---
title: "Ultrasound‑Guided Pulsed Radiofrequency Plus Platelet‑Rich Plasma for Complex Regional Pain Syndro"
id: "pubmed-42660844"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42660844"
content_type: "clinical_feed_article"
specialty: "Pharmacology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42660844/"
doi: "10.3881/j.issn.1000-503X.17212"
published_at: "2026-08-30T00:00:00.000Z"
evidence_level: "Case Reports"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Ultrasound‑Guided Pulsed Radiofrequency Plus Platelet‑Rich Plasma for Complex Regional Pain Syndro
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42660844
- **Specialty:** [Pharmacology](https://medichelpline.com/clinical-feed/pharmacology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42660844/)
- **DOI:** [10.3881/j.issn.1000-503X.17212](https://doi.org/10.3881%2Fj.issn.1000-503X.17212)
- **Published At:** 2026-08-30T00:00:00.000Z
- **Evidence Rating:** Case Reports
## Executive GIST (TL;DR)
- Case report of a 26‑year‑old female who developed bilateral first‑toe severe, electric shock‑like pain and **hyperalgesia** after ankle sprain, with localized redness, swelling, burning sensation and **hyperhidrosis** consistent with **complex regional pain syndrome (CRPS)**. - Initial oral neuropathic pain medications were ineffective. - Intervention: ultrasound‑guided pulsed radiofrequency (PRF) applied to the medial plantar nerve combined with a platelet‑rich plasma (PRP) injection. - Postoperative course showed progressive symptom improvement; by 1 month postprocedure pain score reached 0 and autonomic signs (redness, swelling, abnormal sweating) had completely resolved. - No recurrence reported during a 6‑month postoperative follow‑up. - Authors: Qing Yuan, Jin Wang, Yi Zhang, Xu‑Lei Cui; affiliations include the Department of Anesthesiology at Peking Union Medical College Hospital and Xinxiang Central Hospital, China. - Publication details: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2026 Aug 30;48(4):751–754. PMID 42660844; DOI 10.3881/j.issn.1000-503X.17212. - Keywords highlighted by the report: **complex regional pain syndrome**, **platelet‑rich plasma**, **pulsed radiofrequency**. - Limitations: single‑patient case report; procedural specifics (exact PRF settings, PRP preparation protocol, analgesic regimen details) are not reported in the abstract.
## Clinical Analysis & Structured Key Points
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Affiliations Expand ### Affiliations * 1 Department of Anesthesiology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China. * 2 Department of Anesthesiology，Xinxiang Central Hospital （East Campus），Xinxiang，Henan 453000，China. * PMID: **42660844** * DOI: [ 10.3881/j.issn.1000-503X.17212 ](https://doi.org/10.3881/j.issn.1000-503x.17212) Item in Clipboard Case Reports # Ultrasound-Guided Peripheral Nerve Pulsed Radiofrequency Combined With Platelet-Rich Plasma Injection for Complex Regional Pain Syndrome：Report of One Case Qing Yuan et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2026. Show details Display options Display options Format Abstract PubMed PMID Zhongguo Yi Xue Ke Xue Yuan Xue Bao Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhongguo+Yi+Xue+Ke+Xue+Yuan+Xue+Bao%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42660844/) . 2026 Aug 30;48(4):751-754. doi: 10.3881/j.issn.1000-503X.17212. ### Authors [Qing Yuan](https://pubmed.ncbi.nlm.nih.gov/?term=Yuan+Q&cauthor_id=42660844)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660844/#short-view-affiliation-1 "Department of Anesthesiology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China."), [Jin Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+J&cauthor_id=42660844)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660844/#short-view-affiliation-1 "Department of Anesthesiology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China."), [Yi Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Y&cauthor_id=42660844)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42660844/#short-view-affiliation-2 "Department of Anesthesiology，Xinxiang Central Hospital （East Campus），Xinxiang，Henan 453000，China."), [Xu-Lei Cui](https://pubmed.ncbi.nlm.nih.gov/?term=Cui+XL&cauthor_id=42660844)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42660844/#short-view-affiliation-1 "Department of Anesthesiology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China.") ### Affiliations * 1 Department of Anesthesiology，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China. * 2 Department of Anesthesiology，Xinxiang Central Hospital （East Campus），Xinxiang，Henan 453000，China. * PMID: **42660844** * DOI: [ 10.3881/j.issn.1000-503X.17212 ](https://doi.org/10.3881/j.issn.1000-503x.17212) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract in [ English, ](https://pubmed.ncbi.nlm.nih.gov/42660844/#eng-abstract) [ Chinese ](https://pubmed.ncbi.nlm.nih.gov/42660844/#zho-abstract) Complex regional pain syndrome is a refractory disease characterized by complex pathogenesis，severe chronic pain，and autonomic nervous system dysfunction.This article reports a 26-year-old female patient who presented with severe，electric shock-like pain and hyperalgesia in the first toes of both feet following an ankle sprain.In addition，her symptoms included localized redness，swelling，burning sensation，and hyperhidrosis.She was clinically diagnosed with complex regional pain syndrome.After oral pharmacotherapy for neuropathic pain proved ineffective，she was treated with ultrasound-guided pulsed radiofrequency of the medial plantar nerve combined with platelet-rich plasma injection.Postoperative follow-up showed progressive symptom alleviation.One month after the procedure，the pain score decreased to 0，and autonomic symptoms such as local redness，swelling，and abnormal sweating were completely resolved.No recurrence was observed during the six-month postoperative follow-up period. 复杂性区域疼痛综合征是一种发病机制复杂、以严重慢性疼痛及自主神经功能障碍为特征的难治性疾病。本文报道1例26岁女性患者，在双踝扭伤后出现双足第一足趾剧烈电击样痛、痛觉过敏，并伴有局部红肿、烧灼感及多汗等典型症状，临床确诊为复杂性区域疼痛综合征。经口服神经病理性疼痛药物治疗无效，采用超声引导下足底内侧神经脉冲射频联合富血小板血浆注射治疗。术后随访显示患者症状呈进行性改善，至术后1个月时疼痛评分降至0分，局部红肿、异常出汗等自主神经症状完全消失，且术后随访6个月均无复发。. **Keywords:** complex regional pain syndrome; platelet-rich plasma; pulsed radiofrequency. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ [Ultrasound-guided pulsed and thermal radiofrequency in a patient with neuropathic pain after total ankle arthroplasty: a clinical case]. ](https://pubmed.ncbi.nlm.nih.gov/42229091/) Esteban Vado M, Abdelkader Azirar M, Martínez Luna MB, Pascual Fidalgo C.Esteban Vado M, et al.Rehabilitacion (Madr). 2026 Apr-Jun;60(2):100991. doi: 10.1016/j.rh.2026.100991. Epub 2026 Jun 2.Rehabilitacion (Madr). 2026.PMID: 42229091Spanish. * [ The Efficacy and Safety of Applying the Combination of Pulsed Radiofrequency and Platelet-Rich Plasma to the Gasserian Ganglion for the Treatment of Idiopathic Trigeminal Neuralgia: A Protocol for a Multi-Center, Prospective, Open-Label, Propensity Score Match Cohort Study. ](https://pubmed.ncbi.nlm.nih.gov/40464894/) Ren T, Xia L, Zheng Y, Yang Y, Ji N, Luo F.Ren T, et al.Pain Physician. 2025 May;28(3):E263-E270.Pain Physician. 2025.PMID: 40464894 * [ Pulsed Radiofrequency of Dorsal Root Ganglia for the Treatment of Complex Regional Pain Syndrome in an Adolescent with Poliomyelitis Sequel: A Case Report. ](https://pubmed.ncbi.nlm.nih.gov/25688583/) Apiliogullari S, Aydin BK, Onal O, Kirac Y, Celik JB.Apiliogullari S, et al.Pain Med. 2015 Jul;16(7):1369-72. doi: 10.1111/pme.12710. Epub 2015 Feb 17.Pain Med. 2015.PMID: 25688583 * [ Platelet-rich plasma for the treatment of coccydynia: a case report and review of regenerative medicine for coccydynia. ](https://pubmed.ncbi.nlm.nih.gov/31960759/) Sussman WI, Jerome MA, Foster L.Sussman WI, et al.Regen Med. 2019 Dec;14(12):1151-1154. doi: 10.2217/rme-2019-0102. Epub 2020 Jan 21.Regen Med. 2019.PMID: 31960759Review. * [ Clinical Radiofrequency Ablation Outcomes of Combined Sensory Nerve Branch and Dorsal Entry Root Zone Complex Lesions for Sacroiliac Joint Complex Pain. ](https://pubmed.ncbi.nlm.nih.gov/35678997/) Sam J, Pastrak M, Duda L, Vladicic N, Vrooman B, Ma F, Khandwalla F, Abd-ElSayed A, Catapano M, McGilvray S, Khan JS, Visnjevac O.Sam J, et al.Adv Ther. 2022 Aug;39(8):3539-3546. doi: 10.1007/s12325-022-02183-5. Epub 2022 Jun 9.Adv Ther. 2022.PMID: 35678997Review. 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