&cauthor_id=42734288)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42734288/#short-view-affiliation-1 "Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai200444, P.R. China.") ### Affiliations * 1 Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai200444, P.R. China. * 2 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai200025, P. R. China. * 3 Department of Orthopedics, The First Affiliated Hospital of Bengbu Medical University, Bengbu233004, China. * PMID: **42734288** * DOI: [ 10.1021/acs.biomac.6c00920 ](https://doi.org/10.1021/acs.biomac.6c00920) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Osteoarthritis (OA) is a degenerative joint disease characterized by the failure of cartilage lubrication and persistent inflammation induced by friction-generated debris. Therefore, an effective OA treatment strategy should simultaneously enhance joint long-term lubrication and suppress inflammation. Toward this goal, we developed durable Lipo/PADM microgels via multiple cross-linking to integrate sustained lubrication with matrix metalloproteinase (MMP)-responsive dexamethasone release. The microgels maintained a low coefficient of friction of 0.029, remaining 24.3% lower than PBS after 8 weeks of in vitro degradation. In the MMP-rich OA microenvironment, ester-bond cleavage enabled sustained, on-demand drug release, reaching 70% within 14 days. Lipo/PADM microgels restored type II collagen expression, suppressed MMP-13 in bone marrow mesenchymal stem cells, and alleviated the OA-associated catabolic microenvironment. Intra-articular administration significantly reduced cartilage degeneration and delayed OA progression. These poly(glutamic acid)-based microgels offer a promising OA therapy through durable lubrication, responsive drug delivery, and prolonged intra-articular retention. © 2026 American Chemical Society. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Liposome-based nanocolloids for restoring lubrication and targeted therapy in osteoarthritis. ](https://pubmed.ncbi.nlm.nih.gov/42030858/) Wang X, Fu Y, Lin W.Wang X, et al.Colloids Surf B Biointerfaces. 2026 Sep;265:115723. doi: 10.1016/j.colsurfb.2026.115723. Epub 2026 Apr 22.Colloids Surf B Biointerfaces. 2026.PMID: 42030858Review. * [ A dual responsive nanohydrogel system for sustained drug delivery and cartilage penetration in osteoarthritis therapy. ](https://pubmed.ncbi.nlm.nih.gov/41344484/) Zhou K, He X, Shi K, Hu D, Yang C, Gao M, Wang Y, Liu Y, Yang Q, Chu B, Peng J, Qian Z.Zhou K, et al.J Control Release. 2026 Jan 10;389:114494. doi: 10.1016/j.jconrel.2025.114494. Epub 2025 Dec 2.J Control Release. 2026.PMID: 41344484 * [ Phenotypic screening identified polydatin alleviating cartilage degeneration by modulating SIRT3-dependent mitochondrial dysfunction. ](https://pubmed.ncbi.nlm.nih.gov/40505483/) Mao A, Fu Y, Zhang M, Wu J, Wu M.Mao A, et al.Phytomedicine. 2025 Aug;144:156948. doi: 10.1016/j.phymed.2025.156948. Epub 2025 Jun 3.Phytomedicine. 2025.PMID: 40505483 * [ Intra-bone marrow injection of magnesium isoglyrrhizinate inhibits inflammation and delays osteoarthritis progression through the NF-κB pathway. ](https://pubmed.ncbi.nlm.nih.gov/36045373/) Chen R, Li X, Sun Z, Yin J, Hu X, Deng J, Liu X.Chen R, et al.J Orthop Surg Res. 2022 Aug 31;17(1):400. doi: 10.1186/s13018-022-03294-z.J Orthop Surg Res. 2022.PMID: 36045373Free PMC article. * [ Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis. ](https://pubmed.ncbi.nlm.nih.gov/33572320/) Hu Q, Ecker M.Hu Q, et al.Int J Mol Sci. 2021 Feb 9;22(4):1742. doi: 10.3390/ijms22041742.Int J Mol Sci. 2021.PMID: 33572320Free PMC article.Review. 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