---
title: "Salvia miltiorrhiza exosome-like nanoparticles reduce oxidative stress and inflammation to acceler"
id: "pubmed-42320298"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42320298"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42320298/"
doi: "10.1016/j.bbrc.2026.154115"
published_at: "2026-09-03T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Salvia miltiorrhiza exosome-like nanoparticles reduce oxidative stress and inflammation to acceler
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42320298
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42320298/)
- **DOI:** [10.1016/j.bbrc.2026.154115](https://doi.org/10.1016%2Fj.bbrc.2026.154115)
- **Published At:** 2026-09-03T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Chronic non-healing wounds are a major cause of amputation and mortality in patients with diabetes; new therapies are needed. - Plant-derived nanovesicles that resemble **exosomes** can mediate intercellular communication and transfer bioactive molecules across species, suggesting potential for regenerative medicine. - Researchers isolated and identified **exosome-like nanoparticles** from the traditional medicinal herb **Salvia miltiorrhiza** (SmELNs). - In vitro, SmELNs enhanced cellular behaviors important for repair: proliferation, migration, and angiogenesis, indicating pro-healing activity relevant to diabetic wounds. - In a streptozotocin (STZ)-induced diabetic mouse wound model, subcutaneous administration of SmELNs corrected delayed wound closure and promoted formation of new blood vessels (neovascularization). - SmELN treatment lowered reactive oxygen species production under high-glucose conditions and reduced secretion of proinflammatory cytokines **IL-6, IL-1β and TNF-α**, pointing to antioxidant and anti-inflammatory mechanisms. - No damage to internal organs was observed after SmELN treatment in vivo, suggesting a favorable safety signal in the reported animal experiments. - The authors conclude that an SmELN-enriched preparation is a promising natural nanotherapeutic candidate for diabetic wound repair, likely acting through attenuation of **oxidative stress** and inflammatory responses. - The abstract and metadata report key outcomes and MeSH terms but do not include detailed experimental parameters, dosages, or full methodological specifics in the source summary.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 6. # Exosome-like nanoparticles derived from Salvia miltiorrhiza promote diabetic wound healing by reducing oxidative stress and inflammation [Bona Bai](https://pubmed.ncbi.nlm.nih.gov/?term=Bai+B&cauthor_id=42320298)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42320298/#full-view-affiliation-1 "The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China."), [Yatong Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+Y&cauthor_id=42320298)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42320298/#full-view-affiliation-2 "Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China."), [Limin Tian](https://pubmed.ncbi.nlm.nih.gov/?term=Tian+L&cauthor_id=42320298)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42320298/#full-view-affiliation-3 "The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China; Department of Endocrinology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610000, China. Electronic address: tlm7066@sina.com.") Affiliations Expand ### Affiliations * 1 The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China. * 2 Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China. * 3 The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China; Department of Endocrinology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610000, China. Electronic address: tlm7066@sina.com. * PMID: **42320298** * DOI: [ 10.1016/j.bbrc.2026.154115 ](https://doi.org/10.1016/j.bbrc.2026.154115) Item in Clipboard # Exosome-like nanoparticles derived from Salvia miltiorrhiza promote diabetic wound healing by reducing oxidative stress and inflammation Bona Bai et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42320298/) . 2026 Sep 3:829:154115. doi: 10.1016/j.bbrc.2026.154115. Epub 2026 Jun 6. ### Authors [Bona Bai](https://pubmed.ncbi.nlm.nih.gov/?term=Bai+B&cauthor_id=42320298)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42320298/#short-view-affiliation-1 "The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China."), [Yatong Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+Y&cauthor_id=42320298)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42320298/#short-view-affiliation-2 "Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China."), [Limin Tian](https://pubmed.ncbi.nlm.nih.gov/?term=Tian+L&cauthor_id=42320298)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42320298/#short-view-affiliation-3 "The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China; Department of Endocrinology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610000, China. Electronic address: tlm7066@sina.com.") ### Affiliations * 1 The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China. * 2 Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China. * 3 The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China; Department of Endocrinology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610000, China. Electronic address: tlm7066@sina.com. * PMID: **42320298** * DOI: [ 10.1016/j.bbrc.2026.154115 ](https://doi.org/10.1016/j.bbrc.2026.154115) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract Chronic non-healing wounds remain a major cause of amputation and mortality for diabetic patients. Therefore, finding effective treatment options has become a significant issue that biomedical research needs to address. Nanovesicles that resemble exosomes participate in intercellular communication in plants and may transfer bioactive substances between animals and plants with implications for regenerative medicine. Salvia miltiorrhiza, a traditional medicinal plant, has been used for centuries to treat cardiovascular diseases, infections, inflammation, and wounds. However, little is known of exosome-like nanovesicles derived from Salvia miltiorrhiza (SmELNs), including any actions to promote wound healing in diabetic patients. SmELNs were isolated and identified in the current work and assessment of their impact on proliferation, migration and angiogenesis in vitro indicated the potential to promote diabetic wound healing. In diabetic mouse wound models, subcutaneous SmELN rescued the delayed wound healing caused by streptozotocin-induced diabetes, promoted the formation of new blood vessels and did not damage internal organs in vivo. Subsequent studies further revealed that SmELN reduced reactive oxygen species production in response to high blood sugar and reduced secretion of inflammatory factors, IL-6, IL-1β and TNF-α. These findings suggest that the SmELN-enriched preparation represents a promising natural nanotherapeutic candidate for diabetic wound repair, potentially through attenuation of oxidative stress and inflammatory responses. **Keywords:** Angiogenesis; Anti-inflammatory; Antioxidant; Diabetic wound; Plant exosome-like nanoparticles; Salvia miltiorrhiza. Copyright © 2026. Published by Elsevier Inc. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors have no relevant financial or non-financial interests to disclose. ## Similar articles * [ [Effect of salvia miltiorrhiza combined with roxadustat on wound healing of full-thickness skin defects in diabetic rats and its mechanism]. ](https://pubmed.ncbi.nlm.nih.gov/38664033/) Xia RY, Tang D, Yang B.Xia RY, et al.Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2024 Apr 20;40(4):380-388. doi: 10.3760/cma.j.cn501225-20231020-00124.Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2024.PMID: 38664033Free PMC article.Chinese. * [ Mango ginger-derived exosome-like nanovesicles promotes diabetic wound healing via inducing the promigratory protein, follistatin-like 1. ](https://pubmed.ncbi.nlm.nih.gov/40846023/) Suresh A, Ravilla J, Narayanan J, Sundaram GM.Suresh A, et al.Int J Biol Macromol. 2025 Sep;322(Pt 4):146991. doi: 10.1016/j.ijbiomac.2025.146991. Epub 2025 Aug 20.Int J Biol Macromol. 2025.PMID: 40846023 * [ Sustained ROS scavenging and pericellular oxygenation by lignin composites rescue HIF-1α and VEGF levels to improve diabetic wound neovascularization and healing. ](https://pubmed.ncbi.nlm.nih.gov/40286890/) Jung JP, Olutoye OO 2nd, Prajapati TJ, Jung OS, Yutzy LD, Nguyen KL, Wheat SW, Huang J, Padon BW, Faruk F, Keswani SS, Kogan P, Kaul A, Yu L, Li H, Thevasagayampillai S, Guerra ME, Short WD, Gunaratne PH, Balaji S.Jung JP, et al.Acta Biomater. 2025 Aug;202:205-215. doi: 10.1016/j.actbio.2025.04.047. Epub 2025 Apr 24.Acta Biomater. 2025.PMID: 40286890Free PMC article. * [ Decellularized dermal scaffold biofunctionalized with quercetin nanoparticles enhances angiogenesis and attenuates inflammation in type 2 diabetic wounds. ](https://pubmed.ncbi.nlm.nih.gov/42090926/) Hjazi A.Hjazi A.Tissue Cell. 2026 Oct;102:103562. doi: 10.1016/j.tice.2026.103562. Epub 2026 Apr 29.Tissue Cell. 2026.PMID: 42090926 * [ Diverse-Origin Exosomes Therapeutic Strategies for Diabetic Wound Healing. ](https://pubmed.ncbi.nlm.nih.gov/40529540/) Wang F, Yao J, Zuo H, Jiao Y, Wu J, Meng Z.Wang F, et al.Int J Nanomedicine. 2025 Jun 12;20:7375-7402. doi: 10.2147/IJN.S519379. eCollection 2025.Int J Nanomedicine. 2025.PMID: 40529540Free PMC article.Review. 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