---
title: "Predicting Severe Toxicities and Mortality in Older Patients with Colorectal Cancer"
id: "pubmed-42456539"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42456539"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42456539/"
doi: "10.1016/j.ejca.2026.116935"
published_at: "2026-09-09T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Predicting Severe Toxicities and Mortality in Older Patients with Colorectal Cancer
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42456539
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42456539/)
- **DOI:** [10.1016/j.ejca.2026.116935](https://doi.org/10.1016%2Fj.ejca.2026.116935)
- **Published At:** 2026-09-09T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This article, titled “Predicting severe toxicities and mortality in older patients with colorectal cancer: An analysis of 3 clinical trials and 3 prospective cohorts,” addresses risk prediction for treatment-related **severe toxicities** and **mortality** in **older patients** with **colorectal cancer**. - Publication: Eur J Cancer; Epub 12 Jul 2026; print citation 2026 Sep 9:245:116935. DOI 10.1016/j.ejca.2026.116935; PMID 42456539. The article is available as a free full text link from PubMed/NCBI. - Study design (from title): pooled/combined analysis of three clinical trials and three prospective cohorts; the title indicates comparative or predictive analyses across these six data sources. - Author group: multicenter French team led by Maxime Rémond and collaborators from gastroenterology, medical oncology, geriatrics, clinical epidemiology and geriatric oncology units. Multiple academic and hospital affiliations across France are listed. - Affiliations include Hôpital Saint Louis, Université Paris Cité; IMRB/Inserm U955; FFCD/EPICAD; Hôpital Européen Georges Pompidou; Institut Bergonié; Institut Curie; and multiple regional oncology centers. - The PubMed entry lists full author names and detailed institutional affiliations; contact email provided for the corresponding author (maxime.remond-ext@aphp.fr). - The PubMed summary page and metadata are present, but the abstract and methods/results details are not included in the provided source text. Specifics on sample size, inclusion criteria, predictive variables, statistical models, outcome rates, discrimination/calibration metrics, and study conclusions were not reported in the available source content. - Because the source body lacks the abstract and primary results, no performance measures, recommendations, or validated prediction tools can be reported here without risking invention. - Clinical implication: the topic is clinically important for treatment decision-making and risk stratification in older adults with colorectal cancer, but the PubMed record supplied does not report the study findings or practical guidance. - For clinicians or researchers seeking the study methods and results, consult the full text via the DOI or publisher link; details were not reported in the PubMed excerpt provided here.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jul 12. # Predicting severe toxicities and mortality in older patients with colorectal cancer: An analysis of 3 clinical trials and 3 prospective cohorts [Maxime Rémond](https://pubmed.ncbi.nlm.nih.gov/?term=R%C3%A9mond+M&cauthor_id=42456539)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-1 "Department of Gastroenterology and Digestive Oncology, Hôpital Saint Louis, Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: maxime.remond-ext@aphp.fr."), [Thomas Aparicio](https://pubmed.ncbi.nlm.nih.gov/?term=Aparicio+T&cauthor_id=42456539)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-2 "Department of Gastroenterology and Digestive Oncology, Hôpital Saint Louis, Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Paris, France."), [Claudia Martinez-Tapia](https://pubmed.ncbi.nlm.nih.gov/?term=Martinez-Tapia+C&cauthor_id=42456539)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-3 "Equipe CEpiA \(Clinical Epidemiology and Ageing\), IMRB, U955 Inserm - Université Paris Est Créteil \(UPEC\), France."), [Karine Le Malicot](https://pubmed.ncbi.nlm.nih.gov/?term=Le+Malicot+K&cauthor_id=42456539)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-4 "Federation Francophone de Cancérologie Digestive \(FFCD\), EPICAD INSERM LNC-UMR 1231, University of Burgundy Europe, Dijon, France."), [Elena Paillaud](https://pubmed.ncbi.nlm.nih.gov/?term=Paillaud+E&cauthor_id=42456539)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-5 "Department of Geriatrics, Hôpital Européen Georges Pompidou, Paris Cancer Institute CARPEM, Assistance Publique-Hôpitaux de Paris, Paris, France."), [Rabia Boulahssass](https://pubmed.ncbi.nlm.nih.gov/?term=Boulahssass+R&cauthor_id=42456539)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-6 "Coordination Unit of Geriatric Oncology, Rehabilitation and Autonomy Department, University Hospital of Nice, Nice, France."), [Pierre Soubeyran](https://pubmed.ncbi.nlm.nih.gov/?term=Soubeyran+P&cauthor_id=42456539)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-7 "Department of Oncology, Institut Bergonié, Université de Bordeaux, Inserm, Bordeaux U1312, France."), [Selim Turk](https://pubmed.ncbi.nlm.nih.gov/?term=Turk+S&cauthor_id=42456539)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-8 "Department of Medical Oncology, Hôpitaux Universitaires Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France."), [Michael Bringuier](https://pubmed.ncbi.nlm.nih.gov/?term=Bringuier+M&cauthor_id=42456539)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-9 "Department of Medical Oncology, Institut Curie, 35 rue Dailly, 92210 St Cloud."), [Carine Bellera](https://pubmed.ncbi.nlm.nih.gov/?term=Bellera+C&cauthor_id=42456539)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-10 "Clinical Research & Clinical Epidemiology Unit, Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France; INSERM CIC 14.01 Bordeaux, Clinical epidemiology unit- INSERM U1219 Research Centre, Epicene Team \(Epidemiology of Cancer and Environmental Exposure\), France."), [Sandrine Lavau-Denes](https://pubmed.ncbi.nlm.nih.gov/?term=Lavau-Denes+S&cauthor_id=42456539)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-11 "Department of Medical Oncology, University Hospital, Limoges, France."), [Jacques Cretin](https://pubmed.ncbi.nlm.nih.gov/?term=Cretin+J&cauthor_id=42456539)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-12 "Oncogard, Alès, France."), [Christophe Locher](https://pubmed.ncbi.nlm.nih.gov/?term=Locher+C&cauthor_id=42456539)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-13 "Department of Gastroenterology and Digestive Oncology, Hopital de Meaux/MLV, France."), [Jérôme Martin-Babau](https://pubmed.ncbi.nlm.nih.gov/?term=Martin-Babau+J&cauthor_id=42456539)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-14 "Medical Oncology, Centre Armoricain d'Oncologie - CARIO, 10 rue François Jacob, Plérin, France."), [Sylvie Kirscher](https://pubmed.ncbi.nlm.nih.gov/?term=Kirscher+S&cauthor_id=42456539)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-15 "Medical Oncology Department, Institut Sainte Catherine, Avignon, France."), [Ludovic Evesque](https://pubmed.ncbi.nlm.nih.gov/?term=Evesque+L&cauthor_id=42456539)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-16 "Centre Antoine Lacassagne, Nice, France."), [Soraya Mebarki](https://pubmed.ncbi.nlm.nih.gov/?term=Mebarki+S&cauthor_id=42456539)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-5 "Department of Geriatrics, Hôpital Européen Georges Pompidou, Paris Cancer Institute CARPEM, Assistance Publique-Hôpitaux de Paris, Paris, France."), [Daniel Gonzalez](https://pubmed.ncbi.nlm.nih.gov/?term=Gonzalez+D&cauthor_id=42456539)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-4 "Federation Francophone de Cancérologie Digestive \(FFCD\), EPICAD INSERM LNC-UMR 1231, University of Burgundy Europe, Dijon, France."), [Olayidé Boussari](https://pubmed.ncbi.nlm.nih.gov/?term=Boussari+O&cauthor_id=42456539)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-4 "Federation Francophone de Cancérologie Digestive \(FFCD\), EPICAD INSERM LNC-UMR 1231, University of Burgundy Europe, Dijon, France."), [Florence Canoui-Poitrine](https://pubmed.ncbi.nlm.nih.gov/?term=Canoui-Poitrine+F&cauthor_id=42456539)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#full-view-affiliation-17 "Equipe CEpiA \(Clinical Epidemiology and Ageing\), IMRB, U955 Inserm - Université Paris Est Créteil \(UPEC\), France; Department of Public Health, Hôpitaux Universitaires Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.") Affiliations Expand ### Affiliations * 1 Department of Gastroenterology and Digestive Oncology, Hôpital Saint Louis, Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: maxime.remond-ext@aphp.fr. * 2 Department of Gastroenterology and Digestive Oncology, Hôpital Saint Louis, Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Paris, France. * 3 Equipe CEpiA (Clinical Epidemiology and Ageing), IMRB, U955 Inserm - Université Paris Est Créteil (UPEC), France. * 4 Federation Francophone de Cancérologie Digestive (FFCD), EPICAD INSERM LNC-UMR 1231, University of Burgundy Europe, Dijon, France. * 5 Department of Geriatrics, Hôpital Européen Georges Pompidou, Paris Cancer Institute CARPEM, Assistance Publique-Hôpitaux de Paris, Paris, France. * 6 Coordination Unit of Geriatric Oncology, Rehabilitation and Autonomy Department, University Hospital of Nice, Nice, France. * 7 Department of Oncology, Institut Bergonié, Université de Bordeaux, Inserm, Bordeaux U1312, France. * 8 Department of Medical Oncology, Hôpitaux Universitaires Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France. * 9 Department of Medical Oncology, Institut Curie, 35 rue Dailly, 92210 St Cloud. * 10 Clinical Research & Clinical Epidemiology Unit, Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France; INSERM CIC 14.01 Bordeaux, Clinical epidemiology unit- INSERM U1219 Research Centre, Epicene Team (Epidemiology of Cancer and Environmental Exposure), France. * 11 Department of Medical Oncology, University Hospital, Limoges, France. * 12 Oncogard, Alès, France. * 13 Department of Gastroenterology and Digestive Oncology, Hopital de Meaux/MLV, France. * 14 Medical Oncology, Centre Armoricain d'Oncologie - CARIO, 10 rue François Jacob, Plérin, France. * 15 Medical Oncology Department, Institut Sainte Catherine, Avignon, France. * 16 Centre Antoine Lacassagne, Nice, France. * 17 Equipe CEpiA (Clinical Epidemiology and Ageing), IMRB, U955 Inserm - Université Paris Est Créteil (UPEC), France; Department of Public Health, Hôpitaux Universitaires Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France. * PMID: **42456539** * DOI: [ 10.1016/j.ejca.2026.116935 ](https://doi.org/10.1016/j.ejca.2026.116935) Free article Item in Clipboard # Predicting severe toxicities and mortality in older patients with colorectal cancer: An analysis of 3 clinical trials and 3 prospective cohorts Maxime Rémond et al. Eur J Cancer. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Eur J Cancer Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+J+Cancer%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+J+Cancer%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42456539/) . 2026 Sep 9:245:116935. doi: 10.1016/j.ejca.2026.116935. Epub 2026 Jul 12. ### Authors [Maxime Rémond](https://pubmed.ncbi.nlm.nih.gov/?term=R%C3%A9mond+M&cauthor_id=42456539)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-1 "Department of Gastroenterology and Digestive Oncology, Hôpital Saint Louis, Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: maxime.remond-ext@aphp.fr."), [Thomas Aparicio](https://pubmed.ncbi.nlm.nih.gov/?term=Aparicio+T&cauthor_id=42456539)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-2 "Department of Gastroenterology and Digestive Oncology, Hôpital Saint Louis, Université Paris Cité, Assistance Publique-Hôpitaux de Paris, Paris, France."), [Claudia Martinez-Tapia](https://pubmed.ncbi.nlm.nih.gov/?term=Martinez-Tapia+C&cauthor_id=42456539)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-3 "Equipe CEpiA \(Clinical Epidemiology and Ageing\), IMRB, U955 Inserm - Université Paris Est Créteil \(UPEC\), France."), [Karine Le Malicot](https://pubmed.ncbi.nlm.nih.gov/?term=Le+Malicot+K&cauthor_id=42456539)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-4 "Federation Francophone de Cancérologie Digestive \(FFCD\), EPICAD INSERM LNC-UMR 1231, University of Burgundy Europe, Dijon, France."), [Elena Paillaud](https://pubmed.ncbi.nlm.nih.gov/?term=Paillaud+E&cauthor_id=42456539)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-5 "Department of Geriatrics, Hôpital Européen Georges Pompidou, Paris Cancer Institute CARPEM, Assistance Publique-Hôpitaux de Paris, Paris, France."), [Rabia Boulahssass](https://pubmed.ncbi.nlm.nih.gov/?term=Boulahssass+R&cauthor_id=42456539)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-6 "Coordination Unit of Geriatric Oncology, Rehabilitation and Autonomy Department, University Hospital of Nice, Nice, France."), [Pierre Soubeyran](https://pubmed.ncbi.nlm.nih.gov/?term=Soubeyran+P&cauthor_id=42456539)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-7 "Department of Oncology, Institut Bergonié, Université de Bordeaux, Inserm, Bordeaux U1312, France."), [Selim Turk](https://pubmed.ncbi.nlm.nih.gov/?term=Turk+S&cauthor_id=42456539)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-8 "Department of Medical Oncology, Hôpitaux Universitaires Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France."), [Michael Bringuier](https://pubmed.ncbi.nlm.nih.gov/?term=Bringuier+M&cauthor_id=42456539)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-9 "Department of Medical Oncology, Institut Curie, 35 rue Dailly, 92210 St Cloud."), [Carine Bellera](https://pubmed.ncbi.nlm.nih.gov/?term=Bellera+C&cauthor_id=42456539)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-10 "Clinical Research & Clinical Epidemiology Unit, Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France; INSERM CIC 14.01 Bordeaux, Clinical epidemiology unit- INSERM U1219 Research Centre, Epicene Team \(Epidemiology of Cancer and Environmental Exposure\), France."), [Sandrine Lavau-Denes](https://pubmed.ncbi.nlm.nih.gov/?term=Lavau-Denes+S&cauthor_id=42456539)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-11 "Department of Medical Oncology, University Hospital, Limoges, France."), [Jacques Cretin](https://pubmed.ncbi.nlm.nih.gov/?term=Cretin+J&cauthor_id=42456539)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-12 "Oncogard, Alès, France."), [Christophe Locher](https://pubmed.ncbi.nlm.nih.gov/?term=Locher+C&cauthor_id=42456539)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-13 "Department of Gastroenterology and Digestive Oncology, Hopital de Meaux/MLV, France."), [Jérôme Martin-Babau](https://pubmed.ncbi.nlm.nih.gov/?term=Martin-Babau+J&cauthor_id=42456539)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-14 "Medical Oncology, Centre Armoricain d'Oncologie - CARIO, 10 rue François Jacob, Plérin, France."), [Sylvie Kirscher](https://pubmed.ncbi.nlm.nih.gov/?term=Kirscher+S&cauthor_id=42456539)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42456539/#short-view-affiliation-15 "Medical Oncology Department, Institut Sainte Catherine, Avignon, France."), [Ludovic Evesque](https://pubmed.ncbi.nlm.nih.gov/?term=Evesque+L&cauthor_id=
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