---
title: "Topical Resiquimod Primes CD8+ T Cells to Enhance Anti-PD-1 Response in Melanoma"
id: "pubmed-42275481"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42275481"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42275481/"
doi: "10.1158/2326-6066.CIR-25-0998"
published_at: "2026-09-02T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Topical Resiquimod Primes CD8+ T Cells to Enhance Anti-PD-1 Response in Melanoma
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42275481
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42275481/)
- **DOI:** [10.1158/2326-6066.CIR-25-0998](https://doi.org/10.1158%2F2326-6066.CIR-25-0998)
- **Published At:** 2026-09-02T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The Toll‑like receptor (TLR) **7/8 agonist resiquimod** has clinical promise for cutaneous T‑cell lymphoma and actinic keratosis; its mechanism in melanoma was previously unclear. - In preclinical studies reported by Liu et al., **topical resiquimod** significantly inhibited melanoma growth across multiple genetic and syngeneic mouse models. - Topical application of resiquimod prolonged survival in treated mice and reduced **lymph node metastasis** in vivo. - Resiquimod suppressed growth of B16 melanoma in these models; the abstract states this effect was superior to a comparator but the comparator and quantitative results were not reported in the source excerpt. - The study title indicates resiquimod improves **anti‑PD‑1** therapy and acts via priming of **CD8+ T cells**, implying a systemic immune‑mediated antitumor mechanism after topical treatment. - Details on experimental design, dosing, timing, statistical outcomes, full mechanistic evidence, and comparator treatments were not provided in the PubMed abstract excerpt available in the source. - Authors are based primarily at the Perelman School of Medicine, University of Pennsylvania, and The Wistar Institute; full author list and affiliations are reported in the source citation. - PubMed citation: Cancer Immunol Res. 2026 Sep 2;14(9):1496–1509. PMID 42275481. DOI 10.1158/2326-6066.CIR-25-0998. - Where the abstract or page is truncated, the source did not report additional experimental details, full results, or conclusions in the provided excerpt.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42275481/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42275481%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42275481/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42275481/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42275481/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42275481/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42275481/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42275481/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42275481%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42275481%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42275481/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42275481/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42275481/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42275481/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Silverchair Information Systems full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--aacrjournals.org-images-pubmed-canimm_full.gif) Silverchair Information Systems ](https://aacrjournals.org/cancerimmunolres/article-lookup/doi/10.1158/2326-6066.CIR-25-0998 "See full text options at Silverchair Information Systems") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/42275481/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42275481/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42275481/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42275481/#abstract) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42275481/#similar) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42275481/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42275481/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42275481/#related-links) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42275481/#grants) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42275481/#linkout) Title & authors Abstract Similar articles MeSH terms Substances Related information Grants and funding LinkOut - more resources Cancer Immunol Res Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer+Immunol+Res%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cancer+Immunol+Res%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42275481/) . 2026 Sep 2;14(9):1496-1509. doi: 10.1158/2326-6066.CIR-25-0998. # Topical Resiquimod Elicits Systemic Protection and Improves Anti-PD-1 Therapy in Melanoma via Priming of CD8+ T Cells [Shujing Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+S&cauthor_id=42275481)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-1 "Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Alain H Rook](https://pubmed.ncbi.nlm.nih.gov/?term=Rook+AH&cauthor_id=42275481)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-2 "Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Alexander C Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+AC&cauthor_id=42275481)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-3 "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Amit Maity](https://pubmed.ncbi.nlm.nih.gov/?term=Maity+A&cauthor_id=42275481)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-4 "Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Zhiyuan Qin](https://pubmed.ncbi.nlm.nih.gov/?term=Qin+Z&cauthor_id=42275481)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-5 "Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania."), [Yeqing Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Y&cauthor_id=42275481)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-6 "The Wistar Institute , Philadelphia, Pennsylvania."), [Delu Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+D&cauthor_id=42275481)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-7 "Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Yanxiang Deng](https://pubmed.ncbi.nlm.nih.gov/?term=Deng+Y&cauthor_id=42275481)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-1 "Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Zhi Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+Z&cauthor_id=42275481)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-1 "Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Giorgos C Karakousis](https://pubmed.ncbi.nlm.nih.gov/?term=Karakousis+GC&cauthor_id=42275481)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-8 "Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Tara C Mitchell](https://pubmed.ncbi.nlm.nih.gov/?term=Mitchell+TC&cauthor_id=42275481)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-3 "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Ravi K Amaravadi](https://pubmed.ncbi.nlm.nih.gov/?term=Amaravadi+RK&cauthor_id=42275481)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-3 "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Lynn M Schuchter](https://pubmed.ncbi.nlm.nih.gov/?term=Schuchter+LM&cauthor_id=42275481)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-3 "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Zev A Binder](https://pubmed.ncbi.nlm.nih.gov/?term=Binder+ZA&cauthor_id=42275481)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-9 "Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Donald M O'Rourke](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Rourke+DM&cauthor_id=42275481)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-9 "Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Meenhard Herlyn](https://pubmed.ncbi.nlm.nih.gov/?term=Herlyn+M&cauthor_id=42275481)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-6 "The Wistar Institute , Philadelphia, Pennsylvania."), [Wei Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+W&cauthor_id=42275481)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-5 "Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania."), [Xiaowei Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+X&cauthor_id=42275481)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#full-view-affiliation-1 "Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.") Affiliations Expand ### Affiliations * 1 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 2 Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 3 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 4 Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 5 Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania. * 6 The Wistar Institute , Philadelphia, Pennsylvania. * 7 Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 8 Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 9 Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * PMID: **42275481** * DOI: [ 10.1158/2326-6066.CIR-25-0998 ](https://doi.org/10.1158/2326-6066.cir-25-0998) Item in Clipboard # Topical Resiquimod Elicits Systemic Protection and Improves Anti-PD-1 Therapy in Melanoma via Priming of CD8+ T Cells Shujing Liu et al. Cancer Immunol Res. 2026. Show details Display options Display options Format Abstract PubMed PMID Cancer Immunol Res Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cancer+Immunol+Res%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Cancer+Immunol+Res%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42275481/) . 2026 Sep 2;14(9):1496-1509. doi: 10.1158/2326-6066.CIR-25-0998. ### Authors [Shujing Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+S&cauthor_id=42275481)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-1 "Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Alain H Rook](https://pubmed.ncbi.nlm.nih.gov/?term=Rook+AH&cauthor_id=42275481)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-2 "Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Alexander C Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+AC&cauthor_id=42275481)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-3 "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Amit Maity](https://pubmed.ncbi.nlm.nih.gov/?term=Maity+A&cauthor_id=42275481)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-4 "Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Zhiyuan Qin](https://pubmed.ncbi.nlm.nih.gov/?term=Qin+Z&cauthor_id=42275481)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-5 "Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania."), [Yeqing Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Y&cauthor_id=42275481)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-6 "The Wistar Institute , Philadelphia, Pennsylvania."), [Delu Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+D&cauthor_id=42275481)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-7 "Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Yanxiang Deng](https://pubmed.ncbi.nlm.nih.gov/?term=Deng+Y&cauthor_id=42275481)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-1 "Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Zhi Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+Z&cauthor_id=42275481)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-1 "Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Giorgos C Karakousis](https://pubmed.ncbi.nlm.nih.gov/?term=Karakousis+GC&cauthor_id=42275481)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-8 "Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Tara C Mitchell](https://pubmed.ncbi.nlm.nih.gov/?term=Mitchell+TC&cauthor_id=42275481)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-3 "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Ravi K Amaravadi](https://pubmed.ncbi.nlm.nih.gov/?term=Amaravadi+RK&cauthor_id=42275481)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-3 "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Lynn M Schuchter](https://pubmed.ncbi.nlm.nih.gov/?term=Schuchter+LM&cauthor_id=42275481)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-3 "Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Zev A Binder](https://pubmed.ncbi.nlm.nih.gov/?term=Binder+ZA&cauthor_id=42275481)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-9 "Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Donald M O'Rourke](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Rourke+DM&cauthor_id=42275481)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-9 "Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania."), [Meenhard Herlyn](https://pubmed.ncbi.nlm.nih.gov/?term=Herlyn+M&cauthor_id=42275481)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-6 "The Wistar Institute , Philadelphia, Pennsylvania."), [Wei Guo](https://pubmed.ncbi.nlm.nih.gov/?term=Guo+W&cauthor_id=42275481)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-5 "Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania."), [Xiaowei Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+X&cauthor_id=42275481)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42275481/#short-view-affiliation-1 "Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.") ### Affiliations * 1 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 2 Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 3 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 4 Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 5 Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania. * 6 The Wistar Institute , Philadelphia, Pennsylvania. * 7 Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 8 Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * 9 Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. * PMID: **42275481** * DOI: [ 10.1158/2326-6066.CIR-25-0998 ](https://doi.org/10.1158/2326-6066.cir-25-0998) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract The Toll-like receptor (TLR) 7/8 agonist resiquimod shows promise for treating cutaneous T-cell lymphoma and actinic keratosis, yet its mechanism of action remains unclear. We demonstrated that topical resiquimod significantly inhibited melanoma growth across various genetic and syngeneic mouse models, prolonged survival, and reduced lymph node metastasis in vivo. Resiquimod suppressed B16 melanoma growth, with an effect superior to that of
## Related Clinical Research

- [Inferring tumor kinetics from single routine H&E biopsies to run virtual radiotherapy trials](https://medichelpline.com/clinical-feed/medrxiv-9-effective-tumor-kinetics-inferred-from-single-routine-h-e-biopsies-enable.md)
- [PANoptosis in Diabetes and Complications: Mechanisms, Evidence Gaps, and Therapeutic Prospects](https://medichelpline.com/clinical-feed/frontiers-in-immunology-18-the-role-of-panoptosis-in-diabetes-and-its-complications-mechanisms-and.md)
- [CXCR4 and PD-1 blockade overcomes stroma-driven T-cell exclusion and exhaustion in PDAC 3D models](https://medichelpline.com/clinical-feed/frontiers-in-immunology-17-targeting-stroma-mediated-t-cell-exclusion-and-functional-exhaustion-in.md)
- [Narrow-band TL-01 Phototherapy and Skin Cancer Risk: Nested Case–Control Analysis](https://medichelpline.com/clinical-feed/pubmed-42713961.md) (DOI: 10.2340/actadv.v106.adv-2025-0274)
- [Receptor-guided targeting of a melanoma-enriched noncanonical antigen (EVA003)](https://medichelpline.com/clinical-feed/pubmed-42706244.md) (DOI: 10.1038/s41392-026-02961-5)

## Navigation
- [← Back to Pharmacology Feed](https://medichelpline.com/clinical-feed/pharmacology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.