---
title: "Site-Specific ApoA‑I Glycation Impairs HDL Function and May Promote Atherosclerosis in Diabetes"
id: "pubmed-42639673"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42639673"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42639673/"
doi: "10.1161/CIRCULATIONAHA.125.078171"
published_at: "2026-09-22T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Site-Specific ApoA‑I Glycation Impairs HDL Function and May Promote Atherosclerosis in Diabetes
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42639673
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42639673/)
- **DOI:** [10.1161/CIRCULATIONAHA.125.078171](https://doi.org/10.1161%2FCIRCULATIONAHA.125.078171)
- **Published At:** 2026-09-22T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article titled "Site-Specific Apo AI Glycation Impairs HDL Function and Promotes Atherosclerosis in Diabetes" was published in Circulation with DOI 10.1161/CIRCULATIONAHA.125.078171. - Publication metadata: 2026 Sep 22; volume 154(12):1088–1108; electronic publication ahead of print 2026 Aug 25. - The study topic centers on **ApoA‑I glycation**, its impact on **HDL function**, and a proposed link to **atherosclerosis** in the context of **diabetes**. - Multiple authors from Shanghai Jiao Tong University, Chinese Academy of Sciences, and affiliated institutes contributed; several authors are noted as equal contributors. - Affiliations reported include the Department of Cardiovascular Medicine, Institute of Translational Medicine (Shanghai Jiao Tong University), Rui Jin Hospital, Shanghai Advanced Research Institute, Shanghai Institute of Biochemistry and Cell Biology, and other university research centers. - The source page provides title, author list, affiliations, journal citation, DOI, and links to full text but does not include the article abstract or experimental details in the provided excerpt. - Specific methods, experimental results, quantitative outcomes, statistical measures, and conclusions are not reported in the provided source text and therefore cannot be summarized or inferred. - Readers are directed to the full-text links (Atypon / publisher) for complete methods, data, and conclusions because the PubMed excerpt here is limited to bibliographic and header information.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 25. # Site-Specific Apo AI Glycation Impairs HDL Function and Promotes Atherosclerosis in Diabetes [Yang Dai](https://pubmed.ncbi.nlm.nih.gov/?term=Dai+Y&cauthor_id=42639673)[#](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Qingrun Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Q&cauthor_id=42639673)[#](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-3 "National Facility for Protein Science Shanghai, Shanghai Advanced Research Institute \(Q.L., R. Zeng\), Chinese Academy of Sciences."), [Fenghua Ding](https://pubmed.ncbi.nlm.nih.gov/?term=Ding+F&cauthor_id=42639673)[#](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Shuai Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+S&cauthor_id=42639673)[#](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Feifei Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+F&cauthor_id=42639673)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Ruoxu Gu](https://pubmed.ncbi.nlm.nih.gov/?term=Gu+R&cauthor_id=42639673)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-4 "School of Medicine, College of Life Sciences and Biotechnology \(R.G., J.Z.\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Qingqing Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Q&cauthor_id=42639673)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-5 "CAS Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science \(Q.W., C.C., R. Zeng\), Chinese Academy of Sciences."), [Leying Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+L&cauthor_id=42639673)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Jianwen Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+J&cauthor_id=42639673)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-4 "School of Medicine, College of Life Sciences and Biotechnology \(R.G., J.Z.\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Xiaoqun Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+X&cauthor_id=42639673)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Chengshuang Chu](https://pubmed.ncbi.nlm.nih.gov/?term=Chu+C&cauthor_id=42639673)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-5 "CAS Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science \(Q.W., C.C., R. Zeng\), Chinese Academy of Sciences."), [Qingyun Zheng](https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+Q&cauthor_id=42639673)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-6 "School of Chemistry and Chemical Engineering, School of Pharmacy \(Q.Z., M.P.\), Shanghai Jiao Tong University, China."), [Ying Shen](https://pubmed.ncbi.nlm.nih.gov/?term=Shen+Y&cauthor_id=42639673)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Qiujing Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Q&cauthor_id=42639673)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Jingmeng Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+J&cauthor_id=42639673)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Xuefeng Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+X&cauthor_id=42639673)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-7 "Department of Laboratory Medicine \(Xuefeng Wang\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Yan Peng](https://pubmed.ncbi.nlm.nih.gov/?term=Peng+Y&cauthor_id=42639673)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-8 "Terahertz Technology Innovation Research Institute, Terahertz Spectrum and Imaging Technology Cooperative Innovation Center, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, China \(Y.P., S.Z.\)."), [Songlin Zhuang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhuang+S&cauthor_id=42639673)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-8 "Terahertz Technology Innovation Research Institute, Terahertz Spectrum and Imaging Technology Cooperative Innovation Center, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, China \(Y.P., S.Z.\)."), [Weifeng Shen](https://pubmed.ncbi.nlm.nih.gov/?term=Shen+W&cauthor_id=42639673)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Man Pan](https://pubmed.ncbi.nlm.nih.gov/?term=Pan+M&cauthor_id=42639673)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-6 "School of Chemistry and Chemical Engineering, School of Pharmacy \(Q.Z., M.P.\), Shanghai Jiao Tong University, China."), [Ruiyan Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+R&cauthor_id=42639673)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-1 "Department of Cardiovascular Medicine \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-2 "Rui Jin Hospital, Institute of Cardiovascular Diseases \(Y.D., F.D., S.C., F.L., L. Li, Xiaoqun Wang, Y.S., Q.C., J.L., W.S., R. Zhang, L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Guoyu Meng](https://pubmed.ncbi.nlm.nih.gov/?term=Meng+G&cauthor_id=42639673)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-9 "National Research Center for Translational Medicine \(G.M., L. Lu\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-10 "Institute of Hematology \(G.M.\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-11 "Department of Geriatrics, Medical Center on Aging, State Key Laboratory of Medical Genomics \(G.M.\), Institute of Translational Medicine, National Center for Translational Medicine \(Shanghai\), Shanghai Jiao Tong University, China."), [Rong Zeng](https://pubmed.ncbi.nlm.nih.gov/?term=Zeng+R&cauthor_id=42639673)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42639673/#full-view-affiliation-3 "National Facility for Protein Science Shanghai, Shanghai Advanced Research Institute \(Q.L., R. Zeng\
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