---
title: "Size-Dependent Anti-Inflammatory Nanocarriers Reduce Body Weight and Fat Without Suppressing Food"
id: "pubmed-42708907"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42708907"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42708907/"
doi: "10.1021/acsnano.6c00432"
published_at: "2026-09-08T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Size-Dependent Anti-Inflammatory Nanocarriers Reduce Body Weight and Fat Without Suppressing Food
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42708907
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42708907/)
- **DOI:** [10.1021/acsnano.6c00432](https://doi.org/10.1021%2Facsnano.6c00432)
- **Published At:** 2026-09-08T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Obesity is linked to chronic inflammation in **adipose tissue**, with macrophages as central mediators and current therapies not directly targeting this axis. - The study used dextran-based **nanocarriers** of three hydrodynamic diameters (4–30 nm) to deliver an anti-inflammatory glucocorticoid receptor agonist to adipose tissue macrophages. - In vitro, the three nanocarriers released molecular drug cargo at equivalent rates and showed similar biological potency. - In an in vivo mouse model of obesity, treatment produced **size-dependent** reductions in body weight and body fat after 2–4 weeks. - These changes in body composition occurred without associated reductions in food intake, distinguishing this approach from current clinical weight-loss pharmacotherapies. - Larger dextran nanocarriers demonstrated greater retention in visceral adipose tissue, which correlated with local effects that promoted **browning**: increased mitochondrial abundance and lipid droplet fragmentation. - The platform uses an anti-inflammatory glucocorticoid receptor agonist (dexamethasone is listed among keywords) delivered by dextran carriers, suggesting a targeted immunomodulatory strategy. - Authors propose further development could yield a safe and potent adipose-modulating therapy that avoids direct action on nutrient intake and may mitigate malnutrition and lean body mass loss seen with existing weight-loss drugs. - Keywords indicated: GLP1; **dexamethasone**; drug delivery; metabolism; nanoparticle; semaglutide. - The report emphasizes retention and localization in visceral adipose as the likely mechanism linking carrier size to therapeutic outcome.
## Clinical Analysis & Structured Key Points
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Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#full-view-affiliation-7 "Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.") Affiliations Expand ### Affiliations * 1 Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 2 Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 3 Department of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 4 Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 5 Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 6 Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 7 Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * PMID: **42708907** * DOI: [ 10.1021/acsnano.6c00432 ](https://doi.org/10.1021/acsnano.6c00432) Item in Clipboard # Weight Loss without Food Intake Suppression through Size-Dependent Retention of Anti-Inflammatory Nanomedicines Natalia Gonzalez Medina et al. ACS Nano. 2026. Show details Display options Display options Format Abstract PubMed PMID ACS Nano Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22ACS+Nano%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22ACS+Nano%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42708907/) . 2026 Sep 8;20(35):24305-24317. doi: 10.1021/acsnano.6c00432. ### Authors [Natalia Gonzalez Medina](https://pubmed.ncbi.nlm.nih.gov/?term=Medina+NG&cauthor_id=42708907)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-1 "Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States."), [Yuxiao Cui](https://pubmed.ncbi.nlm.nih.gov/?term=Cui+Y&cauthor_id=42708907)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-1 "Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-2 "Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States."), [Donglai Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+D&cauthor_id=42708907)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-3 "Department of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States."), [Muhammad Fayyaz](https://pubmed.ncbi.nlm.nih.gov/?term=Fayyaz+M&cauthor_id=42708907)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-1 "Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-2 "Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States."), [Fengyuan Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+F&cauthor_id=42708907)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-1 "Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-2 "Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States."), [Mahshad Mirshafeeyan](https://pubmed.ncbi.nlm.nih.gov/?term=Mirshafeeyan+M&cauthor_id=42708907)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-4 "Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States."), [Andrew M Smith](https://pubmed.ncbi.nlm.nih.gov/?term=Smith+AM&cauthor_id=42708907)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-1 "Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-2 "Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-3 "Department of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-5 "Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-6 "Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42708907/#short-view-affiliation-7 "Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States.") ### Affiliations * 1 Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 2 Holonyak Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 3 Department of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 4 Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 5 Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 6 Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * 7 Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois61801, United States. * PMID: **42708907** * DOI: [ 10.1021/acsnano.6c00432 ](https://doi.org/10.1021/acsnano.6c00432) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Obesity is a risk factor for high-mortality health conditions, including cardiovascular diseases and type 2 diabetes, which makes the advancement of efficacious and safe weight loss therapies a high priority in pharmacology. The causal link between obesity and its comorbid conditions is believed to be a chronic state of inflammation originating within adipose tissue, with macrophages playing central roles, an axis that is not targeted directly by current therapies. Here, we use nanocarriers to deliver an anti-inflammatory glucocorticoid receptor agonist to adipose tissue macrophages and report the impact of size on therapeutic effect. Three dextran nanocarriers between 4-30 nm in hydrodynamic diameter released molecular drug cargo at equivalent rates and exhibited similar biological potency in vitro. In vivo in a mouse model of obesity, body weight and body fat were reduced in a size-dependent manner after 2-4 weeks of treatment. Unlike current clinical pharmacotherapies for weight loss, these body composition changes were not associated with changes in food intake. Greater retention of larger dextran nanocarriers in visceral adipose tissue appears to elicit a local change to promote browning by increasing mitochondrial abundance and lipid droplet fragmentation. Further development of this platform may result in a safe and potent modulator of adipose tissue in the state of obesity without direct action on nutrient intake to address malnutrition and lean body mass deficiencies observed with current weight loss pharmacotherapies. **Keywords:** GLP1; dexamethasone; drug delivery; metabolism; nanoparticle; semaglutide. © 2026 The Authors. Published by American Chemical Society. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## MeSH terms * Adipose Tissue / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Adipose+Tissue%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Adipose+Tissue) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42708907/) * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42708907/) * Anti-Inflammatory Agents* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anti-Inflammatory+Agents%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Anti-Inflammatory+Agents) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42708907/) * Anti-Inflammatory Agents* / pharmacology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Anti-Inflammatory+Agents%2Fpharmacology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Anti-Inflammatory+Agents) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42708907/) * Dextrans / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Dextrans%2Fchemistry%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Dextrans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42708907/) * Drug Carriers / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Drug+Carriers%2Fchemistry%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Drug+Carriers) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42708907/) * Eating* / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eating%2Fdrug+effects%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Eating) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42708907/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?ter
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