---
title: "Spatial novelty alters N100m but not the 40-Hz auditory steady-state response"
id: "pubmed-42229828"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42229828"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42229828/"
doi: "10.1016/j.neuroscience.2026.05.042"
published_at: "2026-08-17T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Spatial novelty alters N100m but not the 40-Hz auditory steady-state response
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42229828
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42229828/)
- **DOI:** [10.1016/j.neuroscience.2026.05.042](https://doi.org/10.1016%2Fj.neuroscience.2026.05.042)
- **Published At:** 2026-08-17T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study investigated whether **spatial novelty**—manipulated via **interaural time differences**—modulates the **40-Hz auditory steady-state response (ASSR)** and transient auditory evoked fields in humans. - Magnetoencephalography recordings were obtained from 23 healthy participants presented with binaural 40-Hz stimuli lateralized to left or right in a pseudo-random sequence. - Trials were classified by whether the current stimulus side matched or differed from the preceding stimulus and by the number of preceding stimuli on the different side. - Spatial novelty produced a clear effect on the transient auditory evoked component **N100m**, with larger amplitudes when stimuli followed a different-side stimulus and a graded increase with more preceding different-side stimuli. - In contrast, neither the **power** nor the **phase synchronization** of the **40-Hz ASSR** showed modulation by spatial novelty in this paradigm. - The findings indicate a dissociation between novelty sensitivity reflected in transient evoked fields and that reflected in gamma-band steady-state oscillations: novelty effects on N100m do not necessarily parallel changes in the 40-Hz ASSR. - Authors conclude that sensitivity of the **40-Hz ASSR** to novelty may depend on the specific stimulus dimension (for example temporal or physical features) and may not directly mirror novelty-related activity seen in the **N100m**. - Keywords listed by the authors include **Auditory evoked field**, **Auditory steady-state response**, **Interaural time difference**, **Magnetoencephalography**, **Neural oscillation**, and **Novelty detection**. - The article reports no competing interests and is published as a free article in Neuroscience (2026), PMID 42229828.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 1. # Dissociable sensitivity of auditory evoked fields and 40-Hz auditory steady-state responses to spatial novelty [Ayumi Kuramitsu](https://pubmed.ncbi.nlm.nih.gov/?term=Kuramitsu+A&cauthor_id=42229828)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#full-view-affiliation-1 "Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan."), [Shunsuke Sugiyama](https://pubmed.ncbi.nlm.nih.gov/?term=Sugiyama+S&cauthor_id=42229828)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#full-view-affiliation-2 "Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address: sugiyama.shunsuke.s4@f.gifu-u.ac.jp."), [Yuka Ikegame](https://pubmed.ncbi.nlm.nih.gov/?term=Ikegame+Y&cauthor_id=42229828)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#full-view-affiliation-3 "Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Japan."), [Hirohito Yano](https://pubmed.ncbi.nlm.nih.gov/?term=Yano+H&cauthor_id=42229828)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#full-view-affiliation-3 "Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Japan."), [Jun Shinoda](https://pubmed.ncbi.nlm.nih.gov/?term=Shinoda+J&cauthor_id=42229828)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#full-view-affiliation-4 "Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan."), [Kazutaka Ohi](https://pubmed.ncbi.nlm.nih.gov/?term=Ohi+K&cauthor_id=42229828)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#full-view-affiliation-1 "Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan."), [Toshiki Shioiri](https://pubmed.ncbi.nlm.nih.gov/?term=Shioiri+T&cauthor_id=42229828)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#full-view-affiliation-1 "Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan."), [Makoto Nishihara](https://pubmed.ncbi.nlm.nih.gov/?term=Nishihara+M&cauthor_id=42229828)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#full-view-affiliation-5 "Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan."), [Koji Inui](https://pubmed.ncbi.nlm.nih.gov/?term=Inui+K&cauthor_id=42229828)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#full-view-affiliation-6 "Department of Functioning and Disability, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan; Section of Brain Function Information, National Institute for Physiological Sciences, Okazaki, Japan.") Affiliations Expand ### Affiliations * 1 Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan. * 2 Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address: sugiyama.shunsuke.s4@f.gifu-u.ac.jp. * 3 Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Japan. * 4 Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan. * 5 Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan. * 6 Department of Functioning and Disability, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan; Section of Brain Function Information, National Institute for Physiological Sciences, Okazaki, Japan. * PMID: **42229828** * DOI: [ 10.1016/j.neuroscience.2026.05.042 ](https://doi.org/10.1016/j.neuroscience.2026.05.042) Free article Item in Clipboard # Dissociable sensitivity of auditory evoked fields and 40-Hz auditory steady-state responses to spatial novelty Ayumi Kuramitsu et al. Neuroscience. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Neuroscience Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuroscience%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Neuroscience%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42229828/) . 2026 Aug 17:609:127-136. doi: 10.1016/j.neuroscience.2026.05.042. Epub 2026 Jun 1. ### Authors [Ayumi Kuramitsu](https://pubmed.ncbi.nlm.nih.gov/?term=Kuramitsu+A&cauthor_id=42229828)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#short-view-affiliation-1 "Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan."), [Shunsuke Sugiyama](https://pubmed.ncbi.nlm.nih.gov/?term=Sugiyama+S&cauthor_id=42229828)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#short-view-affiliation-2 "Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address: sugiyama.shunsuke.s4@f.gifu-u.ac.jp."), [Yuka Ikegame](https://pubmed.ncbi.nlm.nih.gov/?term=Ikegame+Y&cauthor_id=42229828)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#short-view-affiliation-3 "Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Japan."), [Hirohito Yano](https://pubmed.ncbi.nlm.nih.gov/?term=Yano+H&cauthor_id=42229828)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#short-view-affiliation-3 "Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Japan."), [Jun Shinoda](https://pubmed.ncbi.nlm.nih.gov/?term=Shinoda+J&cauthor_id=42229828)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#short-view-affiliation-4 "Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan."), [Kazutaka Ohi](https://pubmed.ncbi.nlm.nih.gov/?term=Ohi+K&cauthor_id=42229828)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#short-view-affiliation-1 "Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan."), [Toshiki Shioiri](https://pubmed.ncbi.nlm.nih.gov/?term=Shioiri+T&cauthor_id=42229828)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#short-view-affiliation-1 "Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan."), [Makoto Nishihara](https://pubmed.ncbi.nlm.nih.gov/?term=Nishihara+M&cauthor_id=42229828)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#short-view-affiliation-5 "Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan."), [Koji Inui](https://pubmed.ncbi.nlm.nih.gov/?term=Inui+K&cauthor_id=42229828)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42229828/#short-view-affiliation-6 "Department of Functioning and Disability, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan; Section of Brain Function Information, National Institute for Physiological Sciences, Okazaki, Japan.") ### Affiliations * 1 Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan. * 2 Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan. Electronic address: sugiyama.shunsuke.s4@f.gifu-u.ac.jp. * 3 Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan; Department of Clinical Brain Sciences, Gifu University Graduate School of Medicine, Minokamo, Japan. * 4 Department of Neurosurgery, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Minokamo, Japan; Department of Neurosurgery, Chubu Neurorehabilitation Hospital, Minokamo, Japan. * 5 Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Japan. * 6 Department of Functioning and Disability, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan; Section of Brain Function Information, National Institute for Physiological Sciences, Okazaki, Japan. * PMID: **42229828** * DOI: [ 10.1016/j.neuroscience.2026.05.042 ](https://doi.org/10.1016/j.neuroscience.2026.05.042) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract The 40-Hz auditory steady-state response (ASSR) reflects gamma-band oscillations and has been proposed as a candidate biomarker for psychiatric disorders. Previous work has shown that novelty detection related to temporal and physical stimulus features can modulate the magnitude of the 40-Hz ASSR. The present study examined whether spatial novelty induced by interaural time differences modulates the 40-Hz ASSR in parallel with transient auditory evoked responses. Magnetoencephalography recordings were obtained from 23 healthy participants while listening to binaural auditory stimuli presented at 40 Hz and lateralized to the left or right by interaural time differences in a pseudo-random sequence. Trials were classified according to whether the preceding stimulus was presented on the same or a different side, and further divided based on the number of preceding stimuli. Spatial novelty modulated the N100m, with larger amplitudes observed following stimuli on a different side and a graded increase with the number of preceding different stimuli. In contrast, neither the power nor phase synchronization of the 40-Hz ASSR was influenced by spatial novelty. These findings suggest that the sensitivity of the 40-Hz ASSR to novelty may depend on the dimension of stimulus change and may not directly mirror novelty-related activity reflected in the N100m. **Keywords:** Auditory evoked field; Auditory steady-state response; Interaural time difference; Magnetoencephalography; Neural oscillation; Novelty detection. Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ## Similar articles * [ Translating Adult Electrophysiology Findings to Younger Patient Populations: Difficulty Measuring 40-Hz Auditory Steady-State Responses in Typically Developing Children and Children with Autism Spectrum Disorder. ](https://pubmed.ncbi.nlm.nih.gov/26730806/) Edgar JC, Fisk CL 4th, Liu S, Pandey J, Herrington JD, Schultz RT, Roberts TP.Edgar JC, et al.Dev Neurosci. 2016;38(1):1-14. doi: 10.1159/000441943. Epub 2016 Jan 6.Dev Neurosci. 2016.PMID: 26730806Free PMC article. * [ The age-related changes in 40 Hz Auditory Steady-State Response and sustained Event-Related Fields to the same amplitude-modulated tones in typically developing children: A magnetoencephalography study. ](https://pubmed.ncbi.nlm.nih.gov/35833318/) Arutiunian V, Arcara G, Buyanova I, Gomozova M, Dragoy O.Arutiunian V, et al.Hum Brain Mapp. 2022 Dec 1;43(17):5370-5383. doi: 10.1002/hbm.26013. Epub 2022 Jul 14.Hum Brain Mapp. 2022.PMID: 35833318Free PMC article. * [ Normal ipsilateral/contralateral asymmetries in infant multiple auditory steady-state responses to air- and bone-conduction stimuli. ](https://pubmed.ncbi.nlm.nih.gov/18595185/) Small SA, Stapells DR.Small SA, et al.Ear Hear. 2008 Apr;29(2):185-98. doi: 10.1097/01.aud.0000305157.83012.f4.Ear Hear. 2008.PMID: 18595185 * [ The influence of novelty detection on the 40-Hz auditory steady-state response in schizophrenia: A novel hypothesis from meta-analysis. ](https://pubmed.ncbi.nlm.nih.gov/39029650/) Sugiyama S, Inui K, Ohi K, Shioiri T.Sugiyama S, et al.Prog Neuropsychopharmacol Biol Psychiatry. 2024 Dec 20;135:111096. doi: 10.1016/j.pnpbp.2024.111096. Epub 2024 Jul 17.Prog Neuropsychopharmacol Biol Psychiatry. 2024.PMID: 39029650Review. * [ Neuronal imbalance of excitation and inhibition in schizophrenia: a scoping review of gamma-band ASSR findings. ](https://pubmed.ncbi.nlm.nih.gov/36069299/) Onitsuka T, Tsuchimoto R, Oribe N, Spencer KM, Hirano Y.Onitsuka T, et al.Psychiatry Clin Neurosci. 2022 Dec;76(12):610-619. doi: 10.1111/pcn.13472. Epub 2022 Oct 13.Psychiatry Clin Neurosci. 2022.PMID: 36069299 [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42229828) ## MeSH terms * Acoustic Stimulation Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Acoustic+Stimulation%22%5BMeSH%5D&sort=dat
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