---
title: "Spatial patterns and economic burden of comorbidities in hospitalised pulmonary tuberculosis patie"
id: "pubmed-42663079"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42663079"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42663079/"
doi: "10.7189/jogh.16.04284"
published_at: "2026-08-28T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Spatial patterns and economic burden of comorbidities in hospitalised pulmonary tuberculosis patie
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42663079
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42663079/)
- **DOI:** [10.7189/jogh.16.04284](https://doi.org/10.7189%2Fjogh.16.04284)
- **Published At:** 2026-08-28T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Study used the Guangdong Hospital Discharge Records Database from 2016–2024 to analyse comorbidity patterns among hospitalised **pulmonary tuberculosis** (PTB) patients. - Included 646,114 hospitalised PTB patients; 66.42% had at least one **comorbidity**. - The three most common comorbidities were **hypertension (HTN)**, **diabetes mellitus (DM)**, and **chronic obstructive pulmonary disease (COPD)**. - Spatial autocorrelation methods (Global Moran’s I and local indicators of spatial association) were applied to identify clustering of major PTB comorbidity pairs. - High-high spatial clusters for PTB–HTN were mainly in the central Pearl River Delta; PTB–DM high-high clusters were concentrated in eastern Guangdong with low-low clusters in western Guangdong. - PTB–COPD high-high clusters were primarily in eastern and northern Guangdong; low-low clusters were relatively stable in several Pearl River Delta cities. - Generalised linear models assessed associations between number of comorbidities, spatial clustering patterns, and economic burden. - Number of comorbidities showed a significant positive association with both direct and indirect **economic burden** (P < 0.001); economic burden rose as comorbidity count increased. - The effect of spatial clustering on economic burden varied by comorbidity type, indicating geographic heterogeneity in economic impact. - Authors recommend integrating regional comorbidity epidemiological features into PTB comorbidity management, resource allocation, and prevention strategies that address both direct medical costs and productivity losses.
## Clinical Analysis & Structured Key Points
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Spatial distribution, clustering patterns, and economic burden of comorbidities among hospitalised pulmonary tuberculosis patients in Guangdong province: a spatial epidemiological study based on inpatient big data [Lianrong Ji](https://pubmed.ncbi.nlm.nih.gov/?term=Ji+L&cauthor_id=42663079)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-1 "School of Health Management, Southern Medical University, Guangzhou, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-2 "Department of Medical Insurance Affairs, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Health Management, Southern Medical University, Guangzhou, China."), [Liang Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+L&cauthor_id=42663079)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-3 "State Key Laboratory of Respiratory Disease, Guangzhou Medical University Institute of Tuberculosis, Office of the Dean, Guangzhou Chest Hospital Affiliated to Guangdong Pharmaceutical University, Guangzhou, China."), [Yunlian Xue](https://pubmed.ncbi.nlm.nih.gov/?term=Xue+Y&cauthor_id=42663079)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-2 "Department of Medical Insurance Affairs, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Health Management, Southern Medical University, Guangzhou, China."), [Yue Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+Y&cauthor_id=42663079)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-4 "Guangdong Provincial Center for Public Health Medicine, Guangzhou, China."), [Huizhong Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+H&cauthor_id=42663079)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-5 "Department of Quality Control, Guangdong Provincial Center for Public Health Medicine, Guangzhou, China."), [Xue Jiang](https://pubmed.ncbi.nlm.nih.gov/?term=Jiang+X&cauthor_id=42663079)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-6 "Office of the Party Committee, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China."), [Guihao Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+G&cauthor_id=42663079)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-7 "Department of Scientific Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China."), [Xiaowan Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+X&cauthor_id=42663079)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-8 "Division of Health Policy Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China."), [Shasha Yuan](https://pubmed.ncbi.nlm.nih.gov/?term=Yuan+S&cauthor_id=42663079)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-9 "Institute of Medical Information & Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China."), [Lin Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+L&cauthor_id=42663079)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#full-view-affiliation-10 "Office of the Dean, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.") Affiliations Expand ### Affiliations * 1 School of Health Management, Southern Medical University, Guangzhou, China. * 2 Department of Medical Insurance Affairs, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Health Management, Southern Medical University, Guangzhou, China. * 3 State Key Laboratory of Respiratory Disease, Guangzhou Medical University Institute of Tuberculosis, Office of the Dean, Guangzhou Chest Hospital Affiliated to Guangdong Pharmaceutical University, Guangzhou, China. * 4 Guangdong Provincial Center for Public Health Medicine, Guangzhou, China. * 5 Department of Quality Control, Guangdong Provincial Center for Public Health Medicine, Guangzhou, China. * 6 Office of the Party Committee, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. * 7 Department of Scientific Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. * 8 Division of Health Policy Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. * 9 Institute of Medical Information & Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. * 10 Office of the Dean, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. * PMID: **42663079** * DOI: [ 10.7189/jogh.16.04284 ](https://doi.org/10.7189/jogh.16.04284) Item in Clipboard # Spatial distribution, clustering patterns, and economic burden of comorbidities among hospitalised pulmonary tuberculosis patients in Guangdong province: a spatial epidemiological study based on inpatient big data Lianrong Ji et al. J Glob Health. 2026. Show details Display options Display options Format Abstract PubMed PMID J Glob Health Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Glob+Health%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Glob+Health%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42663079/) . 2026 Aug 28:16:04284. doi: 10.7189/jogh.16.04284. ### Authors [Lianrong Ji](https://pubmed.ncbi.nlm.nih.gov/?term=Ji+L&cauthor_id=42663079)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-1 "School of Health Management, Southern Medical University, Guangzhou, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-2 "Department of Medical Insurance Affairs, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Health Management, Southern Medical University, Guangzhou, China."), [Liang Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+L&cauthor_id=42663079)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-3 "State Key Laboratory of Respiratory Disease, Guangzhou Medical University Institute of Tuberculosis, Office of the Dean, Guangzhou Chest Hospital Affiliated to Guangdong Pharmaceutical University, Guangzhou, China."), [Yunlian Xue](https://pubmed.ncbi.nlm.nih.gov/?term=Xue+Y&cauthor_id=42663079)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-2 "Department of Medical Insurance Affairs, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Health Management, Southern Medical University, Guangzhou, China."), [Yue Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+Y&cauthor_id=42663079)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-4 "Guangdong Provincial Center for Public Health Medicine, Guangzhou, China."), [Huizhong Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+H&cauthor_id=42663079)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-5 "Department of Quality Control, Guangdong Provincial Center for Public Health Medicine, Guangzhou, China."), [Xue Jiang](https://pubmed.ncbi.nlm.nih.gov/?term=Jiang+X&cauthor_id=42663079)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-6 "Office of the Party Committee, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China."), [Guihao Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+G&cauthor_id=42663079)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-7 "Department of Scientific Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China."), [Xiaowan Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+X&cauthor_id=42663079)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-8 "Division of Health Policy Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China."), [Shasha Yuan](https://pubmed.ncbi.nlm.nih.gov/?term=Yuan+S&cauthor_id=42663079)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-9 "Institute of Medical Information & Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China."), [Lin Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+L&cauthor_id=42663079)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42663079/#short-view-affiliation-10 "Office of the Dean, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.") ### Affiliations * 1 School of Health Management, Southern Medical University, Guangzhou, China. * 2 Department of Medical Insurance Affairs, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Health Management, Southern Medical University, Guangzhou, China. * 3 State Key Laboratory of Respiratory Disease, Guangzhou Medical University Institute of Tuberculosis, Office of the Dean, Guangzhou Chest Hospital Affiliated to Guangdong Pharmaceutical University, Guangzhou, China. * 4 Guangdong Provincial Center for Public Health Medicine, Guangzhou, China. * 5 Department of Quality Control, Guangdong Provincial Center for Public Health Medicine, Guangzhou, China. * 6 Office of the Party Committee, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. * 7 Department of Scientific Research, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. * 8 Division of Health Policy Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. * 9 Institute of Medical Information & Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. * 10 Office of the Dean, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. * PMID: **42663079** * DOI: [ 10.7189/jogh.16.04284 ](https://doi.org/10.7189/jogh.16.04284) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Comorbidities may complicate the treatment of pulmonary tuberculosis and exacerbate both the clinical and economic burden. We aimed to examine comorbidity patterns, spatial clustering, and economic burden in hospitalised pulmonary tuberculosis (PTB) patients in Guangdong Province, supporting targeted prevention strategies. **Methods:** Based on the Hospital Discharge Records Database of Guangdong Province from 2016 to 2024, we collected data on hospitalised PTB patients to analyse the characteristics and temporal trends of comorbidity spectra. We used Global Moran's I and local indicators of spatial association analyses to examine the spatial clustering patterns of major comorbidity pairs. Generalised linear models evaluated the impact of comorbidity count and spatial clustering patterns on economic burden among hospitalised PTB patients. **Results:** A total of 646,114 hospitalised PTB patients were included from 2016 to 2024, of whom 66.42% had at least one comorbidity. Hypertension (HTN), diabetes mellitus (DM), and chronic obstructive pulmonary disease (COPD) were the top three comorbidities among hospitalised PTB patients. Spatial analysis indicated that high-high clusters of PTB-HTN were mainly concentrated in the central Pearl River Delta; high-high clusters of PTB-DM in eastern Guangdong and low-low clusters in western Guangdong. High-high clusters of PTB-COPD were primarily located in eastern and northern Guangdong, while low-low clusters remained relatively stable in several cities of the Pearl River Delta region. Among hospitalised PTB patients, the number of comorbidities was significantly positively associated with both direct and indirect economic burden (P < 0.001), with economic burden progressively increasing as the number of comorbidities increased, and the impact of spatial clustering patterns on economic burden exhibited heterogeneity across different comorbidity types. **Conclusions:** The burden of comorbidities among hospitalised PTB patients in Guangdong Province is substantial, with significant spatial clustering characteristics closely linked to direct and indirect economic burden. It is recommended to incorporate regional comorbidity epidemiological characteristics into PTB comorbidity management and resource allocation optimisation. In addition, both direct medical costs and productivity losses should be considered in prevention and control strategies to reduce the socioeconomic burden associated with PTB. **Keywords:** Guangdong Province; comorbidity; disease burden; pulmonary tuberculosis; spatial autocorrelation. © 2026 The Authors. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. ## Similar articles * [ [Spatiotemporal distribution characteristics of and trends in disease burden of dengue fever in China from 2005 to 2024]. ](https://pubmed.ncbi.nlm.nih.gov/42264950/) Feng L, Shang M, Ren J, Wang X, Ji H, Hao X, Li J, Liu Q.Feng L, et al.Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2026 May 28;38(2):137-147. doi: 10.16250/j.32.1915.2025196.Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2026.PMID: 42264950Chinese. * [ Epidemiological Characteristics and Spatiotemporal Clustering of Pulmonary Tuberculosis Among Students in Southwest China From 2016 to 2022: Analy
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