---
title: "Targeting CD28 in T-lineage Malignancies with CAR T Cells — Nat Commun 2026"
id: "pubmed-42844286"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42844286"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42844286/"
doi: "10.1038/s41467-026-78312-3"
published_at: "2026-10-08T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Targeting CD28 in T-lineage Malignancies with CAR T Cells — Nat Commun 2026
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42844286
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42844286/)
- **DOI:** [10.1038/s41467-026-78312-3](https://doi.org/10.1038%2Fs41467-026-78312-3)
- **Published At:** 2026-10-08T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This PubMed entry records a 2026 Nature Communications article titled "Targeting CD28 on T lineage malignancies with chimeric antigen receptor T cells." - Citation details include PMID **42844286** and DOI 10.1038/s41467-026-78312-3. - First author listed is Semjon Willier; a large multi‑institutional German author group and many pediatric hematology/oncology and immunology units are represented. - Multiple affiliations span LMU Munich, University of Freiburg, Helmholtz Munich, DKFZ, TUM, Würzburg, Ulm, Heidelberg, Hamburg and other German centers, indicating a multi‑centre collaboration. - The article appears in Nat Commun, volume/issue metadata dated 2026 Oct 8;17(1):10608. - The PubMed page includes navigation links for Abstract, Conflict of interest statement, References, MeSH terms, Substances, and Grants and funding, but the source content provided here does not include the article abstract, methods, results, or conclusions. - Because the supplied source text contains only bibliographic and website navigation content, no study design, experimental data, endpoints, or clinical recommendations are reported in this record excerpt. - For full study details, readers must consult the full text via DOI, the Nat Commun website, or the PubMed record; the PubMed page lists actions for citation export and direct links to the article details.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42844286/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42844286/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42844286/#conflict-of-interest) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42844286/#references) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42844286/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42844286/#substances) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42844286/#grants) Title & authors Abstract Conflict of interest statement References MeSH terms Substances Grants and funding Nat Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Nat+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Nat+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42844286/) . 2026 Oct 8;17(1):10608. doi: 10.1038/s41467-026-78312-3. # Targeting CD28 on T lineage malignancies with chimeric antigen receptor T cells [Semjon Willier](https://pubmed.ncbi.nlm.nih.gov/?term=Willier+S&cauthor_id=42844286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-1 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany. semjon.willier@uniklinik-freiburg.de.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-2 "German Cancer Consortium \(DKTK\), Partner Site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany. semjon.willier@uniklinik-freiburg.de.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-3 "Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany. semjon.willier@uniklinik-freiburg.de."), [Julian Färber](https://pubmed.ncbi.nlm.nih.gov/?term=F%C3%A4rber+J&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-5 "Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany."), [Theodora Ispyrlidou](https://pubmed.ncbi.nlm.nih.gov/?term=Ispyrlidou+T&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany."), [Jonas Wilhelm](https://pubmed.ncbi.nlm.nih.gov/?term=Wilhelm+J&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany."), [Eileen Mayer](https://pubmed.ncbi.nlm.nih.gov/?term=Mayer+E&cauthor_id=42844286)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-5 "Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany."), [Dana Stenger](https://pubmed.ncbi.nlm.nih.gov/?term=Stenger+D&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany."), [Jannika Seiferling](https://pubmed.ncbi.nlm.nih.gov/?term=Seiferling+J&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-5 "Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany."), [Annika E Brien](https://pubmed.ncbi.nlm.nih.gov/?term=Brien+AE&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany."), [Sophia Nikolaides](https://pubmed.ncbi.nlm.nih.gov/?term=Nikolaides+S&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany."), [Paulina Ferrada-Ernst](https://pubmed.ncbi.nlm.nih.gov/?term=Ferrada-Ernst+P&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany."), [Jens Dominik Maile](https://pubmed.ncbi.nlm.nih.gov/?term=Maile+JD&cauthor_id=42844286)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-5 "Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany."), [Binje Vick](https://pubmed.ncbi.nlm.nih.gov/?term=Vick+B&cauthor_id=42844286)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-6 "Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-7 "German Cancer Consortium \(DKTK\), Partner Site Munich, a partnership between DKFZ and University Hospital LMU Munich, Munich, Germany."), [Andreas Carr](https://pubmed.ncbi.nlm.nih.gov/?term=Carr+A&cauthor_id=42844286)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-8 "Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich \(TUM\), Munich, Germany."), [Franziska Blaeschke](https://pubmed.ncbi.nlm.nih.gov/?term=Blaeschke+F&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-9 "German Cancer Research Center \(DKFZ\), Heidelberg, Germany.")[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-10 "Hopp Children's Cancer Center Heidelberg \(KiTZ\), Heidelberg, Germany.")[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-11 "Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany."), [Dirk H Busch](https://pubmed.ncbi.nlm.nih.gov/?term=Busch+DH&cauthor_id=42844286)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-8 "Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich \(TUM\), Munich, Germany.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-12 "German Center for Infection Research \(DZIF\), Partner Site Munich, Munich, Germany."), [Peter Spieler](https://pubmed.ncbi.nlm.nih.gov/?term=Spieler+P&cauthor_id=42844286)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-13 "Chair for Cellular Immunotherapy, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany."), [Thomas Nerreter](https://pubmed.ncbi.nlm.nih.gov/?term=Nerreter+T&cauthor_id=42844286)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-13 "Chair for Cellular Immunotherapy, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany."), [Ramin Lotfi](https://pubmed.ncbi.nlm.nih.gov/?term=Lotfi+R&cauthor_id=42844286)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-14 "Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, Ulm, Germany."), [Martina Rudelius](https://pubmed.ncbi.nlm.nih.gov/?term=Rudelius+M&cauthor_id=42844286)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-15 "Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany."), [Theresa Kaeuferle](https://pubmed.ncbi.nlm.nih.gov/?term=Kaeuferle+T&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-5 "Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-12 "German Center for Infection Research \(DZIF\), Partner Site Munich, Munich, Germany."), [Christoph Klein](https://pubmed.ncbi.nlm.nih.gov/?term=Klein+C&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany.")[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-16 "German Center for Child and Adolescent Health \(DZKJ\), Partner Site Munich, Munich, Germany."), [Gabriele Escherich](https://pubmed.ncbi.nlm.nih.gov/?term=Escherich+G&cauthor_id=42844286)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-17 "Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf \(UKE\), Hamburg, Germany."), [Irmela Jeremias](https://pubmed.ncbi.nlm.nih.gov/?term=Jeremias+I&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-6 "Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-7 "German Cancer Consortium \(DKTK\), Partner Site Munich, a partnership between DKFZ and University Hospital LMU Munich, Munich, Germany."), [Ulrike Burk](https://pubmed.ncbi.nlm.nih.gov/?term=Burk+U&cauthor_id=42844286)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-5 "Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany."), [Tobias Feuchtinger](https://pubmed.ncbi.nlm.nih.gov/?term=Feuchtinger+T&cauthor_id=42844286)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-4 "Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany.")[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-18 "German Cancer Consortium \(DKTK\), Partner Site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-5 "Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.")[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42844286/#full-view-affiliation-12 "German Center for Infection Research \(DZIF\), Partner Site Munich, Munich, Germany.") Affiliations Expand ### Affiliations * 1 Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany. semjon.willier@uniklinik-freiburg.de. * 2 German Cancer Consortium (DKTK), Partner Site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany. semjon.willier@uniklinik-freiburg.de. * 3 Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany. semjon.willier@uniklinik-freiburg.de. * 4 Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, LMU Munich, Munich, Germany. * 5 Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany. * 6 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany. * 7 German Cancer Consortium (DKTK), Partner Site Munich, a partnership between DKFZ and University Hospital LMU Munich, Munich, Germany. * 8 Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany. * 9 German Cancer Research Center (DKFZ), Heidelberg, Germany. * 10 Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. * 11 Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany. * 12 German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. * 13 Chair for Cellular Immunotherapy, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany. * 14 Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, Ulm, Germany. * 15 Institute of Pathology, Ludwig-Maximilians-University of Munich, Munich, Germany. * 16 German Center for Child and Adolescent Health (DZKJ), Partner Site Munich, Munich, Germany. * 17 Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. * 18 German Cancer Consortium (DKTK), Partner Site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany. * PMID: **42844286** * DOI: [ 10.1038/s41467-026-78312-3 ](https://doi.org/10.1038/s41467-026-78312-3) Item in Clipboard # Targeting CD28 on T lineage malignancies with chimeric antigen receptor T cells Semjon Willier et al. Nat Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Nat Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Nat+Commun%22%5Bjour%5D&sort=date&sort_order=
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