---
title: "Sodium alginate nanoparticles-hydrogel beads for intestinal-targeted delivery of pea peptide"
id: "pubmed-42378997"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42378997"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42378997/"
doi: "10.1016/j.foodchem.2026.150245"
published_at: "2026-09-30T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Sodium alginate nanoparticles-hydrogel beads for intestinal-targeted delivery of pea peptide
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42378997
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42378997/)
- **DOI:** [10.1016/j.foodchem.2026.150245](https://doi.org/10.1016%2Fj.foodchem.2026.150245)
- **Published At:** 2026-09-30T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study developed a **multifunctional hybrid delivery system** combining ferulic acid-modified sodium alginate nanoparticles and sodium alginate hydrogel beads to protect and deliver **pea peptides (PP)**. - Ferulic acid-modified sodium alginate (FA-SA) was used to form **FA-SA-PP NPs**, achieving reported peptide encapsulation efficiency (EE) of **99.69%**, forming the first (“I-level”) protective fence. - FA-SA-PP NPs were further embedded into **SA-based hydrogel beads** (forming FA-SA-PP NPs@SA HBs) with an overall EE of **99.87%**, creating a second (“II-level”) protective fence. - The hybrid system showed stability in simulated gastric fluid (SGF) and exhibited gradual swelling with release of FA-SA-PP NPs in simulated intestinal fluid (SIF), supporting **intestinal-targeted release**. - Digestion products from FA-SA-PP NPs@SA HBs retained **antioxidant activity** and **DPP-IV inhibitory activity**, indicating preserved bioactivity after simulated digestion. - The authors propose the **“double fence” protection mechanism** as a means to combine antioxidant and hypoglycemic functions and to deliver PP for potential nutrition-based diabetes intervention and reduction of oxidative stress. - The paper reports no declared competing interests. - Keywords reported include **Delivery system**, **Hydrogel beads**, **Hypoglycemic**, **Nanoparticles**, and **Pea peptides**. - Full experimental details, quantitative release kinetics beyond EE, in vivo data, and specific assay methods were not reported in the PubMed abstract and must be consulted in the full text for complete methodology and results.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 29. # A multifunctional hybrid delivery system of sodium alginate-based nanoparticles-hydrogel beads "double fence" effect for pea peptide [Guocong Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+G&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#full-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Mingwu Qiao](https://pubmed.ncbi.nlm.nih.gov/?term=Qiao+M&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#full-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Dan Hai](https://pubmed.ncbi.nlm.nih.gov/?term=Hai+D&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#full-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Yan Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+Y&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#full-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Ge Bai](https://pubmed.ncbi.nlm.nih.gov/?term=Bai+G&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#full-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Peijun Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+P&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#full-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Xianqing Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+X&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#full-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Xinyu Sun](https://pubmed.ncbi.nlm.nih.gov/?term=Sun+X&cauthor_id=42378997)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#full-view-affiliation-2 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Postdoctoral station of Crop science, College of Agronomy, Henan Agricultural University, Zhengzhou 450046, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. Electronic address: sunxinyu_sp@163.com."), [Lianjun Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+L&cauthor_id=42378997)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#full-view-affiliation-3 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. Electronic address: slj69@126.com.") Affiliations Expand ### Affiliations * 1 College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. * 2 College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Postdoctoral station of Crop science, College of Agronomy, Henan Agricultural University, Zhengzhou 450046, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. Electronic address: sunxinyu_sp@163.com. * 3 College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. Electronic address: slj69@126.com. * PMID: **42378997** * DOI: [ 10.1016/j.foodchem.2026.150245 ](https://doi.org/10.1016/j.foodchem.2026.150245) Item in Clipboard # A multifunctional hybrid delivery system of sodium alginate-based nanoparticles-hydrogel beads "double fence" effect for pea peptide Guocong Ma et al. Food Chem. 2026. Show details Display options Display options Format Abstract PubMed PMID Food Chem Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Food+Chem%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Food+Chem%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42378997/) . 2026 Sep 30:524:150245. doi: 10.1016/j.foodchem.2026.150245. Epub 2026 Jun 29. ### Authors [Guocong Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+G&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#short-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Mingwu Qiao](https://pubmed.ncbi.nlm.nih.gov/?term=Qiao+M&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#short-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Dan Hai](https://pubmed.ncbi.nlm.nih.gov/?term=Hai+D&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#short-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Yan Ma](https://pubmed.ncbi.nlm.nih.gov/?term=Ma+Y&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#short-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Ge Bai](https://pubmed.ncbi.nlm.nih.gov/?term=Bai+G&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#short-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Peijun Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+P&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#short-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Xianqing Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+X&cauthor_id=42378997)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#short-view-affiliation-1 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China."), [Xinyu Sun](https://pubmed.ncbi.nlm.nih.gov/?term=Sun+X&cauthor_id=42378997)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#short-view-affiliation-2 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Postdoctoral station of Crop science, College of Agronomy, Henan Agricultural University, Zhengzhou 450046, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. Electronic address: sunxinyu_sp@163.com."), [Lianjun Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+L&cauthor_id=42378997)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42378997/#short-view-affiliation-3 "College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. Electronic address: slj69@126.com.") ### Affiliations * 1 College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. * 2 College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Postdoctoral station of Crop science, College of Agronomy, Henan Agricultural University, Zhengzhou 450046, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. Electronic address: sunxinyu_sp@163.com. * 3 College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, Henan, China; Zhengzhou City Key Laboratory for Soybean Refined Processing, China. Electronic address: slj69@126.com. * PMID: **42378997** * DOI: [ 10.1016/j.foodchem.2026.150245 ](https://doi.org/10.1016/j.foodchem.2026.150245) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract Pea peptides (PP) with hypoglycemic activity were prone to decrease activity due to their sensitivities to pH, temperature and enzymes. Herein, ferulic acid modified sodium alginate conjugate was prepared and employed as the carrier for fabricating FA-SA-PP NPs with the PP encapsulation efficiency (EE) of 99.69%, which formed the I-level fence for protecting PP. Further, SA-based hydrogel beads loaded with FA-SA-PP NPs (EE: 99.87%) were prepared for forming the II-level fence to protect PP. Results showed that FA-SA-PP NPs@SA HBs had good stability in SGF, and gradually swelled and released FA-SA-PP NPs in SIF. Besides, the digested products of FA-SA-PP NPs@SA HBs still showed good antioxidant and DPP-IV inhibitory activities. Overall, the "double fence" effect protection mechanism can achieve the combination of antioxidant and hypoglycemic functions, and realize the intestinal-targeted release of PP, which shows great application potential in reducing oxidative stress damage and nutrition intervention to diabetes. **Keywords:** Delivery system; Hydrogel beads; Hypoglycemic; Nanoparticles; Pea peptides. Copyright © 2026 Elsevier Ltd. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Epigallocatechin gallate-loaded alginate-peanut protein hydrogel beads: Influence of pectin-based crosslinking and chitosan-based coating strategies. ](https://pubmed.ncbi.nlm.nih.gov/42002352/) Wang Y, Wang X, Zhu Y, Chen Q, Guo Z, Kong B, Liu H, Li W.Wang Y, et al.Carbohydr Polym. 2026 Jun 15;382:125286. doi: 10.1016/j.carbpol.2026.125286. Epub 2026 Apr 6.Carbohydr Polym. 2026.PMID: 42002352 * [ Development and characterization of ferulic acid-loaded chitosan nanoparticle embedded- hydrogel for diabetic wound delivery. ](https://pubmed.ncbi.nlm.nih.gov/38885910/) Bhardwaj H, Jangde RK.Bhardwaj H, et al.Eur J Pharm Biopharm. 2024 Aug;201:114371. doi: 10.1016/j.ejpb.2024.114371. Epub 2024 Jun 15.Eur J Pharm Biopharm. 2024.PMID: 38885910 * [ A biocompatible Ag NP/SA.GL hydrogel for enhanced delivery and sustained release of doxorubicin in cancer treatment. ](https://pubmed.ncbi.nlm.nih.gov/41206853/) Ganjali M, Ganjali M, Sereshki SMA, Aghabarari B, Serajion R, Marashi SMB, Ahmadinasab N.Ganjali M, et al.J Biomater Sci Polym Ed. 2026 Aug;37(12):2179-2198. doi: 10.1080/09205063.2025.2581632. Epub 2025 Nov 9.J Biomater Sci Polym Ed. 2026.PMID: 41206853 * [ Polysaccharides-based delivery system for efficient encapsulation and controlled release of food-derived active peptides. ](https://pubmed.ncbi.nlm.nih.gov/35698398/) Han C, Fang L, Song S, Min W.Han C, et al.Carbohydr Polym. 2022 Sep 1;291:119580. doi: 10.1016/j.carbpol.2022.119580. Epub 2022 May 7.Carbohydr Polym. 2022.PMID: 35698398 * [ Advancement in Sodium Alginate-Based Drug Delivery Systems: Applications and Future Prospects. ](https://pubmed.ncbi.nlm.nih.gov/42087019/) Kumari A, Varunteja B, Mohanty S, Mishra A, Gupta N, Mukherjee T, Sharma B, Nayak N, Sahu A, Pattnaik A, Prabhakar PK, Mishra UK.Kumari A, et al.AAPS PharmSciTech. 2026 May 5;27(4):196. doi: 10.1208/s12249-025-03284-4.AAPS PharmSciTech. 2026.PMID: 42087019Review. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42378997) ## MeSH terms * Alginates* / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Alginates%2Fchemistry%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Alginates) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42378997/) * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42378997/) * Antioxidants / chemistry Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Antioxidants%2Fchemistry%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Antioxidants) * [ Add to Search ](http
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