---
title: "TH-positive Neurons in RVLM Linked to Electroacupuncture Effects on Intestinal Motility in Constip"
id: "pubmed-42908447"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42908447"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42908447/"
doi: "10.13702/j.1000-0607.20260528"
published_at: "2026-10-25T00:00:00.000Z"
evidence_level: "English Abstract"
license: "CC-BY-NC-4.0 / Informational Use"
---
# TH-positive Neurons in RVLM Linked to Electroacupuncture Effects on Intestinal Motility in Constip
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42908447
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42908447/)
- **DOI:** [10.13702/j.1000-0607.20260528](https://doi.org/10.13702%2Fj.1000-0607.20260528)
- **Published At:** 2026-10-25T00:00:00.000Z
- **Evidence Rating:** English Abstract
## Executive GIST (TL;DR)
- The paper title reports that **TH-positive neurons** in the **rostral ventrolateral medulla** (RVLM) mediate the effect of **electroacupuncture** on **intestinal motility** dysfunction in mice with functional constipation. - The article is published in Zhen Ci Yan Jiu, in Chinese; authors are affiliated with Chengdu University of Traditional Chinese Medicine and its key laboratories and centers. - The source entry on PubMed provides bibliographic metadata: PMID 42908447 and DOI 10.13702/j.1000-0607.20260528. - The PubMed record lists multiple authors (Dan Wang et al.) and institutional affiliations in Chengdu, China; corresponding author contact appears to be Fang Zeng (email listed on PubMed). - The PubMed page, as captured here, did not include an English abstract or trial/methodological details in the visible content; specific experimental methods, sample sizes, dosing, stimulation parameters, outcome measures, statistical results, and endpoints were not reported in the captured source text. - Because the abstract and results are not present in the captured record, the article’s specific findings, quantitative outcomes, and experimental design cannot be independently verified from this source alone. - Key open questions based on the available record include: which experimental models and behavioural/physiologic assays were used, how **electroacupuncture** was applied (acupoints and parameters), how **TH-positive neurons** were identified or manipulated, and the magnitude and reproducibility of any reported effect on **intestinal motility**.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42908447/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42908447/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42908447/#conflict-of-interest) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42908447/#references) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42908447/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42908447/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42908447/#substances) Title & authors Abstract Conflict of interest statement References Publication types MeSH terms Substances Zhen Ci Yan Jiu Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhen+Ci+Yan+Jiu%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhen+Ci+Yan+Jiu%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42908447/) . 2026 Oct 25;51(10):1309-1318. doi: 10.13702/j.1000-0607.20260528. # [TH-positive neurons in the rostral ventrolateral medulla mediating electroacupuncture to improve intestinal motility dysfunction in functional constipated mice] [Article in Chinese] [Dan Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+D&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Zhaoxuan He](https://pubmed.ncbi.nlm.nih.gov/?term=He+Z&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Mingkai Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+M&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Ruohan Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+R&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Xiao Deng](https://pubmed.ncbi.nlm.nih.gov/?term=Deng+X&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Yucai Luo](https://pubmed.ncbi.nlm.nih.gov/?term=Luo+Y&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Yifan Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Y&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Peng Lai](https://pubmed.ncbi.nlm.nih.gov/?term=Lai+P&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Xiaoheng Yao](https://pubmed.ncbi.nlm.nih.gov/?term=Yao+X&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Tao Yin](https://pubmed.ncbi.nlm.nih.gov/?term=Yin+T&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Fang Zeng](https://pubmed.ncbi.nlm.nih.gov/?term=Zeng+F&cauthor_id=42908447)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-4 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. zengfang@cdutcm.edu.cn.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-5 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075. zengfang@cdutcm.edu.cn.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#full-view-affiliation-6 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075. zengfang@cdutcm.edu.cn.") Affiliations Expand ### Affiliations * 1 Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. * 2 Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075. * 3 Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075. * 4 Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. zengfang@cdutcm.edu.cn. * 5 Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075. zengfang@cdutcm.edu.cn. * 6 Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075. zengfang@cdutcm.edu.cn. * PMID: **42908447** * DOI: [ 10.13702/j.1000-0607.20260528 ](https://doi.org/10.13702/j.1000-0607.20260528) Item in Clipboard # [TH-positive neurons in the rostral ventrolateral medulla mediating electroacupuncture to improve intestinal motility dysfunction in functional constipated mice] [Article in Chinese] Dan Wang et al. Zhen Ci Yan Jiu. 2026. Show details Display options Display options Format Abstract PubMed PMID Zhen Ci Yan Jiu Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhen+Ci+Yan+Jiu%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhen+Ci+Yan+Jiu%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42908447/) . 2026 Oct 25;51(10):1309-1318. doi: 10.13702/j.1000-0607.20260528. ### Authors [Dan Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+D&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Zhaoxuan He](https://pubmed.ncbi.nlm.nih.gov/?term=He+Z&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Mingkai Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+M&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Ruohan Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+R&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Xiao Deng](https://pubmed.ncbi.nlm.nih.gov/?term=Deng+X&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Yucai Luo](https://pubmed.ncbi.nlm.nih.gov/?term=Luo+Y&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-1 "Acupuncture-moxibustion and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-2 "Key Laboratory of Acupuncture for Senile Disease, Ministry of Education, Chengdu University of Traditional Chinese Medicine, Chengdu 610075.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#short-view-affiliation-3 "Acupuncture & Brain Research Center, Chengdu University of Traditional Chinese Medicine, Chengdu 610075."), [Yifan Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Y&cauthor_id=42908447)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42908447/#sh
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