---
title: "Prevalence and determinants of vaccine hesitancy in Buenos Aires: results of a 2025 household surv"
id: "pubmed-42603507"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42603507"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42603507/"
doi: "10.1016/j.vaccine.2026.129045"
published_at: "2026-09-17T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Prevalence and determinants of vaccine hesitancy in Buenos Aires: results of a 2025 household surv
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42603507
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42603507/)
- **DOI:** [10.1016/j.vaccine.2026.129045](https://doi.org/10.1016%2Fj.vaccine.2026.129045)
- **Published At:** 2026-09-17T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This population-based study measured **vaccine hesitancy** in the City of Buenos Aires using a stratified multistage probabilistic household survey carried out between April and June 2025. - A culturally adapted version of the Vaccine Hesitancy Scale was administered and psychometrically evaluated; household-level hesitancy was defined using two complementary outcomes. - **Strict hesitancy**: explicit refusal of recommended vaccines. The weighted prevalence was **7.1%** (95% CI 5.8–8.6). - **Extended hesitancy**: refusal plus reported vaccination delays tied to access, convenience, or organizational barriers. The weighted prevalence was **24.1%** (95% CI 21.8–26.5). - Key independent correlates of strict hesitancy included **female respondent sex** (adjusted OR 2.77; 95% CI 1.68–4.57) and **lower vaccine confidence** (adjusted OR 4.19; 95% CI 2.65–6.64). - For extended hesitancy, independent associations included **lower vaccine confidence** (adjusted OR 2.10; 95% CI 1.61–2.74), **female respondent sex** (adjusted OR 1.33; 95% CI 1.03–1.74), younger age, and residence in **informal settlements** (adjusted OR 2.00; 95% CI 1.30–3.08). - The study surveyed **1934 households** and analyses accounted for sampling weights, strata, and primary sampling units. - Authors conclude outright refusal was uncommon, but broader forms of hesitancy linked to delays and access barriers affected a substantial proportion of households, with **vaccine confidence** the most consistent correlate. - The report included a conflict-of-interest statement: the authors declared no known competing interests. - Details beyond the abstract (for example full psychometric results, questionnaire items, or additional subgroup analyses) were not reported in the provided source excerpt.
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Epub 2026 Aug 15. # Prevalence and determinants of vaccine hesitancy in the City of Buenos Aires, Argentina: A probabilistic household survey [Patricia Angeleri](https://pubmed.ncbi.nlm.nih.gov/?term=Angeleri+P&cauthor_id=42603507)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42603507/#full-view-affiliation-1 "Fundación GESICA, Buenos Aires, Argentina. Electronic address: patriciaang1983@gmail.com."), [Cristián Biscayart](https://pubmed.ncbi.nlm.nih.gov/?term=Biscayart+C&cauthor_id=42603507)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42603507/#full-view-affiliation-2 "Fundación GESICA, Buenos Aires, Argentina."), [Daniel Ferrante](https://pubmed.ncbi.nlm.nih.gov/?term=Ferrante+D&cauthor_id=42603507)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42603507/#full-view-affiliation-2 "Fundación GESICA, Buenos Aires, Argentina."), [Alejandro Macchia](https://pubmed.ncbi.nlm.nih.gov/?term=Macchia+A&cauthor_id=42603507)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42603507/#full-view-affiliation-2 "Fundación GESICA, Buenos Aires, Argentina.") Affiliations Expand ### Affiliations * 1 Fundación GESICA, Buenos Aires, Argentina. Electronic address: patriciaang1983@gmail.com. * 2 Fundación GESICA, Buenos Aires, Argentina. * PMID: **42603507** * DOI: [ 10.1016/j.vaccine.2026.129045 ](https://doi.org/10.1016/j.vaccine.2026.129045) Item in Clipboard # Prevalence and determinants of vaccine hesitancy in the City of Buenos Aires, Argentina: A probabilistic household survey Patricia Angeleri et al. Vaccine. 2026. Show details Display options Display options Format Abstract PubMed PMID Vaccine Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Vaccine%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Vaccine%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42603507/) . 2026 Sep 17:90:129045. doi: 10.1016/j.vaccine.2026.129045. Epub 2026 Aug 15. ### Authors [Patricia Angeleri](https://pubmed.ncbi.nlm.nih.gov/?term=Angeleri+P&cauthor_id=42603507)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42603507/#short-view-affiliation-1 "Fundación GESICA, Buenos Aires, Argentina. Electronic address: patriciaang1983@gmail.com."), [Cristián Biscayart](https://pubmed.ncbi.nlm.nih.gov/?term=Biscayart+C&cauthor_id=42603507)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42603507/#short-view-affiliation-2 "Fundación GESICA, Buenos Aires, Argentina."), [Daniel Ferrante](https://pubmed.ncbi.nlm.nih.gov/?term=Ferrante+D&cauthor_id=42603507)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42603507/#short-view-affiliation-2 "Fundación GESICA, Buenos Aires, Argentina."), [Alejandro Macchia](https://pubmed.ncbi.nlm.nih.gov/?term=Macchia+A&cauthor_id=42603507)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42603507/#short-view-affiliation-2 "Fundación GESICA, Buenos Aires, Argentina.") ### Affiliations * 1 Fundación GESICA, Buenos Aires, Argentina. Electronic address: patriciaang1983@gmail.com. * 2 Fundación GESICA, Buenos Aires, Argentina. * PMID: **42603507** * DOI: [ 10.1016/j.vaccine.2026.129045 ](https://doi.org/10.1016/j.vaccine.2026.129045) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Vaccine hesitancy represents a growing challenge for immunization programs worldwide. In Latin America, population-based estimates derived from probabilistic surveys remain scarce, limiting the design of evidence-informed interventions. **Methods:** We conducted a population-based study in the City of Buenos Aires, Argentina, between April and June 2025 using a stratified multistage probabilistic sampling design embedded within an official periodic household survey. A culturally adapted version of the Vaccine Hesitancy Scale was administered and psychometrically evaluated. Household-level vaccine hesitancy was assessed using two complementary outcomes: strict hesitancy, defined as explicit refusal of recommended vaccines, and extended hesitancy, defined as a broader programmatic outcome combining refusal and reported vaccination delays related to access, convenience, or organizational barriers. Analyses accounted for sampling weights, strata, and primary sampling units. **Results:** A total of 1934 households were surveyed. The weighted prevalence of strict vaccine hesitancy was 7.1% (95% CI: 5.8-8.6).Female respondent sex (adjusted OR 2.77; 95% CI: 1.68-4.57) and lower vaccine confidence (adjusted OR 4.19; 95% CI: 2.65-6.64) were independent associated with strict vaccine hesitancy. The weighted prevalence of extended vaccine hesitancy was 24.1% (95% CI: 21.8-26.5). Lower vaccine confidence (adjusted OR 2.10; 95% CI: 1.61-2.74), female respondent sex (adjusted OR 1.33; 95% CI: 1.03-1.74), younger age, and residence in informal settlements (adjusted OR 2.00; 95% CI: 1.30-3.08) were independently associated with extended hesitancy. **Conclusions:** Outright vaccine refusal was uncommon, but broader forms of hesitancy linked to delays and access barriers affected a substantial proportion of households. Vaccine confidence was the most consistent correlate across definitions. **Keywords:** Household survey; Immunization programs; Latin America; Population-based survey; Vaccine confidence; Vaccine hesitancy. Copyright © 2026 Elsevier Ltd. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Vaccine hesitancy in Argentina: Validation of WHO scale for parents. ](https://pubmed.ncbi.nlm.nih.gov/34238609/) Gentile A, Pacchiotti AC, Giglio N, Nolte MF, Talamona N, Rogers V, Berenstein A, Castellano VE.Gentile A, et al.Vaccine. 2021 Jul 30;39(33):4611-4619. doi: 10.1016/j.vaccine.2021.06.080. Epub 2021 Jul 5.Vaccine. 2021.PMID: 34238609 * [ Predictors of the willingness to accept a free COVID-19 vaccine among households in Nigeria. ](https://pubmed.ncbi.nlm.nih.gov/39216208/) Eyawo O, Ugoji UC, Pan S, Oyibo P, Rehman A, Mahboob M, Esimai OA.Eyawo O, et al.Vaccine. 2024 Oct 3;42(23):126225. doi: 10.1016/j.vaccine.2024.126225. Epub 2024 Aug 30.Vaccine. 2024.PMID: 39216208 * [ Age and vaccine information sources drive vaccine hesitancy: A household survey in Central-Western Brazil. ](https://pubmed.ncbi.nlm.nih.gov/42085451/) do Nascimento AI, Dos Santos Conrado D, Mareto LK, de Azevedo MV, Pereira da Cunha JC, Ramires Koch GS, Osório LG, Pires ST, Arakaki LS, Pinto Borges SR, Gomes E Silva RF, Pucci RM, de Novaes Corrêa JG, Barrio JV, de Souza Rodrigues ME, Bianchi AJ, de Medeiros MJ, Sayuri Sato AP, Araújo Ajalla ME, Bocage Santos-Pinto CD, Falcão de Oliveira E.do Nascimento AI, et al.PLoS One. 2026 May 5;21(5):e0348412. doi: 10.1371/journal.pone.0348412. eCollection 2026.PLoS One. 2026.PMID: 42085451Free PMC article. * [ Association of modified 5C scale and influenza vaccine hesitancy among the elderly population in Ningbo, China: a cross-sectional study. ](https://pubmed.ncbi.nlm.nih.gov/41826978/) Zhu Z, Shi H, Pan X, Wang J, Jiang D, Zhao X, Zhang Y, Zhang D.Zhu Z, et al.BMC Public Health. 2026 Mar 13;26(1):1299. doi: 10.1186/s12889-026-26785-8.BMC Public Health. 2026.PMID: 41826978Free PMC article. * [ International prevalence and associated factors of parental vaccine hesitancy in human papillomavirus vaccination: A systematic review and meta-analysis. ](https://pubmed.ncbi.nlm.nih.gov/41072334/) Wang M, Tian X, Zeng Y, Yue Y, Zhu Z, Li Z, Li Y, Sun Y.Wang M, et al.Int J Nurs Stud. 2025 Dec;172:105239. doi: 10.1016/j.ijnurstu.2025.105239. 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