by Jinpeng Cong, Rui Hu, Jinyan Ren, Xinfeng Wang, Na Li, Ying Sun Background Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity worldwide. Early vascular aging (EVA) is an independent predictor of cardiovascular risk in young and middle-aged adults.
The plausible association between EVA and vitamin D warrants further investigation. Methods This study examined the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and EVA in young and middle-aged healthy adults.This cross-sectional study included 2047 eligible participants who underwent physical examinations at the Health Management Center of the Affiliated Hospital of Qingdao University between May 2023 and May 2025.
Participants were categorized into EVA group (n = 687) and control group (n = 1360) based on brachial ankle pulse wave velocity (baPWV). Logistic regression and restricted cubic splines assessed the association between 25(OH)D and EVA, with an inflection point identified using two-piecewise linear regression.
Subgroup analyses and interaction tests were conducted by age, sex, blood collection month, smoking status, alcohol drinking status, hypertension, diabetes, and body mass index (BMI). Results The prevalence of EVA was 33.56%.
PLOS ONE (Medicine) published a clinical update in Research Highlights on 20 May 2026.
The item focuses on Association between serum 25-hydroxyvitamin D levels and Early Vascular Aging in young and middle-aged adults.
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