---
title: "Spousal Health Effects After Major Diagnoses: Evidence from a US Matched Event Study"
id: "pubmed-42496175"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42496175"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42496175/"
doi: "10.1093/aje/kwag178"
published_at: "2026-10-07T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Spousal Health Effects After Major Diagnoses: Evidence from a US Matched Event Study
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42496175
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42496175/)
- **DOI:** [10.1093/aje/kwag178](https://doi.org/10.1093%2Faje%2Fkwag178)
- **Published At:** 2026-10-07T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Using the US Health and Retirement Study (1992–2020), authors examined population-level **health spillovers** to spouses after a partner's first diagnosis of **cancer**, **stroke**, or **heart disease**. The analytic sample included **29,166** matched observations. - The study used a **stacked event-study design with matching** to compare spouses of newly diagnosed patients to matched controls over time, focusing on changes following the partner's first major diagnosis. - Outcomes assessed included self-rated health, doctor-diagnosed conditions, limitations in basic and instrumental activities of daily living (ADL/IADL), depressive symptoms, health behaviors, and use of preventive care. - Main results showed modest but persistent adverse effects among spouses: increased reports of poor health (β = 0.02, 95% CI: 0.00, 0.03), more doctor-diagnosed conditions (β = 0.05, 95% CI: 0.01, 0.08), and higher **depressive symptoms** (β = 0.08, 95% CI: 0.01, 0.16). - Health behaviors and use of preventive care were largely unchanged following the partner's diagnosis. - Heterogeneity analyses indicated larger effects for women whose male partners were diagnosed and for spouses with lower education or fewer assets, identifying subgroups at higher risk. - The authors conclude findings support early, spouse-focused support and targeted interventions for spouses most vulnerable to health declines after a partner's major diagnosis. - Details on some analytic choices, full covariate lists, and secondary analyses are provided in the full text; if not reported in the abstract, those specifics were not available in the source abstract.
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Affiliations Expand ### Affiliations * 1 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, United States. * 2 Division of Geriatrics, University of California San Francisco, San Francisco, CA, United States. * PMID: **42496175** * DOI: [ 10.1093/aje/kwag178 ](https://doi.org/10.1093/aje/kwag178) Free article Item in Clipboard # Health consequences of spousal health shocks: evidence from a matched event study in the United States Ah-Reum Lee et al. Am J Epidemiol. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Am J Epidemiol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Am+J+Epidemiol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Am+J+Epidemiol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42496175/) . 2026 Oct 7;195(10):2518-2527. doi: 10.1093/aje/kwag178. ### Authors [Ah-Reum Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+AR&cauthor_id=42496175)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42496175/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, United States."), [Ashwin Kotwal](https://pubmed.ncbi.nlm.nih.gov/?term=Kotwal+A&cauthor_id=42496175)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42496175/#short-view-affiliation-2 "Division of Geriatrics, University of California San Francisco, San Francisco, CA, United States."), [Jacqueline M Torres](https://pubmed.ncbi.nlm.nih.gov/?term=Torres+JM&cauthor_id=42496175)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42496175/#short-view-affiliation-1 "Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, United States.") ### Affiliations * 1 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, United States. * 2 Division of Geriatrics, University of California San Francisco, San Francisco, CA, United States. * PMID: **42496175** * DOI: [ 10.1093/aje/kwag178 ](https://doi.org/10.1093/aje/kwag178) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract Major disease diagnoses can create shocks that ripple through households. Population-level evidence in the US on how spouses and partners fare after a partner's major diagnosis remains sparse and is often limited to caregiver or employment-related outcomes. Using the US Health and Retirement Study (1992-2020), we evaluated population-level health spillovers to spouses after a partner's first diagnosis of cancer, stroke, or heart disease, employing a stacked event-study design with matching (n = 29 166). Outcomes included subjective health, doctor-diagnosed conditions, limitations in basic and instrumental activities of daily living (ADL/IADL), and health behaviors and use of preventive care. We evaluated heterogeneity by sociodemographic and economic conditions. Spouses of newly diagnosed patients experienced modest but persistent declines: more frequent reports of poor health ($\boldsymbol{\beta}$ = .02, 95% CI, 0.00, 0.03), more doctor-diagnosed conditions ($\boldsymbol{\beta}$ = .05, 95% CI, 0.01, 0.08), and higher depressive symptoms ($\boldsymbol{\beta}$ = .08, 95% CI, 0.01, 0.16). Effects were greater among women whose male partners received a diagnosis and among spouses with lower education or fewer assets. Health and preventive care behaviors were largely unchanged. Findings motivate early, spouse-focused support and underscore the need for targeted interventions for spouses at highest risk. **Keywords:** acute disease; mental health; morbidity; outcome assessment; spouses. © The Author(s) 2026. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. 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