---
title: "Remote ischemic conditioning reduces albuminuria in adults with type 2 diabetes: RICADIME randomiz"
id: "pubmed-42095727"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42095727"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42095727/"
doi: "10.1093/postmj/qgag040"
published_at: "2026-08-21T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Remote ischemic conditioning reduces albuminuria in adults with type 2 diabetes: RICADIME randomiz
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42095727
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42095727/)
- **DOI:** [10.1093/postmj/qgag040](https://doi.org/10.1093%2Fpostmj%2Fqgag040)
- **Published At:** 2026-08-21T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This randomized, double-blind, sham-controlled parallel-group trial (RICADIME) evaluated **remote ischemic conditioning (RIC)** in adults with type 2 diabetes and moderate to severely increased **albuminuria**. - Forty normotensive diabetic adults were randomized 1:1 to weekly RIC (n = 20) or sham (n = 20) for 8 weeks. - The primary outcome was percentage reduction in urinary albumin at 8 weeks; secondary outcomes included serum **creatinine**, estimated glomerular filtration rate (**eGFR**), and **HbA1c**. - At 8 weeks the RIC group had a median albuminuria reduction of 37.9% (IQR: -7.5, 43.9) versus a 1.1% increase (IQR: -5.6, 15.2) in the sham group (P = 0.015). - Serum creatinine decreased in the RIC arm from 1.00 to 0.83 mg/dL and increased in the sham arm from 0.97 to 1.10 mg/dL (P = 0.0004). - Mean **eGFR** improved in the RIC group from 85 to 99 mL/min/1.73 m2 (P = 0.0001). - No significant change in **HbA1c** was detected between groups. - Mild procedural pain occurred in 10% of participants in the RIC group; no adverse effects were reported in the sham group. - The trial is registered (CTRI/2024/09/074453). Details such as exact RIC protocol parameters, baseline characteristics beyond normotension and albuminuria severity, longer-term outcomes, and full safety reporting were not reported in the abstract.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Department of Medicine, VMMC & Safdarjung Hospital, Ansari Nagar, Delhi 110029, India. * 2 Department of Paediatrics, AlIMS, Ansari Nagar, Delhi 110029, India. * PMID: **42095727** * DOI: [ 10.1093/postmj/qgag040 ](https://doi.org/10.1093/postmj/qgag040) Item in Clipboard Randomized Controlled Trial # Effect of remote ischemic conditioning on albuminuria in adults with diabetes mellitus (ricadime): a parallel group, double blind, sham controlled, randomized clinical trial Nishanth Dev et al. Postgrad Med J. 2026. Show details Display options Display options Format Abstract PubMed PMID Postgrad Med J Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Postgrad+Med+J%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Postgrad+Med+J%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42095727/) . 2026 Aug 21;102(1211):840-846. doi: 10.1093/postmj/qgag040. ### Authors [Nishanth Dev](https://pubmed.ncbi.nlm.nih.gov/?term=Dev+N&cauthor_id=42095727)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42095727/#short-view-affiliation-1 "Department of Medicine, VMMC & Safdarjung Hospital, Ansari Nagar, Delhi 110029, India."), [Garima Kumar](https://pubmed.ncbi.nlm.nih.gov/?term=Kumar+G&cauthor_id=42095727)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42095727/#short-view-affiliation-1 "Department of Medicine, VMMC & Safdarjung Hospital, Ansari Nagar, Delhi 110029, India."), [Gaurav Singh](https://pubmed.ncbi.nlm.nih.gov/?term=Singh+G&cauthor_id=42095727)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42095727/#short-view-affiliation-1 "Department of Medicine, VMMC & Safdarjung Hospital, Ansari Nagar, Delhi 110029, India."), [Jhuma Sankar](https://pubmed.ncbi.nlm.nih.gov/?term=Sankar+J&cauthor_id=42095727)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42095727/#short-view-affiliation-2 "Department of Paediatrics, AlIMS, Ansari Nagar, Delhi 110029, India.") ### Affiliations * 1 Department of Medicine, VMMC & Safdarjung Hospital, Ansari Nagar, Delhi 110029, India. * 2 Department of Paediatrics, AlIMS, Ansari Nagar, Delhi 110029, India. * PMID: **42095727** * DOI: [ 10.1093/postmj/qgag040 ](https://doi.org/10.1093/postmj/qgag040) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Introduction:** Diabetic kidney disease (DKD), a chronic microvascular complication is leading cause of End Stage Kidney disease (ESKD). Reduction of ≥30% urinary albumin is recommended to slow ESKD progression. Remote Ischemic conditioning (RIC) induces brief episodes of ischemia and reperfusion and has protective effect on various organs. The current study aims to explore the effects of RIC on albuminuria reduction in adults with type-2 Diabetes Mellitus. **Materials and methods:** In this double blind, sham controlled, Randomized Clinical Trial, we assigned 40 normotensive Diabetic adults with moderate and severely increased albuminuria to RIC group (n = 20) or Sham group (n = 20) weekly for 8 weeks. Primary outcome was reduction in albuminuria at the end of 8 weeks. Secondary outcomes were changes in serum creatinine, e-Glomerular Filtration Rate (eGFR), and HbA1c levels. **Results:** The reduction in albuminuria at the end of 8 weeks was 37.9% [Median (IQR): -7.5, 43.9] in the RIC group while it increased by 1.10% (-5.6, 15.2) in the Sham group (P = 0.015). Significant reduction was noted in serum creatinine in RIC group from 1 to 0.83 mg/dl as compared to increase in Sham group from 0.97 to 1.1 mg/dl (P = 0.0004). The mean eGFR in the RIC group improved from 85 to 99 (ml/min/1.73m2) P = 0.0001). No significant change was detected in HbA1C levels. Mild pain was the only adverse effect noted in 10% in the RIC group and none in the Sham group. **Conclusion:** Among adults with DKD, treatment with RIC significantly reduced albuminuria and serum creatinine while improving the eGFR (CTRI/2024/09/074453). **Keywords:** albuminuria; diabetes mellitus; diabetic kidney disease; remote ischemic conditioning. © The Author(s) 2026. Published by Oxford University Press on behalf of the Fellowship of Postgraduate Medicine. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Efficacy of Long-Term Remote Ischemic Conditioning on Vascular and Neuronal Function in Type 2 Diabetes Patients With Peripheral Arterial Disease. ](https://pubmed.ncbi.nlm.nih.gov/31215299/) Hansen CS, Jørgensen ME, Fleischer J, Bøtker HE, Rossing P.Hansen CS, et al.J Am Heart Assoc. 2019 Jul 2;8(13):e011779. doi: 10.1161/JAHA.118.011779. 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